STROKE

This study tests a new device called CLAAS that closes a small pouch in the heart to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 1,600 participants will be randomly assigned to get either the new device or an already-approved device. The goa…

This study tests whether a new, less invasive surgery to remove blood clots from the brain within 8 hours of a stroke can improve recovery compared to standard medical care. About 240 adults with a large brain bleed will be randomly assigned to either the new surgery or usual tre…

This study tests whether keeping blood pressure very low (below 120 mmHg) after a stroke procedure improves recovery compared to standard care (140-180 mmHg). It involves 910 adults who had a stroke due to a blocked artery and received a clot-removal treatment. The goal is to see…

This study tests two programs for people recovering from a stroke who are leaving inpatient rehab and going home. Half of the 520 participants (age 55+) will get a stroke education program, and the other half will get a program focused on making their home environment safer. The …

This study tests whether the clot-busting drug tenecteplase can help people who have a stroke caused by a blocked artery in the brain, even when treatment starts 24 to 72 hours after symptoms begin. About 330 adults with moderate to severe stroke will receive either tenecteplase …

This study tests whether Diroximel Fumarate, a drug already used for multiple sclerosis, can reduce harmful brain swelling that often occurs after a hemorrhagic stroke. The trial will enroll 192 adults who have had a stroke, giving the drug within 48 hours of symptoms. The goal i…

This study tests whether a combination of an over-the-counter supplement (MitoQ) and a brief arm-cuff inflation (ischemic conditioning) can improve blood vessel function in 30 stroke survivors. Poor vascular health after a stroke raises the risk of another stroke and heart proble…

This study is testing whether two drugs, colchicine (an anti-inflammatory) and ticagrelor (a blood thinner), can reduce the risk of another stroke, heart attack, or related death in people who have already had an ischemic stroke. About 2,800 high-risk participants will take these…

This study looks at whether a cardiac rehabilitation program can improve recovery for people who have had a stroke. Researchers will compare standard care plus cardiac rehab to standard care alone in 150 adults. They will measure walking ability, daily function, hospital readmiss…

This study tests if the drug Dimephosphon can improve recovery in people who have had an acute ischemic stroke (a stroke caused by a blood clot). The trial involves 184 adults aged 35-80 who will receive either Dimephosphon or a placebo within 24-72 hours of their stroke. The mai…

This study tests an experimental drug called DM199 in people who have had a moderate stroke and cannot receive standard clot-removal treatments. About 728 participants will receive either DM199 or a placebo within 24 hours of their stroke. The goal is to see if the drug improves …

This study tests a new approach for people who had a stroke at least 6 months ago and have severe arm weakness. It combines non-invasive brain stimulation (rTMS) with a therapy that uses electrical currents to help open the hand (CCFES). The goal is to see if this combination imp…

This study looks at whether adjusting blood pressure differently during clot-busting treatment for stroke can lower the risk of dangerous bleeding in the brain. About 340 adults aged 18 to 80 with acute ischemic stroke and high blood pressure will take part. Researchers will comp…

This study looks at two ways to help people who have had a stroke lower their blood pressure. One way is checking blood pressure at home. The other adds group medical visits where people learn together. The goal is to see if combining both methods works better to prevent another …

This study tests whether placing a small tube (stent) in a hardened brain artery during a stroke helps patients recover better than the usual clot-removal methods. About 500 adults with severe stroke who did not improve after initial treatment will be randomly assigned to one of …

This early study tests a wireless brain implant from Neuralink that aims to let people with severe paralysis or ALS communicate just by thinking. The device is placed in the brain by a robot. The study will check if it is safe and works for 6 adults who cannot speak or use their …

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after a serious brain bleed (aneurysmal subarachnoid hemorrhage) and aneurysm clipping surgery. RIC uses a blood pressure cuff on the arm to create short, harmless …

This study tests whether using a remote-controlled CT scanner with live video guidance from stroke experts can help smaller hospitals start clot-busting treatment faster for stroke patients. About 52 adults with suspected stroke within 24 hours of symptoms will take part. The goa…

This study tests a telehealth weight-loss program designed for people who have had a stroke. The goal is to help participants lose weight and improve their health, especially those who have limited access to in-person programs. About 94 adults who are at least one year past their…

This study looks at whether taking blood thinners can prevent strokes in people who have brief episodes of atrial fibrillation (irregular heartbeat) triggered by stress, such as after surgery or a serious illness. About 2,270 participants with additional stroke risk factors will …

This study looks at 60 people who already have a deep brain stimulation (DBS) device for movement problems like tremor, stroke, or brain injury. Researchers will adjust the device's settings and then test how well participants can move their hands, speak, swallow, and control fac…

This study tests whether taking algae supplements (spirulina or seaweed) for 20 weeks can improve markers of heart health and change gut bacteria in 150 adults aged 50+ with conditions like heart disease, diabetes, or kidney disease. Participants are randomly assigned to receive …

