MAJOR DEPRESSIVE DISORDER

This study tests deep brain stimulation (DBS) in 20 people with severe depression that hasn't improved with other treatments. The device delivers electrical pulses to a brain region called the subcallosal cingulate, which may reset mood circuits. Researchers will record brain sig…

This study tests whether valbenazine can reduce involuntary muscle movements (tardive dyskinesia) in adults who still have symptoms while taking or after stopping another similar drug. About 50 people with schizophrenia, bipolar disorder, or major depression will take valbenazine…

This early study tests if deep brain stimulation (DBS) is safe and effective for people with severe depression that hasn't improved with other treatments. Twenty adults will have a device implanted in their brain and be monitored for five years. The device will be turned on and o…

This study tests whether using a person's genetic information to guide medication choices leads to better recovery for people with mood, anxiety, or psychotic disorders. Over 2,500 participants will receive either standard care or personalized medication advice based on their gen…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study tests a long-acting injection of cariprazine given once a month, instead of daily pills, for people with schizophrenia, bipolar I disorder, or major depression. The trial involves 24 clinically stable adults and will check safety, side effects, and how well the drug wo…

This study tests whether reducing the frequency of rTMS sessions can maintain the antidepressant effect in people with treatment-resistant depression who already responded to daily rTMS. 75 participants will receive either standard maintenance, clustered, or sham rTMS over 6 mont…

This Phase 3 study tests whether adding NBI-1065845 to standard antidepressants can delay the return of depressive symptoms in adults with major depression. About 550 people who have not fully responded to current antidepressants will take either the study drug or a placebo pill.…

This study tests whether giving stronger medications earlier can help people with schizophrenia, major depression, or bipolar depression who did not get better with their first treatment. Over 1,200 participants will receive either standard second-line treatment or an intensified…

This study tests whether giving e-cigarettes to smokers with mental illness—along with optional behavioral coaching—helps them switch from regular cigarettes and lower their exposure to harmful chemicals. The trial enrolls 250 daily smokers who have tried to quit before but aren'…

This study tests a program called Taking Action, where trained peers help college students with serious mental illnesses like depression, bipolar disorder, or schizophrenia learn to manage their condition. About 300 students will be randomly assigned to either the program or just…

This study tests whether long-term use of ketamine (given by IV) followed by esketamine (a nasal spray) can reduce suicide risk in people with major depression who are at high risk. One hundred adults hospitalized for depression will receive up to 8 ketamine infusions, then 13 we…

This study is testing whether combining internet-based cognitive behavioural therapy (i-CBT) with intravenous ketamine can quickly reduce suicidal thoughts and behaviors in people with treatment-resistant depression. All 110 participants will receive weekly i-CBT for 13 weeks, an…

This study tests simple methods to help adults with depression take their antidepressant medication regularly. Researchers will use electronic pill bottles to track adherence and measure depression symptoms over 12 weeks. The goal is to find practical ways to improve both medicat…

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation teletherapy plus a non-SSRI antidepressant, or the antidepressant plus teletherap…

This study in Zimbabwe tests whether adding antidepressants (fluoxetine or sertraline) to a proven talk therapy program (Friendship Bench) works better than talk therapy alone for adults with moderate to severe depression. About 296 participants will be randomly assigned to one o…

This study compares a new, lower-energy seizure therapy (LAP-ST) to standard electroconvulsive therapy (ECT) for quickly reducing suicidal thoughts in people with depression, bipolar disorder, or schizoaffective disorder. The goal is to see if the gentler approach works just as w…

This study tests whether clemastine, a common antihistamine, can improve brain white matter and make antidepressants work better for adults over 60 with depression. Eighty participants will receive either clemastine or a placebo alongside their antidepressant. The goal is to see …

This study tests whether wearing a headset that delivers a flickering 60Hz white light for 30 minutes a day can help ease depression symptoms. Adults with major depressive disorder will use the device at home for three weeks. Researchers will measure how well people stick with th…

This phase 3 study is testing an oral drug called DT120 (related to LSD) against a placebo in 165 adults with major depressive disorder. Participants will take the drug or placebo for 12 weeks, followed by a 40-week period where everyone can receive DT120. The main goal is to see…

This study tests whether a noninvasive brain stimulation technique called tDCS can reduce depression in people with multiple sclerosis. Participants use a headband-like device at home for 30 minutes a day over 30 days, while listening to mindfulness meditation. Half receive real …

This study is testing whether a single session that combines two types of brain stimulation (TMS and tACS) with psychotherapy can safely and feasibly help people with major depression that hasn't improved with standard treatments. The researchers will enroll 30 adults aged 18-70 …

This Phase 3 trial is testing whether an experimental drug called NBI-1065845 can help reduce depression symptoms in adults who haven't responded well to standard antidepressants. About 200 participants will take either the drug or a placebo alongside their current antidepressant…

This study tests an experimental oral drug called CYB003 in 220 adults with major depressive disorder. Participants receive either CYB003 or a placebo alongside their usual treatment. The goal is to see if CYB003 safely reduces depression symptoms better than placebo.

