DEPRESSIVE DISORDER

This study tests whether measurement-based care — where therapists regularly track symptoms using questionnaires — adds extra benefit to weekly psychotherapy for adults with depression or anxiety. Participants are randomly assigned to measurement-based care, standard therapy, or …

This study tests whether adding the diabetes drug metformin to standard antidepressants helps people with both depression and obesity lose weight and feel better. Researchers will also check if certain gene variants affect how well the combination works. The trial involves 200 ad…

This study in India tests two common depression treatments—a talk therapy called the Healthy Activity Program and the antidepressant fluoxetine—in 1,500 adults with moderate to severe depression. The goal is to see which treatment works best for different people and to compare co…

This study tests a new approach for people with depression that hasn't responded to medication. It combines an FDA-approved brain stimulation technique called rTMS with digital mindfulness exercises. The goal is to see if this combination can improve both mood and cognitive funct…

This study explores whether eye-tracking technology in a virtual reality headset can help identify schizophrenia, bipolar disorder, and depression. Researchers will compare eye movement patterns of 120 participants (including healthy controls) to find specific markers for each co…

This study tests whether a unique music therapy, based on Traditional Chinese Medicine's five-element theory, can help men with depression and anxiety when added to their usual medication. One hundred male inpatients will receive either standard drugs alone, drugs plus regular mu…

This study looks at whether nicotine patches can safely improve mood and thinking in adults aged 60 and older with depression. Participants who completed a previous blinded trial will wear a patch daily for up to 12 weeks, then taper off. The goal is to see if nicotine helps the …

This study tests whether nicotine patches can improve cognitive control (like focus and memory) and mood in adults aged 60 and older with depression. Sixty participants will wear either a nicotine or placebo patch daily for 12-15 weeks. Researchers will measure changes in depress…

This pilot study tests whether a brief cognitive behavioral therapy delivered via video conference can help adults with mood disorders who are at high risk for suicide. Forty participants will either receive the video therapy plus usual care, or usual care alone. The study will m…

This study tests a short, enhanced cognitive behavioral therapy (E-BCBT) for people hospitalized after a suicide crisis. 30 participants will either receive 5 therapy sessions during their stay or standard care. The goal is to see if this therapy reduces suicide attempts and suic…

This study tests a program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use disorders. The program teaches veterans to identify their health goals and communicate them to doctors and family. Researchers want to see if it improves social an…

This pilot study tests whether using a soft baby carrier for extra physical contact helps mothers with prenatal anxiety or depression feel more connected to their baby. Forty moms in Montreal will either use the carrier or be on a waitlist. Researchers will measure bonding, brain…

This study looks at whether music therapy can help children and teenagers with mood disorders who also hurt themselves (called non-suicidal self-injury, or NSSI). About 54 participants will take part, and researchers will use questionnaires, brain scans, and electrical brain acti…

This study tests whether using a virtual reality (VR) relaxation session can lower anxiety in people about to receive electroconvulsive therapy (ECT). Twenty adults already receiving ECT for depression will try VR relaxation, breathing exercises, or no extra relaxation. Researche…

This study tests a brief behavioral therapy program delivered via telehealth (STEP-UP) for children and teens aged 8 to 16 with anxiety or depression. Participants are recruited from community health centers and randomly assigned to either STEP-UP or a referral to local mental he…

This study tests whether adding a group therapy called Kiesler Circle Training (KCT) to standard cognitive behavioral therapy (CBT) helps people with depression or anxiety improve their interpersonal skills. About 156 participants will receive either CBT alone or CBT plus KCT. Th…

This study tests whether a smartphone app based on cognitive behavioral therapy (CBT) can help adults who are already taking antidepressants feel better. 150 participants in Sweden will use the app for 9 weeks, with extra online materials and therapist support available. The goal…

This study looks at whether taking vitamin D supplements for six months can improve depression symptoms. About 319 adults with depression are getting either a low or high dose of vitamin D daily, while continuing their usual treatment. Researchers will track their mood and health…

This study looks at how vagus nerve stimulation (VNS) affects the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. Researchers will measure things like nerve activity, blood pressure, and heart rate during di…

This study is creating a large registry of 5,000 young people aged 8 to 20 who have depression or suicidal thoughts. Researchers will collect data from clinics across Texas to better understand these conditions and develop models to predict outcomes. The goal is to improve popula…

This study explores whether a personalized therapy method called Process-based Therapy is practical in regular mental health clinics. About 40 adults with depression or anxiety will try this approach, and researchers will measure how satisfied patients and therapists are with it.…

This study will use advanced heart scans (coronary CT angiography) on 4,000 people with rheumatoid arthritis aged 50-75. The goal is to better understand why people with this condition have higher risks of heart attacks, strokes, and lung problems. Researchers will track particip…

This study was designed to track stress in real time by measuring things like heart rate, sweat, and temperature, along with how people feel. It planned to include both healthy volunteers and people with psychiatric disorders to find better ways to diagnose stress-related problem…

This study follows 192 teens aged 12 to 20 who are already receiving either Cognitive Behavioral Therapy (CBT) or Brief Strategic Therapy (BST) for anxiety, depression, or OCD. Researchers will track their progress using questionnaires and interviews over 9 months. The goal is to…

This research studies a program that places social workers in 25 children's doctor offices across Indiana. The goal is to help doctors spot and treat mental health issues like depression and anxiety sooner. About 575 patients and staff will take part to see if this approach impro…