This study tests whether helping stroke survivors with social needs like housing, food, and transportation can improve their recovery. Researchers will enroll 275 Black and Hispanic adults aged 18-75 who have had a stroke and face at least three social barriers. Participants will…

This study tests if a non-invasive nerve stimulation (taVNS) combined with occupational therapy can help people who had a stroke more than 6 months ago improve arm and hand movement. The treatment is given through the skin on the neck, no surgery needed. 60 adults with arm weakne…

This study tests a new AI-based system that guides stroke survivors through arm exercises at home. About 192 people who had a stroke at least 6 months ago will be split into three groups: one using the AI system, one using the same system without AI, and one getting standard care…

This early study tests a brain-computer interface (BCI) called Connexus in 2 people with severe paralysis from conditions like ALS or spinal cord injury. The device is designed to decode imagined speech and allow users to control a computer, helping them communicate. The main goa…

This study tests whether combining a gentle brain stimulation technique (tDCS) with training that does two things at once (like walking while counting) can improve movement and thinking in people who had a stroke. Researchers will measure walking speed, mental performance, and br…

This study tests whether a device called GORE® CARDIOFORM can safely close a small hole in the heart (PFO) to reduce the risk of another stroke. About 636 people who had a stroke of unknown cause within the past year will get the device plus blood-thinning medicine. Researchers w…

This study compares two common procedures (radiofrequency and cryoablation) for treating persistent atrial fibrillation, a heart rhythm problem that raises stroke risk. Researchers will track 158 adults over 24 months to see which method better prevents strokes, mini-strokes, and…

This study tests whether a smartphone app that uses virtual and augmented reality can help people who had a stroke improve their arm and hand function. Seventy adults who are at least three months past their stroke will use the app at home or receive standard therapy for six week…

This study tests if a small filter placed in the neck arteries can catch blood clots before they reach the brain, preventing strokes in people with atrial fibrillation who already had a stroke. About 2,000 participants will either get the implant plus blood thinners or just blood…

This study looks at whether adding a blood thinner to standard aspirin therapy helps prevent strokes and blood clots in people who develop a new irregular heartbeat after coronary bypass surgery. About 3,200 adults who had bypass surgery and then had a short-lasting or repeated i…

This study tests whether the IV drug clevidipine can lower blood pressure quickly and keep it stable in people having a bleeding stroke. About 1,000 adults with high blood pressure and a recent intracerebral hemorrhage will receive either clevidipine or another IV blood pressure …

This study tests whether a robotic exoskeleton (Gloreha Sinfonia®) can improve arm and hand recovery in people who had a stroke within the past 3 months. 130 participants will be randomly assigned to get either robotic therapy plus standard rehab, or standard rehab alone. The goa…

This study tests whether using a balloon guide catheter that temporarily stops blood flow during clot removal can improve outcomes for people having a stroke caused by a blockage in the internal carotid artery. About 364 adults will be randomly assigned to receive either the ball…

This study tests whether starting a special exercise program soon after a stroke can help protect the brain from memory loss and dementia. Researchers will work with 126 people who had a stroke in the last 6 months. Participants will do a mix of exercises, and their thinking skil…

This study tests a pharmacy-led program to help low-income patients with multiple chronic conditions take their medications correctly after leaving the hospital. The program provides free medications, bedside delivery, and health coaches to address common barriers like cost and t…

This study looks at whether a procedure called endovascular thrombectomy (EVT) helps people who already have a moderate-to-severe disability and then have a major stroke. About 1,060 adults will be randomly assigned to get EVT or standard medical care. The goal is to see if EVT i…

This study tests whether a simple set of treatments—lowering blood pressure, controlling fever, and managing blood sugar—can help people recover better after a brain bleed (intracerebral hemorrhage). About 3,500 adults in Sweden and Australia will receive either the care bundle o…

This study tests whether a spinal cord stimulator, combined with physical therapy, can help improve arm and hand movement in people who have had a stroke. Twenty adults with lasting arm weakness will first do therapy alone, then get a spinal implant and repeat therapy with stimul…

This study compares two treatments for arm muscle tightness (spasticity) caused by stroke, spinal cord injury, or brain injury. Thirty adults will receive both surgery and botulinum toxin injections at different times, so each person acts as their own comparison. The goal is to s…

This study tests whether giving a powerful cholesterol-lowering drug (PCSK9 inhibitor) before a clot-removal procedure helps people recover better from a severe stroke. About 652 adults who are having a stroke due to a large blocked artery in the front part of the brain will be r…

This study tests a treatment that combines deep brain stimulation with physical rehab to improve arm function in people who had a stroke 1 to 6 years ago. About 202 participants will receive either the active treatment or a control. The goal is to see if the treatment leads to me…