This Phase 3 study is testing the long-term safety of an experimental drug called NBI-1065845 (TAK-653) in 850 adults with major depressive disorder who haven't gotten enough relief from standard antidepressants. Participants take the drug alongside their usual antidepressant for…

This study tests whether using a gentle brain stimulation device (tDCS) twice a day at home can help people with depression who are not on medication. Thirty participants will be split into three groups: one gets real stimulation, one gets a sham (placebo) device, and one waits w…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce depression symptoms in people who have had a heart attack or related heart problem and a stent placed. About 120 adults will use the device at home for 8 weeks, and their mood…

This study compares two drugs, pramipexole and escitalopram, to treat major depression in people with HIV. Some participants also have mild memory or thinking problems. The goal is to see which medication is safer and more effective at easing depression symptoms. About 186 adults…

This study looks at whether adding a magnesium supplement (magnesium bisglycinate) to standard antidepressant medication can help adults with major depression feel better. About 84 people aged 18-65 who are already on a stable antidepressant will receive either the supplement or …

This study tests an experimental drug, icalcaprant, for adults with major depressive disorder who are currently having a depressive episode. About 195 participants will take either the drug or a placebo daily for 6 weeks. Researchers will measure changes in depression symptoms an…

This study tests a non-invasive brain stimulation technique called tACS to treat anhedonia (loss of interest or pleasure) in people aged 60 and older with major depression. Eighty participants will receive either real or sham stimulation over two weeks, with follow-up at three mo…

This study tests a smartphone app that shares stories from teens who have overcome suicidal thoughts. The goal is to see if these stories help other at-risk teens feel less suicidal and more connected. The study involves 46 adolescents in The Bronx who have had recent suicidal th…

This study looks at whether two different exercise programs can help reduce depression in people with multiple sclerosis (MS) who also have major depressive disorder. Researchers will enroll 146 adults aged 18 to 64. One group will do a structured exercise program, while the othe…

This Phase 2 trial tests whether TNX-102 SL, a tablet taken under the tongue at bedtime, can improve depression symptoms in adults with moderate to severe major depressive disorder. About 360 participants will receive either the drug or a placebo nightly for 6 weeks. Researchers …

This study tests an experimental drug called azetukalner in 450 adults with moderate-to-severe major depression. Participants take the drug or a placebo daily for 6 weeks to see if it reduces depression symptoms like low mood and loss of pleasure. The goal is to find a new treatm…

This study tests a new type of transcranial magnetic stimulation called theta burst stimulation (TBS) to see if it can reduce suicidal thoughts in adolescents aged 12-18 with major depressive disorder. Participants receive TBS over 10 days and are followed for one year. The goal …

This study tests whether giving flumazenil, a drug that reverses the effects of benzodiazepines, right before electroconvulsive therapy (ECT) can reduce cognitive side effects like memory loss in hospitalized patients with depression. About 145 participants will either continue t…

This study looks at how Behavioral Activation (BA) therapy affects the brains of depressed teenagers. 136 teens aged 15-17 with depression will receive up to 16 therapy sessions focused on increasing rewarding activities. Researchers will use brain scans (fMRI) to see if BA thera…

This study tests whether a new oral drug called zelquistinel can reduce depression symptoms in adults with major depressive disorder. Participants take one tablet weekly for 6 weeks and have their depression severity checked at each clinic visit. The trial compares the drug again…

This study tests a new oral drug called zelquistinel to see if it can reduce symptoms of major depressive disorder in adults. About 164 people aged 18 to 64 will take either the drug or a placebo once a week for 6 weeks. Researchers will measure changes in depression severity usi…

This study tests an accelerated form of transcranial magnetic stimulation (TMS) for people with major depression that hasn't improved with medication. Over five days, 35 adults will receive multiple sessions of targeted brain stimulation. Researchers will track changes in depress…

This study tests whether a daily medication called vortioxetine can safely reduce depression symptoms in Japanese teenagers aged 12 to 17 with major depressive disorder. About 180 participants will receive either the drug or a placebo for 14 weeks, with follow-up for 4 more weeks…

This Phase 2 trial tests LV232, a new capsule for major depressive disorder, in 400 adults aged 18-65. Participants are randomly assigned to receive one of two doses of LV232, the active comparator escitalopram, or a placebo for 8 weeks. The main goal is to find the best dose and…

This study is testing whether psilocybin (the active ingredient in magic mushrooms) combined with therapy is safe and helpful for people with non-small cell lung cancer who also have major depression. Ten participants will receive psilocybin in a controlled setting along with cou…

This study tests whether taking D-serine (an amino acid) before transcranial magnetic stimulation (TMS) can improve depression symptoms more than TMS alone. Sixty adults with major depressive disorder will receive either D-serine or a placebo before TMS sessions for six weeks. Th…

This study looks at people with depression that hasn't improved with other treatments. If they don't get better after four sessions of one type of ECT (right unilateral), they will either continue with that type or switch to another type (bitemporal). The goal is to see which app…

