EPILEPSY

This Phase 3 trial tests a single inhaled dose of alprazolam (a fast-acting sedative) to stop prolonged seizures in people aged 12 and older. The goal is to see if it can end a seizure within 90 seconds and prevent it from coming back for at least 2 hours. About 350 participants …

This phase 3 study tests whether an investigational drug called RAP-219 can safely reduce the number of focal seizures in adults with epilepsy. About 312 participants will take either a low or medium dose of RAP-219 or a placebo pill daily. The main goal is to see if the drug low…

This study is testing whether cannabidiol (CBD) oil can reduce seizures in children aged 1 to 18 with severe epilepsy that doesn't respond to standard treatments. Each child will receive both CBD and a placebo in alternating periods, and their seizures will be tracked using a sma…

This study looks at whether removing a brain tumor and the nearby area where seizures start can help people with tumor-related epilepsy. About 100 people aged 8 and older with brain tumors and seizures will have surgery and be followed for up to a year. The goal is to see if seiz…

This study tests an experimental drug called RAP-219 in 333 adults with focal seizures (a type of epilepsy). The goal is to see if the drug safely reduces how often seizures happen compared to a placebo. Participants must be 18-75, have had focal epilepsy for at least 2 years, an…

This early-stage trial tests a new drug called SIF001, a monoclonal antibody designed to treat epilepsy. Researchers are giving the drug to healthy volunteers and people with epilepsy to check its safety, how the body processes it, and what side effects may occur. The study uses …

This study tests whether giving calcium and vitamin D supplements based on vitamin D levels can improve pregnancy outcomes in women with epilepsy. Researchers will enroll 80 women who are planning pregnancy or are in early pregnancy. Participants will receive different doses of c…

This study tests brain surgery as a treatment for people whose epilepsy doesn't improve with medication. About 300 children and adults aged 8 and older will have surgery to remove or treat the part of the brain causing seizures. The goal is to stop or greatly reduce seizures, tho…

This study tests whether a smartphone app called Medilepsy®, which uses artificial intelligence to personalize reminders, helps teens and young adults (ages 14-24) with epilepsy take their anti-seizure medicine more regularly. The study will enroll 200 underserved participants in…

This study follows 210 people with epilepsy who already have the Minder device implanted. The device helps doctors make better treatment decisions by detecting seizures that standard tests miss. Participants will be monitored every six months for two years to see how the device i…

This study tests whether a new system that shares tasks among healthcare workers and uses an electronic medical records system can help people with epilepsy in Kenya take their medication regularly and stay in care. About 650 people aged 12 and older who have epilepsy but are not…

This study tests a new drug called SPN-817 in 60 adults whose epilepsy does not improve with standard treatments. The main goal is to see if the drug is safe and tolerable. Researchers will also track whether it reduces the number of motor seizures. Participants take the drug as …

This early-phase trial tests an injection of special brain cells (GABAergic interneuron progenitors) in 6 adults with drug-resistant mesial temporal lobe epilepsy. The goal is to see if the treatment is safe and can reduce seizure frequency. Participants will receive the cell the…

This pilot study tests a device called NaviFUS that uses low-intensity focused ultrasound to calm overactive brain areas. It involves 16 adults with drug-resistant epilepsy who still have frequent seizures despite trying at least three medications. The goal is to see if the treat…

This pilot study tests whether everolimus, a drug usually used for cancer, can help control seizures in people with drug-resistant focal epilepsy. Only 5 adults aged 18-60 will take the drug during seizure events for 12 weeks. The goal is to see if seizure frequency drops and if …

This Phase 3 trial tests whether taking levetiracetam three times daily (instead of the usual twice daily) leads to more seizure-free days in adults with uncontrolled epilepsy. 120 participants will take the drug three times a day for 12 months and compare their results to their …

This study tests whether L-serine, a natural amino acid taken as a supplement, can improve overall functioning in children and young adults (ages 2-30) with GRIN-related neurodevelopmental disorders caused by certain gene variants. Each participant will receive both L-serine and …

This study tests an experimental drug called ASO-GNAO1 (Tianasen) in 5 children aged 1 to 14 with a specific GNAO1 gene mutation that causes severe epilepsy and movement problems. The drug is given via spinal injections over 12 months to see if it can reduce seizures and improve …

This study tests the long-term safety of an experimental drug called RAP-219 in 30 adults whose focal seizures do not respond well to current treatments. Participants must have already completed a related earlier study. The goal is to see if RAP-219 remains safe and helps reduce …

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce seizures in people with drug-resistant epilepsy. About 60 participants will receive either real or sham (fake) stimulation over 10 days. The goal is to see if this approach safely lowers se…

This study tests a new tool called BioEP that helps doctors decide if someone has epilepsy. About 559 adults who had their first possible seizure will take part. The tool analyzes EEG brain wave results to improve diagnostic accuracy.

