University Of California, San Diego

This study tests whether adding team-building tools—like team charters, communication handoffs, and performance monitoring—to an existing school-based ADHD program (the Collaborative Life Skills Program) makes it work better. Researchers will compare the enhanced program to the s…

This early-stage trial tests whether injecting an immune-boosting drug (mitazalimab) directly into the tumor during a special electrical ablation procedure (IRE) is safe for people with locally advanced pancreatic cancer. The goal is to see if this approach can strengthen the bod…

This study looks at whether THC, the active part of marijuana, can change how the body handles sugar and affects blood vessel health in people with type 2 diabetes. About 30 adults will take THC or a placebo for two weeks, then have their blood sugar and blood vessel function tes…

This study tests whether giving tranexamic acid (TXA) before a second-trimester dilation and evacuation (D&E) procedure can reduce heavy bleeding. Heavy bleeding is a rare but serious risk of D&E. The trial will include 276 pregnant people aged 18 and older who are between 18 and…

This phase 2 trial tests whether adding the immunotherapy drug cemiplimab to standard chemotherapy gemcitabine can help people with a certain genetic type of advanced pancreatic cancer live longer. The study enrolls 43 adults whose cancer has spread and who have already tried one…

This study tests three ways to give the antibiotic vancomycin during knee replacement surgery: into the joint, into the bone, or through a vein. The goal is to see if the simpler joint injection works as well as the others to prevent serious infections. Thirty adults having a fir…

This early-phase study tests adding fampridine to standard imatinib (Gleevec) in 18 adults with a specific type of GIST tumor. Participants take the drugs for at least 2 months before surgery to find the safest dose and see if the combination shrinks tumors. The goal is to improv…

This study tests whether acetazolamide, a cheap and well-tolerated diuretic, can help people with obstructive sleep apnea who cannot use a CPAP mask. Sixty adults with moderate to severe sleep apnea will receive either the drug or a placebo for 4 weeks each. Researchers will meas…

This study tests whether a high-quality form of coenzyme Q10, a natural substance, can help reduce symptoms and improve daily life in veterans with Gulf War illness. Researchers will compare the supplement to a placebo in 192 veterans. The goal is to see if this approach offers a…

This study tests a program led by trained peers (other women with HIV) that combines acceptance and commitment therapy, exercise, and social support. The goal is to help 300 women in four counties stick to their HIV medication and manage substance use and trauma. Researchers will…

This early-phase trial tests a new approach for people with advanced liver cancer that cannot be removed by surgery. Doctors will freeze part of the tumor (cryoablation) and deliver an immune-boosting drug directly into the liver's blood supply. After that, participants receive t…

This study tests whether reducing the frequency of rTMS sessions can maintain the antidepressant effect in people with treatment-resistant depression who already responded to daily rTMS. 75 participants will receive either standard maintenance, clustered, or sham rTMS over 6 mont…

This study looks at whether a therapeutic ketogenic diet (a high-fat, low-carb diet) can normalize brain metabolism and reduce lingering eating disorder symptoms in people who have recovered from anorexia nervosa. About 90 participants, including healthy controls, will undergo br…

This study tests whether an artificial intelligence model can identify patients with advanced HR+ HER2- breast cancer whose tumors might still respond to a second CDK4/6 inhibitor after the first stopped working. About 105 participants will either receive the AI-recommended drug …

This early-phase trial is testing whether adding the drug fostamatinib to standard chemotherapy can help people with resectable pancreatic cancer. Fostamatinib is already approved for a blood disorder but has not been tried in pancreatic cancer. The study will enroll 36 participa…

This study tests a program called Regulation of Cues (ROC) in 30 Latina women with prediabetes and obesity. The program teaches awareness of eating triggers and coping strategies to reduce weight and prevent type 2 diabetes. Researchers are first checking if participants find the…

This early-phase study tests a new drug called SB-4826 in adults with advanced solid tumors or non-Hodgkin lymphoma. The main goal is to find a safe dose and see if the drug shrinks tumors. Some participants with lymphoma will also receive the drug combined with rituximab. The st…

