MAJOR DEPRESSIVE DISORDER

This study is testing whether a drug called baricitinib, which reduces inflammation, can help improve symptoms of depression in people who have both depression and high levels of inflammation. About 100 adults with depression, low motivation, and a specific blood marker of inflam…

This study is testing if adding the antibiotic minocycline to standard antidepressants is a practical and acceptable approach for people who have both obesity and depression that hasn't responded to other treatments. Researchers want to see if participants can complete the 8-week…

This study is testing whether adding an investigational drug called NBI-1065845 to a person's current antidepressant medication can help reduce symptoms of major depressive disorder. It is for adults who have not gotten enough relief from their standard antidepressants alone. Par…

This study is testing if a new weekly pill called GATE-251 (zelquistinel) can safely reduce symptoms of major depression in adults. About 164 participants will be randomly assigned to take either the real pill or a placebo (a dummy pill) once a week for six weeks. Researchers wil…

This study is testing whether adding an investigational drug called NBI-1065845 to a person's current antidepressant medication helps reduce depression symptoms more effectively. It's for adults with moderate-to-severe major depression who haven't gotten enough relief from their …

This study is testing whether combining psilocybin (a psychedelic compound) therapy with a rapid form of non-invasive brain stimulation is safe and more effective for treating severe depression that hasn't responded to other treatments. One hundred adults will receive either a hi…

This study is testing if adding a 12-week supervised exercise program to standard antidepressant medication helps people with depression feel better. Researchers want to see if exercise reduces brain inflammation and improves symptoms more than medication alone. They will enroll …

This study is testing whether a daily oral medication called vortioxetine is safe and effective at reducing depression symptoms in Japanese teenagers aged 12 to 17. About 180 participants will be randomly assigned to receive either the real medication or a placebo (a pill with no…

This study is testing whether adding an investigational drug called ABX-002 to a person's current antidepressant helps reduce depression symptoms. It will involve about 230 adults with moderate to severe depression who haven't gotten enough relief from their current medication al…

This study is testing a new, personalized approach to treat depression that hasn't responded to medication. Researchers will use a special brain scan to identify a patient's 'brain type' and then use that information to choose the best spot to apply magnetic stimulation therapy. …

This study is testing a new psychological therapy program for people with depression. It compares a specialized program focused on self-identity to a standard acceptance-based therapy. Researchers will measure how well symptoms improve and whether depression returns within 6 mont…

This study aims to understand how ketamine, a drug with rapid antidepressant effects, works in the brain. Researchers are enrolling 150 adults with major depression and healthy volunteers to receive repeated ketamine infusions while undergoing brain scans and other tests. The goa…

This study is testing a faster version of a non-invasive brain stimulation treatment for people experiencing depression during pregnancy or within a year after giving birth. Instead of daily treatments for 6-8 weeks, participants receive multiple sessions per day for just 5 days.…

This study is testing whether a non-invasive brain stimulation treatment called rTMS can help reduce symptoms of depression in young people (ages 16-35) who also have autism. Participants will receive either the real magnetic stimulation treatment or a sham (placebo) version for …

This study is testing if doing moderate exercise right before a therapy session makes the therapy work better for people with depression. Researchers will compare two groups of 100 adults: one group will exercise before their weekly therapy, while the other will rest quietly. The…

This study is testing whether a new oral medication called NMRA-335140 can help reduce symptoms of major depression. About 332 adults with moderate to severe depression will take either the medication or a placebo pill for 6 weeks. Researchers will measure changes in depression s…

This study is testing whether a new oral medication called azetukalner can help reduce symptoms in adults with moderate-to-severe major depression. About 450 participants will be randomly assigned to receive either the active drug or a placebo pill for 6 weeks, and neither they n…

This study is testing a new, personalized approach to therapy for major depression. Researchers want to see if matching therapy to a person's unique relationship patterns, called their 'synchrony signature,' leads to better mental health. The study will involve 78 adults with dep…

This study is testing if an oral medication called CYB003 can help people with moderate to severe major depression who are still struggling despite taking a standard antidepressant. About 220 adults will be randomly assigned to receive either CYB003 or a placebo pill, in addition…

This study aims to test a personalized approach for selecting depression medications. Researchers will use brain scans, blood tests, and other measures to predict which of two common antidepressant combinations works better for each patient. The goal is to help doctors choose the…

This study is testing if a combination of intravenous ketamine and online cognitive behavioral therapy (i-CBT) can quickly and effectively reduce suicidal thoughts and behaviors in people with treatment-resistant depression. Over 13 weeks, 110 participants will all receive weekly…

This study is testing an experimental drug called GM-2505 for people with major depressive disorder. Researchers want to see if it's safe and if it shows early signs of helping with depression symptoms. The trial has three parts: testing the drug alone in some patients, testing i…

