Brain zaps meet mindfulness: a new hope for Treatment-Resistant depression?
NCT ID NCT06399406
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new approach for people with depression that hasn't responded to medication. It combines an FDA-approved brain stimulation technique called rTMS with digital mindfulness exercises. The goal is to see if this combination can improve both mood and cognitive function better than stimulation alone. The trial involves 70 participants and is currently active but not recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- repetitive transcranial magnetic stimulation (rTMS) combined with digital mindfulness exercises
- What this could lead to
- If it works, this could offer a new treatment option for people with depression that hasn't improved with medication, potentially improving both mood and thinking skills.
- What could go wrong
- This is a small, early-phase study (70 people) testing a new combination. It may not show clear benefits, and the effects may not last or apply to everyone with depression.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of California San Diego
La Jolla, California, 92093, United States
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