This study tests a drug called elranatamab in 33 people with multiple myeloma that has returned or not responded after 1 to 3 prior treatments. The goal is to see if the drug can make cancer cells undetectable in tests. Participants will receive elranatamab alone, and the study w…

This study tests whether a program led by community health workers can help refugees with high blood pressure take their medication as prescribed and lower their blood pressure. The program includes an education booklet, a pill organizer, and two counseling sessions. Researchers …

This study compares two common surgical procedures for a specific type of ankle injury called syndesmosis injury, often linked with ankle fractures. About 140 adults who need surgery will be randomly assigned to receive either a suture button or a Fibulink implant. Researchers wi…

This study is testing a special 3D-printed cage called the TRUMATCH Graft Cage to help repair large bone defects in the arm or leg. Five adults with hard-to-heal breaks will receive the cage during surgery. Researchers will track healing, complications, and recovery time over thr…

This study is testing a new type of metal nail (RFN-advanced) to repair broken thigh bones. About 40 adults with a fracture in the lower part of the thigh bone or the shaft will receive this implant. Researchers will track how well the bone heals, pain levels, and any problems ov…

This phase 2 trial tests whether a combination of two immunotherapy drugs (Opdualag) works better than one drug (nivolumab) alone when given before surgery for high-risk basal cell carcinoma. About 30 people with large or hard-to-treat skin cancers will receive either the combo o…

This study tests whether limiting all eating to a consistent 10-hour window each day can improve blood sugar, cholesterol, and other health measures in people with metabolic syndrome or prediabetes. About 140 adults will either follow this eating schedule plus standard nutritiona…

This study tests a structured plan for slowly removing breathing support (CPAP) from preterm infants born before 30 weeks. The goal is to see if keeping babies on CPAP until a specific age reduces breathing problems and lung damage. About 130 infants will be randomly assigned to …

This early-phase trial is testing whether combining two drugs—retifanlimab and ruxolitinib—can safely help people with advanced lung or kidney cancer whose disease has progressed after prior immunotherapy. About 40 participants will take ruxolitinib pills twice daily and receive …

This study is testing whether an anti-inflammatory diet can help people with rheumatoid arthritis feel better and reduce disease activity. Researchers will compare two different anti-inflammatory diets in 124 adults with low to moderate disease activity. The goal is to see if die…

This study gives families on Medi-Cal who have a child with type 2 diabetes monthly vouchers worth $105 to buy fresh fruits, vegetables, beans, and legumes at participating markets. The goal is to see if easier access to healthy food improves blood sugar levels, food security, an…

This study is testing a program called Women SHINE, which uses online peer support sessions and group therapy to help women living with HIV who have experienced interpersonal violence. The goal is to see if this approach helps them take their HIV medication more consistently and …

This Phase 3 trial is testing whether adding a precise, high-dose radiation treatment called SABR to standard therapies can delay cancer progression in people with up to 10 metastatic tumors. About 300 participants will be randomly assigned to receive either standard care alone o…

This study is testing a new, portable device called LiverScope that uses magnetic fields to check the liver for disease, similar to an MRI but smaller and easier to use. Researchers want to see if LiverScope gives the same results as a standard MRI. About 26 adults with a type of…

This study is testing whether advanced ultrasound techniques can accurately detect fatty liver disease (MASLD) in children aged 9 to 18. Researchers will compare ultrasound results to MRI scans and blood tests in 120 children with risk factors for the condition. If the ultrasound…

This study is testing a computer tool called Kawasaki MATCH that helps doctors decide if a child with fever has Kawasaki Disease. The tool uses patient age, lab results, and symptoms to give a risk score. Researchers want to see if using this tool leads to faster treatment. About…

This long-term study is looking for the best methods to detect glaucoma and track its worsening over time, especially in people with nearsightedness (myopia) and those of African or European descent. Researchers will use advanced eye imaging to monitor changes in the back of the …

