Northwestern University

This early-stage trial tests whether anti-estrogen drugs (fulvestrant or anastrozole) can shrink inguinal hernias in men aged 50 and older. Thirty men with a symptomatic hernia will receive one of the drugs for 6 months. The main goal is to check safety and see if the hernia gets…

This study tests a technology-based program to help women aged 18-44 with high blood pressure lower their blood pressure before getting pregnant. Participants will receive support through their primary care clinic and use online tools. The goal is to improve heart health and medi…

This study tests a drug called zanzalintinib (XL092) in 29 people with advanced leiomyosarcoma that has spread or cannot be removed by surgery. The drug works by blocking signals that help cancer cells grow. The goal is to see if it can slow the cancer's progression longer than c…

This phase II trial is testing the drug pemetrexed in people with advanced bladder cancer or other solid tumors that have spread and carry certain gene mutations (MLL4, UTX, or MTAP). The goal is to see if pemetrexed can shrink tumors. About 64 participants will receive the drug …

This study tests whether giving a lower dose of radiation to the lymph nodes in the neck that are not directly affected by cancer can reduce side effects while still curing the disease. It includes 100 people with early-stage HPV-related throat cancer. The goal is to maintain exc…

This study is testing whether artificial intelligence (AI) can help doctors choose the right radiation dose for people with lung cancer or tumors that have spread to the lung. The treatment uses a precise type of radiation called SBRT, and the AI aims to personalize the dose to e…

This study is for adults with advanced liver cancer (hepatocellular carcinoma) that is hard to treat. It compares two standard drug regimens — immunotherapy (atezolizumab + bevacizumab) or targeted pills (lenvatinib or cabozantinib) — given after a liver-directed radiation treatm…

This study looks at whether a less invasive lung surgery, called segmentectomy, can completely remove lung cancer in people whose tumors have shrunk after initial treatment (chemotherapy or immunotherapy). About 25 adults with non-small cell lung cancer that has reduced to 3 cm o…

This study tests a pill called upadacitinib for people with eyelid dermatitis that hasn't gotten better with standard creams. Ten adults aged 18-70 will take the drug for 12 weeks to see if it reduces redness and irritation. The goal is to find a new option for those who haven't …

This study tests whether combining a brain-computer interface training with audio cues played during sleep can improve arm function in people who had a stroke at least 6 months ago. 70 participants will practice moving a cursor on a screen using muscle signals, then hear related …

This study tests whether adding selenium supplements to standard advanced therapies (like biologics) helps people with moderate to severe ulcerative colitis achieve remission. About 180 participants will receive either selenium or a placebo for a set period. The goal is to see if…

This trial tests a new approach for glioblastoma, an aggressive brain cancer. A device implanted in the skull uses ultrasound to temporarily open the blood-brain barrier, allowing immune-boosting drugs to reach the tumor. The study involves 25 adults who have completed radiation,…

This study tests a telehealth program to help cancer survivors quit smoking, lose weight, and get more active. About 1500 participants will either get coaching sessions or just information. The goal is to see which approach works better for improving long-term health.

The PROVE trial is testing whether a weight loss program combined with walking exercise can improve or maintain walking ability in people with peripheral artery disease (PAD) who are overweight. 212 participants will be randomly assigned to either weight loss plus exercise or exe…

This early-phase trial tests whether combining a topical immune-boosting cream (imiquimod) with local radiation can better treat mycosis fungoides, a rare skin lymphoma. About 25 adults with stable but active disease who have tried at least one other therapy will receive the crea…

This early-stage trial tests two drugs—triapine and temozolomide—together in people whose glioblastoma has returned. The goal is to find the safest dose and see how well patients tolerate the combination. About 30 adults with recurrent grade 2-4 glioma will take part.