This study is testing whether a new digital test battery, Mindmore Distance, can accurately assess thinking and memory skills in people with neurological conditions like stroke, Parkinson's, or multiple sclerosis. Researchers will compare results from home-based computer tests wi…

This study is testing a small device that fits in the ear to detect seizures by measuring brain waves. Researchers will first test it on 5 healthy people, then on 10 people with epilepsy who are already scheduled for a standard scalp EEG. The goal is to see if the in-ear device i…

This study is testing a new type of EEG device called tripolar EEG (tEEG) to see if it can detect seizures in people with epilepsy better than the standard EEG. Researchers will compare recordings from both devices in 90 adults and children. The goal is to see if tEEG reduces int…

This study is testing a wearable device that sits on the ears and uses sensors to detect and predict seizures in people with epilepsy. The device records brain, muscle, and eye activity, along with heart rate and skin signals. It will be compared to standard hospital EEG monitori…

This study tests whether giving the drug sirolimus early in life can prevent or delay seizures in infants with tuberous sclerosis complex (TSC). About 64 babies under 7 months old will receive either sirolimus or a placebo. Researchers will track when seizures first appear and mo…

This study tests if the drug levetiracetam can prevent epileptic seizures in 120 adults over 40 with Down syndrome and Alzheimer's disease. Participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop seizures and possibly slow brai…

This study tests a new educational program called ReBOOT for adults with epilepsy who are scheduled for brain surgery. The program includes virtual group sessions and homework over 5-6 weeks before surgery, designed to help reduce the risk of cognitive decline or support recovery…

This study tests whether a 12-week virtual group program led by a neuropsychologist can improve memory, focus, and daily functioning in adults with epilepsy. Participants learn brain-health strategies and practice them for a year. Researchers compare their progress to a group tha…

This early-phase study tests whether breathing in rose scent can reduce the number of times people with epilepsy stop breathing during seizures. Forty adults admitted to a hospital epilepsy monitoring unit will have their brain activity and breathing tracked for 48 hours, with ro…

This study tests a sleep improvement program for children with epilepsy, combining clinic visits and a smartphone app. It includes 150 children ages 1.5 to 9 and their parents. The goal is to improve sleep quality and overall health for both children and parents.

This study compares two self-management programs (UPLIFT and PACES) against usual care for adults with epilepsy. Researchers will track depression symptoms, quality of life, and seizures over 12 months in 108 participants. The goal is to see if these programs help people manage t…

This study tests whether listening to specific music daily can reduce seizure-related brain activity in adults with drug-resistant epilepsy. Participants have an implanted device that records brain activity and will listen to different music types over several months. The goal is…

This study tracks 50 people in Japan who receive BUCCOLAM (midazolam) for status epilepticus, a type of prolonged seizure. Doctors will record side effects and whether the drug stops seizures within 10 minutes. The goal is to ensure the medicine is safe and works well in everyday…

This pilot study tests whether participating in the Lullaby Project—where pregnant women with epilepsy work with musicians to create a personal lullaby—can improve their quality of life and reduce anxiety, depression, and stress. Thirty first-time pregnant women with epilepsy wil…

This study tests whether shining low-level infrared light on the scalp (photobiomodulation) can lower stress and improve seizure control in people with epilepsy. Eighty adults with epilepsy will attend 45 sessions over 15 weeks. Researchers will measure changes in perceived stres…

This study tests whether methylphenidate (Ritalin), a drug used for ADHD, can improve attention and memory in adults with epilepsy. 226 participants will be randomly assigned to take either the drug or a placebo for 8 weeks, then all can take the drug for another 8 weeks. The goa…

This study is testing whether high doses of vitamin D, followed by a lower maintenance dose, can reduce seizure frequency, fatigue, and improve quality of life in adults with epilepsy. Two hundred participants will receive vitamin D supplements and be monitored for three months. …