This study tests whether a multimedia campaign using radio, TV, and community outreach can help women and couples in Nigeria make informed choices about family planning. Researchers will follow 4,000 women aged 15-44 in three states over three years to see if the program increase…

This phase 2 trial tests whether TriCalm Hydrogel, an over-the-counter gel, can reduce itching caused by immune checkpoint inhibitors used in cancer therapy. About 28 adults with grade 1-3 itch will use either the gel or a standard steroid cream for one cycle. The study measures …

This study tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, combined with therapy can help reduce burnout in doctors. Ten UCSD physicians with long-term burnout symptoms will receive the drug and be monitored for safety and mood changes. It is …

This study is testing whether a time-restricted eating plan (eating only during an 8-10 hour window each day) combined with a healthy plant-based diet is safe and doable for people with liver cancer, cirrhosis, or fatty liver disease. Fifty overweight or obese adults will either …

This study tests whether a higher-than-usual dose of the seizure medicine levetiracetam can safely stop seizures in newborns. About 133 full-term infants with seizures will first receive a standard dose, and if seizures continue, they will be randomly assigned to get either a hig…

This study is testing a psychological treatment for chronic pain that is adapted to the culture of American Indian and Alaska Native peoples. About 30 adults with chronic pain will take part to see if the program is acceptable and helpful. The goal is to gather information for a …

This study tests whether restricting eating to a 10-hour daytime window (fasting 14 hours overnight) can reduce sleep problems and cognitive decline in people with mild cognitive impairment or early-to-moderate Alzheimer's disease. Sixty older adults will try the diet for 3 or 6 …

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training to help improve mood and thinking skills. About 120 adults with moderate to severe depre…

This study tests a new approach for treating depression in people who have had a mild traumatic brain injury (concussion). Participants will receive a personalized cognitive training program combined with either real or sham brain stimulation over 4 weeks. The goal is to see if t…

This study is testing a new approach to help people with suicidal thoughts by creating a personalized plan based on each person's unique patterns. Researchers will use daily surveys and data analysis to identify what triggers suicidal thoughts and then teach specific coping skill…

This study looks at whether using a weighted blanket before breast surgery can lower anxiety and reduce pain afterward. About 168 adults will sleep with either a heavier or lighter blanket for up to 3 months and report their feelings and pain levels. The goal is to see if blanket…

This study tests whether a whole food plant-based diet can reduce pain in women with endometriosis. 120 women aged 18-45 with moderate to severe pelvic pain will be randomly assigned to either follow the special diet or stay on their usual diet for 12 weeks. The goal is to see if…

This study looks at whether a Mediterranean diet or a Mediterranean diet combined with time-restricted eating (eating only during a 10-hour window) can help college students with mild to moderate depression. Researchers will track sleep, mood, and daily activity to see if these d…

This study tests a smartphone app called mSITE that encourages people with schizophrenia or schizoaffective disorder to have more social interactions. Researchers will track participants' social activity and symptoms over time. The goal is to see if the app helps reduce social wi…

This Phase 3 trial tests whether having a full or empty bladder during pelvic radiation therapy reduces short-term side effects like bladder or bowel irritation. 300 adults with pelvic cancers (genitourinary, gynecological, or gastrointestinal) will be randomly assigned to one of…

This study compares two types of radiation for prostate cancer: one that targets only the tumor and one that treats the whole prostate. The goal is to see if the focused approach causes fewer short-term side effects like bladder or bowel problems. About 150 men with intermediate-…

This study tests a 16-week video exercise program for breast cancer survivors who have recently had mastectomy surgery. The program includes twice-weekly classes focused on aerobic fitness, balance, and strength. Researchers will track attendance and measure improvements in fitne…

This study tests a 10-session meditation practice combined with real-time brain feedback to help ease depression. Twenty-seven adults with moderate depression will participate. The goal is to see if this approach can improve mood and reduce symptoms.