This study tests whether high-intensity treadmill exercise can slow the worsening of motor symptoms in people with early-stage Parkinson's disease. 370 participants who have not yet started Parkinson's medication will be assigned to either moderate or high-intensity treadmill ses…

This study tests two programs to help young people aged 15-24 in Nigeria. One program focuses on finding undiagnosed HIV cases using mobile health tools and peer support. The other helps those already diagnosed stick to their HIV medication to achieve viral suppression. The goal …

This study tests whether adding targeted radiation, guided by a special PET scan, to standard hormone therapy can better control prostate cancer that has spread. About 125 men with metastatic hormone-sensitive prostate cancer will be randomly assigned to receive either standard t…

This study is for people with liver cancer who need surgery but don't have enough healthy liver left. Doctors use a special radiation treatment (Y90) to help the liver grow larger. Once the liver is big enough, patients can have surgery to remove the cancer. The study compares st…

This study tests a program that combines peer support and text message reminders to help young LGBTQ+ people with HIV in Nigeria stay on their medication and lower their virus levels. One hundred participants aged 15-29 will receive the program for 24 weeks. The goal is to see if…

This study tests whether a special vacuum-assisted wound system (NPWTi) helps heal chronic pressure sores better than standard wet-to-dry dressings. About 62 adults with stage 3 or 4 pressure sores on the tailbone or sitting bones will be randomly assigned to one of the two treat…

This study tests whether a single surgery to replace an infected artificial knee works as well as the standard two-surgery approach. About 153 patients with a chronic knee infection will be randomly assigned to one of the two treatments. Researchers will track pain, function, and…

This study looks at whether adding GLP-1 agonists (a type of diabetes drug) to the MS medication ocrelizumab can reduce disability progression in people with multiple sclerosis. Researchers will track 100 adults with MS over 72 weeks, measuring changes in walking, hand function, …

This study tests a drug called Ublituximab (Briumvi) given twice a year to people with early relapsing multiple sclerosis. Researchers want to see if it is safe and how it affects a nerve damage marker in the blood. About 40 adults with mild disability will take part for about on…

This study is testing whether giving fresh frozen plasma (FFP) to people with moderate to severe traumatic brain injury can improve their recovery. About 357 adults aged 18-65 will be randomly assigned to receive either standard care alone or standard care plus two units of FFP. …

This study looks at different ways to perform a liver transplant in people whose colorectal cancer has spread to the liver and cannot be removed by surgery. Researchers will compare living versus deceased donor transplants, whole versus split organs, and one-stage versus two-stag…

This study aims to find the best way to sequence two parent-led therapies for young children with autism: one focused on social communication and another on disruptive behavior. Researchers will enroll 184 children aged 18-48 months and their caregivers to compare different thera…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people hospitalized with moderate to severe ulcerative colitis flares. The goal is to see if this treatment can stop symptoms like rectal bleeding and frequent stools, and…

This trial tests whether adding the drug WP1066 to standard radiation therapy can help people with newly diagnosed glioblastoma, a fast-growing brain cancer. WP1066 targets a protein called STAT3 that helps tumors grow and hide from the immune system. The study will enroll 39 pat…

This study is testing two simple tools to help women with type 2 diabetes better manage their condition and understand reproductive health risks. The tools include a personalized medication list for patients and an alert for doctors during checkups. Researchers will track blood s…

This phase 2 trial is testing whether adding a CDK4/6 inhibitor (palbociclib, abemaciclib, or ribociclib) to elacestrant works better than elacestrant alone for people with advanced ER+/HER2- breast cancer that has already been treated with a CDK4/6 inhibitor. The study will enro…

This early-phase trial tests a new type of proton radiation called P-SFRT, which delivers high doses to tumors while sparing nearby organs. It is for people with newly diagnosed retroperitoneal soft tissue sarcoma that has not been treated yet. The study aims to find the best dos…

This phase 2 trial is testing whether the immunotherapy drug cemiplimab can help people with NUT carcinoma, a rare and aggressive cancer that has spread or cannot be removed by surgery. The study will enroll 15 participants and measure how long they live and whether their tumors …

