Can a common muscle relaxant unlock better stroke rehab?

NCT ID NCT06666673

Recruiting now Knowledge-focused Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests how Tizanidine, a drug used for muscle stiffness, changes arm movement in people who have had a stroke. Researchers will measure brain activity, muscle responses, and movement patterns in 64 participants. The goal is to understand what limits movement after stroke, which could lead to better rehabilitation techniques.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tizanidine (Zanaflex)
What this could lead to: If successful, this study could point toward better rehabilitation methods for arm movement after stroke.
What could go wrong: This is a very early, small study (64 people) focused on understanding brain mechanisms, not on proving a new treatment. Tizanidine is already approved for spasticity, but its effects on voluntary movement are unclear.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ischemic stroke Muscle Spasticity stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STROKE

Contacts and locations

Locations

Northwestern University, Dept. of PTHMS 645 N Michigan Ave, Suite 1100
RECRUITING

Chicago, Illinois, 60611, United States

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