Targeting depression: can MRI-Guided brain zaps rewire key circuits?

NCT ID NCT05090397

Completed Knowledge-focused Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This study tests whether a mild electrical brain stimulation technique called transcranial direct current stimulation (tDCS) can alter brain activity in adults with major depression. Using MRI to guide the stimulation, researchers will measure changes in brain connectivity and also track depressive symptoms over five sessions. The goal is to understand how tDCS affects the brain, not yet to prove it as a treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial direct current stimulation (tDCS), a mild electrical current applied to the scalp, guided by MRI
What this could lead to: If it works, this could point toward a more targeted, personalized way to use brain stimulation for depression.
What could go wrong: This is a small, early-stage study focused on brain changes, not proof of treatment benefit. Results may not translate into lasting symptom relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION

Contacts and locations

Locations

CTI Northwestern

Chicago, Illinois, 60611, United States

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