EPILEPSY

This study tests a program where community health workers help adults with epilepsy who frequently visit the emergency room. Over 9 to 12 months, the health workers provide home visits and phone support to help with medication, seizure tracking, and connecting to doctors. The goa…

This early-phase study tested a new drug called BHV-7000 in 5 people with epilepsy who have a brain implant (RNS) that records brain activity. The goal was to see if the drug reduces abnormal electrical activity linked to seizures. Participants took the drug for 4 weeks, and thei…

This program provides brivaracetam (Briviact) to epilepsy patients who were already taking it in earlier studies, bridging the gap until the drug is commercially available. Patients continue their individual doses, up to 200 mg per day, with adjustments based on seizure control a…

This study tests a 12-week self-management program (SMART-U) for adults with epilepsy in Uganda. The program includes group sessions and phone follow-up to help people manage their condition. Researchers will compare seizure frequency and quality of life between those in the prog…

This study tests whether fine-tuning a vagal nerve stimulator (VNS) using a brain wave measure called phase lag index (PLI) can better reduce seizures in people with epilepsy that doesn't respond to medication. About 140 participants who already have a VNS device will have their …

This pilot study tests deep brain stimulation (DBS) of the medial pulvinar, a new target in the brain, for people with drug-resistant epilepsy who have not improved with other treatments. Twelve adults aged 18 to 60 will receive the stimulation and track their seizures for 12 mon…

This study tests a brain-responsive neurostimulation system in 24 people aged 12 and older with Lennox-Gastaut syndrome whose seizures are not controlled by medication. The device detects and responds to seizure activity in the brain to reduce drop seizures. The goal is to see if…

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older who are already on a keto diet or starting the modified Atki…

This study tests a new wireless device called UNEEG EpiSight, which is implanted under the skin to record brain activity (EEG) continuously for up to 13 months. It involves 19 adults with uncontrolled epilepsy whose seizures can be detected by the implant. The goal is to see if t…

This study looks at whether a statin drug (atorvastatin) and swapping some saturated fats for healthier ones can safely lower cholesterol in adults with epilepsy who have been on a modified Atkins diet for at least a year. The diet helps control seizures but can raise cholesterol…

This study looks at how well the drug cenobamate works for adults with focal seizures that don't improve with at least two other epilepsy medicines. Researchers are collecting data from Italian clinics and a compassionate use program to measure seizure reduction and side effects.…

This study compares a new ultra-high resolution PET/CT scanner, the NeuroEXPLORER, with standard clinical PET/CT scanners for imaging the head and neck. Researchers aim to see if the new device provides more detailed images to improve diagnosis of conditions like dementia, Parkin…

This study tests a new dry electrode headset that records brain waves (EEG) without needing a specialist to operate it. The goal is to make it easier for Veterans with epilepsy in rural areas to get this key diagnostic test. Researchers will compare the headset's performance to s…

This pilot trial tests a 15-week telehealth program called Surviving and Thriving in the Real World (STRW) for teens aged 14–18 with epilepsy who struggle with daily living skills. The program includes weekly caregiver-teen sessions and separate caregiver group meetings, all deli…

This study planned to test whether a brain-computer interface (BCI) could help children with drug-resistant epilepsy improve their attention. Participants would have used brain electrodes already implanted for epilepsy surgery to train a decoder that gives real-time feedback when…

This study tests whether playing a low-frequency sound during deep sleep can reduce seizure activity in people with epilepsy. About 36 adults will use a smartphone app and headphones at home for two months. The goal is to see if this simple, non-invasive method is feasible and ef…

This small study tested whether a non-invasive brain stimulation technique called tDCS can be used safely at home to reduce seizures in people with epilepsy. Four adults with hard-to-control seizures used the device daily for several weeks. Researchers tracked seizure counts, sev…

This study tests a pair of smart glasses called NEXA that can read brain signals through dry electrodes. The glasses aim to predict epileptic seizures in real time and alert the wearer with vibrations, lights, or sounds. Researchers will test the device on 47 adults with epilepsy…

This study tests a cognitive rehabilitation program for adults with epilepsy. The program includes six one-on-one therapy sessions and two group sessions over two months, focusing on memory strategies, coping skills, and social support. Researchers will measure changes in quality…

This study looked at how sounds played during sleep affect brain waves and memory in children with Rolandic epilepsy. Researchers used brain scans (MRI, MEG/EEG) to understand which brain circuits are involved. The goal was to find new treatment ideas for this type of childhood e…

This study investigates how the brain processes speech sounds to understand language. Researchers will record brain activity from people with epilepsy or brain tumors who already have electrodes implanted for medical reasons. Participants listen to short speech sounds while their…

This study investigates how the brain's emotion network works by recording brain activity directly from the surface of the brain in people with epilepsy who are already undergoing surgery for seizure monitoring. Participants watch short video clips designed to trigger emotions li…

This study looks at how vagus nerve stimulation (VNS) affects the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. Researchers will measure things like nerve activity, blood pressure, and heart rate during di…

This study tests whether Electrical Impedance Tomography (EIT) can produce accurate images of brain activity in people with epilepsy. EIT uses harmless electrical signals through electrodes on the scalp or brain to create images, and is compared to standard methods like MRI and E…

