Brain zaps on a schedule: new trial tests if less frequent rTMS can stop depression relapse
NCT ID NCT06938841
First seen May 03, 2026
Summary
This study tests whether reducing the frequency of rTMS sessions can maintain the antidepressant effect in people with treatment-resistant depression who already responded to daily rTMS. 75 participants will receive either standard maintenance, clustered, or sham rTMS over 6 months. The goal is to see if brain connectivity changes and depression scores stay stable.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Australian National University
RECRUITINGCanberra, Australian Capital Territory, 2601, Australia
Contact
Contact Email: •••••@•••••
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University of California, San Diego
RECRUITINGSan Diego, California, 92127, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Weill Cornell Medicine
RECRUITINGNew York, New York, 10065, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Transcranial Magnetic Stimulation (TMS)
What this could lead to
If successful, this could provide a practical maintenance schedule for rTMS to keep depression at bay longer, reducing the need for daily treatments.
What could go wrong
This is an early-phase study with only 75 participants, so results may not apply widely. The maintenance effect may be modest, and some people might still relapse.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.