This study is for adults with major depression whose first antidepressant didn't work well enough. It compares two next steps: switching to a different standard pill (usual care) versus quickly adding a stronger treatment, esketamine (a nasal spray or IV infusion), to a pill. The…

This study is testing whether a non-invasive brain stimulation technique can help people who have both major depression and chronic pain. It will involve 54 adults who haven't gotten enough relief from standard medications. Participants will receive 30 sessions of magnetic stimul…

This study is testing whether a new oral medication called NMRA-335140 can reduce symptoms of major depression. Over 6 weeks, 332 adults with moderate-to-severe depression will receive either the active drug or a placebo pill, with neither participants nor doctors knowing which i…

This study is testing a new brain training technique for people with depression. While lying in an MRI scanner, participants see real-time feedback about their brain activity and try to learn to control it. Researchers hope this training can help people better manage their depres…

This study is testing whether nitrous oxide (commonly known as laughing gas) can help reduce symptoms of depression. Researchers will give 172 adults with major depressive disorder weekly one-hour breathing sessions of either nitrous oxide or a placebo air mixture for four weeks.…

This study is testing whether a new oral medication called Icalcaprant can help control symptoms of major depression. About 195 adults currently experiencing a depressive episode will take either the drug or a placebo pill daily for six weeks. Researchers will measure changes in …

This study tests whether a new, lower-power version of electroconvulsive therapy (ECT) works better for reducing suicidal thoughts than standard ECT. Researchers will compare both treatments in 30 adults with severe depression, bipolar disorder, or related conditions who have sui…

This study is testing a medication called valbenazine for people with tardive dyskinesia (TD), which causes uncontrollable movements. It is for adults with TD who still have symptoms while taking a similar medication or after stopping one. The main goal is to see if switching to …

This study is testing whether adding an investigational drug called NBI-1065845 to standard antidepressant medication helps people with major depression who haven't gotten enough relief from their current treatment. It will involve about 200 adults with moderate to severe depress…

This study is testing a new, personalized approach to brain stimulation for people with depression who haven't been helped by medication. Researchers are using a technique called rTMS, which uses magnetic pulses to stimulate the brain, but this time they are measuring brain activ…

This large international study is testing a new treatment strategy for serious mental health conditions. It aims to see if using more powerful, combination medications right after a person's first treatment fails works better than the standard, slower approach. The trial will enr…

This study is testing whether an experimental medication called SP-624 can help reduce symptoms of major depression in adults. About 456 participants will be randomly assigned to receive either SP-624 or a placebo pill, and neither they nor the doctors will know which one they ge…

This study is testing whether a special brain training technique using MRI scans can help people with depression. During the training, participants see their own brain activity in real-time and learn to strengthen positive emotional responses. Researchers will compare this active…

This study aims to learn about the long-term safety and effectiveness of an investigational drug called NMRA-335140 for people with major depressive disorder. It is a one-year extension study for up to 1,000 participants who have already completed a shorter, earlier phase of rese…

This study is testing if a pill called pregnenolone can help reduce depression in people living with HIV. About 120 participants will take either pregnenolone or a placebo (sugar pill) for 8 weeks while staying on their current depression medications. Researchers will use brain s…

This study is testing a faster, personalized version of a non-invasive brain stimulation treatment for people hospitalized with severe depression. Researchers want to see if they can safely give 25 treatments over just five days, using a person's unique brain rhythm to potentiall…

This study is testing whether a long-term treatment plan using ketamine and esketamine can help reduce suicide risk in people with severe depression. It will involve 100 patients who are currently hospitalized for suicidal thoughts. Participants will receive a series of ketamine …

This study is testing whether a new oral medicine called azetukalner can help reduce symptoms in adults with moderate-to-severe major depression. About 450 participants will be randomly assigned to receive either the real medicine or a placebo pill for 6 weeks, and neither they n…

This study is testing a faster version of a non-invasive brain stimulation treatment called TMS for people with major depression. Instead of treatments spread over several weeks, this approach delivers 36 sessions in just 5 days. Researchers want to see if this accelerated schedu…

This study is testing a brain implant called deep brain stimulation (DBS) for people with severe depression that hasn't improved with other treatments. The implant delivers small electrical pulses to a specific brain area. Researchers will also use the device to record brain sign…

This study in Zimbabwe is testing if a proven talk therapy program works better for adults with moderate to severe depression when it is combined with antidepressant medication. The trial will compare the standard talk therapy alone to the same therapy plus antidepressants prescr…

This study is testing if an investigational medicine called NBI-1065845 can help prevent depression symptoms from returning in people with major depressive disorder. It is for adults who are already taking standard antidepressants but still have significant symptoms. The main goa…

