Scientists probe the vagus nerve: what happens when It's stimulated?
NCT ID NCT06143293
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how vagus nerve stimulation (VNS) affects the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. Researchers will measure things like nerve activity, blood pressure, and heart rate during different stimulation settings. The goal is to learn more about how VNS works, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vagus nerve stimulation device
What this could lead to
If successful, this study could help doctors better understand how vagus nerve stimulation works, potentially leading to improved stimulation settings for treating epilepsy and depression.
What could go wrong
This is an observational study, not a treatment trial. It does not test a new therapy, so there is no direct benefit for participants. The results may not lead to immediate changes in clinical practice.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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99 Commercial Road
Prahan, Victoria, 3182, Australia
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Alfred Health
Melbourne, Victoria, 3004, Australia
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Alivation Research, LLC
Lincoln, Nebraska, 68526, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Stanford University
Stanford, California, 54304, United States
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University of Minnesota
Minneapolis, Minnesota, 55414, United States
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Washington University in St. Louis
St Louis, Missouri, 63110, United States