Scientists probe Brain's response to TMS to boost depression treatment

NCT ID NCT05996900

Recruiting now Knowledge-focused Sponsor: Stanford University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to understand how repetitive brain stimulation (TMS) changes brain activity. Researchers will use special electrodes placed inside the brain (in people with epilepsy) and noninvasive recordings to track these changes. The goal is to find reliable brain markers that show TMS is working, which could help make depression treatment more effective. The study involves 49 adults with either depression or epilepsy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial magnetic stimulation (TMS) and intracranial electrodes
What this could lead to: If successful, this could lead to better, more targeted TMS treatments for depression and other psychiatric disorders by identifying clear brain markers of response.
What could go wrong: This is an early-stage, observational study focused on understanding brain mechanisms, not testing a new treatment. It may not directly lead to improved therapies, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

epilepsy major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY MAJOR DEPRESSIVE DISORDER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Stanford University
RECRUITING

Stanford, California, 94305, United States

Contact Email: •••••@•••••

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