EPILEPSY

This pilot study tests a new deep brain stimulation target—the medial pulvinar thalamic nucleus—in 12 adults with drug-resistant epilepsy who cannot have surgery or did not benefit from vagal nerve stimulation. The goal is to see if this approach can significantly reduce seizure …

This study tests a brain-responsive neurostimulation system in 24 people aged 12 and older with Lennox-Gastaut syndrome (LGS), a severe form of epilepsy. The device detects abnormal brain activity and delivers small electrical pulses to stop seizures before they start. The goal i…

This study collects information from over 900 adults in Italy whose focal seizures are not controlled by at least two other seizure medicines. Researchers are tracking how well cenobamate reduces seizure frequency and how safe it is in everyday medical practice. The goal is to be…

This study tests a self-management program (SMART-U) for adults with epilepsy in Uganda. The program includes group sessions and phone follow-ups over 24 weeks. Researchers will compare seizure frequency and quality of life between those in the program and those receiving usual c…

This study follows 300 adults with focal onset seizures who are starting an additional anti-seizure medicine (ASM) alongside their current treatment. Researchers will track changes in seizure frequency and quality of life over 12 months in real-world conditions. The goal is to un…

This study looks at adults with epilepsy who have been on a modified Atkins diet for at least a year and have high cholesterol. Researchers want to see if changing the diet or adding a statin can safely lower cholesterol without causing more seizures. The goal is to help doctors …

This study tests a new dry electrode headset that records brain waves (EEG) without needing a specialist to operate it. The goal is to make epilepsy diagnosis easier for Veterans living in rural areas. Researchers will compare the headset's performance to standard EEG in 700 part…

This study tests a psychological and cognitive rehabilitation program for 70 adults with active epilepsy. The program is designed to improve quality of life, memory, and emotional well-being. Participants will be randomly assigned to start the program right away or after a waitin…

This study tests whether adjusting a vagal nerve stimulator based on brain wave patterns (called PLI) can better reduce seizures in people with epilepsy that doesn't respond to medication. About 140 participants with a newly implanted stimulator will have their device settings ch…

This study explores whether playing a low-frequency sound (1 Hz) during deep sleep can reduce seizure activity in people with epilepsy. Thirty-six adults will use a smartphone app and special headphones at home for two months. The goal is to see if this simple, non-invasive appro…

This small study tests a new drug called BHV-7000 in 5 people with epilepsy who have a brain implant (RNS) that records seizure activity. The goal is to see if the drug reduces abnormal brain signals compared to a period before treatment. Participants take the drug for 4 weeks, t…

This study aimed to see if rhythmic electrical stimulation of the brain could improve working memory in people with drug-resistant epilepsy. Researchers planned to test this in patients already undergoing brain surgery monitoring. However, the study was withdrawn before any volun…

This study looks at how two small parts deep in the brain (the thalamus) are involved in spreading seizures and forming memories. Researchers will record brain activity from 100 epilepsy patients who already have electrodes implanted for medical reasons. The goal is to better und…

This study looks at how the brain processes spoken language by recording brain activity in people with epilepsy or brain tumors who already have electrodes placed for medical reasons. Researchers will compare brain signals from English, Spanish, and Mandarin speakers to uncover u…

This study was designed to collect and analyze fluid from the part of the brain being removed during epilepsy surgery. Researchers wanted to look for signs of inflammation that might lead to new ways to control seizures in people who don't respond to medication. However, the stud…

This study looks at how electrical brain stimulation affects brain cells and speech areas during surgery for epilepsy or brain tumors. Researchers will test 65 participants doing simple tasks like reading or naming pictures. The goal is to better understand the process, which cou…

This study looks at how two different anesthetic drugs, fentanyl and ketamine, affect brain wave readings during surgery in children aged 2-18 who have epilepsy and a brain tumor. The goal is to see which drug helps surgeons better detect seizure-related brain activity. The trial…

This study looks at how certain brain waves during sleep help form memories. Researchers will play short bursts of noise at specific times during sleep to see if they can strengthen these brain waves and improve memory. The study involves 24 epilepsy patients who already have ele…

This study aimed to create a database of high-frequency brain signals to better understand epilepsy, migraines, and other brain conditions. It planned to use advanced software to map brain functions in healthy volunteers. However, the study was withdrawn before enrolling anyone, …

This study looks at brain tissue from 10 people with temporal lobe epilepsy and hippocampal sclerosis who are having surgery. Researchers will analyze gene activity in the removed tissue to find clues about what causes the disease and how it progresses. The goal is to better unde…

This study looks at how mild electrical stimulation to certain brain areas changes working memory in 50 adults with epilepsy who already have electrodes implanted for monitoring. Participants do a memory task while receiving short bursts of stimulation. The goal is to learn which…

This study was designed to see if a brain-computer interface (BCI) could help improve attention in children with epilepsy who do not respond to medication. Participants would have had brain electrodes implanted for epilepsy surgery, and the BCI would give them feedback to help th…

This study gathers information from 8,000 people who had a stroke and later developed seizures or epilepsy. Researchers will analyze this data to understand how these patients recover and to create a tool that predicts who might develop epilepsy after a stroke. The goal is to imp…

This study looks at how repeated seizures may harm breathing and heart control in people with Dravet syndrome, a severe form of epilepsy. Researchers will monitor 92 children and adults over time to find early warning signs that could help prevent sudden unexpected death. The goa…

This study tests whether a brain implant (RC+S) and a handheld device can safely track seizures, mood, and thinking in 5 people with hard-to-treat epilepsy. The system records brain activity and can stimulate the brain to try to prevent seizures. The goal is to see if the approac…

This study looks at how the brain forms and retrieves memories by recording brain cell activity in people with epilepsy who are already having brain surgery. Up to 200 adults aged 18-65 will play memory games on a laptop while their brain activity is monitored. The goal is to fin…

This study tests a new wireless device that records brain activity for a long time in people with epilepsy that is not controlled by medication. Nineteen adults will use the implant day and night for 13 months to see if it works safely and reliably. The goal is to improve seizure…

This study looks at how ketogenic diets (like the modified Atkins diet) impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. About 105 adults aged 18 and older who are already on or startin…

This study tests a new device that records brain activity in people with epilepsy that doesn't respond to medication. The device aims to detect unusual brain signals and deliver small electrical pulses to prevent seizures. In this early phase, researchers are checking if the devi…

This study follows 300 children who had seizures as newborns to understand how genes influence their risk of developing epilepsy later in childhood. Researchers will combine genetic, brain scan, and EEG data to create a risk score. The goal is to better predict which children nee…

This study tests a pair of smart glasses that can read brain signals to predict epileptic seizures before they happen. About 47 adults with epilepsy will wear the glasses in real-life settings to see how safe and accurate the device is. The goal is to improve the device and work …

This study was designed to test a wearable device called EpiCare@Home that tracks brain, heart, and body signals to detect focal seizures. It planned to enroll people with epilepsy and compare the device's recordings to standard hospital monitoring. The goal was to see if the dev…

This study tests a tiny device placed under the scalp that tracks brain activity for up to 15 months in people with epilepsy and mild to moderate intellectual disability. The goal is to see if it can accurately detect seizures, improve quality of life, and be comfortable and easy…