This phase 3 trial tests whether adding cannabidiol (CBD) to standard treatment can improve symptoms, thinking, and inflammation in people with early psychosis. About 120 adolescents and adults will receive either CBD or a placebo for 8 weeks. Researchers will also explore what f…

This study tests whether a safe, at-home brain stimulation device called tDCS can help people with depression that hasn't improved with standard treatments. Ten participants will use the device at home under remote supervision for two weeks. The goal is to see if the approach is …

This study tests a simple idea: before surgery to reverse an ileostomy, participants will infuse their own ostomy contents back into the inactive part of their intestine. The goal is to 'retrain' that section to handle digestion again, potentially speeding up recovery after the o…

This study tests a non-invasive brain stimulation technique called accelerated theta burst stimulation to reduce suicidal thoughts in people with treatment-resistant depression. About 76 adults will receive either bilateral or unilateral stimulation to see which works better. The…

This study tests a computer program called COGENT, designed to improve thinking skills like memory and attention in people with anxiety, depression, or PTSD. 128 adults will be randomly assigned to either the COGENT training or a sham program. Researchers will compare changes in …

This study tests whether using a mental health app called SuperBetter can help adolescent dancers recover from foot or ankle injuries. Fifty dancers aged 13 to 18 will use the app for 10 minutes a day, 5 days a week, for 12 weeks alongside their usual physical therapy. The goal i…

This study tests whether a therapeutic ketogenic diet can reduce troubling eating disorder symptoms like the drive to restrict, binge, or purge, and body dissatisfaction. It includes adults with anorexia nervosa (both weight-recovered and underweight) and bulimia nervosa. Over 14…

This study tests whether taking a daily multivitamin and mineral supplement can improve how your cells produce energy, which is linked to healthy aging. Researchers will give 150 adults aged 40-60 either one of two multivitamin formulas or a placebo pill for a set period. They wi…

This study looks at 20 adults with psoriatic arthritis and fatty liver disease to see if the drug guselkumab can improve liver fat, joint swelling, and skin plaques. Participants will have two visits over 24 weeks to track changes. The goal is to understand shared disease mechani…

This study observes children with eosinophilic esophagitis (EoE) to understand how their symptoms, endoscopy findings, and inflammatory markers change over time during standard care. Researchers will collect data from up to 1,500 participants during routine clinic and endoscopy v…

This study looks at how inhaled cannabis affects the brain in people with chronic low back pain. Researchers will use MRI scans to measure changes in brain blood flow and oxygen levels, and ask participants to rate their pain. The goal is to understand the brain mechanisms behind…

This study tests whether a program called COMPRENDO, which uses trained peer navigators, can help more Hispanic children with cancer enroll in clinical trials. The navigators provide education and support to parents in English or Spanish. The study will compare enrollment rates a…

This study looks at how having both sleep apnea and COPD (called overlap syndrome) affects the heart. Researchers will compare people with one or both conditions and test two breathing treatments—a special mask that helps breathing at night and extra oxygen—to see which may impro…

This study uses brain scans (fMRI) and computer tasks to understand how women with anorexia or bulimia nervosa learn to avoid certain situations. Researchers will compare brain activity in 78 women—26 with anorexia, 26 with bulimia, and 26 healthy controls—to see if avoidance lea…

This study looks at how CBD and THC, two compounds found in cannabis, affect inflammation and brain health in people with HIV. About 90 participants will take both substances in a random order over six weeks. Researchers will measure blood markers and brain function to better und…

This study looks at how cannabis ingredients (THC and CBD) affect decision-making, attention, and motivation in people with and without HIV. About 138 adults who use cannabis infrequently will take either THC, CBD, or a placebo for 5 days and complete thinking tests and brain flu…

This study uses brain scans (fMRI) to investigate how the brain processes 'liking', 'wanting', and learning in women with anorexia or bulimia. Researchers will compare 189 women with eating disorders to 63 healthy women, using computer tasks and a test meal. The goal is to unders…

This study looks at how blood pressure changes when standing affect thinking and brain blood flow in people with Parkinson's disease. About 60 participants, with and without orthostatic hypotension (low blood pressure on standing), will take thinking tests while lying down and st…

