University Of California, San Diego

This study tests a drug called elranatamab in people with multiple myeloma that has returned or not responded to previous treatments. About 33 participants who have already tried 1 to 3 other therapies will receive elranatamab alone. The goal is to see if the drug can make cancer…

This study tests whether an artificial intelligence model can identify patients with advanced HR+ HER2- breast cancer who might benefit from a second CDK4/6 inhibitor after the first one stops working. About 105 participants will either receive a second CDK4/6 inhibitor plus fulv…

This study is testing a special 3D-printed cage called the TRUMATCH Graft Cage to help repair large gaps in the arm or leg bones that are hard to fix with standard surgery. Up to 5 adults with these severe bone breaks will receive the cage and be followed for 3 years to see how w…

This study tests whether trained community health workers can help refugees with high blood pressure stick to their medication and lower their blood pressure. About 250 adult refugees will either receive extra support sessions or just standard information and a home blood pressur…

This study looks at whether keeping very premature babies (born before 30 weeks) on a breathing machine called CPAP until they are 32-34 weeks old helps them come off support more successfully. About 130 babies will be randomly assigned to either a structured weaning plan or stan…

This study tests a simple idea: before surgery to reverse an ileostomy, participants will infuse their own ostomy contents back into the inactive part of the bowel. The goal is to 'retrain' that section to handle digestion again, potentially helping bowel function return faster a…

This study tests whether a peer-led program combining acceptance and commitment therapy, exercise, and social support can help women living with HIV improve their medication adherence. The program also addresses substance use, trauma, and violence. Researchers will enroll 300 wom…

This early-phase trial tests whether adding fostamatinib (a drug already approved for a blood disorder) to standard chemotherapy can help people with resectable pancreatic cancer. About 36 adults will receive the combination before and after surgery. The main goal is to see if th…

This study is testing whether an anti-inflammatory diet can improve disease activity in people with rheumatoid arthritis. Researchers will enroll 124 adults with low to moderate disease activity who are not changing their current treatments. The goal is to see if the diet reduces…

This study tests whether a combination of two immunotherapy drugs (Opdualag) works better than one drug (nivolumab) alone for people with high-risk basal cell carcinoma that can be surgically removed. About 30 participants will receive treatment before surgery to see if the cance…

This early-phase study tests adding fampridine to standard imatinib (Gleevec) in people with a specific type of gastrointestinal stromal tumor (GIST) that has a KIT gene mutation. The goal is to find the safest dose of the combination and see if it shrinks tumors before surgery. …

This study is for people with hard-to-treat depression who have already benefited from a type of brain stimulation called rTMS. It tests whether continuing rTMS sessions over 6 months can help maintain that improvement. 75 participants will be randomly assigned to one of three gr…

This study tests a 4-month online program called Women SHINE for 360 women living with HIV who have experienced violence and struggle to take their HIV medication regularly. The program includes one-on-one coaching, support groups, and online resources to help improve medication …

This study tests a combination of an immunotherapy drug (cemiplimab) and chemotherapy (gemcitabine) in people with advanced pancreatic cancer that has a specific genetic change (SWI/SNF). Participants must have already tried standard chemotherapy. The goal is to see if this combo…

This study compares two standard surgical methods—suture button and Fibulink implant—for repairing ankle syndesmosis injuries. About 140 adults with acute ankle fractures requiring surgery will be randomly assigned to one of the two procedures. Researchers will measure pain, func…

This study tests whether adding precise, high-dose radiation (SABR) to standard treatments can keep cancer from growing longer in people whose cancer has spread to up to 10 spots. About 300 adults with solid tumors that have spread to a limited number of sites will be randomly as…

This study tests whether a high-quality form of coenzyme Q10, a natural substance that helps cells produce energy, can improve symptoms and quality of life in veterans with Gulf War illness. Researchers will compare the supplement to a placebo in 192 veterans. The goal is to see …

This early-phase study tests a new drug called SB-4826 in adults with advanced solid tumors or non-Hodgkin lymphoma. The main goal is to find a safe dose and see if it shrinks tumors. Some lymphoma patients will also get the drug combined with rituximab. Participants take SB-4826…

This study provides families on Medi-Cal who have a child with type 2 diabetes with a prescription for free fresh fruits and vegetables. The goal is to help families eat more healthy food, reduce food insecurity, and improve the child's blood sugar and overall health. About 200 c…