This study tests whether a community program centered in churches can help people on Chicago's South Side better control their blood pressure. Researchers will work with local health workers and church leaders to adapt proven strategies from a large health system. The goal is to …

This study explores whether a special cardiac MRI can detect complications after heart transplantation without the need for invasive biopsies or angiography. Researchers will scan 247 adults and children, including healthy volunteers and transplant recipients, to see if MRI measu…

This study tests four digital tools—expert videos, self-persuasion tasks, storytelling, and motivational interviewing—to help Vietnamese parents in the U.S. get their teens the HPV vaccine. About 96 parents of unvaccinated adolescents will try different combinations of these tool…

This study tests an online program called all2GETHER that teaches relationship and communication skills to gay, bisexual, and queer men, as well as transgender and non-binary people who partner with cisgender men. The goal is to see if the program can lower HIV and STI rates. 5,0…

This study tests whether a virtual group program called Mothers and Babies can prevent postpartum depression in immigrant Latinas who are at risk. About 300 pregnant women and new mothers will either join the program via Zoom or receive usual support services. Researchers will tr…

This study tests whether describing a common pain shot (epidural steroid injection) in a very positive way helps reduce leg pain more than a neutral description. Researchers will compare three groups: positive framing of the shot, neutral framing of the shot, and neutral framing …

This study compares two different lasers used during surgery for an enlarged prostate (BPH). The goal is to see which laser reduces bleeding time during the operation. About 180 men will take part, and the results will help surgeons choose the best tool for this common procedure.

This study tests a training method called MINT that helps stroke survivors reduce abnormal muscle co-activation in their legs. The goal is to improve walking speed and endurance. Researchers will enroll 72 adults who had a stroke at least 6 months ago and have moderate to severe …

This study tests a smartphone app designed to help teenagers aged 14-18 who self-harm and are not currently in therapy. The app teaches coping skills and connects them with support through a friendly chatbot. The goal is to see if the app is easy to use and helps reduce self-inju…

This study tests whether a single injection of morphine into the spinal fluid can reduce pain and the need for other painkillers after video-assisted or robotic lung surgery. About 90 adults undergoing elective lung surgery will be randomly assigned to receive either the morphine…

This study compares a new, ejaculation-sparing version of standard prostate surgery (HoLEP) for men with enlarged prostates. The goal is to relieve urinary symptoms while preserving the ability to ejaculate normally. Researchers will enroll 48 sexually active men and track ejacul…

This study looks at whether a needle-free device called the J-Tip can reduce pain and anxiety during a procedure that drains fluid from the belly (paracentesis) in people with liver cirrhosis. About 110 adults will be randomly assigned to receive numbing medicine either through a…

This study tests whether injecting Botox into the bladder wall during a standard prostate surgery (HoLEP) can better control overactive bladder symptoms like sudden urges to urinate and leakage. About 66 men aged 18-89 with these symptoms will be randomly assigned to get Botox or…

This study tests whether giving misoprostol (a drug often used for stomach ulcers and labor) before hysteroscopic fibroid removal can reduce the amount of fluid absorbed by the body during surgery. Too much fluid can be dangerous. Forty women with small fibroids (1-3 cm) will rec…

This study tests an online program called My Wellbeing Guide for cancer patients who feel depressed or anxious. The program uses videos, activities, and written tips based on cognitive behavioral therapy over 7 weeks. About 6,500 participants will be randomly assigned to the prog…

This study tests a personalized physical activity program for women over 60 with gynecologic cancers who are receiving chemotherapy or other systemic treatments. The program includes a wearable activity tracker and a smartphone app, plus optional features like an exercise partner…

This study tests whether taking cocoa flavanols daily for six months can improve walking distance in people aged 55 and older with peripheral artery disease (PAD), a condition that causes leg pain and limits mobility. Researchers will compare a cocoa flavanol supplement to a plac…

This study tests a noninvasive device that gently stimulates a nerve in the ear to help people wake up faster after surgery. Researchers will also see if it reduces confusion and depression after the operation. The study involves 40 adults having lumbar spine surgery.