This study compares how people with anorexia nervosa, those who have recovered, and healthy controls metabolize food after eating a breakfast sandwich. Researchers aim to understand genetic and biochemical factors that influence food metabolism and anxiety around eating. The goal…

This study looks at whether virtual reality (VR) can measure how smokers pay attention to smoking-related cues, which may help understand nicotine addiction. Two hundred daily smokers will take either a medication (varenicline) or a placebo, and their eye movements and cravings w…

This study looks at whether adjusting sleep timing and using bright light therapy can improve mood and sleep in perimenopausal women with depression. Researchers will have 120 women either advance or delay their sleep for one night, then use a light box for 30 minutes daily for t…

This study follows 100 people who had atrial fibrillation (AF) during a hospital stay for surgery or illness. Participants get a small heart monitor implanted to track AF over 12 months. The goal is to see how often AF returns and whether the cause (heart surgery, other surgery, …

This study tests whether using a smartphone app (Owaves) for 7 weeks can improve college students' well-being by helping them align their daily activities with their natural sleep-wake rhythm. Researchers will measure changes in happiness, focus, energy, and mindfulness in 400 un…

This study looks at better ways to provide cervical cancer screening and treatment to women living with HIV in Nigeria. About 2,400 women will take part. Researchers will compare two sets of strategies to see which works best for getting women screened and treated. The goal is to…

This study tests whether a simple team debriefing tool, called an After-Action Review, can help child welfare teams better connect children and families to mental health services. Researchers will work with 320 participants, including caseworkers and family members, to see if the…

This study tests a device called OneMark that helps doctors see breast cancer during surgery and over time. About 60 people with breast cancer will take part. The goal is to see if OneMark works better than current methods for surgeons and radiologists, especially in women with d…

This study looks at how the brain activity of people with opioid use disorder aligns with a therapist during meditation. Researchers will measure brain synchrony and feelings of connection to see if they relate to opioid cravings. The goal is to better understand the brain proces…

This study is testing whether a special 3D ultrasound technique can help doctors better monitor how liver tumors respond to treatment. About 80 adults with liver cancer that started in the colon or rectum will be scanned before and during therapy. The goal is to see if this imagi…

This study tests a program called iTEST for people with schizophrenia or related disorders. The program combines daily brain-training exercises on a mobile device with coaching to help participants more accurately judge their own skills. Researchers want to see if this improves h…

This study looks at how taking testosterone (male-level hormones) affects the reproductive system in healthy transgender men and cisgender women. Researchers will measure hormone levels and track menstrual bleeding patterns. The goal is to understand how testosterone changes the …

This study is testing a telehealth program to help young cancer patients (ages 0-50) get fertility care that matches their personal goals. The program includes needs screening, counseling, and fertility preservation services. Researchers want to see if this approach increases the…

This study tests a program where doctors' offices help families who struggle to afford food get connected to community nutrition support. About 600 families with children aged 5-18 who have certain health conditions and receive Medicaid or SNAP will take part. The goal is to see …

This study looks at how people who speak two languages or speak one language and sign another manage to switch between them. Researchers will have 360 healthy adults complete tasks like naming pictures or classifying words in different languages. The goal is to understand the men…

This study aims to understand how common respiratory viruses like COVID-19, flu, and RSV spread in communities. Researchers will track up to 25,000 people of all ages using at-home test kits and symptom surveys. The goal is to better predict outbreaks and improve public health re…

This study looks at why some people getting CAR T-cell therapy for cancer develop brain-related side effects called neurotoxicity. Researchers will use advanced brain scans, thinking tests, and blood markers to find early warning signs. The goal is to create a tool that identifie…

This study looks at whether waking patients with brain bleeding every hour for checks (standard care) versus every two hours affects their confusion and long-term thinking. Researchers will track 120 adults in the ICU for delirium and later cognitive function. The goal is to see …

This pilot study tests a program to help young female cancer survivors in rural Imperial County, California, get reproductive health care that matches their personal goals. The program includes a quick needs assessment during oncology visits, followed by a session with a social w…