EPILEPSY

This study tests an experimental drug called ASO-GNAO1 (Tianasen) in 5 children aged 1-14 with a specific genetic form of epilepsy and movement disorders. The drug is given via spinal injection over 12 months to see if it can reduce seizures and improve symptoms. Because the dise…

This study looks at whether removing a brain tumor and the nearby area where seizures start can reduce or stop seizures. About 100 people aged 8 and older with brain tumors and related seizures will have surgery and be followed for up to a year. The goal is to see if surgery impr…

This study tests whether a gentle, non-invasive brain stimulation technique called tDCS can reduce seizures in people with drug-resistant epilepsy. Sixty participants will receive either real or sham (fake) stimulation over 10 days. The goal is to see if the treatment safely lowe…

This early-phase study tests whether everolimus, a drug that targets a specific cell pathway, can safely reduce seizures in adults with focal epilepsy that doesn't respond to standard treatments. Five participants will take everolimus alongside their usual medication for 12 weeks…

This study tests whether taking levetiracetam three times daily helps adults with epilepsy have more seizure-free days than the standard twice-daily schedule. About 120 participants who already take high-dose levetiracetam will track their seizures and side effects in a diary. Th…

This early-stage trial tests an injection of special brain cells (GABAergic interneuron progenitors) in 6 adults with drug-resistant mesial temporal lobe epilepsy. The goal is to see if the treatment is safe and can reduce seizure frequency. Participants receive the cell therapy …

This study tests brain surgery as a treatment for people with epilepsy that medication cannot control. It includes children and adults aged 8 and older who have partial seizures starting in one area of the brain. The goal is to remove or treat the seizure-causing brain area to st…

This study tests whether adding a risk prevention program to standard epilepsy education helps adults with uncontrolled epilepsy manage their safety better. About 74 participants will be split into two groups: one gets the extra risk prevention session, the other gets usual care.…

This study tests whether a smartphone app called Medilepsy®, which uses artificial intelligence to personalize reminders, can help underserved teens and young adults (ages 14-24) with epilepsy take their anti-seizure medicine more consistently. Participants will use either the AI…

This study tests whether sharing epilepsy care tasks with trained non-specialists, supported by an electronic medical records system, helps people in western Kenya take their medication regularly and stay in care. About 650 people with epilepsy who are not currently taking their …

This study tests the long-term safety of an experimental drug called RAP-219 in 30 adults with refractory focal epilepsy—seizures that don't respond well to current treatments. Participants must have completed a prior RAP-219 study. The main goal is to track side effects, while a…

This study follows 210 people with epilepsy who already have the Minder device implanted. The device helps doctors monitor seizures that standard tests miss. Researchers will check every 6 months for 2 years to see if the device helps guide treatment decisions and improve well-be…

This study tests a new medicine called SPN-817 in 60 adults whose seizures are not controlled by current treatments. The main goal is to see if the drug is safe and tolerable. Researchers will also check if it reduces the number of motor seizures per month.

This study tests a tool called BioEP that analyzes EEG brain wave recordings to help doctors decide if a person has epilepsy. About 559 adults who had their first possible seizure and a normal EEG will take part. The goal is to see if BioEP makes epilepsy diagnosis more accurate …

This study compares a new tripolar EEG (tEEG) device to standard EEG in 90 adults and children with epilepsy. The goal is to see if tEEG can record brain waves more accurately, reduce interference, and help doctors spot seizure activity sooner. Participants will also have their s…

This study will test whether a special brain scan called magnetoencephalography (MEG) can help doctors better diagnose children with conditions like epilepsy, autism, ADHD, and brain tumors. Researchers will compare MEG signals from 1500 children with these disorders to signals f…

This study tests if levetiracetam, a seizure medication, can prevent epileptic seizures in 120 adults over 40 with Down syndrome and Alzheimer's disease. Participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop seizures and poss…

This study tests whether giving sirolimus early can prevent or delay seizures in infants with tuberous sclerosis complex (TSC). About 64 babies under 7 months old will receive either sirolimus or a placebo. The goal is to see if the drug can stop epilepsy from developing and impr…