This early study tests a device that uses low-intensity focused ultrasound to calm overactive brain areas in people with drug-resistant temporal lobe epilepsy. Eight adults will receive up to three 10-minute ultrasound sessions. Researchers will track side effects and check if se…

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep issues, anxiety, depression, or epilepsy. Researchers will track changes in symptoms using standard questionnaires over 24 weeks. The goal is to see how well medical cannabis work…

This study aims to help people with epilepsy who have repeated seizures learn how to use rescue medication more effectively. In the first phase, patients, caregivers, and doctors will help design an educational program. In the second phase, about 35 adults will try the program fo…

This study tests whether listening to Mozart or other age-appropriate songs can reduce seizure activity in children with epilepsy. Ten children aged 4 to 17 staying in an epilepsy monitoring unit will listen to short music clips through earbuds. Researchers will measure changes i…

This study tests whether a 24-week collaborative care program can improve quality of life for adults with epilepsy who also have anxiety or depression. The program includes regular check-in calls and expert recommendations from a psychiatrist and neurologist. Researchers will com…

This study compares two 8-week telephone support programs for 120 adults with epilepsy who have mild to moderate depression. One program teaches skills to manage depression, while the other offers group support. Researchers will track mood, quality of life, and seizures for a yea…

This early-stage study is testing whether a contrast agent called mangafodipir can safely highlight areas where the blood-brain barrier is broken in people with drug-resistant epilepsy. Forty adults will undergo MRI scans with mangafodipir and gadolinium to see if these scans can…

This study investigates how social information—like knowing a task will be easy or hard—affects brain activity in people with epilepsy. Participants, who already have electrodes implanted in their brains for medical reasons, will rate their doctors and then complete tasks involvi…

This study explores how a technique called Temporally Interfering Electric Fields Stimulation (TIEFS) affects brain activity and thinking. TIEFS uses electrodes on the scalp to send electrical currents that can reach deep brain areas without surgery. Researchers will test it in a…

This study investigates how rehearsal (repeating information) and sleep help solidify memories in people with epilepsy. Participants learn object-location pairs, with some pairs rehearsed and others not, and their memory is tested after a short delay and again after 12 hours—eith…

This study looks at how the brain processes emotions by using tiny electrical pulses in people with epilepsy who already have electrodes implanted for surgery. Researchers will measure brain activity and physical responses like sweat to understand how certain brain areas control …

This observational study follows 150 people with MEHMO syndrome or related conditions to better understand how the disease progresses. Researchers will collect medical history, imaging, and lab samples to find biological markers that could help monitor the disease. No treatment i…

This study aims to understand why some people with epilepsy die suddenly (SUDEP). Researchers will measure how well patients sense carbon dioxide in their blood and how seizures affect breathing and heart function. 335 adults with epilepsy will be followed for up to 10 years. The…

This study uses advanced brain scans (MRI and MEG) to better locate seizure-causing areas in people with epilepsy who are considering surgery. Researchers will also create a database of normal brain images from healthy volunteers. The goal is to improve surgical outcomes by compa…

This study aims to create a large database linking brain wave recordings (EEG) and medical records from up to 20,000 epilepsy patients at the University of New Mexico. By combining these two types of information, researchers hope to find patterns that predict seizures and improve…

This study looks at how the brain's arousal systems work when we see, hear, or feel things. Researchers will use brain scans, eye tracking, and electrical recordings in healthy volunteers and epilepsy patients. The goal is to understand shared brain pathways that help us stay ale…

This study tests a 12-week group educational program for people aged 55+ with epilepsy. The program covers healthy aging, chronic disease management, and dementia risk factors. Researchers want to see if it improves dementia knowledge, health literacy, and quality of life. 380 pa…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This study looks at brain activity in 100 adults with epilepsy who already have electrodes implanted for seizure monitoring. Researchers will record brain signals while participants answer questionnaires and perform memory and impulse-control tasks. The goal is to find links betw…

This study looks at whether a device called the Minder, implanted under the scalp, can help doctors make better treatment plans for people with epilepsy whose standard brain wave tests (EEG) are not clear. About 210 adults with drug-resistant epilepsy will either get the Minder d…

