EPILEPSY

This study is testing whether a gentle, focused ultrasound beam can safely calm overactive brain areas in people with movement disorders like Parkinson's or essential tremor, and conditions like epilepsy or addiction. Researchers will measure changes in brain activity and symptom…

This study offers standard surgical procedures to people aged 8 and older whose seizures are not controlled by medication. The goal is to remove or treat the specific area of the brain causing the seizures to reduce or stop them. Researchers will collect data from these routine t…

This study is testing the long-term safety and effectiveness of an investigational drug called RAP-219 for adults with focal epilepsy that doesn't respond well to current medications. It follows 30 participants who have already completed a related short-term study to see how well…

This study is testing whether a dietary supplement called L-serine can help improve overall health and daily functioning in children and young adults (ages 2-30) with rare genetic brain disorders known as GRIN-related disorders. Each participant will try both the L-serine supplem…

This small, early-stage study is testing whether adding the drug everolimus to a person's current anti-seizure medications can help reduce seizure frequency in adults with focal epilepsy that doesn't respond well to standard drugs. The idea is based on research suggesting everoli…

This study is testing whether measuring specific, fast brain signals called 'fast-ripples' can help doctors better plan surgery for people with drug-resistant epilepsy. It will compare surgery outcomes for 440 patients, where half have their brain surgery plan informed by these s…

This study is for people who have seizures because of a brain tumor. Researchers want to see if surgery to remove the tumor can also reduce or stop the seizures. Participants will have the surgery and then be followed for several months to track their seizure activity, quality of…

This study is testing if taking the epilepsy drug levetiracetam three times a day works better and is easier to tolerate than the standard twice-a-day schedule. It involves 120 adults whose seizures are not fully controlled on their current high-dose, twice-daily regimen. Each pa…

This study is testing a special education program designed to help adults whose epilepsy is not well controlled. The program teaches patients how to recognize and manage risks in their daily lives to stay safer. Researchers will compare this new program to the usual education to …

This study follows 210 people with hard-to-track epilepsy who already have a small, FDA-approved device implanted under their scalp. The goal is to see how the long-term data from this device helps their doctors make better decisions about their treatment over two years. It is an…

This study is testing a new support program to help people with epilepsy in Kenya stay on their medication and keep up with their doctor visits. Researchers will compare the new system, which uses task-sharing and electronic tracking, to usual care for 650 participants over 18 mo…

This study is testing whether a personalized, non-invasive brain stimulation treatment can reduce seizure frequency in people with drug-resistant epilepsy. 60 participants aged 9+ will receive either real or sham stimulation for 10 days in a crossover design. Researchers will mea…

This study is testing a new drug called Tianasen for children with a rare and severe genetic brain disorder called GNAO1-encephalopathy. The goal is to see if the drug can safely reduce seizures and movement problems and possibly slow the disease's progression. All participants w…

This study is testing whether a medication called levetiracetam, commonly used for seizures, can prevent epileptic seizures in adults with Down syndrome who also have Alzheimer's disease. Researchers also want to see if the drug can slow down the brain changes and memory loss lin…

This study is testing a self-management program designed to help adults with epilepsy better use their rescue medication to control breakthrough seizures. First, patients and caregivers will help design the program materials. Then, about 35 participants will try the 6-month progr…

This study is testing whether a smartphone app with AI personalization can help teens and young adults with epilepsy take their seizure medication more reliably. It will compare the AI version of the app to a standard version without AI. The goal is to see if the app improves med…

This study aims to compare two advanced brain scanning techniques—magnetoencephalography (MEG) and high-resolution electroencephalography (EEG)—to see which is better at pinpointing the exact area of the brain causing seizures. It involves 100 people with drug-resistant epilepsy …

This study is testing a new in-ear device called SeizEAR to see if it can safely and effectively monitor brain waves and detect seizures in people with epilepsy. Researchers will compare the device's readings to the standard method, which involves placing many electrodes on a per…

This study is testing a new type of brain wave monitor (called tEEG) to see if it can detect epileptic seizures better than the standard EEG equipment. Researchers will compare the new device against current methods in both children and adults with epilepsy. The goal is to see if…

This study is testing a new, comfortable device worn in the ear that aims to detect and predict epileptic seizures. Researchers will compare the device's accuracy to standard hospital EEG monitoring in 40 adult patients. The goal is to create a less intrusive way to monitor seizu…

This study is testing whether a special type of brain scan, called a resting-state functional MRI, can help predict if surgery will successfully control seizures in children with drug-resistant epilepsy. Researchers will analyze brain network patterns from the scans of 200 childr…

This study aims to improve how doctors use MRI brain scans to find the exact spot in the brain causing seizures in people with uncontrolled epilepsy. Researchers will compare scans from 500 epilepsy patients before and after surgery with scans from 200 healthy volunteers to creat…

This study is testing if a drug called sirolimus, given early in life, can prevent or delay the onset of seizures in infants diagnosed with Tuberous Sclerosis Complex (TSC). It will enroll 64 infants under 7 months old who have TSC but have not yet had seizures. The goal is to se…