This study monitors the safety and effectiveness of a midazolam oral solution for people with a severe, prolonged seizure called status epilepticus. About 50 participants in Japan will receive the drug as part of their normal care, and doctors will track side effects and whether …

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep, anxiety, depression, or epilepsy. Researchers will track changes in symptoms and quality of life over 24 weeks using standard questionnaires. The goal is to understand how effect…

This early study tests if low-intensity focused ultrasound can safely reduce seizures in people with temporal lobe epilepsy that doesn't respond to medication. Eight adults will receive the non-invasive treatment. The main goal is to check safety and see if seizure frequency impr…

This study tests a new educational program called ReBOOT for adults with epilepsy who are about to have brain surgery. The goal is to see if the program can lower the risk of memory or thinking problems after surgery, or help people cope if they do have problems. Participants wil…

This study tests whether L-serine, a dietary supplement, can improve overall functioning in 40 children and young adults (ages 2-30) with GRIN-related neurodevelopmental disorders caused by loss-of-function gene variants. Each participant will receive both L-serine and a placebo …

This study is testing a program that teaches people with epilepsy how to use rescue medication to manage repeated seizures. The program is adapted from an existing self-management tool (SMART) with input from patients, caregivers, and doctors. About 30 adults with epilepsy who ha…

This study tests whether a special music app can reduce seizure-related brain activity in adults with drug-resistant epilepsy who have a brain implant (RNS). Participants will listen to music at home over several months. The goal is to see if this simple, self-administered therap…

This study tests a 24-week collaborative care program for 60 adults with epilepsy who also have anxiety or depression. The program adds a care manager to usual neurology visits to support emotional well-being. The goal is to see if this approach improves quality of life more than…

This study compares two 8-week telephone programs for 120 adults with epilepsy who have mild-to-moderate depression. One program teaches skills to manage depression, while the other offers peer support groups. Researchers will track changes in mood, quality of life, and seizures …

This study tests whether methylphenidate, a drug used for ADHD, can improve memory and attention in adults with epilepsy. About 226 participants will be randomly assigned to take either the drug or a placebo for 8 weeks, then all can take the drug for 2 more months. The goal is t…

This study tests whether creating a personalized lullaby can improve quality of life and reduce stress, anxiety, and depression in pregnant women with epilepsy. Thirty first-time mothers-to-be will be randomly assigned to either take part in the Lullaby Project or receive standar…

This study tests a sleep improvement program for children with epilepsy, who often have worse sleep problems. The program combines clinic visits with technology support. Researchers will measure sleep quality and quantity using a wrist-worn device. The goal is to help both childr…

This study tests whether a non-invasive light treatment called photobiomodulation (PBM) can lower stress and improve seizure control in adults with epilepsy. Participants will attend 45 sessions over 15 weeks and wear a special ring to track health data. The goal is to see if thi…

This study is testing whether high doses of vitamin D, followed by a lower maintenance dose, can reduce seizure frequency, ease fatigue, and improve quality of life in adults with epilepsy. Researchers will track 200 participants for three months. The goal is to see if this simpl…

This study tests a device called NaviFUS™ that uses low-intensity focused ultrasound to calm overactive brain areas in people with epilepsy that doesn't respond to medication. About 16 adults will be randomly assigned to receive the ultrasound treatment or continue standard care.…

This study looks at whether listening to Mozart or other age-appropriate music can lower the number of seizures or abnormal brain signals in children with epilepsy. Ten children aged 4 to 17 staying in a hospital epilepsy monitoring unit will participate. Researchers will measure…

This study is testing a small device that fits in the ear to see if it can detect seizures by measuring brain waves. Researchers will first test it in 5 healthy people, then in 10 people with epilepsy who are already scheduled for a standard scalp EEG. The goal is to see if the e…

This study looks at kidney function in 100 children with epilepsy, ages 1 month to 15 years. Researchers will test blood, urine, and use ultrasound to see if long-term seizure medicines cause kidney problems. The goal is to understand and detect any kidney damage early.