This early-phase study tests a new treatment approach for people with advanced liver cancer. It combines freezing the tumor (cryoablation) with a drug infusion into the liver (SD-101) and two immunotherapy drugs (durvalumab and tremelimumab). The main goal is to check safety and …

This study tests a new combination of two drugs (retifanlimab and ruxolitinib) in people with advanced lung or kidney cancer whose disease got worse after standard immunotherapy. The main goal is to find the safest dose of ruxolitinib when given with retifanlimab, and to see if t…

This study looks at whether time-restricted eating (eating all meals within a set daily window) can improve health markers like blood sugar and cholesterol in people with metabolic syndrome or pre-diabetes. About 140 adults who typically eat over 12 hours a day will be randomly a…

This study looks at whether a 14-week ketogenic (high-fat, low-carb) diet can help normalize brain activity and reduce lingering eating disorder thoughts in people who have already regained weight from anorexia. About 90 participants (including healthy controls) will have brain s…

This study tests a program that helps families with food insecurity get connected to nutrition support through their child's clinic. About 600 children aged 5-18 with conditions like diabetes or heart disease will take part. The goal is to see if this approach is practical and im…

This study aims to see if advanced ultrasound techniques can accurately detect fatty liver disease in children without the need for invasive biopsies or costly MRI scans. Researchers will enroll 120 children aged 9 to 18 who have risk factors for the condition. The new ultrasound…

This long-term study aims to find the best methods for detecting glaucoma and tracking its worsening over time, especially in people with nearsightedness (myopia) and those of European or African descent. Researchers will use advanced eye imaging to monitor changes in the back of…

This study is testing a small, portable device called LiverScope that uses MRI-like technology to check for liver disease without needles or surgery. About 26 adults with fatty liver disease (MASLD or NAFLD) will have their liver scanned with LiverScope and compared to a standard…

This study looks at how to better provide cervical cancer screening and treatment to women living with HIV in Nigeria. About 2,400 women will take part. The goal is to find the best way to combine cancer care with existing HIV services to prevent cervical cancer and improve healt…

This study tests a program called Regulation of Cues (ROC) adapted for Latinas who have prediabetes and obesity. The goal is to see if it helps them lose weight and prevent type 2 diabetes. Thirty women aged 18-55 will attend 14 sessions and rate how helpful the program is.

This study tests whether a multimedia campaign using radio, TV, and community outreach can help women and couples in Nigeria make informed decisions about family planning. Researchers will follow 4,000 women aged 15-44 in three states over three years to see if the program increa…

This study tests whether eating only between 10 a.m. and 8 p.m. (14 hours of nightly fasting) can reduce sleep problems, memory loss, and disease markers in people with mild cognitive impairment or early-to-moderate Alzheimer's disease. Sixty older adults will try this eating sch…

This study tests whether adding cannabidiol (CBD) to standard treatment can improve symptoms, thinking, and inflammation in people with early psychosis. About 120 adolescents and adults will receive either CBD or a placebo for 8 weeks. The goal is to see if CBD helps control symp…

This study tests whether a gentle, at-home brain stimulation technique called tDCS is safe and practical for people with depression that hasn't improved with standard treatments. Ten adults in San Diego will use a headset for three hours a day, five days a week, for two weeks, un…

This study tests whether higher doses of the seizure drug levetiracetam can safely control seizures in newborns. About 133 full-term infants with seizures or at risk for them will receive the medicine and be monitored with continuous EEG. The goal is to find the best dose that st…

This study tests a procedure called cryoneurolysis, which uses a small probe to freeze specific nerves in the foot, to see if it can reduce chronic pain from diabetic neuropathy. About 30 adults with painful diabetic nerve pain in their feet will either get the real freezing trea…

This study tests a low-cost pill called acetazolamide for people with moderate to severe sleep apnea who cannot tolerate a CPAP mask. Sixty adults will receive either the drug or a placebo for 4 weeks each, and researchers will measure sleep quality, memory, and quality of life. …

This study tests a non-invasive brain stimulation technique called accelerated theta burst stimulation (aTBS) to see if it can reduce suicidal thoughts in people with treatment-resistant depression. Researchers will compare two types of stimulation (bilateral vs. unilateral) in 7…

This study tests a smartphone-based program called mSITE that encourages social interaction for people with schizophrenia or related conditions. About 125 adults will use the app, which tracks conversations and prompts social activity. The goal is to reduce social withdrawal and …