This study aims to develop a better way to measure how the brain uses sugar (glucose) for energy. Researchers will use advanced MRI-like scans at 3 or 7 Tesla strength in 20 healthy volunteers and people with Glut1 deficiency, a rare condition that affects brain fuel. Participant…

This study screens children and adults aged 8 and older with known or suspected epilepsy, especially those whose seizures are not controlled by medication. Participants undergo tests like EEG, MRI, and PET scans to characterize their epilepsy. The goal is to find suitable candida…

This study aims to create a detailed map of the vagus nerve's internal wiring during routine epilepsy surgery. Researchers will use special electrode cuffs to stimulate different parts of the nerve and record which organs respond, while also taking quick electrical images. The go…

This study tests a structured program to help adolescents with epilepsy transition from pediatric to adult healthcare. Researchers will compare how many patients attend their first adult clinic appointment and whether they return to pediatric care. The goal is to improve self-man…

This study looks at whether using different electrical stimulation frequencies can better pinpoint where seizures start in the brains of people with epilepsy that doesn't respond to medication. Twenty patients who already need brain electrodes as part of their surgical workup wil…

This study looks at how children with epilepsy learn things without trying, like picking up new skills or habits automatically. Researchers will compare 40 children—some with epilepsy and some without—using a simple computer task. The goal is to see if this type of hidden learnin…

This study records brain activity from epilepsy patients who already have electrodes implanted for medical reasons. While listening to sentences and stories, their neural signals are analyzed to map how the brain processes language. The goal is to understand the brain's language …

This study uses PET and MRI scans to look at serotonin pathways in the brainstem of adults with Dravet syndrome, a severe form of epilepsy. Researchers want to see if these pathways are different in Dravet patients compared to those with other drug-resistant epilepsy and healthy …

This study tests a special electrode that can record the activity of individual brain cells during epileptic seizures. Thirty adults with drug-resistant epilepsy who already need brain monitoring for surgery will have these electrodes implanted for a few weeks. The main goal is t…

This study looks at how anti-seizure medications are processed in the bodies of pregnant women with epilepsy. Researchers will measure drug levels in the blood and urine to understand how much reaches the unborn baby and nursing infant. The goal is to help doctors choose safer do…

This study looks at pregnant women with epilepsy to see how often doctors follow recommended care guidelines. Researchers will track pregnancy, delivery, and baby health, as well as epilepsy control. The goal is to understand if following guidelines leads to better outcomes for b…

This observational study looks at how controlled sensory stimulation, such as music, changes brain activity in people with epilepsy and healthy volunteers. Researchers will measure brain networks and track anxiety and depression symptoms. The goal is to better understand brain fu…

This study aims to find biological markers in the blood that may help explain brain development disorders like autism, epilepsy, and brain tumors. Researchers will compare children with and without these conditions to identify unique patterns. Up to 500 children will participate …

This study aims to understand how ketamine causes dissociative symptoms—feelings of detachment from oneself or reality—in people with epilepsy. Researchers will give ketamine to 20 adults staying in Stanford's epilepsy monitoring unit and measure their dissociative experiences us…

This study uses three brain imaging methods—PET, MRI, and EEG—to see how epilepsy alters brain metabolism and electrical activity. Researchers will compare scans from 30 adults with and without epilepsy. No treatment is given; the goal is to better understand the condition.

This study uses a thin needle to record signals from the vagus nerve in awake adults with epilepsy who already have a vagal nerve stimulator implanted. Researchers aim to identify which nerve fibers are activated during stimulation and how different settings affect them. The goal…

This study looks at medical records of 1000 children with conditions like autism, epilepsy, and Down syndrome to find common biological patterns. Researchers want to understand what causes these disorders and how children respond to treatments. The goal is to improve diagnosis an…

This study looks at how different parts of the brain handle mental effort in adults with epilepsy. Researchers will use tiny electrical pulses on the brain's surface while patients do thinking tasks. The goal is to create detailed maps of brain function to help guide future epile…

This study looks at how the bacteria in your gut might affect epilepsy that doesn't get better with standard medicines. Researchers will follow 120 people aged 3 to 50 who have drug-resistant epilepsy and are starting a new treatment like surgery or a special diet. The goal is to…

This study has two parts. First, researchers survey patients and doctors to find out what stops people with epilepsy from getting surgery. Then, they test a video-based education program called PEERS that teaches patients how social factors like income and housing can affect thei…