This study looks at how the bacteria in your gut might affect epilepsy that doesn't get better with standard medicines. Researchers will follow 120 people aged 3 to 50 who have drug-resistant epilepsy and are starting a new treatment like surgery or a special diet. By tracking ch…

This study is testing whether a special MRI dye called mangafodipir is safe and can show areas where the blood-brain barrier is broken in people with epilepsy that doesn't get better with medication. About 40 adults aged 18-60 will get the dye and have several MRI scans over a fe…

This study looks at how breathing and waking from sleep are connected in people with drug-resistant epilepsy. Researchers will measure carbon dioxide levels and breathing responses during deep sleep in 60 participants. The goal is to better understand why some patients face a hig…

This study looks at how scopolamine, a drug that can cause memory problems, changes brain activity during memory tasks. About 60 adults with epilepsy who are already having brain surgery for seizure monitoring will take part. They will receive either scopolamine or a saltwater pl…

This study looks at how metabolism and the immune system might be connected to brain development in children with autism, epilepsy, brain tumors, or other psychiatric conditions. Researchers will collect blood samples and do behavioral assessments from up to 500 children to find …

This study aims to improve how doctors locate the exact spot in the brain causing seizures in people with epilepsy that doesn't respond to medication. Researchers will use advanced MRI and other brain scans to create a detailed map of normal brains, then compare them to the brain…

This study looks at why some people with epilepsy die suddenly and unexpectedly (SUDEP). Researchers will monitor how seizures affect breathing, heart function, and the ability to wake up. They want to see if a weak response to high carbon dioxide levels during sleep or after a s…

This study aims to understand how repetitive brain stimulation (TMS) changes brain activity. Researchers will use special brain recordings from people with epilepsy or depression to find markers that show TMS is working. The goal is to make TMS a more effective treatment for depr…

This study uses a powerful 7T MRI scanner to look at brain structure and function in people with migraine, visual snow, or epilepsy, and compares them to healthy volunteers. The goal is to better understand how these conditions affect the brain and why they often occur together. …

This study looks at how a part of the brain called the hippocampus works when people explore what they see. Researchers will record brain activity in epilepsy patients while they look at different scenes or move around. The goal is to learn more about memory and navigation, not t…

This study compares two advanced brain-mapping techniques—MEG and high-resolution EEG—to see which better locates the seizure-causing area in people with drug-resistant epilepsy who are candidates for surgery. One hundred participants will undergo both scans before surgery. The g…

This study is testing a small, ear-worn device that can detect and predict seizures in people with epilepsy. About 40 adults staying in a hospital epilepsy monitoring unit will wear the device while their brain activity is recorded with standard equipment. The goal is to see how …

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse disorder. Researchers will measure brain responses and any changes in movemen…

This study follows up to 150 people with MEHMO syndrome or related disorders to learn how the disease progresses. Researchers will collect blood, urine, spinal fluid, and skin samples, along with imaging and health checks. The goal is to find biological markers that could help di…

This study looks at how anti-seizure medications are processed in the bodies of pregnant women with epilepsy. Researchers will measure drug levels in the blood and urine to understand how much reaches the unborn baby and nursing infant. The goal is to help doctors choose safer do…

This study surveys 400 adults with epilepsy in France to understand why they are less physically active than others. Researchers will look at how fear, stigma, and personal beliefs affect exercise habits. The goal is to find ways to help people with epilepsy be more active and im…

This study looks at people with epilepsy that doesn't get better with medication. These patients already need brain electrodes to find where seizures start. Researchers want to see if using a wider range of electrical stimulation frequencies than usual helps better pinpoint the s…

This study aims to find out why some people with epilepsy do not get surgery that could help them, and to test an educational program that teaches patients about social factors affecting their care. About 310 adults with epilepsy and their healthcare providers will take surveys a…

This study looks at the medical records of 1,000 children with conditions like autism, epilepsy, and Down syndrome. The goal is to find common biological patterns that may help explain why these disorders develop. Researchers hope this will lead to better diagnosis and treatment …

This study looks at how people with temporal lobe epilepsy (TLE) remember spatial information, like directions, over several weeks compared to healthy volunteers. Researchers want to understand if these patients forget spatial details faster than usual, which can affect daily lif…

This study tests whether a type of MRI scan, called resting-state fMRI, can predict how well children with drug-resistant epilepsy will do after brain surgery. Researchers will scan 200 children aged 6 to 18 before surgery and check their seizure control one year later. The goal …