This study is testing whether checking for heart and blood vessel risk factors in people over 50 who have a new seizure can help prevent future strokes and heart problems. Researchers will follow 420 participants for one year to see if managing these risks makes a difference. The…

This study tests whether a team-based care program can improve emotional well-being for adults with epilepsy who also experience anxiety or depression. Researchers will compare the new program against standard neurology care in 60 participants over 24 weeks. The program involves …

This study is testing a new educational program for adults scheduled for epilepsy surgery. The goal is to see if the training can help prevent or manage declines in memory and thinking that sometimes happen after surgery. Participants will attend virtual sessions before their ope…

This study is testing two different 8-week phone support programs to help people with epilepsy who are also experiencing depression. Researchers will compare a depression self-management program (UPLIFT) against general support groups (BOOST), both delivered in weekly one-hour ca…

This study is testing a sleep education program for children with epilepsy, who often have trouble sleeping. About 150 children, aged 1.5 to 9 years old, will try a program that combines in-person and digital sleep tips. Researchers will measure sleep using a wrist-worn activity …

This study is testing whether listening to specific music every day can reduce seizure activity and improve mood for adults with hard-to-treat epilepsy. Participants, who already have a special brain implant to monitor seizures, will listen to different music tracks at home for s…

This study is testing whether listening to recorded music, including a specific Mozart piece, can reduce the number of seizures and abnormal brain activity in children with epilepsy. Researchers at Johns Hopkins will have children aged 4 to 17 listen to music during their hospita…

This study aims to find better ways to assess if people with epilepsy can drive safely. Researchers will use a driving simulator and brain activity tests to measure attention and driving skills in 40 participants with epilepsy. The goal is to gather information that could help do…

This study aims to understand how our mood is connected to our brain activity, facial expressions, and speech. Researchers at Stanford will record video and audio of 10 participants with depression or epilepsy who have brain implants for medical treatment. They will analyze these…

This study is observing how a midazolam oral spray works for people experiencing prolonged epileptic seizures in Japan. It aims to collect information on any side effects and how well the spray stops seizures in everyday medical practice. The study will follow about 50 participan…

This study aims to understand how brain activity relates to mood, particularly in depression. Researchers will record brain signals directly from 58 participants who are already undergoing monitoring for epilepsy or treatment for severe depression. Using advanced computer analysi…

This study aims to see if a new type of MRI scan can safely and clearly show areas of the brain affected by drug-resistant epilepsy. Researchers are testing a contrast agent called mangafodipir to see if it can highlight where the brain's protective barrier is breaking down durin…

This study aims to understand if long-term epilepsy medications affect kidney function in children. Researchers will check the kidney health of 100 children with epilepsy, looking at blood tests, urine tests, and ultrasound scans. The goal is to gather information to help doctors…

This study aims to understand exactly how vagus nerve stimulation (VNS) therapy works for epilepsy. Researchers will use a fine needle to record nerve signals in 60 adults with epilepsy who already have a VNS implant. The goal is to see which specific nerve fibers are activated b…

This study aims to develop a new technology platform called CAMERA that uses multiple sensors to measure brain activity, body signals, and behavior. Researchers want to see if they can use this data to predict a person's anxiety levels and memory performance throughout the day. T…

This study aims to better understand MEHMO syndrome, a rare genetic disorder causing intellectual disability, seizures, and other serious health problems. Researchers will observe 150 participants, including affected individuals and their family members, to track symptoms over ti…

This study aims to understand how stimulating the vagus nerve affects the body's automatic functions like heart rate, blood pressure, and inflammation. Researchers will measure these effects in 144 adults who already have or will receive a vagus nerve stimulator for drug-resistan…

This study aims to understand how breathing and the brain's sleep-wake systems interact in people whose epilepsy doesn't respond well to medication. Researchers will monitor 60 participants overnight to measure their breathing responses and arousal thresholds during sleep. The go…

This study aims to better understand epilepsy and identify people who may be eligible for other research studies. It will screen and observe up to 1000 adults and children (age 8+) with diagnosed or suspected epilepsy. The main goal is to gather detailed clinical information to h…

This study aims to understand how the bacteria in our gut and mouth are connected to epilepsy and might influence how well seizure medications work. Researchers will collect samples from 1,500 people, including those newly diagnosed with epilepsy and healthy volunteers, to look f…

This study aims to better understand rare genetic disorders that cause both epilepsy and movement problems in children. Researchers are collecting medical history and genetic information from 500 children worldwide who have these conditions. By analyzing this data, they hope to f…

This study aims to understand how the human brain learns complex motor-sensory skills, like playing a musical instrument. Researchers will record brain activity from 50 patients who are already undergoing awake brain surgery for epilepsy or a brain tumor. During surgery, patients…

This study aims to improve surgery for people with drug-resistant epilepsy. Researchers will use advanced MRI brain scans to create detailed maps of a patient's brain network. The goal is to better predict where seizures start and spread, which could help surgeons plan more preci…