This study looks at whether the antidepressant vortioxetine can help people who suffer from both depression and migraine. Researchers will track 31 adults over 12 weeks to see if their mood and headache symptoms improve. The goal is to find a treatment that works for both conditi…

This phase 3 trial tests whether adding a low dose of ketamine to electroconvulsive therapy (ECT) can better relieve depression and reduce memory problems in people with treatment-resistant major depressive disorder. Thirty hospitalized adults will receive either ketamine or a pl…

This study is testing two types of talk therapy for major depression: supportive-expressive therapy and emotion-focused therapy. The goal is to see if people do better when the therapy matches their personal style—whether they tend to think deeply about their problems (insight) o…

This study compares a blended group therapy (online and in-person sessions) to standard in-person group therapy for adults with anxiety or depression. About 144 participants will receive 16 weeks of treatment. The goal is to see if the blended approach works as well and is accept…

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training to help improve mood and thinking skills. About 120 adults with moderate to severe depre…

This study tests whether an 8-week mindful self-compassion program can reduce symptoms of anxiety and depression. It compares attending the program in person versus through videoconference. The study involves 80 adults diagnosed with anxiety disorders or major depression who also…

This study looks at whether a 16-week resistance exercise program can reduce symptoms of major depression in 200 adults. Participants will do either high or low dose strength training. Researchers will measure changes in mood, thinking, and blood flow in the brain to see if exerc…

This study tests a new approach for treating depression in people who have had a mild traumatic brain injury (concussion). Participants will receive a personalized cognitive training program combined with either real or sham brain stimulation over 4 weeks. The goal is to see if t…

This study tests a smartphone app that prompts people with depression to reach out to friends or family for support at the right moments. Over 21 days, 120 adults awaiting therapy will be randomly assigned to different versions of the app or no app at all. The goal is to see if t…

This study tests whether tocilizumab, a drug that blocks inflammation, can help people with major depression who have lost interest or pleasure in things (anhedonia). About 20 adults with depression and signs of immune activation will receive the drug for 8 weeks, while 20 health…

This study tests a new, non-invasive brain stimulation technique called temporal interference stimulation (TIS) to see if it can reduce non-suicidal self-injury (like cutting) in adolescents with major depression. About 60 teens aged 12-22 will receive either real TIS or a sham t…

This study tests whether a keto-like supplement, taken as a drink three times daily for 8 weeks, changes brain activity in people with moderate to severe depression. Researchers will use brain scans to compare the supplement to a placebo in 75 adults. The goal is to see if the su…

This study tests whether peer recovery specialists—people who have themselves recovered from mental health or substance use problems—can effectively deliver a therapy called behavioral activation to reduce depression and substance use. The trial will enroll 250 low-income adults …

This study tests whether a single 25 mg dose of psilocybin can relieve major depression in 100 adults with cancer, compared to a very low 1 mg dose. Participants must be 20–80 years old, have had depression for at least a month after their cancer diagnosis, and stop other antidep…

This study tests whether a type of talk therapy called Interpersonal Psychotherapy (IPT), delivered in groups by trained non-specialists, can reduce depressive symptoms in young adults aged 18-24 in Porto Alegre, Brazil. Half of the 50 participants will receive the 8-week group t…

This early study tests a new, personalized brain stimulation method (tACS) for depression during pregnancy. Ten women (5 with depression and 5 healthy) will receive the treatment to see if it is safe, tolerable, and practical. The goal is to gather initial data to guide larger fu…

This study aims to find the best dose of a safe, non-invasive brain stimulation technique called accelerated TMS to improve both depression and thinking skills in people aged 60-85 with mild cognitive impairment and depression. About 60 participants will receive different doses o…

This study aims to find out whether DMT, a psychedelic drug, helps with depression because of the 'trip' itself or because of biological changes in the brain. 112 adults with major depression will receive DMT or a placebo, and some will also be sedated with propofol to block the …

This study is testing whether a structured breathing practice is a practical and acceptable option for teenagers aged 12 to 17 who have been diagnosed with anxiety or depression. The program, called Seokmun Hoheup, starts with 15-minute sessions and gradually increases to 36 minu…

This study tests whether a 9-week therapy called Engage & Connect can improve brain function related to social reward and reduce suicidal thoughts in older adults with depression. Researchers will use brain scans to measure changes in key brain networks. The study involves 128 pe…

This study is testing whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) applied to the cerebellum can improve cognitive deficits and mood in people with schizophrenia, autism, bipolar disorder, depression, or Parkinson's…

This study tests whether a non-invasive brain stimulation technique called rTMS can safely and effectively reduce depression in autistic youth aged 16-24. Eighty participants will receive either real or sham rTMS over 30 sessions. The goal is to see if this approach, already used…

This study compares two brain stimulation treatments—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—in 200 people with major depression. The goal is to see which one works better and has fewer side effects. Participants must be 12 to 80 years old and on a stab…

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can improve pain and depression in people with knee osteoarthritis. Thirty adults aged 50 and older with chronic knee pain and moderate to severe depression will receive rTMS while also ta…