This study is testing whether a new digital test battery, Mindmore Distance, can accurately assess thinking and memory skills in people with brain conditions like stroke, Parkinson's, or multiple sclerosis. Researchers will compare results from home-based tests with standard in-p…

This study looks at how controlled sensory stimulation, such as music, changes brain activity in people with epilepsy and healthy volunteers. Researchers will measure brain networks and track anxiety and depression levels. The goal is to better understand brain function, not to p…

This study explores whether combining a driving simulator with an EEG (a brain activity test) can better assess driving ability in people with epilepsy. Researchers will measure attention, reaction time, and driving performance in 40 adults with epilepsy who hold a valid driver's…

This study looks at how children with epilepsy learn things without trying, like riding a bike or picking up social cues. Researchers will compare 40 children—some with epilepsy and some without—using a simple computer task. The goal is to see if this type of learning is affected…

This study aims to learn more about rare genetic disorders that affect brain development, such as Syt-1 disorder and Baker Gordon Syndrome. Researchers will collect health information and samples from 100 participants (children and adults) and their caregivers to track symptoms, …

This study looks at how bacteria in the gut and mouth are linked to different types of epilepsy and whether they affect how well seizure medicines work. Researchers will collect stool, saliva, and blood samples from 1,500 people with newly diagnosed epilepsy and healthy volunteer…

This study looks at how vagus nerve stimulation (VNS) changes the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. It is not a treatment study—it aims to learn how VNS works. About 144 adults aged 18 and olde…

This study aims to improve how doctors plan epilepsy surgery by using advanced MRI scans to map brain connections. Researchers will compare these scans with electrical recordings from inside the brain in 290 people with drug-resistant epilepsy. The goal is to develop noninvasive …

This study looks at how well pregnant women with epilepsy follow recommended care guidelines and how that affects their health and their baby's health. Researchers will track 80 women from two Toronto hospitals to see if following guidelines leads to better outcomes. The goal is …

This study observes brain electrical activity in epilepsy patients who already have electrodes implanted for surgery. Participants do simple computer tasks to test memory, language, emotions, and more. The goal is to learn which brain areas control these functions, not to provide…

This study aims to better understand how the brain controls mood by recording brain activity directly in people with depression or epilepsy. Researchers will use artificial intelligence to analyze these recordings and link them to mood changes. The goal is to improve treatments f…

This study uses PET and MRI scans to look at serotonin pathways in the brainstem of adults with Dravet syndrome, a severe epilepsy. Researchers want to see if these pathways are different in Dravet patients compared to those with other drug-resistant epilepsy and healthy people. …

This study tests whether a special micro-electrode can safely record the activity of individual brain cells during epileptic seizures. It involves 30 adults with drug-resistant epilepsy who are already scheduled for brain surgery. The goal is to better understand what happens in …

This study looks at whether special brain wave patterns can predict if someone will have memory or thinking problems after surgery for epilepsy. About 50 adults with drug-resistant epilepsy who need brain electrode monitoring will do simple thinking tasks while their brain activi…

This study looks at whether people who have their first seizure after age 50 should be checked for hidden heart and stroke risks like high blood pressure or diabetes. Researchers will screen 420 participants and track if starting medications for these risks lowers future strokes.…

This study uses special brain recordings (intracranial electrodes) to map how the brain processes social and emotional information in people with treatment-resistant depression or epilepsy. Researchers aim to understand the brain networks involved in these feelings, which could l…

This study follows 1,000 children and teens with rare epileptic syndromes like West and Dravet syndrome. Researchers want to see how different treatments affect seizure control and thinking skills over time. The goal is to gather real-life data to help doctors and families make b…

This study uses three types of brain scans (PET, MRI, and EEG) to see how epilepsy affects brain activity and energy use. Researchers will compare scans from 30 adults with epilepsy and healthy volunteers. No treatments or drugs are given—the goal is simply to learn more about th…

This study looks at ways to better diagnose and treat people with drug-resistant focal epilepsy, a condition where seizures start in one part of the brain and don't respond to medication. About 337 adults will be followed to see how well different treatments—like surgery, focused…

