Northwestern University

This study is testing if adding the drug hydroxychloroquine to two standard cancer drugs helps control advanced colon cancer that has a specific genetic change (BRAF V600E) and has stopped responding to prior treatments. Researchers believe hydroxychloroquine may help overcome th…

This study is testing if giving the drug misoprostol before a specific type of fibroid surgery makes the procedure safer. The surgery uses fluid to see inside the uterus, and absorbing too much fluid is a main risk. Researchers want to see if misoprostol helps the uterus contract…

This study is testing whether adding fresh frozen plasma (FFP) to standard emergency care helps people recover better from moderate to severe traumatic brain injuries. Researchers will compare patients receiving standard care alone to those who also get two units of FFP shortly a…

This study is testing whether adding an experimental drug called WP1066 to standard radiation therapy can better control a fast-growing type of brain cancer called glioblastoma. The drug is designed to block a specific pathway that helps the tumor grow and hide from the body's im…

This study is for people with liver cancer (HCC) who need surgery to remove their tumor but currently don't have enough healthy liver tissue left to safely undergo the operation. Researchers are testing a treatment called Y90 radioembolization, where tiny radioactive beads are in…

This study is testing whether the chemotherapy drug pemetrexed works better for people with advanced cancers that have spread and carry specific genetic mutations. It will enroll 64 adults with metastatic bladder cancer or other solid tumors who have already tried other treatment…

This study is testing whether breathing pure oxygen in a pressurized chamber helps people hospitalized with severe ulcerative colitis flare-ups. Researchers want to see if this therapy can quickly reduce symptoms like bleeding and diarrhea, and help patients avoid needing stronge…

This study is testing the safety and effects of Ublituximab (brand name Briumvi) in people recently diagnosed with relapsing multiple sclerosis. Researchers will follow 40 adults with early MS for about two years while they receive the medication every 24-26 weeks. The main goal …

This early-stage study is testing the safety of a new treatment for aggressive brain tumors called high-grade glioma. Doctors are using specially engineered stem cells that carry a virus designed to target and kill cancer cells. The treatment is given directly into the brain mult…

This study is testing if a special vacuum-assisted wound cleaning system helps heal severe pressure sores better than traditional wet-to-dry dressings. It will involve 62 hospitalized patients with deep sores on their lower back or tailbone area. Researchers will compare how long…

This study compares two types of temporary antibiotic spacers used to treat infections in artificial knee joints. Researchers will randomly assign patients to receive either a standard cement spacer or a more durable spacer made with real joint components. They will follow patien…

This study tests whether a proven blood pressure control program can work when delivered through churches in Chicago's underserved South Side. The program uses community health workers and ministry facilitators to help adults manage their high blood pressure through monitoring, s…

This study is for people with advanced or metastatic breast cancer that is estrogen-receptor-positive and HER2-negative, and whose cancer has grown despite prior treatments including a specific type of targeted drug (a CDK4/6 inhibitor). It aims to find out if taking the drug ela…

This study is testing a new, targeted form of proton radiation therapy for people newly diagnosed with a rare abdominal cancer called retroperitoneal sarcoma. The goal is to see if this new technique, which aims to deliver higher radiation doses directly to the tumor while sparin…

This study aims to find the best way to handle a small, hidden hernia sometimes discovered during surgery to fix a hernia on the other side of the groin. It will randomly assign patients to either have the hidden hernia repaired immediately or to simply monitor it over time. Rese…

This study is testing whether a combination of two drugs, pembrolizumab and tazemetostat, can help prevent aggressive B-cell lymphoma from coming back after a patient has received a stem cell transplant or CAR T-cell therapy. The drugs are given as a 12-month maintenance treatmen…

This study is testing a new, 'smarter' approach to weight loss management. It compares a smartphone app that adjusts support based on your progress against a standard, more expensive group program and a self-guided approach. The main goal is to see if the adaptive app can help pe…