This study looks at people with drug-resistant focal epilepsy, a condition where seizures start in one part of the brain and don't respond to medication. Researchers will use advanced tests to better pinpoint the seizure source and guide treatment, which may include surgery or le…

This study looks at how breathing and waking up from sleep are linked in people with drug-resistant epilepsy. About 60 adults with epilepsy and healthy volunteers will have their breathing tested during deep sleep. The goal is to understand why some people with epilepsy are at ri…

This study uses magnetoencephalography (MEG), a non-invasive brain scan, to compare brain signals in 1,500 children with neurodevelopmental disorders (like epilepsy, autism, ADHD) and healthy children. The goal is to improve diagnosis and understanding of these conditions. No tre…

This study collects information from 500 children worldwide who have both epilepsy and movement disorders caused by specific gene changes. Researchers will analyze medical records to find patterns linking symptoms to genetics. The goal is to create a shared database that helps do…

This study aims to understand how repetitive brain stimulation (TMS) changes brain activity. Researchers will use special electrodes placed inside the brain (in people with epilepsy) and noninvasive recordings to track these changes. The goal is to find reliable brain markers tha…

This study looks at how the brain makes sense of sentences. Researchers will record brain activity from electrodes already placed in the brains of people with epilepsy for medical reasons. Participants read or listen to sentences word by word and pick a picture that matches. In s…

This study aims to better understand how brain activity relates to mood in people with depression or epilepsy. Researchers will record brain signals directly from electrodes placed inside the skull while participants complete mood assessments and tasks. The goal is to use explain…

This study looks at whether people who have their first seizure after age 50 should be checked for stroke risk factors like high blood pressure, diabetes, and high cholesterol. Researchers will screen 420 participants and track whether starting medications for these risks improve…

This study aims to understand how the hippocampus, a brain region key for memory and navigation, behaves when people look around and explore. Researchers will record brain activity in 56 adults with epilepsy who already have electrodes implanted for medical reasons. Participants …

This study follows 1,000 children and teens with rare epilepsies (like West and Dravet syndromes) to see how different treatments affect their seizures and thinking skills. Researchers will compare care across hospitals to find what works best. The goal is to give families cleare…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse. Researchers will use brain recordings and movement tests to see if the ultra…

This study combines advanced MRI scans with intracranial EEG recordings to map brain networks in people with drug-resistant epilepsy. Researchers aim to develop noninvasive imaging biomarkers that predict where seizures start and how they spread. The goal is to improve surgical o…

This study is developing a platform called CAMERA that uses wristband sensors and smartphone data to predict anxiety and memory states in people with epilepsy. Researchers will monitor 40 patients in the hospital to see how brain, body, and behavior signals relate. The goal is to…

This study looks at whether a special brain imaging method called dynamic spectral imaging (ISD) can predict if someone will have memory or thinking problems after epilepsy surgery. Researchers will map brain activity during cognitive tasks in 50 adults with epilepsy who are alre…

This study compares two advanced brain-mapping techniques—magnetoencephalography (MEG) and high-resolution EEG (EEG HR)—to see which better locates the seizure-causing area in people with drug-resistant epilepsy who are candidates for surgery. Researchers will enroll 100 particip…

This study records brain electrical activity in epilepsy patients who already have electrodes implanted for surgery. Participants perform tasks like viewing pictures, recalling details, and naming objects while their brain signals are measured. The goal is to map where memory, la…

This study observes 100 people with rare genetic neurodevelopmental disorders like Baker Gordon Syndrome and Syt-1 disorder. Researchers will track symptoms, collect genetic and imaging data, and create cell models to better understand these conditions. The goal is to improve dia…

Researchers at Boston Children's Hospital are recruiting 5,000 people with epilepsy to study their genes. By comparing DNA from patients and their parents, they hope to find genetic changes linked to epilepsy. This study does not test a new drug or treatment, but aims to better u…

This study looks at how the brain learns to control sound by having patients play a theremin-like instrument during awake brain surgery. Researchers will record brain activity directly from the surface of the brain to understand sensorimotor learning. The study involves 50 people…

This study is testing whether a type of MRI scan, called resting-state functional MRI, can predict if epilepsy surgery will be successful in children aged 6 to 18. The scan measures how different parts of the brain communicate while at rest. Researchers hope this will help doctor…