This study aims to understand how ketamine produces feelings of dissociation (feeling detached from yourself or reality). Researchers will give ketamine to 20 adults with epilepsy who are staying in a monitoring unit at Stanford. They will measure dissociative symptoms using a st…

This study uses powerful MRI scanners to look at the brains of 700 people, including those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's, as well as healthy volunteers. The goal is to understand why some brains stay healthy while others develop disease. Re…

This study looks at how the brain's arousal systems respond to sights and sounds. Researchers will use brain scans and recordings from healthy volunteers and epilepsy patients who already have electrodes implanted. The goal is to understand shared brain pathways, not to treat any…

This study looks at how a device that stimulates the vagus nerve (used for depression or epilepsy) changes how the stomach works. Researchers will measure stomach emptying and capacity in 16 adults who already have the device. The goal is to understand the connection, not to test…

This study is looking for 100 adults with drug-resistant epilepsy to see if their body odor changes before a seizure. Researchers will collect scent samples and analyze them to find unique chemical markers. If successful, this could lead to a non-invasive device that warns people…

This study aims to learn more about the vagus nerve in people with epilepsy. Researchers will use a thin needle to record nerve signals while participants are awake, both with and without a vagus nerve stimulator device. The goal is to understand which nerve fibers are activated …

This study aims to create detailed maps of brain areas involved in thinking and effort in adults with epilepsy. Researchers will use mild electrical stimulation on the brain while patients perform tasks during their hospital stay. The goal is to better understand how different br…

This study looks at how the brain learns to control fine movements, like playing an instrument, by recording brain activity during awake surgery. About 50 people with epilepsy or brain tumors will use a theremin-like device while their brain signals are recorded. The goal is to b…

This study looks at whether routine EEG tests can help predict who will develop epilepsy after a stroke. Researchers will monitor 100 stroke patients with EEGs to find hidden seizures and identify early risk factors. The goal is to improve care and prevent future complications.

This study aims to uncover genetic factors that contribute to epilepsy and related disorders. Researchers at Boston Children's Hospital will analyze DNA from 5000 people with epilepsy to find gene changes that may explain the wide range of symptoms and outcomes. The goal is to be…

This study aims to learn more about epilepsy, especially in people whose seizures don't improve with medication. Researchers will screen up to 1,000 adults and children aged 8 and older using tests like EEGs, MRIs, and memory assessments. The goal is to better understand these se…

This study looks at how the brain manages emotions, especially fear, in people with epilepsy who already have electrodes implanted for surgery. Researchers will record brain activity and use mild electrical stimulation to see how certain brain areas talk to each other during emot…

This study tests whether using very small electrical currents to trigger seizures can help doctors better understand where seizures start in the brain. It involves children, teens, and young adults (ages 1–30) with drug-resistant epilepsy who are already scheduled for brain monit…

This study looks at whether measuring fast-ripples (very fast brain waves) during epilepsy testing can help surgeons decide where to operate. About 440 adults with drug-resistant epilepsy will take part. Half will have special electrodes that detect fast-ripples; the other half w…

This study looks at how facial expressions and speech patterns can show what someone is feeling inside. Researchers will record brain activity in people with depression or epilepsy while they watch videos and answer questions. The goal is to find better ways to measure mood conti…

This study looks at children who have both epilepsy (seizures) and movement problems like twitching or trouble controlling muscles. Researchers will collect medical and genetic information from 500 children across many countries. The goal is to learn more about these rare conditi…

This study is for people with epilepsy whose seizures are hard to capture with standard brain-wave tests. It tests a small device placed under the scalp that records brain activity for weeks. The goal is to see if the device helps doctors make better treatment decisions compared …

This study is looking for genetic heart problems in people with epilepsy that might raise their risk of sudden unexpected death. Researchers will test DNA from 600 adults and their relatives to find known heart-related gene changes. The goal is to better understand why some epile…

This study aims to develop a system called CAMERA that uses signals from the brain, body, and behavior to predict anxiety and memory states. Researchers will work with 40 epilepsy patients who are already undergoing brain monitoring. The goal is to create a tool that can continuo…

This study aims to understand how the human brain processes and understands language. Researchers will record brain activity from 40 adults with epilepsy who are already undergoing monitoring for their condition. By analyzing these recordings while participants listen to speech, …