This study is testing if the immunotherapy drug cemiplimab can help control advanced NUT carcinoma, a rare and aggressive cancer with very few treatment options. It will enroll about 15 adults whose cancer has spread or cannot be removed by surgery. The main goal is to see if the…

This study aims to find the best order for parents to learn two different skills to help their young child with autism. It will test whether to start with a social communication program or a behavior management program first, and then adjust the second program based on how well t…

This study is testing whether artificial intelligence (AI) software can help doctors determine the best radiation dose for each patient's lung tumor. It aims to see if this personalized approach can better control the cancer and reduce side effects compared to standard dosing. Ab…

This study is testing a new approach for treating glioblastoma, a very aggressive brain cancer. Researchers are implanting a small ultrasound device in the brain to temporarily open the protective blood-brain barrier. The goal is to allow powerful immune-boosting drugs to better …

This study is testing whether assigning a personal guide, called a patient navigator, to low-income pregnant women leads to better health for both mother and baby. The navigator helps women from early pregnancy through the weeks after birth by identifying and overcoming barriers …

This study is testing an oral drug called zanzalintinib (XL092) for people with advanced leiomyosarcoma, a type of cancer that has spread or cannot be removed by surgery. The main goal is to see if the drug can help control the cancer and keep it from getting worse for at least s…

This study is looking at whether adding GLP-1 agonist medications (often used for diabetes and weight loss) to the standard MS drug ocrelizumab can better slow down disability progression in people with multiple sclerosis. It will follow 100 adults with MS for about 18 months, tr…

This study is testing whether combining two hormone-blocking drugs with radiation therapy works better than standard treatments for men with very high-risk prostate cancer. The goal is to more aggressively control the cancer and prevent it from returning. Researchers will follow …

This study is testing a new smartphone app designed to help teenagers and young adults with leukemia remember to take their daily oral chemotherapy pills. For two months, 60 participants will use the app, which sends personalized reminder messages based on their daily mood and sc…

This study is testing whether adding targeted radiation to standard drug treatments helps men with advanced prostate cancer that has spread. Doctors use a special PET scan to find active cancer spots, then aim radiation directly at those areas. The goal is to see if this combined…

This study is testing a program that uses technology to help women with type 2 diabetes better manage their health, especially if they are thinking about pregnancy. It uses doctor visit prompts and daily text messages to encourage healthy habits and provide important information.…

This study aims to compare different approved liver transplant methods for patients whose colorectal cancer has spread to the liver and cannot be removed by standard surgery. Researchers will track 80 adult patients to see which transplant approach—using living or deceased donors…

This study is testing a new, brief iPad-based tool called MyCog to help primary care doctors detect early signs of memory loss and dementia more effectively. It focuses on helping older adults from Black, Hispanic/Latino, and low-income communities who often face delays in diagno…

This study aims to help prevent HIV among women by making information about prevention medication (PrEP) more accessible. Researchers will send educational videos and materials in English or Spanish to 120 women through their patient portal. The goal is to support women in making…

This study is testing if a text message program can encourage more teenagers to get tested for HIV. Researchers will enroll 360 adolescents (ages 13-19) across the US and randomly assign them to receive either the special text messages or general health information. The main goal…

This study is testing a 5-week educational program designed to help foster parents better understand their child's mental health needs and find appropriate services. Researchers want to see if the program is practical, useful, and satisfactory for the 12 participating foster pare…

This study compares two different approaches to knee replacement surgery for people with severe knee arthritis. One method positions the new joint in a neutral position, while the other tries to match the knee's natural alignment. Researchers want to see which technique leads to …

This study aims to see if over-the-counter hearing aids or special communication strategies can make conversations easier for older adults who have both hearing loss and early-stage memory problems. Researchers will compare the two approaches in 50 participants and their communic…