This study tests a procedure called Genicular Artery Embolization for people with mild-to-moderate knee osteoarthritis. Doctors inject tiny particles into arteries that supply the knee lining to reduce blood flow and hopefully ease pain. Fifteen participants will be followed for …

This study compares a shorter muscle cut (4-5 cm) during a procedure called POEM to the standard longer cut (8-10 cm) for people with certain swallowing disorders. The goal is to see if the shorter cut works just as well at relieving symptoms like trouble swallowing and chest pai…

This study tests whether a nerve block (stellate ganglion block) or the drug ketamine, alone or together, can reduce headaches and PTSD symptoms in people who have had a traumatic brain injury. About 175 adults will receive one of four treatments, including sham procedures, to se…

This early-phase study is testing whether dupilumab, a drug already used for eczema, can reduce severe itching in people with various genetic skin disorders. The trial will enroll 30 participants and last 26 months, including a 16-week treatment period and a longer extension phas…

This study compares two common surgeries for removing kidney stones: mini-PCNL (a small incision in the back) and flexible ureteroscopy with a special suction tube. About 80 adults with kidney stones between 1 and 3 cm will be randomly assigned to one procedure. The main goal is …

This study tests whether dupilumab (Dupixent) can improve sleep and reduce itching in 40 children aged 6-17 with moderate to severe eczema. Participants receive dupilumab for 12 weeks, and researchers measure sleep quality and itch using questionnaires and overnight sleep tests. …

This study is testing whether taking pumpkin seed oil extract can improve bladder function in people with overactive bladder. Researchers will ask 40 participants to take the supplement for 12 weeks and track their symptoms using surveys. The goal is to see if this natural option…

This study tests whether a device that delivers targeted sound waves (shockwave therapy) can reduce hard scar tissue that sometimes forms after breast surgery. Researchers will enroll 100 adults who have firmness in their breast tissue after plastic surgery. They will measure cha…

This study tests whether drinking beetroot juice daily for 4 months can improve walking distance in people with peripheral artery disease (PAD). Researchers will compare a beetroot juice group to a placebo group in 210 adults aged 50 and older. The main goal is to see if beetroot…

This pilot study tests whether fisetin, a natural compound found in strawberries, can reduce aging cells and improve walking ability in 34 people aged 50+ with peripheral artery disease (PAD). Participants will receive either fisetin or a placebo for 4 months. The main goal is to…

This study tests whether shining a specific red light on the legs each day before a walking session can help people with peripheral artery disease (PAD) walk farther. PAD causes leg pain and difficulty walking due to poor blood flow. The trial will involve 32 adults aged 50 and o…

This study tests whether adding nitrate-rich beetroot juice to exercise helps people with peripheral artery disease (PAD) walk farther and with less pain. 210 adults aged 50+ with PAD will be assigned to either supervised treadmill or home walking, plus either beetroot juice or a…

This study tests an 8-week group mindfulness program designed for African American adults who have both high blood pressure and depression. Researchers want to see if the program improves mood and blood pressure, and if it works well in a community setting. Participants will lear…

This study tests a wearable device called a myoelectric-computer interface (MCI) that helps stroke survivors improve arm movement by reducing abnormal muscle co-activation. The device uses muscle signals to guide a video game, providing feedback to retrain coordination. Researche…

This study looks at whether alternate day fasting (eating very little every other day) before chemotherapy can help reduce side effects and improve quality of life for women with ovarian, endometrial, or uterine cancer. About 30 women who have had surgery and are about to start c…

This study compares two methods of knee replacement surgery: traditional mechanical alignment (MA) and newer kinematic alignment (KA) that mimics the knee's natural position. About 95 adults with knee arthritis will be randomly assigned to one method and followed for 6 weeks. The…

