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Brain zaps on a schedule: new trial tests if less frequent rTMS can stop depression relapse

NCT ID NCT06938841

Recruiting now Disease control Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether reducing the frequency of rTMS sessions can maintain the antidepressant effect in people with treatment-resistant depression who already responded to daily rTMS. 75 participants will receive either standard maintenance, clustered, or sham rTMS over 6 months. The goal is to see if brain connectivity changes and depression scores stay stable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Transcranial Magnetic Stimulation (TMS)
What this could lead to
If successful, this could provide a practical maintenance schedule for rTMS to keep depression at bay longer, reducing the need for daily treatments.
What could go wrong
This is an early-phase study with only 75 participants, so results may not apply widely. The maintenance effect may be modest, and some people might still relapse.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER TREATMENT RESISTANT DEPRESSION

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Australian National University

    RECRUITING

    Canberra, Australian Capital Territory, 2601, Australia

  • University of California, San Diego

    RECRUITING

    San Diego, California, 92127, United States

  • Weill Cornell Medicine

    RECRUITING

    New York, New York, 10065, United States

    Contact Email: •••••@•••••

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