This study tests whether a therapeutic ketogenic diet (low-carb, high-fat) can reduce harmful eating behaviors like the urge to restrict, binge, or purge, and improve mood and body image. It includes 20 adults with anorexia (weight-recovered or underweight) or bulimia. Participan…

This study tests a special gel, TriCalm Hydrogel, to see if it can reduce the severe itching some cancer patients get from immunotherapy. About 28 adults on immunotherapy who develop itching will use the gel or a standard steroid cream. The goal is to find a gentler way to ease t…

This study looks at whether having a full or empty bladder during radiation therapy for pelvic cancers (like prostate, gynecological, or colorectal) causes fewer side effects. About 300 adults getting radiation will be assigned to one of the two bladder protocols. The goal is to …

This study tests whether a whole food plant-based diet can reduce pain in women with endometriosis. 120 participants will either follow the special diet or their usual diet for 12 weeks. The goal is to see if changing what you eat can ease pelvic pain.

This study looks at whether using a weighted blanket before breast surgery can lower anxiety and reduce pain afterward. About 168 adults will sleep with either a heavier or lighter blanket for up to 3 months and report their anxiety, pain, and medication use. The goal is to see i…

This study tests a new way to give radiation for prostate cancer. Instead of treating the whole prostate, doctors will focus the radiation only on the tumor. The goal is to see if this causes fewer short-term side effects like bladder or bowel problems. About 150 men with interme…

This study tests a 16-week video exercise program for breast cancer survivors who had surgery. The program includes live, small-group classes focused on fitness, balance, and strength. Researchers want to see if it helps improve physical function and quality of life. About 15 peo…

This study tests whether a mental health app can help adolescent dancers recover from foot and ankle injuries. About 50 dancers aged 13-18 will use the app to build self-compassion and track their return to dance. The goal is to see if emotional support can improve recovery and r…

This study looks at whether changing eating habits can help college students with mild to moderate depression. About 30 students will either follow a Mediterranean diet or combine it with time-restricted eating (eating only during a 10-hour window). The goal is to see if these di…

This study tests a new approach that combines meditation with real-time brain feedback to help people with moderate depression. 27 adults will try the intervention to see if it reduces depression symptoms and improves mindfulness. No medications are used, and the goal is to ease …

This study tests a new approach for people with treatment-resistant depression by combining FDA-approved brain stimulation (iTBS) with digital mindfulness training. The goal is to improve brain plasticity, thinking skills, and mood. About 120 adults with moderate to severe depres…

This study tests whether a computer-based cognitive training program can improve thinking skills like memory and attention in people with anxiety, depression, or PTSD. 128 adults aged 21-55 will be randomly assigned to either the active training or a sham version. The goal is to …

This early-stage study is testing whether psilocybin-assisted therapy can help reduce burnout in physicians. Researchers at UC San Diego will give a small group of 10 burned-out doctors psilocybin (the active compound in 'magic mushrooms') alongside psychological support sessions…

This study looks at three methods of giving the antibiotic vancomycin during total knee replacement surgery: into the joint, into the bone, or through a vein. The goal is to see which method delivers the most antibiotic to the tissues that need it most, to prevent serious infecti…

This study looks at why some people getting CAR T-cell therapy for cancer develop brain-related side effects called neurotoxicity. Researchers will use brain scans, thinking tests, and blood tests to find early warning signs. The goal is to create a tool that can predict which pa…

This study is testing a new type of metal rod (nail) used to fix broken thigh bones. Researchers want to see if this new design helps bones heal better and causes fewer problems than current nails. About 40 adults with certain thigh fractures will get the new nail and be followed…

This study looks at how male-level testosterone affects the reproductive hormone system in transgender men starting testosterone therapy, compared to cisgender women. Researchers will measure hormone levels and track menstrual bleeding patterns. The goal is to understand how test…

This study tests whether virtual reality (VR) can measure how smokers pay attention to cigarette-related cues, and if the medication varenicline changes that attention. Two hundred daily smokers, aged 22 and older, will have their eye movements tracked in VR before and after taki…

This study looks at how the brain activity of people who use opioids syncs with a therapist during meditation. Researchers want to see if this connection relates to less craving and better understanding. About 60 adults who use opioids daily will participate.

