EPILEPSY

This study is observing how well the drug cenobamate works for adults with focal epilepsy whose seizures are not controlled by at least two other medications. It follows 936 patients in Italy for one year to see how much it reduces seizure frequency and to check for side effects.…

This study is testing the safety and early effectiveness of an implanted brain stimulation device for people with a severe form of epilepsy called Lennox-Gastaut Syndrome (LGS). The device, called the RNS System, is designed to detect and respond to abnormal brain activity to hel…

This study is testing whether playing very low, gentle sounds through headphones during sleep can help reduce seizures and abnormal brain activity in adults with epilepsy. Researchers are checking if people can comfortably use the sound system at home every night and measuring if…

This study aims to see how well an add-on anti-seizure medication works for adults with focal epilepsy in real-world settings. It will follow 300 patients for 12 months to measure changes in seizure frequency, safety, and quality of life. The goal is to understand the drug's effe…

This study aims to find safe ways to lower high cholesterol in adults with epilepsy who are on a special high-fat, low-carb diet that controls their seizures. Researchers will test if making small changes to the diet or adding a common cholesterol-lowering pill (a statin) can imp…

This study is testing the safety and basic function of a new brain implant system for people with severe, hard-to-treat epilepsy. The device senses brain activity, uses a computer program to predict seizure risk, and can deliver small electrical pulses to try to prevent seizures …

This small pilot study is testing whether stimulating a specific, deep part of the brain called the medial pulvinar can reduce seizures in people with epilepsy that hasn't responded to drugs, surgery, or other devices. It involves 12 adults who have tried and failed other treatme…

This study is following 140 adults with severe epilepsy who have received a surgically implanted brain stimulation device. The goal is to collect three years of real-world data to see how well the device continues to reduce seizure frequency and to monitor for any long-term safet…

This study is testing whether an experimental drug called BHV-7000 can reduce abnormal brain activity in people with epilepsy who have a special implanted brain device (RNS System). Five participants will take the drug for four weeks, and researchers will compare their brain reco…

This study is testing whether using a specific brain wave measurement from a scalp EEG can help doctors find the best settings for a vagus nerve stimulator (VNS) device. The VNS is already implanted in people with epilepsy that doesn't respond well to medication. Researchers want…

This study is testing special smart glasses designed to detect patterns in brain activity that may predict when an epileptic seizure is about to happen. The glasses have built-in sensors that read brain signals without needing messy gels. Researchers are checking how well the gla…

This study is testing a small, implanted device that records brain waves continuously for 40 days in people with uncontrolled epilepsy. The goal is to see if the device works reliably and safely over a long period. It aims to provide doctors with better long-term data to understa…

This study is testing a small device implanted under the scalp to monitor brain activity for up to 15 months in people with epilepsy and intellectual disability. The goal is to see if this long-term monitoring is safe, acceptable, and can accurately detect seizures that might oth…

This study is testing a small device called Minder that gets implanted under the scalp to monitor brain activity in people with epilepsy. It's designed for people whose seizures aren't well captured by standard EEG tests, making treatment decisions difficult. The research will co…

This study aimed to use advanced brain scanning to find the exact spots in the brain that cause seizures in people with hard-to-treat epilepsy. The goal was to create a better, non-invasive map to guide surgeons, potentially helping more people become seizure-free after surgery. …

This study is testing a new, easy-to-use EEG (brain wave recording) headset designed to improve access to epilepsy diagnosis for Veterans living in rural areas. The dry-electrode headset doesn't require a specialist to operate and could be used in local clinics as part of a teleh…

This study aimed to test a wearable device called EpiCare@Home for detecting epileptic seizures. The device, worn behind the ear, records brain activity, heart rate, and movement to help doctors monitor seizures more accurately than patient diaries. The trial was withdrawn before…

This study is testing a new psychological support program designed to help adults with epilepsy. The program aims to improve memory, reduce anxiety and depression, and enhance overall quality of life. Researchers will compare results between a group that receives the therapy righ…

This research study aims to understand how seizures spread in the brain and how memory works in people with epilepsy. Researchers will examine specific brain regions using special monitoring equipment already placed for medical care. The goal is to gather knowledge that could inf…

This study aims to understand how sleep helps memory and if playing quiet, timed sounds during sleep can improve it. It involves 24 epilepsy patients who already have special electrodes implanted for medical monitoring. Researchers will measure brain activity and test memory afte…

This study aims to determine which of two common anesthesia drugs (fentanyl or ketamine) works better for mapping brain activity during surgery for children with brain tumors and epilepsy. Doctors place electrodes directly on the brain during surgery to identify areas causing sei…

This study is testing a new type of brain implant system to see if it can detect very early, specific brainwave patterns that happen before an epileptic seizure. Researchers will use the device externally (not implanted) on 12 people with drug-resistant epilepsy to see if it can …

This study aimed to understand if gentle electrical stimulation, delivered through electrodes already placed in the brain for epilepsy surgery planning, could improve a person's working memory. It planned to test this in adults with drug-resistant epilepsy. The goal was to gather…

This study is creating a large international database to collect information from about 8,000 people who had a stroke and later developed seizures (post-stroke epilepsy). Researchers will analyze this data to better understand how seizures affect recovery and to build a tool that…

This study aims to learn how memory works by recording brain activity in epilepsy patients who already have electrodes implanted for their medical care. Researchers will have participants play memory games on a computer while monitoring their brain signals, and may gently stimula…

This study aims to understand how repeated seizures in people with Dravet Syndrome affect the body's automatic functions like breathing and heart rate. Researchers will monitor 92 children and adults with this severe form of epilepsy during sleep and around the time of their seiz…

This study is a survey to check if doctors and pharmacists in Saudi Arabia are aware of and following important safety warnings for the epilepsy drug Depakine (sodium valproate). It involves 3,500 healthcare professionals who prescribe or dispense the medication. No treatments ar…

This study aims to discover how the human brain understands speech across different languages like English, Spanish, and Mandarin. Researchers will record brain activity from patients already undergoing brain surgery for epilepsy or tumors. The goal is to map how speech sounds ar…

This study aims to understand if a child's genes affect their risk of developing epilepsy later in life after having seizures as a newborn. Researchers are following about 300 children and their parents to look for genetic clues. The goal is to combine genetic information with br…

This study aims to better understand how a common brain stimulation technique works. It is for people already scheduled for brain surgery to treat epilepsy or remove a tumor. Researchers will use the stimulation and a safe cooling technique during surgery to learn how it affects …

This study aims to understand the long-term effects of ketogenic diets on heart health in adults with epilepsy. Researchers are measuring cholesterol, blood pressure, weight, and artery wall thickness over two years. The study includes adults already on the diet and those startin…