This study places a physical therapist directly in the emergency department to treat low back pain right away, instead of sending patients to an outside clinic. Researchers want to see if this approach is practical and can be done at multiple hospitals. The trial will enroll 140 …

This study tests a web-based toolkit called CONNECT designed to help rural older adults who have survived cancer manage emotional distress and anxiety. The toolkit offers interactive activities, educational materials, and personalized mental health resource recommendations. Resea…

This study looks at whether over-the-counter hearing aids can improve communication for older adults with mild cognitive impairment and mild to moderate hearing loss. Fifty participants and their communication partners will be randomly assigned to try hearing aids first or receiv…

This study tests a program called FOREST that teaches positive emotion skills to staff working in gun violence prevention. The goal is to reduce burnout, anxiety, and depression, and improve well-being and job retention. One hundred employees from UCAN in Chicago will take part o…

This study tests a mobile app called ADAPTS designed to help teenagers and young adults with leukemia remember to take their oral chemotherapy. The app sends personalized messages based on the user's mood, pain, or location. The goal is to see if the app is easy to use and accept…

This study looks at what to do when a surgeon finds a small, hidden hernia on the opposite side during groin hernia repair. Some doctors fix it immediately, others prefer to watch and wait. The trial will randomly assign 380 adults to either immediate repair or monitoring, tracki…

This study enrolls 750 adults in Chicago to see if working with a trained health navigator (a non-clinical guide) helps people complete recommended cancer screenings. Participants are randomly assigned to standard navigation or navigation plus a health checklist. The study lasts …

This study is testing whether an automated text-messaging program can help young adults (ages 18-24) who have suicidal thoughts create and use a personalized safety plan. The program sends daily messages about coping strategies, crisis resources, and support networks over four we…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can help predict how well pancreatic cancer patients respond to chemotherapy. Researchers will track ctDNA levels before, during, and after treatment in 500 patients whose cancer has not spread. The goal …

This study tests whether a special band-aid (called the A-Band) and a smartwatch can measure pain in women with chronic pain using AI. About 115 women with chronic pain and healthy women will wear the devices for a week and report their pain levels. The goal is to see if the devi…

This study follows women aged 18 to 44 who are trying to conceive at a fertility clinic. Researchers want to learn how lifestyle habits like sleep, nutrition, and physical activity before pregnancy affect the chances of having a baby. Participants will be followed for up to 25 ye…

This study tests how Tizanidine, a drug used for muscle stiffness, changes arm movement in people who have had a stroke. Researchers will measure brain activity, muscle responses, and movement patterns in 64 participants. The goal is to understand what limits movement after strok…

This study tests whether a visual education tool can help new mothers recognize and report urgent warning signs after childbirth, such as deep vein thrombosis. Forty postpartum women will view pictures of complications and then answer questions to see if they understand and would…

This study looks at whether giving extra money to lower-income parents for three years can improve their children's mental health and brain function. Researchers will follow 500 children, ages 5 to 14 at the start, and measure stress, inflammation, and brain activity using scans.…

This study looks at the bacteria living on the skin and in the gut of 100 adults with and without vitiligo. Researchers want to see if people with active or stable vitiligo have different bacteria compared to healthy volunteers. No treatments or drugs are given—just samples colle…

This study looks at how the pupils of people with Delayed Sleep-Wake Phase Disorder react to light. Researchers want to see if there are differences in light sensitivity and whether a single dose of citalopram (a serotonin-boosting drug) can increase melatonin suppression during …

This study compares two surgical techniques for removing a uterine septum—a wall of tissue inside the uterus that can cause pregnancy complications. One method uses scissors without electricity, while the other uses a heated wire. Researchers will track surgery time, costs, and r…

This study tests whether a brief, self-guided computer program can alter how people with anxiety and intolerance of uncertainty make decisions when outcomes are unclear. Researchers will measure changes in brain activity and decision-making before and after the 30-minute session.…

This study is a registry that collects information from 120 adults who are having all or part of their esophagus removed using a robotic surgical technique. The goal is to track short- and long-term health outcomes, such as complications and recovery times, to better understand t…