This study tests whether using tiny electrical currents to trigger seizures can help doctors better understand where seizures start in the brains of children with drug-resistant epilepsy. About 86 children and young adults (ages 1-30) who are already scheduled for brain monitorin…

This study is looking at how people with conditions like schizophrenia, bipolar disorder, depression, and neurological diseases (such as Alzheimer's or stroke) perform on computer-based thinking tests. The goal is to create a detailed map of cognitive strengths and weaknesses acr…

This study looks at how the choices we make affect what we remember. Researchers will record brain activity from 50 epilepsy patients while they perform decision-making and memory tasks. The goal is to understand the brain processes that link decision-making to memory, which coul…

This study looks at kidney function in 100 children with epilepsy, aged 1 month to 15 years, at Sohag University Hospital. Researchers will measure blood and urine markers and use ultrasound to check for kidney stones or damage linked to long-term anti-seizure medication. No new …

This study explores whether a driving simulator combined with an EEG (brain wave monitor) can better assess driving ability in people with epilepsy. Researchers will measure attention, speed, and braking in 40 licensed drivers with epilepsy. The goal is to improve how doctors dec…

This study is testing whether people with epilepsy release specific odors that can predict a seizure before it happens. Researchers will collect skin swabs from 100 adults with drug-resistant epilepsy during and between seizures. The goal is to identify the chemical 'signature' o…

This study surveys 400 adults with epilepsy in France to understand why they are less physically active than the general population. Researchers will look at how fear, stigma, and personal beliefs affect exercise habits. The goal is to find ways to help people with epilepsy be mo…

This observational study looks at how bacteria in the gut and mouth are linked to epilepsy and whether they affect how well seizure medicines work. Researchers will collect stool, saliva, and blood samples from 1,500 people with newly diagnosed epilepsy and healthy controls. By a…

This study aims to understand how the brain processes social and emotional information in people with treatment-resistant depression or epilepsy. Researchers will use special electrodes placed inside the brain to record activity while participants perform mood-related tasks. The …

This study looks at how a device that stimulates the vagus nerve (used for depression or epilepsy) affects stomach emptying and digestion. Researchers will compare stomach function in 16 people who already have the device to healthy controls. The goal is to understand the connect…

This study looks at how memories are processed during sleep by recording brain activity in epilepsy patients. Researchers will use gentle electrical and sound stimulation during sleep to see if it changes memory recall. The goal is to understand the brain's natural memory consoli…

This study uses a powerful 7T MRI scanner to look at brain structure and activity in people with migraine, visual snow, or epilepsy, as well as healthy volunteers. The goal is to better understand how these conditions affect the brain. No treatment or medication is tested—only ob…

This early-phase study investigates how scopolamine, a drug known to affect memory, changes brain activity in people with epilepsy who are already undergoing brain monitoring for seizures. Sixty participants will receive either scopolamine or a placebo and perform memory tasks wh…

This study tests whether adding a risk prevention program to standard epilepsy education helps adults with uncontrolled epilepsy improve their safety behaviors. 74 participants will be split into two groups: one gets the extra risk prevention session, the other gets usual care. T…

This study uses powerful MRI scanners to look at the brains and spinal cords of 700 people, including healthy volunteers and those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's. The goal is to understand why some brains stay healthy while others decline. R…

This study aims to understand how the brain processes rewards in people with depression. Researchers will record brain activity from epilepsy patients who also have depression while they play a gambling task. The goal is to identify abnormal brain signals that could guide future …

This study will use routine EEG recordings in 100 stroke patients to see if brain activity patterns can predict who will develop epilepsy. Researchers also aim to detect hidden (subclinical) seizures that may affect recovery. The study is observational, meaning no new treatment i…

This study looks at whether measuring a specific type of brain wave called 'fast-ripples' can help surgeons do a better job treating drug-resistant epilepsy. About 440 patients will have brain monitoring with special electrodes before surgery. Half will have fast-ripple informati…

This study looks at a part of the brain called the posterior cingulate cortex (PCC) to understand how it helps us make memory-based decisions, like recognizing a picture we've seen before. Researchers will record brain activity from 130 epilepsy patients who already have brain mo…

This study from Mayo Clinic looks for genetic heart conditions in people with epilepsy that might raise the risk of sudden unexpected death (SUDEP). Researchers will analyze DNA from 600 adults aged 18-50 with epilepsy or related symptoms, plus their blood relatives. The goal is …