This study is testing whether shining a special, invisible light on the forehead can change blood flow in the brain of people with depression. Researchers will use brain scans to see if this light treatment improves blood flow and reduces depression symptoms. About 120 adults wit…

This study is testing whether a weekly oral medication called GATE-251 (zelquistinel) can safely reduce symptoms of major depression in adults. About 164 participants will be randomly assigned to take either the study drug or a placebo pill once a week for six weeks. Researchers …

This study is testing whether a 4-week digital brain training program can help reduce apathy and improve brain function in older adults with depression. Researchers will enroll 84 participants aged 60+ who have both depression and significant apathy. The program aims to strengthe…

This study is testing whether lifting weights can help treat depression. Researchers will compare a high-intensity weight training program to a low-intensity one over 16 weeks in 200 adults with depression. The goal is to see if exercise reduces symptoms and to understand how it …

This study is testing a new 12-week therapy program designed to reduce suicide risk in adults who experienced childhood trauma and currently have suicidal thoughts. The therapy combines suicide prevention skills training with trauma-focused treatment. Researchers are enrolling 20…

This study is testing whether adding a structured day of nature tourism activities to standard medication helps adults with major depressive disorder feel better. Researchers will compare two groups: one gets medication plus a nature activity day, while the other gets medication …

This is a small, early-stage study to see if a personalized, non-invasive brain stimulation technique is safe and tolerable for pregnant women with depression. Researchers will test the approach on 10 participants—five healthy women and five with antenatal depression—to check for…

This study is testing a 12-week group program designed to help young adults with conditions like schizophrenia, bipolar disorder, or major depression improve their skills for romantic relationships. The program focuses on communication, emotional understanding, and building healt…

This study is testing whether a program called 'Taking Action,' led by trained peers, can help college students with serious mental illnesses like depression, bipolar disorder, or schizophrenia. About 300 students will be randomly assigned to either try the five-session program o…

This study is testing a non-invasive brain stimulation treatment for depression in people over 60 who have Alzheimer's disease or mild memory loss. Participants who haven't been helped by antidepressant medications will receive daily magnetic stimulation sessions for four weeks. …

This study is testing whether psilocybin, the active compound in 'magic mushrooms,' can help reduce depression in adults who have both cancer and major depressive disorder. Fifty-six participants will receive either psilocybin or a placebo vitamin in group therapy sessions, with …

This study is testing whether a drug that blocks a specific immune signal (IL-6) can help improve the brain's reward system and reduce the loss of pleasure in adults with major depression. Up to 20 participants with depression and signs of immune system activation will receive th…

This study aims to find out which type of talk therapy works better for people with depression, depending on their personal strengths. Researchers will compare two different therapy styles over 16 sessions to see if focusing on a person's strong points leads to better results. Th…

This study is testing whether daily exposure to a special 40 Hz flickering light can help reduce depression symptoms. Researchers will enroll 60 adults with major depression who will use a light device at home for one hour daily for six weeks. The goal is to see if this non-invas…

This study aims to see if a personalized form of magnetic brain stimulation can reduce persistent negative thoughts and emotions in people with depression or anxiety. Researchers will first map each participant's unique brain patterns linked to negative feelings using an MRI scan…

This small, early-stage study is testing if a medication called empagliflozin, which is normally used for type 2 diabetes, can help reduce symptoms of major depression. Researchers think the drug might help by helping the body produce ketones, which can serve as an alternative fu…

This study aims to see if using hormone patches and pills can help women whose depression gets worse before their period. Researchers will test if stabilizing hormone levels during this time improves mood and the brain's ability to feel pleasure. About 75 women will try the hormo…

This study is testing if a weekly injection of semaglutide, a medication known for weight loss, can help improve mood when added to usual depression treatment. It will involve 116 adults with major depression who also have overweight or obesity. Participants will receive either t…

This study is testing two new treatment strategies for depression in people with chronic kidney disease (CKD). Researchers will compare a 16-week program of either a specific type of talk therapy (delivered remotely) or a non-SSRI antidepressant medication, with the option to add…

This study aims to understand how a non-invasive brain stimulation treatment works for depression. Researchers will use MRI scans and mood tests to see how stimulating different brain networks affects connectivity and symptoms in 80 participants, including both healthy individual…

This study aims to understand how emotional reactions to everyday stress affect blood vessel function, and whether this link is stronger in adults with depression. Researchers will track the daily stress and emotions of 18 working-age adults (with and without depression) for two …

This study aims to understand how our mood is connected to our brain activity, facial expressions, and speech. Researchers at Stanford will record video and audio of 10 participants with depression or epilepsy who have brain implants for medical treatment. They will analyze these…

This study aims to understand if childhood trauma increases suicide risk by looking for biological markers in the blood. Researchers will enroll 450 adults with depression or no mental illness to analyze genetic material and stress responses. The goal is to identify potential bio…