This study tests whether guanfacine, a medication typically used for blood pressure, can improve brain network function and reduce cognitive problems in people with depression. Researchers will enroll 162 adults aged 18-60 who are currently experiencing a major depressive episode…

This study is testing a safe, non-invasive treatment called rTMS (repetitive transcranial magnetic stimulation) for depression in people with spinal cord injury. Fourteen adults with a spinal cord injury and major depression will receive daily rTMS sessions for four weeks. The go…

This study tests whether real-time brain feedback can help people with major depression. Participants learn to increase activity in the amygdala, a brain region linked to emotion, by recalling positive memories. The goal is to see if this training can reduce depressive symptoms a…

This study looks at whether doing moderate aerobic exercise right before a therapy session (CBT) helps people with major depression get more out of their treatment. One hundred adults will be randomly assigned to either exercise or rest quietly before each of 8 weekly therapy ses…

This study tests whether a device that shines 40 Hz flickering light can help reduce depression symptoms. Sixty adults with major depression will use the device at home for one hour each day over six weeks. Half will get the active flickering light, and half will get a sham light…

This study tests whether taking omega-3 (EPA) supplements for 12 weeks can reduce depressive symptoms in overweight or obese adults who have depression and low omega-3 levels. Half of the 50 participants will receive EPA, and half will receive a placebo. Researchers will also loo…

This study tests a new, faster version of a brain stimulation treatment called TMS for people with depression or OCD. Instead of daily sessions for weeks, participants get 10 hours of TMS each day for just 5 days. The goal is to see if this quick approach can improve symptoms and…

This study tests whether advancing sleep timing (going to bed and waking up earlier) can improve depression symptoms. 150 adults with moderate to severe depression, recently discharged from a psychiatric ward, will either receive usual care or a psychotherapeutic program focused …

This study tests whether using a brain scan (fMRI) to guide magnetic stimulation (rTMS) can better treat depression that hasn't improved with medication. About 348 adults aged 22-65 with major depression will receive rTMS, and researchers will track changes in depression scores. …

This study tests an experimental drug called GM-2505 in people with major depressive disorder. Participants receive two doses of the drug two weeks apart. The study has three parts: one for people not on antidepressants, one for those partially responding to current treatment, an…

This study tests whether shining near-infrared light on the forehead can change blood flow in the brains of people with major depression. Researchers will measure brain activity using fMRI and track mood changes with a standard depression questionnaire. The goal is to see if this…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help improve mood in people with major depression who are also overweight or obese. Over 26 weeks, 116 participants will receive either semaglutide or a placebo added to their usual depression tre…

This study is for teenagers aged 13 to 18 with depression that hasn't gotten better after their first treatment. It will test different common antidepressants to find which one works best next. The goal is to help teens feel better and provide doctors with clear evidence on what …

This study tests whether adjusting the electrical amplitude of ECT (electroconvulsive therapy) to each person can better treat depression and reduce memory problems. Researchers will compare a personalized amplitude approach to the standard fixed 800 mA setting in 50 older adults…

This study looks at whether omega-3 fatty acids can reduce depression symptoms in young people aged 12-25 with major depressive disorder. Over 12 weeks, 60 participants will take either omega-3 supplements or a placebo. Researchers will track mood changes, gut bacteria, and blood…

This study tests a program called 'Need to Be Needed' (N2BN) that uses volunteering to help adults with serious mental illness feel more connected and less lonely. 120 participants will either join the volunteering program or receive weekly listening support. Researchers will mea…

This study tests whether adding ABX-002 to a current antidepressant can improve symptoms in adults with moderate to severe major depression. About 230 participants will receive either ABX-002 or a placebo for 6 weeks, with follow-up for up to 6 months. The goal is to see if ABX-0…

This pilot study tests a 12-week therapy called Integrated Suicide and Trauma Therapy (ISTT) in 20 adults with a history of childhood trauma and current suicidal thoughts. The therapy combines coping skills training with trauma-focused treatment to address both suicide risk and t…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study tests whether adding a low dose of esketamine (a fast-acting anesthetic) to standard electroconvulsive therapy (ECT) can improve depression outcomes in adolescents aged 13-17 with severe depression. About 220 participants will be randomly assigned to receive either esk…

This study tests whether adding a 12-week exercise program (daily walking plus two weekly combined aerobic and strength sessions) to standard antidepressant treatment can improve depression symptoms in 124 adults with major depressive disorder. Researchers will also use brain sca…

This study tests a 12-session group program called 'Better Together' for young adults with severe mental illness (like schizophrenia, bipolar disorder, or major depression) who are single and want to improve their romantic relationships. The program teaches communication, emotion…

This study is testing whether structured nature-based tourism activities can improve symptoms of major depressive disorder. Researchers will compare an intervention group that takes part in these activities with a control group receiving usual care, while both groups continue the…

This study tests whether fampridine, a drug used for walking problems in multiple sclerosis, can improve working memory in people with mild to moderate depression. About 38 adults will receive both fampridine and a placebo in random order to see if the drug helps them perform bet…

