DEPRESSIVE DISORDER

This study is testing a short, 6-session group program called Resilience Training for Teens. The goal is to see if it can help high school students who have mild symptoms of depression, anxiety, or unusual feelings avoid developing more serious mental illnesses. The study will in…

This study looks at whether cognitive-behavioral therapy (CBT), exercise training, or both can help prevent type 2 diabetes in teenage girls who are at risk. The researchers want to see if these approaches lower stress, improve mood, boost physical activity, and reduce insulin re…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce depression symptoms in people who have had a heart attack or related heart problem and a stent placed. About 120 adults will use the device at home for 8 weeks, and their mood…

This study tests whether a new drug called HNK can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depression …

This study tests a new parent group program for teens aged 12-17 with autism who also have anxiety or depression. The program teaches parents skills to support their teen's mental health. Researchers will see if the program is practical and helpful for families.

This study tests a modified version of dialectical behavior therapy (DBT) for people with anxiety or depressive disorders. Researchers will enroll 250 adults across two medical centers and randomly assign them to receive the adapted DBT or standard care. The goal is to see if thi…

This study tests whether a culturally adapted version of Dialectical Behavior Therapy skills training (DBT-A-ST) helps teens aged 12-18 with emotional disorders like depression, anxiety, or ADHD. Participants are randomly assigned to either the DBT group or a standard support gro…

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training to help improve mood and thinking skills. About 120 adults with moderate to severe depre…

This study tests whether a precise type of radiation, called stereotactic radiotherapy, can safely reduce symptoms in people with treatment-resistant depression. Nine adults aged 18 to 50 who have not improved after at least two antidepressant trials will receive the treatment. R…

This study tests whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants attend online group sessions and use a WeChat mini-program for daily exerci…

This study tests whether a natural hormone called pregnenolone can improve daily functioning in veterans with anxiety and depression. 84 veterans will take either pregnenolone or a placebo for 8 weeks. The goal is to see if it helps with mood, sleep, and pain, with minimal side e…

This study is testing whether a structured breathing practice is a practical and acceptable option for teenagers aged 12 to 17 who have been diagnosed with anxiety or depression. The program, called Seokmun Hoheup, starts with 15-minute sessions and gradually increases to 36 minu…

This study tests whether a 9-week therapy called Engage & Connect can improve brain function related to social reward and reduce suicidal thoughts in older adults with depression. Researchers will use brain scans to measure changes in key brain networks. The study involves 128 pe…

This study tests whether a single dose of psilocybin mushrooms, combined with therapy, can help adults with treatment-resistant depression. Half of the 24 participants will also take the antidepressant fluoxetine to see if it changes the effects. The main goal is to measure mood …

This study tests whether combining a gentle brain stimulation technique (tDCS) with cognitive-behavioral therapy (CBT) can reduce repetitive negative thinking in adults with generalized anxiety disorder or depression. About 85 participants will receive either real or sham tDCS du…

This study tests whether temporal interference stimulation (TIS), a non-invasive brain stimulation technique, can improve memory and mood in people with depression. Sixty adults with depression will receive either real or sham TIS over 30 minutes. Researchers will measure changes…

This study tests whether a smartphone app that provides personalized lifestyle advice can help reduce depression symptoms in adults visiting their general practitioner. 216 participants will either use the app alongside their usual care or receive usual care alone. The app helps …

This study compares three ways to treat moderate depression in adults aged 18-65: usual care from a general practitioner, behavioral therapy from a psychologist, or a structured step-by-step treatment plan from a GP. The goal is to see if the structured plan works better at easin…

This study tests whether EL-SHIN Therapy can help ease symptoms of depression, anxiety, and stress. About 80 adults with moderate depression will try this new approach alongside their usual care. The goal is to see if it improves mood, sleep, and quality of life.

This study tests whether a special type of talk therapy, delivered via video calls, can reduce anxiety and depression in young adults (ages 18-64) with type 1 diabetes. The therapy also includes reviewing continuous glucose monitor data to help link emotions and blood sugar level…

This study is testing whether hyperbaric oxygen therapy (HBOT) can improve thinking, mood, and quality of life in veterans who have traumatic brain injury, PTSD, anxiety, or depression. Fifty-four veterans will receive multiple HBOT sessions in a pressurized chamber while breathi…

This study is testing a therapy program called the Unified Protocol for Children (UP-C) and Adolescents (UP-A) to help young people aged 7-17 with anxiety, depression, or other emotional difficulties. The program involves up to 24 sessions with a therapist, either in groups or in…

This study investigates whether the quality of parent-adolescent communication at the start of psychiatric inpatient treatment predicts how much symptoms improve six months later. Researchers will track 60 adolescents hospitalized for depression, anxiety, or other mental disorder…

This study at Yale University is testing whether blocking a specific brain receptor (AMPA) stops ketamine from reducing suicidal thoughts. Thirty adults with depression, bipolar disorder, or PTSD who have current suicidal thoughts will receive either perampanel (an AMPA blocker) …

This study tests whether psilocybin, the active ingredient in magic mushrooms, changes brain activity in people with depression. Fifty participants will receive either psilocybin or a placebo and undergo MRI scans to measure blood flow and brain network connections. The goal is t…

This study looks at gut bacteria and related chemicals in 120 adults to understand why inflammatory bowel disease (IBD) and depression often occur together. Researchers will compare people with both conditions, those with IBD only, and healthy volunteers. The goal is to find uniq…

This study is building a Canadian platform to collect standardized biomarker data from 900 people with mood disorders like depression and bipolar disorder. The goal is to create a large, organized pool of participants and data that can be used in future trials to match individual…

This study is looking at how people with conditions like schizophrenia, bipolar disorder, depression, and neurological diseases (such as Alzheimer's or stroke) perform on computer-based thinking tests. The goal is to create a detailed map of cognitive strengths and weaknesses acr…

This study looks at whether a person's mental state—like anxiety or depression—can influence how well immunotherapy works for triple-negative breast cancer. About 120 women will receive standard treatment, complete psychological surveys, and give blood and saliva samples. Researc…

This pilot study tests whether an intensified schedule of repetitive transcranial magnetic stimulation (iTBS) — six sessions a day for five days — works better than the standard one-session-a-day for six weeks in people with depression and Post-COVID condition. Researchers will m…

This study talks to children aged 8-12 who have depressive symptoms, and their parents, to learn about their daily stresses and how they cope. The goal is to use this information to design a smartphone app that uses games to teach emotion regulation skills. Only 15 children and t…