This study tests whether a cone-shaped blood pressure cuff placed on the forearm gives more accurate readings than the standard cuff on the upper arm in pregnant women. High blood pressure during pregnancy can lead to serious decisions like early delivery or C-section, so better …

This pilot study tests a digital mindfulness program called Wakeful for pediatric residents. Participants can choose their program length (3, 5, or 7 weeks) or be assigned a length. The goal is to see if having a choice improves how often they use the program and how satisfied th…

This study collects blood, skin, and spinal fluid samples along with health information from 2,500 adults with neuromuscular diseases like ALS, neuropathy, and muscular dystrophy. The goal is to store these samples and share them with researchers to speed up discoveries about how…

This study is looking at 1,000 liver transplant recipients to see if testing their blood, urine, and tissue samples can detect early signs of chronic kidney disease, acute rejection, or hepatitis C. The goal is to find simple biomarkers that could lead to earlier treatment and fe…

This study observes how doctors decide the length of the muscle cut during POEM surgery for people with swallowing disorders like achalasia. Researchers will follow 200 adults for 2 years, tracking symptoms and whether retreatment is needed. The goal is to see if tailoring the su…

This observational study aims to map which parts of the amygdala—a brain region involved in emotion and memory—receive signals directly from the nose. Researchers will present various odors to 100 healthy adults while recording their brain activity. The goal is to better understa…

This study explores whether practicing breathing exercises while awake and then replaying them during sleep can change how people breathe at night and boost their thinking skills. Researchers will recruit 18 adults with untreated obstructive sleep apnea. Participants will train a…

This study aims to understand how different parts of the amygdala, a brain region involved in emotion and smell, process odors. Researchers will use mild electrical stimulation in 12 adults who are already undergoing brain surgery for other reasons. Participants will rate smells …

This study looks at how different parts of the brain's amygdala, which receives smell signals, affect our perception of odors. Researchers will ask 40 healthy adults to rate smells in different situations. The goal is to better understand the brain's role in smell, not to treat a…

This study is testing whether a non-invasive brain stimulation technique called iTBS, combined with computer-based attention training, can improve focus and daily functioning in people with persistent attention problems after a mild traumatic brain injury (mTBI), with or without …

This study is testing a small wearable device worn around the neck that takes pictures of what you eat and drink without recording sound. About 72 adults will wear it at home for several weeks to see if it's comfortable and reliable. The goal is to learn if this technology can he…

This study looks for better ways to monitor kidney transplant recipients for signs of rejection or long-term damage. Researchers will collect blood, urine, and tissue samples from 1000 patients during routine biopsies to find early warning markers. The goal is to replace less sen…

This study looks at whether a special training and support program can help addiction clinics start using contingency management, a proven method that gives rewards to patients who stay off stimulants. Researchers will work with 76 clinics and track how many patients and counselo…

This study looks at the bacteria living on the skin of people with cutaneous T cell lymphoma, a rare type of skin cancer. Researchers will compare these bacteria to those on healthy people and people with other skin conditions like psoriasis. The goal is to understand if certain …

This study looks at whether simpler hearing aid settings work better for older adults with Alzheimer's dementia or mild memory problems. Researchers will test two different hearing aid programs in 20 participants to see which one helps them understand speech in noisy settings and…

This study aims to find out if brain-based tests can predict who will get pain relief from common knee osteoarthritis treatments. About 180 adults with knee pain will be randomly assigned to take duloxetine, celecoxib, or a placebo for 20 weeks. Researchers will use brain MRIs, k…

This study tests three different approaches to speech therapy for toddlers with developmental delays. About 1,269 children will receive either therapist-led sessions, caregiver coaching, or a combination of both. The goal is to find which method helps children and families the mo…

This study aims to test new MRI sequences in 2000 adults (patients and healthy volunteers) to see if they can produce better images than current methods. Participants will undergo additional scans during their regular MRI. The goal is to improve diagnostic capabilities without di…