This small study tests whether empagliflozin (Jardiance), a diabetes medication, can reduce symptoms of major depression. The drug helps the body produce ketones, which may provide an alternative energy source for the brain. Sixteen adults with moderate to severe depression will …

This Phase 3 trial tests whether adding NBI-1065845 to standard antidepressants can better ease depression symptoms in 200 adults who haven't fully responded to current treatments. Participants take the drug or a placebo for 8 weeks, and doctors measure changes in mood and daily …

This study is for adults aged 22-65 with major depression that hasn't improved with other treatments. Researchers want to see if giving psilocybin (the active ingredient in magic mushrooms) followed by a quick, focused brain stimulation technique is safe and can help reduce depre…

This study tests whether heart rate data can help guide a non-invasive brain stimulation technique called tDCS for people with mild to moderate depression. One hundred participants will receive either real or sham tDCS at home over 10 sessions. Researchers will monitor heart rate…

This study looks at whether combining two common therapy techniques—changing negative thoughts and practicing detached mindfulness—works better than using them alone for people with anxiety or depression. Researchers will compare the effects of each technique and their order. The…

This study tests whether dapagliflozin, a drug normally used for diabetes, can help reduce depression symptoms when added to standard antidepressant treatment. Sixty adults with moderate to severe depression will receive either dapagliflozin plus fluoxetine or fluoxetine alone. T…

This study tests a digital program called UKADO for people waiting for face-to-face therapy for depression or anxiety. About 312 adults will try different versions of the program—some focused on problems, others on strengths—with or without human support. The goal is to see which…

This study looks at whether minocycline, an antibiotic that reduces inflammation, can help people who have both obesity and depression that hasn't improved with other treatments. Researchers will test if this approach is practical and acceptable for 35 participants. The goal is t…

This study tests whether a single session of whole-body heat therapy (using an infrared sauna) with or without a cold water plunge can reduce depression symptoms. Researchers will enroll 162 adults with depressive symptoms and track their mood changes over two weeks. The goal is …

This study tests a device that delivers mild electrical stimulation to the brain (tDCS) while people practice mindfulness, all done remotely via video calls. The goal is to see if this combination can reduce depression symptoms in 25 adults with major depressive disorder. Partici…

This study tests whether adding NBI-1065845 to standard antidepressants can better relieve depression symptoms in adults who haven't gotten enough help from their current medication. About 200 participants will receive either the study drug or a placebo for 8 weeks. The main goal…

This study tests a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) in 28 adults over 60 who have Alzheimer's disease or mild cognitive impairment along with depression that hasn't improved with medication. Participants receive daily d…

This study tests whether a new medication called azetukalner can reduce depression symptoms in adults with moderate-to-severe major depressive disorder. About 450 participants will receive either the drug or a placebo for 6 weeks. The main goal is to see if the drug improves mood…

This study tests whether a 4-week digital brain-training program can reduce apathy (lack of motivation) in older adults with depression. Researchers will measure changes in brain scans and apathy scores. The goal is to see if this non-drug approach can improve brain function and …

This study tests a new type of talk therapy called Correct Self-Identification Program for people with major depression. 86 adults will be randomly assigned to either this new therapy or a standard therapy (ACT). The goal is to see if the new therapy reduces depression symptoms m…

This study tests a new depression treatment that combines cognitive behavioral therapy with faith-based principles, delivered by therapists and pastors in church settings. It aims to reduce depressive symptoms in African American adults. The trial will enroll 50 participants and …

This study tests whether a 6-week intensified drug treatment can help people with major depression who did not get better on their first antidepressant. About 418 adults aged 18–65 will receive either the stronger treatment or usual care. The goal is to reduce depression symptoms…

This study tests a single injection of apimostinel, a fast-acting antidepressant, in 150 adults with major depression. Half also receive digital cognitive training sessions to see if it extends the drug's effects. The trial is placebo-controlled and double-blind, meaning neither …

This study tests whether a daily probiotic blend (called psychobiotics) can help ease depression and improve metabolic health in adults with pre-metabolic or metabolic syndrome. Sixty participants will take either the probiotic or a placebo for 12 weeks. Researchers will measure …

This pilot study tests whether a faster, personalized version of transcranial magnetic stimulation (TMS) is safe and feasible for inpatients with major depressive disorder. Thirty participants will receive up to 25 TMS sessions over two weeks, with the frequency tailored to their…

This study tests whether mindfulness programs or a brain stimulation device can improve mood and thinking in older adults with depression. Researchers will track brain activity and well-being over time. The goal is to find safe, non-drug ways to help seniors feel better.