This study looks at how the brain handles avoidance learning in women with anorexia or bulimia nervosa compared to healthy women. Researchers will use brain imaging (fMRI) and computer tasks to see differences in brain activity. The goal is to better understand the thinking patte…

This study is testing a program called iTEST for people with schizophrenia or related disorders. The program combines daily brain-training exercises on a mobile device with coaching to help participants accurately judge their own abilities. Researchers want to see if this improve…

This study aims to develop and test a personalized suicide prevention program called PRECISE for adults with suicidal thoughts. Researchers will use daily surveys and data analysis to tailor coaching sessions to each person's unique triggers. The goal is to see if a highly person…

This study follows 100 people who had atrial fibrillation (AF) during a hospital stay for surgery or illness. Participants get a small heart monitor implanted to track AF over 12 months. The goal is to learn how often AF returns and whether the cause (heart surgery, other surgery…

This study aims to track how common respiratory viruses like COVID-19, flu, and RSV spread in communities and households. Researchers will enroll up to 25,000 people of all ages, collecting nasal swabs and symptom reports over time. The goal is to better understand infection rate…

This study tests a program to help young women who have had cancer and live in rural areas get reproductive health care that matches their personal goals. About 64 participants will receive screening, counseling, and telehealth consultations. The goal is to see if this approach i…

This study tests whether trained peer navigators can help Hispanic families enroll their children with cancer in clinical trials. About 450 parents of Hispanic children (ages 0-17) with newly diagnosed cancer will be randomly assigned to receive either peer navigation or standard…

This study looks at how people who speak two languages (like Mandarin and English) or a spoken language and sign language (like ASL and English) control which language they use. Researchers will have 360 healthy adults do tasks like naming pictures or sorting words in different l…

This study tests a telehealth program designed to help young cancer patients (ages 0-50) get fertility care that matches their personal goals. Researchers will track whether the program increases the number of patients who receive fertility counseling or preservation services. Th…

This study looks at how the brain processes pleasure, desire, and learning in women with anorexia or bulimia. Researchers will use brain scans (fMRI) and computer tasks to compare 252 women with eating disorders to healthy controls. The goal is to understand the brain differences…

This study is testing whether a special 3D ultrasound technique can help doctors better monitor how liver tumors respond to cancer therapy. About 80 adults with untreated liver cancer will have this imaging before and during treatment. The goal is to see if the method provides us…

This study is testing a computer program that helps doctors decide if a child with fever has Kawasaki Disease. About 200 children with fever and signs of Kawasaki will take part. The goal is to see if the tool helps doctors start treatment sooner.

This study looks at how blood pressure changes when standing up affect thinking and blood flow in the brain for people with Parkinson's disease. About 60 participants, some with and some without low blood pressure upon standing, will take thinking tests while lying down and stand…

This study looks at how people with anorexia nervosa break down food compared to healthy individuals. Researchers will measure changes in metabolism and food-related anxiety after a meal. The goal is to find biological clues that could lead to more effective treatments. The study…

This study looks at how sleep and light affect mood in women going through menopause. Researchers want to see if changing sleep timing for one night and using a light box for two weeks can help reset the body's internal clock and improve depression. Participants will provide urin…

This study looks at a new way to help children in the child welfare system get connected to mental health services. Researchers are testing a team meeting method called After Action Review to make sure families and children have a real say in their care plans. About 320 caseworke…

This study looks at whether doing neurological checks every 2 hours instead of every hour in the ICU can reduce confusion (delirium) and long-term memory problems in older adults with a brain bleed. About 120 participants will be randomly assigned to one of two check frequencies.…

This study looks at how cannabis ingredients (THC and CBD) affect decision-making, attention, and motivation in people with and without HIV. About 138 adults aged 18-65 who use cannabis infrequently will take either THC, CBD, or a placebo for 5 days and then complete thinking tes…

This study tests a device called OneMark that helps doctors see breast cancer during surgery and follow-up scans. About 60 people with breast cancer will take part. The goal is to see if OneMark is easier to see than the current standard device, especially in women with dense or …

This study looks at how cannabis ingredients (CBD and THC) impact inflammation and brain health in people with HIV. Researchers will give 90 participants both compounds in different orders over 6 weeks, then measure blood markers and brain barriers. The goal is to understand how …

This study tests whether an app that tracks your natural sleep-wake cycle (chronotype) and gives personalized daily tips can improve well-being in college students. Researchers will enroll 400 UCSD undergraduates to use the app for seven weeks and measure changes in happiness, fo…

This study looks at how having both sleep apnea and COPD (called overlap syndrome) affects the heart and blood vessels. Researchers will compare 240 adults aged 40-79 who have one or both conditions. They will also test if using a breathing machine at night or extra oxygen can im…