This study looks at how the brain creates and recalls memories by recording brain activity in people with epilepsy who already have electrodes placed for surgery. Participants play memory games on a laptop while their brain signals are recorded, and sometimes small electrical pul…

This study will collect and analyze genetic data from 1000 people with suspected inherited metabolic diseases, including conditions like epilepsy and mitochondrial disorders. Researchers at Karolinska University Hospital aim to improve diagnosis by using advanced genetic testing …

This study looks at how the brain handles two different tasks: finding your way around and remembering daily events, like when you last took medicine. Researchers want to understand what parts of the brain are used for each task and how prior knowledge helps. The goal is to find …

This study looks at gene activity in brain tissue removed during surgery from 10 people with temporal lobe epilepsy and hippocampal sclerosis. The goal is to find which genes are linked to the disease and may help predict outcomes. No new treatment is being tested; instead, resea…

This study looks at how electrical stimulation of the brain affects working memory in 50 people with epilepsy who already have electrodes implanted. Participants perform a memory task while receiving different types of stimulation. The goal is to understand brain rhythms and impr…

This study uses low-intensity focused ultrasound (LIFU) to gently stimulate the brain while recording responses with implanted electrodes. Researchers aim to map how different brain regions communicate in real time. About 30 adults with epilepsy or other conditions who already ha…

This study was designed to collect and analyze fluid from the brain during epilepsy surgery. The goal was to look for signs of inflammation that might help develop new ways to control seizures in people who don't respond to medication. However, the study was withdrawn before any …

This study tests a new brain implant system (CorTec Brain Interchange) in 12 people with drug-resistant epilepsy. The device records brain signals at high speed to detect abnormal activity that may lead to seizures. Unlike current devices that wait for a seizure to start, this sy…

This study was designed to test whether giving small electrical pulses directly to the brain could improve working memory in people with epilepsy. Researchers planned to use electrodes already placed in the brain for epilepsy surgery. However, the study was withdrawn before any p…

This study tests a brain implant that records brain activity and can deliver small electrical pulses to prevent seizures in people with epilepsy. Five participants will use the device along with a handheld tool to track mood, anxiety, and thinking. The main goal is to see if the …

This study follows about 300 children who had seizures shortly after birth to see if their genes influence whether they develop epilepsy later in childhood. Researchers will combine genetic information with brain scans and EEG results to create a risk score. No new treatments are…

This study planned to use high-frequency brain signals to locate important brain areas and understand conditions like epilepsy, migraine, and ADHD. It aimed to create a large database of brain activity in people aged 1 day to 69 years. However, the study was withdrawn before any …

This study looks at whether a tiny device placed under the scalp can safely and comfortably track seizures in adults with mild to moderate intellectual disability and epilepsy. Nine participants will wear the monitor for up to 6 months, and researchers will compare the device's r…

This study aims to build a research group of 100 people with neurological diseases like stroke, Parkinson's, epilepsy, or dementia. Researchers will use overnight sleep tests and questionnaires to measure sleep patterns, breathing, and heart rate during sleep. The goal is to bett…

This study looks at how repeated seizures affect breathing and heart function in people with Dravet syndrome, a severe form of epilepsy. Researchers will monitor 92 children and adults for 24-48 hours using video, brain wave, heart, and breathing recordings. The goal is to find c…

This study looks at how brief, carefully timed bursts of noise played during sleep might help strengthen memory in people with epilepsy who have electrodes implanted in their brain. Researchers will measure brain activity and memory performance to see if the sounds improve how th…

This study looks at how two parts of the thalamus (ANT and PLV) are connected to other brain areas and how they are involved in seizures and memory. Researchers will record brain activity from 100 epilepsy patients who already have electrodes implanted for medical reasons. The go…

This study gathers information from 8,000 stroke patients worldwide to learn more about seizures that happen after a stroke. Researchers will analyze the data to see how well patients recover and to create a tool that can predict who might develop epilepsy. The goal is to improve…

This study uses virtual reality to understand how people learn fear and safety. Participants already have a brain implant (RNS device) for epilepsy. They wear a VR headset while researchers measure brain activity, heart rate, and sweat. The goal is to better understand anxiety an…

This study records brain activity from people with epilepsy or brain tumors who already have electrodes implanted for medical reasons. Participants listen to short speech sounds in English, Spanish, or Mandarin while their brain signals are measured. The goal is to understand how…

This study compares two anesthetic drugs, fentanyl and ketamine, to see which one better helps surgeons find seizure-causing brain tissue during epilepsy surgery in children. Eighty-eight children aged 2-18 with brain tumors and epilepsy will receive one of the drugs during surge…

This study follows 300 adults with focal epilepsy who are starting an additional anti-seizure medication (ASM) alongside their current treatment. Researchers will track changes in seizure frequency and quality of life over 12 months in everyday clinical settings. The goal is to s…

This study looks at how electrocortical stimulation (ECS) affects brain cells and speech areas during brain surgery for epilepsy or tumors. Researchers will have 65 participants perform simple tasks while their brains are mapped, sometimes with mild cooling. The goal is to unders…

This study planned to test a wearable device called EpiCare@Home that records brain activity, heart rate, and movement to detect focal seizures. It was designed for people with epilepsy, both in the hospital and at home. However, the study was withdrawn before enrolling any parti…