This study tests whether a non-invasive brain stimulation technique called rTMS can improve symptoms of major depression and chronic pain at the same time. Fifty-four adults with moderate depression and pain will receive 30 sessions of active rTMS over several weeks. Researchers …

This study tests whether baricitinib, an anti-inflammatory drug used for arthritis, can improve motivation and brain function in people with major depression who have high inflammation. One hundred adults aged 25-55 with depression and elevated C-reactive protein will receive eit…

This study is testing whether a single low dose of esketamine, given during a colonoscopy, can reduce symptoms of irritable bowel syndrome (IBS) in adults who also have anxiety or depression. The trial plans to enroll 552 participants and will measure symptom severity and quality…

This study tests whether a pill called pregnenolone can help reduce depression in people with HIV. Participants take either the study drug or a placebo for 8 weeks while staying on their current antidepressants. Researchers will use brain scans and mood questionnaires to see if t…

This study tests an accelerated form of Transcranial Magnetic Stimulation (TMS) for depression in pregnant and postpartum individuals. Instead of daily sessions for weeks, participants receive multiple treatments over just 5 days. The goal is to see if this faster approach is saf…

This study at the University of Pennsylvania is testing whether personalized brain stimulation can reduce negative emotions in people with depression and anxiety. Researchers will use brain scans to map each participant's negative emotion patterns, then apply different types of t…

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

This study follows 500 adults already receiving care for depression, bipolar disorder, or suicide risk at the NIH. Researchers will conduct weekly interviews and optional tests like blood draws and brain scans to track symptoms and treatment responses. The goal is to better under…

This study looks at how nicotine changes brain function in people with and without major depressive disorder (MDD). Researchers will give 620 non-smokers either a nicotine patch or a placebo and then scan their brains using MRI. Participants will also answer questions about their…

This study looks at how tiny changes in your RNA (a molecule that reads your DNA) might help predict whether depression treatments will work. Researchers will follow 120 adults with unipolar or bipolar depression to see if these RNA changes match up with improvements in mood. The…

This study uses PET scans to measure levels of COX-1 and COX-2, enzymes linked to inflammation, in the brains of people with major depressive disorder (MDD) during a depressive episode. Researchers will compare these levels between MDD participants and healthy volunteers. The goa…

This study aims to see if people with major depressive disorder have lower levels of an enzyme called PDE4B in their brains compared to healthy volunteers. Researchers will use PET and MRI scans along with an experimental radioactive tracer to measure this enzyme. The study invol…

This study looks at children and teens ages 7-17 who have severe mood problems like chronic anger, sadness, or irritability, along with extreme tantrums. Researchers will use interviews, tests, and brain imaging to understand what happens in the brain. Up to 2,350 participants wi…

This research study examines how brain activity changes during emotional and thinking tasks in people with depression and healthy volunteers. Using brain scans (EEG, fMRI) and mild brain stimulation (TMS), researchers aim to understand the brain circuits involved in mood and suic…

This study looks at how ketamine affects the brain in people with major depression and healthy volunteers. Researchers use brain scans, blood tests, and other measures to understand why a single dose works quickly but briefly. The goal is to find biomarkers that could lead to bet…

This study looks at how ketamine, a fast-acting antidepressant, affects the brain. Researchers want to understand if a specific brain receptor (AMPA) is key to its effects. Seventy adults with treatment-resistant depression will take part, receiving ketamine and a drug that block…

This study aims to find out if a special algorithm can predict which antidepressant will work best for each person with major depression. Researchers will use brain scans, EEGs, and blood tests from 400 adults to see if they can match people to the right medication faster. The go…

This study tests whether a gentle brain stimulation technique called tDCS, done at home, can improve sleep quality in adults with moderate depression. Researchers will track sleep changes and see if better sleep leads to better mood. The study involves 35 participants and aims to…

This study aims to improve MRI imaging methods to better understand how mood and anxiety disorders affect the brain. Researchers will scan healthy volunteers and people with major depressive disorder while they perform tasks or view images. The goal is to refine these techniques …

This study tests a technique called real-time fMRI neurofeedback, where people with depression learn to control brain activity by watching a visual pattern change in real time during an MRI scan. Researchers want to see if this can help regulate brain networks linked to depressio…

This study tests a non-invasive brain stimulation technique called tDCS for depression. Researchers use MRI scans to see how the stimulation affects brain networks. 144 adults with depression will receive either real or sham tDCS while performing a memory task. The goal is to fin…

This study tests a program to help doctors in psychiatric clinics prescribe medications for alcohol use disorder to patients who also have serious mental illness. The program uses an external facilitator to work with clinic staff and overcome barriers to prescribing. The goal is …

This study looks at whether inflammation in the brain causes symptoms like loss of interest and slow movement in depressed people with HIV. Sixty participants will receive either the anti-inflammatory drug baricitinib or a placebo for 10 weeks. Researchers will use brain scans an…

This study looks at how a single dose of ketamine changes brain chemistry and decision-making in people with major depression. Researchers will measure brain glutamate levels and stress responses in 140 participants. The goal is to understand why ketamine helps some people with d…

This study tests three types of non-invasive brain stimulation (intermittent, continuous, and sham) in 200 adults with major depression. Participants receive each type in separate sessions while undergoing MRI scans and mood assessments. The goal is to understand how different st…

This study is a large survey of up to 20,000 adults with conditions like depression, anxiety, or borderline personality disorder. Researchers will ask about medical history and symptoms to see who might qualify for future industry-sponsored clinical trials. The goal is to make it…