This study aims to better understand rare genetic disorders that affect brain development, such as Baker Gordon Syndrome and Syt-1 Disorder. Researchers will collect information from 100 participants with these conditions to track how symptoms change over time and identify marker…

This study uses a powerful 7 Tesla MRI scanner to take detailed pictures of the brain in people with migraine, drug-resistant epilepsy, or visual snow syndrome. Researchers want to see how the brain's structure and activity differ in these conditions compared to healthy volunteer…

This study aims to understand if people with epilepsy who are at high risk of sudden death might have an underlying genetic heart condition. Researchers are recruiting 600 adults with epilepsy or their family members to provide DNA samples for genetic testing. The goal is to iden…

This study aims to understand how specific deep-brain arousal circuits influence visual perception. Researchers will measure brain activity in epilepsy patients who already have implanted electrodes, while they perform simple visual tasks. The findings could help develop better t…

This early-stage study aims to see how a new version of an experimental capsule (NPT 2042) is absorbed by the body compared to the original version. It involves a small group of healthy adults who will take single doses of each capsule. The goal is to gather basic information to …

This study aims to identify specific odors people release before an epileptic seizure. Researchers will collect air samples from 100 adults with drug-resistant epilepsy during their hospital stay. The goal is to find a chemical 'signature' that could one day lead to a non-invasiv…

This study aims to better understand rare childhood epilepsies by following 1000 children and adolescents in real-world settings. Researchers will track how different treatments affect seizure frequency and how thinking skills and mental health change over time. The goal is to ga…

This study aims to understand how the human brain processes and understands speech. Researchers will record brain activity from up to 40 adults with epilepsy who are already undergoing a medical procedure involving brain monitoring. By comparing this brain activity to computer mo…

This study aims to understand how a vagus nerve stimulator (VNS), a device used to treat severe depression or epilepsy, affects how the stomach works. Researchers will measure how quickly the stomach empties and how much it expands after a meal in 16 people who already have the V…

This study is testing whether a routine brain wave test (EEG) can help predict which patients will develop epilepsy after having a stroke. Researchers will give EEGs to 100 stroke patients shortly after their stroke, even if they show no seizure symptoms. The main goal is to see …

This study aims to understand how the brain changes and adapts in various neurological conditions and during normal aging. Researchers will use advanced, high-powered MRI scans to look at brain structure, function, and energy use in 700 participants, including people with disease…

This study aims to understand how the brain processes social and emotional information in people with severe, treatment-resistant depression or epilepsy. Researchers will record brain activity using electrodes placed inside the skull for clinical monitoring. The goal is to map th…

This study aims to better predict whether epilepsy surgery might affect a patient's memory, attention, or other thinking skills. Researchers will map brain activity in 50 adults with drug-resistant epilepsy while they perform thinking tasks, using electrodes already implanted for…

This study aims to understand how magnetic brain stimulation (TMS) works to treat depression. Researchers will measure brain activity in people with epilepsy who are already having brain monitoring, comparing responses to real and sham stimulation. The goal is to find brain marke…

This study aims to discover genetic factors that cause epilepsy, particularly severe forms that begin in childhood. Researchers will analyze DNA from 5,000 patients with epilepsy to identify genetic patterns. The findings could lead to better diagnosis and future treatments, but …

This study aims to understand how a key memory area of the brain, the hippocampus, works while people look at and explore their surroundings. Researchers will measure brain activity in epilepsy patients who already have monitoring devices implanted, as well as in healthy voluntee…

This study aims to understand how a drug called scopolamine affects brain activity during memory tasks. Researchers will work with 60 adults who have epilepsy and already have electrodes implanted in their brains for medical monitoring. Participants will complete memory games on …

This study aims to learn if safely triggering seizures with tiny electrical currents can help doctors better map where seizures start in the brain of children and young adults with drug-resistant epilepsy. Researchers will test this stimulation method in 86 participants (ages 1-3…

This study aims to understand why some people with epilepsy experience dangerous breathing problems after seizures, which can lead to sudden unexpected death (SUDEP). Researchers will monitor 335 adults with epilepsy during hospital stays, testing how their bodies respond to incr…

This study aims to understand how temporal lobe epilepsy affects long-term spatial memory, like remembering a route. Researchers will compare how 37 people with epilepsy and healthy volunteers perform on a navigation task after learning it, testing their memory again one hour and…

This study is a survey aiming to understand why adults with epilepsy are often less physically active than others. It will enroll 400 participants to explore how factors like fear of seizures, stigma, and personal identity affect exercise habits. The goal is to gather knowledge t…

This study aims to understand how different parts of the human brain work by recording its electrical activity. It enrolls people with epilepsy who already have electrodes implanted for their medical care, as well as healthy volunteers. Participants complete simple computer tasks…

This study aims to understand how the brain processes and controls emotions like fear and anxiety. Researchers will use mild electrical stimulation and recordings in 30 epilepsy patients who already have electrodes implanted for their medical care. The goal is to map brain circui…