This study is testing if a drug (ketamine) or a nerve-blocking injection (stellate ganglion block), alone or together, can reduce headaches and PTSD symptoms in people with traumatic brain injury (TBI). It will involve 175 adults who have had these conditions for over 3 months. T…

This study is testing a 9-month wellness program designed to help staff who work to prevent gun violence. The program teaches skills to manage emotions, reduce burnout, and improve mental health. It aims to see if this support helps workers feel better and stay in their jobs long…

This study tests whether a small dose of morphine injected into the spinal fluid before chest surgery reduces pain and medication needs afterward. 90 adults having elective chest surgery will receive either the morphine injection or a placebo saline injection. Researchers will me…

This study is testing if having a physical therapist right in the emergency department (ER) helps people who come in with sudden, severe low back pain. At two major hospitals, one ER will have a therapist start care immediately, while the other uses standard care. The main goal i…

This study is testing if injecting Botox directly into the bladder wall during a common prostate surgery helps men with overactive bladder symptoms. Researchers want to see if this one-time injection reduces urgent bathroom trips and leakage after surgery. The study will compare …

This study is testing an 8-week online program designed to help family caregivers of people with dementia cope with stress and emotional challenges. The program teaches positive emotion skills through self-guided lessons and includes social features like discussion boards. Resear…

This study is testing a web-based toolkit called CONNECT, designed to help older cancer survivors living in rural areas manage the emotional distress and anxiety that can follow cancer treatment. The program provides interactive activities, helps set up telehealth visits, and off…

This study investigates whether the way a doctor describes a common back pain injection influences how much pain relief patients feel. Researchers will compare a very positive description, a neutral description, and standard medication therapy in 210 adults with sciatica-like leg…

This study aims to understand how the body reacts to major abdominal hernia repair surgery, especially when the repair is done under high tension. Researchers will observe 25 patients and 5 healthy volunteers, measuring inflammation markers and pressure inside the abdomen. The go…

This study is exploring whether practices inspired by an ancient tradition called Dream Yoga, combined with modern virtual reality training, can change how the brain works during sleep and wakefulness. Researchers are recruiting 70 healthy adults who recall dreams regularly to co…

This study aims to understand how the human brain recognizes and identifies different smells. Researchers will record brain activity from patients who are already undergoing surgery for epilepsy while they smell various odors and describe what they perceive. The goal is to link s…

This study aims to understand if a single session of personalized magnetic brain stimulation can create lasting changes in how people make approach or avoid decisions. Researchers will test healthy adults using different stimulation methods while measuring brain activity. The goa…

This study is testing whether learning online skills to boost positive emotions can improve well-being and affect markers of biological aging. Researchers will enroll 80 adults aged 40-70 to use a self-guided program focused on gratitude and mindfulness. They will measure changes…

This study aims to create a large collection of medical information and biological samples from adults with various nerve and muscle diseases. Researchers will follow 2,500 patients over time, collecting blood, skin samples, and clinical data every six months. The goal is to prov…

This study uses special brain scans to see how stroke survivors' brains control arm movement. Researchers want to understand which brain pathways are used after a stroke causes arm weakness. This knowledge could help design better physical therapy exercises to improve recovery.

This study aims to understand if a single, brief intervention can change how people with anxiety and depression make decisions when faced with uncertainty. Researchers will measure changes in decision-making behavior and brain activity before and after the session. The goal is to…

This study collects breast tissue samples from women undergoing surgery for breast cancer to create a research bank. The goal is to help scientists better understand breast cancer by studying these samples in future research projects. Participants contribute tissue that would oth…

This study aims to understand how the brain and language abilities change over time in people with Primary Progressive Aphasia (PPA), a disorder that causes gradual loss of speech and language. Researchers will track 500 participants through cognitive tests and brain scans every …

This study aims to understand how the brain changes after a stroke and how those changes affect a person's ability to move their arm and hand. Researchers will use special brain scans and movement tests on 120 stroke survivors at several points over six months. The goal is to fin…