This study looks at how stress and a sense of control affect brain activity in teenage girls with major depression. Researchers will use brain scans and smartphone surveys to understand these connections. The goal is to learn more about depression, not to test a new treatment. Ab…

This study looks at whether a child's genes can predict if they will have certain side effects from common antidepressants (SSRIs). Researchers will collect saliva samples from 120 children and young adults aged 6 to 24 with depression, anxiety, or OCD. The goal is to find geneti…

This study at Yale University is testing whether blocking a specific brain receptor (AMPA) stops ketamine from reducing suicidal thoughts. Thirty adults with depression, bipolar disorder, or PTSD who have current suicidal thoughts will receive either perampanel (an AMPA blocker) …

This study aims to identify different types of depression by tracking how people manage their emotions in daily life and how their nervous system responds. Researchers will test whether a simple biofeedback exercise done at home for 10 days can improve emotional regulation. The s…

This study looks at whether treating depression with a common antidepressant (escitalopram) can change brain and blood markers linked to Alzheimer's disease. Researchers will compare the drug to a placebo in 60 adults aged 60 and older who have major depression but no memory prob…

This study aims to find brain-based markers that can predict how individuals with major depression will respond to the antidepressant sertraline (Zoloft). Researchers will use fMRI and EEG brain scans to measure brain activity and connections before treatment. Fifty adults with c…

This Mayo Clinic study uses a safe, noninvasive light-based device called fNIRS to measure brain activity in 200 adults with major depression, bipolar disorder, or mild cognitive impairment. By comparing brain blood flow patterns across these groups, researchers hope to better un…

This study looks at how stress impacts pain, hormone levels, and mood in 120 people with and without HIV, cannabis use disorder, and depression. Participants will complete two sessions of a pain stress task and provide blood samples to measure cortisol and other stress hormones. …

This study looks at how the immune system and brain talk to each other in people with major depression. Researchers will give a harmless substance (LPS) to temporarily activate the immune system and then measure brain activity and mood changes. The goal is to understand the links…

This study is testing a new family-based program (Fam-AID) for teens aged 13-21 who are getting treatment for substance use and also have anxiety or depression. The program adds extra support for mental health and family involvement to their usual care. Researchers want to see if…

This study compares women with PMDD, major depressive disorder (MDD), and healthy controls to see how their brains, stress responses, and inflammation differ. Researchers will use brain scans, stress tasks, and blood/saliva tests in 75 naturally cycling women aged 18-40. The goal…

This study looks at why women with PTSD have a higher chance of heart disease later in life. Researchers will test if beetroot juice, a natural source of nitric oxide, can improve blood vessel function in 30 premenopausal women who have experienced trauma. The goal is to understa…

This study looks at how childhood trauma and stress affect tiny genetic molecules called microRNAs in the blood. Researchers will compare people with major depression and healthy volunteers to see if these molecules can help explain the link between early life stress and suicidal…

This study tests whether psilocybin, the active ingredient in magic mushrooms, changes brain activity in people with depression. Fifty participants will receive either psilocybin or a placebo and undergo MRI scans to measure blood flow and brain network connections. The goal is t…

This study aims to understand why some people with depression don't get better with standard medications. Researchers will use brain scans to compare dopamine receptors in 45 people: those with treatment-resistant depression, those whose depression responds to treatment, and heal…

This study aims to understand how repetitive brain stimulation (TMS) changes brain activity. Researchers will use special electrodes placed inside the brain (in people with epilepsy) and noninvasive recordings to track these changes. The goal is to find reliable brain markers tha…

This study looks at how transcranial magnetic stimulation (TMS) changes brain activity in healthy adults and people with depression. Participants will have brain scans while receiving single and repeated magnetic pulses. The goal is to understand the brain mechanisms behind TMS, …

This study tests whether a non-invasive brain stimulation technique called tACS can improve goal-directed behavior in people with depression who have lost interest in activities (anhedonia). 72 participants will receive five daily sessions of stimulation. The goal is to see if th…

This study aims to find the brain areas responsible for depression in people with Parkinson's disease. Researchers will use brain scans to compare 120 participants aged 40-80 who have both conditions. The goal is to identify targets for future treatments, not to test a new therap…

This study is a registry that will follow up to 1,000 adults with treatment-resistant depression or obsessive-compulsive disorder (OCD) who receive electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), or ketamine/esketamine. Researchers will collect data from…

This study uses transcranial magnetic stimulation (TMS) to explore how the brain controls social motivation in adults who avoid social situations due to depression or social anxiety. Forty participants will undergo MRI scans, computer tasks, and personalized TMS over four visits.…

This study observes 100 people with depression who are already receiving transcranial magnetic stimulation (TMS) therapy. Researchers use brain scans and symptom questionnaires to see how brain networks change during treatment and whether these changes can predict who gets better…

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in 180 adults with depression, OCD, anxiety, or schizophrenia. Participants receive accelerated TMS over two days while completing behavioral tests and questionnaires. The goal is to understand which br…

This study uses PET and MRI scans to look at brain changes in people who developed depression within three months after a mild or moderate COVID-19 infection. Researchers will compare brain scans of 90 participants to see if key brain chemicals are altered. The goal is to better …