This study aims to understand how depression affects the brain in people with Parkinson's disease. Researchers will use PET and MRI scans to compare brain activity in four groups: people with Parkinson's and depression, Parkinson's without depression, depression alone, and health…

This study aims to identify biological markers that predict how well different brain stimulation and medication treatments work for severe depression and obsessive-compulsive disorder (OCD). Researchers will collect data from 1,000 patients receiving treatments like electroconvul…

This study aims to understand how stimulating different parts of the brain with magnetic pulses affects symptoms of several mental health conditions. Researchers will enroll 180 adults with depression, anxiety, OCD, or schizophrenia to receive non-invasive brain stimulation at ra…

This study aims to understand why people with major depression are twice as likely to use nicotine and have a harder time quitting. Researchers will use brain scans (MRI) to see how a single dose of nicotine affects brain function in non-smokers with and without depression. The g…

This research study aims to understand how the brain controls social motivation in people who avoid social situations. Researchers will use brain scans and a non-invasive magnetic stimulation technique on adults with depression or social anxiety. The goal is to learn about brain …

This study aims to understand how ketamine, a drug known to relieve depression symptoms within hours, works in the brain. Researchers will test whether blocking a specific brain receptor (called AMPA) reduces ketamine's antidepressant effects. About 70 adults with major depressio…

This study aims to understand the brain changes linked to depression that starts after a COVID-19 infection. Researchers will use special brain scans to look at the brain chemistry of 90 adults who developed depression within 3 months of having mild or moderate COVID. The goal is…

This is a long-term observational study aiming to understand why medical students experience high rates of depression and anxiety. Researchers will follow up to 10,000 students over many years, comparing those in medical school to those who were not accepted. The goal is to ident…

This study aims to understand how depression changes the brain's reward system. Researchers will record brain activity from 10-24 epilepsy patients who are also being monitored for depression while they play a simple gambling game. The goal is to identify specific brain patterns …

This study aims to understand how a therapy called Behavioral Activation helps people with depression. Researchers will follow 120 depressed adults through 12 therapy sessions to see if the treatment works by changing their habit of negative, repetitive thinking. They'll also che…

This study aims to understand how anxiety affects the developing brain in children and teenagers. Researchers will use brain scans and thinking tasks to compare youth with anxiety disorders to healthy youth, both before and after they receive standard treatments like therapy or m…

This study aims to understand how people with depression or bipolar disorder respond to their regular treatments. Researchers will observe 500 adults already receiving care, tracking their symptoms weekly for about 12 weeks. The goal is to find patterns that might help predict wh…

This study aims to improve depression treatment by finding better ways to measure brain activity. Researchers will test different brain stimulation methods on 145 adults with moderate-to-severe depression. The goal is to identify reliable brain markers that could help personalize…

This study aims to understand how a new, faster form of magnetic brain stimulation (iTBS) works to treat depression. Researchers will use PET and MRI brain scans to compare the effects of real treatment versus a sham (fake) treatment in 22 adults with major depression. The goal i…

This study aims to understand if a mild, non-invasive brain stimulation technique can improve thinking skills like memory, focus, and decision-making. It will involve 600 people with conditions such as depression, ADHD, bipolar disorder, or a history of brain injury, as well as h…

This study aims to understand how stress affects the brain and body in teenage girls who have a parent with depression, compared to those who don't. Researchers will track 148 girls aged 13-15 over 18 months using brain scans, smartwatches, and phone surveys to see how they respo…

This study aims to find genetic markers that can predict which children and young adults might experience a troubling side effect called 'behavioral activation' from common antidepressant medications (SSRIs). Researchers will compare the DNA of 160 young people (ages 6-24) who ei…

This study aims to understand if a specific type of non-invasive brain stimulation can help people with depression who struggle to feel pleasure or motivation. Researchers will test the stimulation on 72 adults with major depression and high anhedonia over five consecutive days. …

This study aims to understand how depression affects the brain and decision-making. Researchers will use MRI and PET brain scans, along with blood tests and behavioral tasks, on 228 adults with current or past depression. The goal is to identify brain patterns that might predict …

This early-stage study aims to understand if an investigational drug called SP-624 changes brain activity patterns in healthy adults and people with major depression. Researchers will use a special cap to measure brain waves and AI software to analyze them. The study will also ch…

This study aims to understand how magnetic brain stimulation (TMS) works to treat depression. Researchers will measure brain activity in people with epilepsy who are already having brain monitoring, comparing responses to real and sham stimulation. The goal is to find brain marke…

This study aims to learn more about how a type of talk therapy called schema therapy might help people with depression that hasn't improved with standard treatments. It will closely follow three patients as they receive about 30 therapy sessions over a year. The goal is to unders…