This study looks at whether giving men with low-risk prostate cancer two extra tests—a genomic test (GPS) and a special MRI—helps them stick with active surveillance (monitoring instead of immediate treatment). Researchers will track 222 men for 18 months to see if these tests im…

This study looks at how dapagliflozin, a diabetes drug, affects heart function and metabolism in people with chronic kidney disease. Researchers will measure heart strain, oxygen use during exercise, and blood chemicals in 60 adults. The goal is to understand how the drug works b…

This study is looking at 1,000 people with and without heart failure to better understand the different types of the condition. Researchers will use heart images and blood tests to find patterns that could lead to more personalized treatments. The goal is to improve care for peop…

This study looks at heart tissue from 180 people with a type of heart failure called HFpEF. Researchers take tiny samples of heart muscle during a routine procedure to find changes in the tissue. The goal is to learn what causes this condition so better treatments can be develope…

This study looks at whether having a physical therapist available in the emergency department (ED) can improve care for people with dizziness. Researchers will compare two hospitals: one where physical therapy is offered in the ED and one where usual care is given. The main goal …

This study is testing whether a patient navigator program helps low-income pregnant women have healthier pregnancies and babies. 600 women will be randomly assigned to get a navigator or usual care. Navigators help with barriers like transportation, knowledge, and access to care …

This study looks at how a brain chemical called norepinephrine affects sleep and thinking in older adults with insomnia, who are at higher risk for Alzheimer's. Researchers will measure this chemical in the blood and use a light therapy to try to improve sleep and mental sharpnes…

This study looks at whether text messages can encourage teenagers (ages 13-19) to get tested for HIV. About 360 teens who have had sex and are HIV-negative or don't know their status will receive either helpful texts or general information. Researchers will check if more teens ge…

This study follows 500 people with primary progressive aphasia, a condition that slowly damages the brain's language areas. Researchers will use brain scans and language tests to map how the disease progresses over time. The goal is to better understand the disease, not to test a…

This study looks at how much tension is placed on the abdominal wall during hernia repair surgery and how that affects the body's inflammation and immune response. Researchers will measure inflammatory markers in blood and fluid from the surgery site in 25 adults undergoing herni…

This study explores whether dream yoga practices can improve sleep and reduce anxiety. About 70 healthy adults with mild anxiety will learn techniques using virtual reality and home sleep monitors. The goal is to understand how these practices affect brain activity and dreaming, …

This study looks at how the brain recognizes different smells. Researchers will record brain activity from epilepsy patients who are already undergoing brain surgery. Participants will smell various odors and rate what they perceive. The goal is to find patterns in brain signals …

This study tests a 5-week program called Family Navigator Plus (FN+) for foster parents of youth aged 6-17 with mental health needs. The program uses video sessions to teach parents how to find and access mental health services. Researchers want to see if parents find the program…

This study tests whether an online program teaching positive emotion skills can improve mental well-being and slow biological aging. Researchers will measure changes in mood and biological age markers in 80 adults aged 40-70 from the Chicago area. The goal is to understand if boo…

This study collects tumor tissue and medical information from 10,000 women undergoing breast cancer surgery. The samples are stored and used for future research to better understand breast cancer. No treatment or experimental drug is given.

This study uses fMRI to look at brain and spinal cord activity in people who have had a stroke and have weakness on one side. Participants will perform a simple shoulder movement while being scanned. The goal is to understand which neural pathways are used for movement after a st…

This study tests whether a personalized form of brain stimulation, called theta-burst stimulation (TBS), can cause lasting changes in how people approach or avoid situations. Researchers will use EEG to tailor the stimulation to each person's natural brain rhythms. The study invo…

This study follows 120 stroke survivors for six months, using brain scans and movement tests to understand why some people develop arm stiffness and weakness. Researchers hope to find early signs that predict recovery, which could guide future rehabilitation. Participants must ha…