This Stanford study is testing new ways to measure brain activity in people with depression using transcranial magnetic stimulation (TMS). The goal is to find better markers that could make TMS treatment more effective. The study involves 145 adults with moderate-to-severe depres…

This study looks at how a type of talk therapy for depression changes the gut microbiome, immune system, and brain function in people living with HIV. Researchers will enroll 150 adults with HIV and depression to understand these connections. The goal is to learn more about how t…

This study looks at how adults with depression respond to heat stress compared to those without depression. Researchers will measure skin blood flow, sweating, and core temperature during passive heating. The goal is to understand if depression or antidepressant medications like …

This study looks at 55 women who have a chronic (long-term) infection with the Toxoplasma parasite and also have a mental health condition like schizophrenia, depression, or bipolar disorder. Researchers want to see if tiny molecules called microRNAs in the blood can help tell th…

Latino teens are less likely to get depression treatment than their peers. This study asks teens, parents, and doctors which of three strategies—peer support groups, parent-teen training, or care navigation—they prefer. Researchers will interview 15 teens, 15 parents, and 5 healt…

This study follows up to 10,000 medical students in Orléans, France, for up to 22 years to understand what puts them at risk for depression and other mental health issues. Participants fill out an annual online questionnaire. The goal is to identify early warning signs so that fu…

This study looks at how a new, non-invasive brain stimulation technique called temporal interference (TI) affects social reward processing in people with depression. Researchers will use brain scans and tests to see if TI can change brain activity linked to social function. The g…

This study uses brain imaging to explore how severe childhood stress may cause chemical changes in the brain that increase depression risk. Researchers will scan the brains of 160 women aged 20-32, some with a history of childhood adversity and some without. The goal is to unders…

This study looks at how the natural rhythm of connection between a therapist and patient—called synchrony—might help treat depression. Researchers will track 78 adults with major depressive disorder over 16 weeks of supportive-expressive therapy. The goal is to see if each person…

This study looks at how the 24-hour patterns of sleep and social activity relate to mood and suicidal thoughts in older adults who recently lost a spouse or life partner. Researchers will track 169 participants for 12 months using surveys and activity monitors. The goal is to und…

This study uses brain imaging and a single dose of the anti-anxiety drug lorazepam to understand how people with both depression and anxiety disorders process threats differently than those with depression alone. About 165 adults will complete two sessions involving startle tests…

This study looks at how natural ups and downs of estrogen and progesterone during the menstrual cycle affect mood and the ability to feel pleasure in women whose depression gets worse before their period. Researchers will give 75 women hormone patches and pills to temporarily sta…

This study looks at how teen girls with a family history of depression respond to stress compared to those without. Researchers will use brain scans, smartphone surveys, and smartwatches to track stress reactions in real time. The goal is to find early warning signs that could le…

This study investigates how a brain chemical system called nociceptin/orphanin FQ relates to major depression. Researchers will use PET and MRI scans, along with behavioral tasks, to examine brain activity and decision-making in people with current or past depression. The goal is…

This study uses MRI scans to observe how the brain changes in people with depression during a 5-day accelerated transcranial magnetic stimulation (TMS) treatment. Researchers aim to see if a new imaging method called INSCAPE can track individual recovery patterns. Twenty adults w…

This study is testing whether brain scans can predict how well people respond to internet-based cognitive behavioral therapy (iCBT) for depression, insomnia, and social anxiety. Researchers will scan the brains of 150 participants before they start 12 weeks of online therapy. The…

This study uses a non-invasive brain stimulation technique called iTBS to explore how stimulating specific brain networks changes mood, thinking, and brain activity in people with major depression and healthy volunteers. Researchers aim to understand the brain mechanisms behind t…

This study aims to understand how the brain processes rewards in people with depression. Researchers will record brain activity from epilepsy patients who also have depression while they play a gambling task. The goal is to identify abnormal brain signals that could guide future …

This study follows 700 people with chronic diseases like arthritis, diabetes, or heart disease for 4 years. Participants wear a small movement sensor for 5 days, three times a year, to track their physical activity and sedentary time. Researchers want to see if a person's unique …

This study looks at how people's emotional reactions to daily stress relate to the health of their small blood vessels. Researchers will measure blood vessel function in the skin of 18 adults—some with depression, some without—using a mild drug that temporarily blocks a key blood…

This study looks at whether the quality and function of HDL (often called 'good' cholesterol) is different in people with depression compared to healthy controls. Researchers will analyze blood samples from 90 adults with moderate to severe depression and a control group. The goa…

This study is testing whether a non-invasive brain stimulation technique called tDCS can improve executive functions—like working memory, attention, and decision-making—in people with conditions such as traumatic brain injury, depression, bipolar disorder, schizophrenia, ADHD, bo…

This study is looking for genetic markers linked to a side effect called behavioral activation—feeling overly excited or agitated—that can happen when children and youth take SSRI antidepressants for depression, anxiety, or OCD. Researchers will collect DNA from 160 participants …