Can a nasal spray break through tough depression?

NCT ID NCT06103760

Recruiting now Disease control Sponsor: Royal North Shore Hospital Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial is testing whether esketamine nasal spray, when added to a person's usual antidepressant, can help adults with major depression who haven't improved after trying two or more medications. Participants will receive supervised esketamine treatments over several weeks and complete questionnaires to track mood and functioning. The study aims to see how well esketamine works in real-world settings and which patients might benefit most.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Esketamine nasal spray (Spravato)
What this could lead to: If effective, this could offer a new option for people with hard-to-treat depression, potentially improving symptoms and daily functioning when standard antidepressants haven't worked.
What could go wrong: This is an early, uncontrolled study without a placebo group, so results may not prove esketamine's benefit. Esketamine can cause side effects like dizziness, nausea, and temporary blood pressure changes, and not everyone may respond.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

Royal North Shore Hospital
RECRUITING

St Leonards, New South Wales, 2065, Australia

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