This study tests whether injecting a clot-dissolving medicine directly into the brain's arteries can improve recovery for people having a stroke caused by a medium-sized blood vessel blockage. About 282 adults with this type of stroke will be randomly assigned to receive either t…

This study tests a healthy lifestyle program that has been adapted for Hispanic/Latino people who have had a stroke. The goal is to help participants lose weight and improve health markers like blood sugar and cholesterol. The program includes a smart scale for home use and in-pe…

This study tests whether hydroxyurea can prevent first strokes in 220 high-risk children with sickle cell anemia in Nigeria. Participants take low or moderate doses of the drug and are monitored for strokes or mini-strokes. The goal is to see if this approach works in real-world …

This study compares two treatments for people having a small type of stroke called a lacunar stroke. One group gets a standard clot-busting medicine through an IV, while the other takes a combination of antiplatelet pills (similar to aspirin). The goal is to see if the pills work…

This study tests whether stroke patients who take blood thinners (FXa inhibitors) can safely receive a standard clot-busting drug (IVT). Current guidelines deny IVT to these patients due to bleeding fears, but new evidence suggests it may be safe. The trial will compare recovery …

This study tests whether adding the antibiotic minocycline to standard stroke care helps people with moderate strokes recover better. About 1,164 adults will be randomly assigned to receive either minocycline pills for five days plus usual care, or usual care alone. Researchers w…

This study looks at whether losing weight, with or without exercise, can improve walking and emotional well-being in veterans who have had a stroke and are overweight. About 130 people aged 35-85 who had a stroke at least 6 months ago will take part. Participants will join a life…

This study tests a tool called Savvy that combines phone exercises, a weekly pill organizer, and text reminders to help stroke survivors take their medication as prescribed. The goal is to see if it improves medication adherence and blood pressure control. The study involves 150 …

This study looks at two methods of performing the Valsalva maneuver (bearing down) during a heart ultrasound to detect a small hole called PFO, which can cause strokes. About 488 people who need this test will try both the standard self-directed method and a new goal-directed met…

This study tests a special sensor that listens to chest sounds to help doctors find pneumonia sooner in people who have had a stroke or are on dialysis. About 50 adults will take part. The sensor detects abnormal sounds that may mean pneumonia, which is then checked with a chest …

This study looks at whether a simple, safe ultrasound of the optic nerve can help doctors quickly detect brain swelling and inflammation in ICU patients with conditions like meningitis, stroke, or brain tumors. Researchers will measure the optic nerve sheath diameter and compare …

This study tests whether a special dye (Florbetaben) used with a PET scan can detect inflamed plaque in the arteries of people who recently had a heart attack, stroke, or mini-stroke. The goal is to see if this imaging method is feasible for identifying dangerous plaque that migh…

This study tests whether a detailed CT scan (multimodal CT) can more accurately identify the blocked artery in people with a medium vessel stroke compared to standard scans. About 622 adults with acute ischemic stroke will be enrolled within 24 hours of symptoms. The goal is to i…

This study aims to develop a quick blood test to tell whether a stroke is caused by bleeding or a clot, which is critical for giving the right treatment fast. Researchers will test a protein called GFAP in 527 adults with suspected stroke arriving at the hospital within 3 hours o…

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to quickly identify patients with a large vessel occlusion stroke who need to go directly to a hospital equipped for clot removal. About 275 adult…

This study tests whether nurse-led health education for first-time stroke patients and their family caregivers can lower the chance of having another stroke. The program focuses on managing risk factors like blood pressure and lifestyle habits. Researchers will compare stroke rec…

This study tests a music-inspired program called Music4Health to see if it can lower blood pressure and improve stroke awareness in Nigerian youth (ages 14-24) and their caregivers (ages 40+). About 1,400 participants will join as pairs. The program involves listening sessions an…

This study is testing a new, non-invasive brain stimulation technique called 'mirror-PAS' to help people who have had a stroke or suffer from phantom limb pain. The goal is to see if this method can improve movement in stroke patients and reduce pain in those with phantom limb pa…

This study tests whether personalized brain stimulation (rTMS) can improve arm and hand function better than standard treatment in people who had a stroke within the past 3 months. About 120 participants will receive either a customized or conventional stimulation protocol. The g…

This study is testing whether two non-invasive stimulation techniques—one for the brain and one for the arm muscles—can improve arm function in people who have had a stroke. Researchers will compare results from stroke survivors with arm weakness, those without arm issues, and he…

This study tests whether a 12-week home telerehabilitation program using the MindMotion GO device can help stroke survivors improve motor function. The program adds 300 minutes of weekly active therapy to standard care, with remote monitoring by a therapist. Researchers will enro…

This study tests whether a program combining physical activity counseling and a personalized exercise plan can help stroke survivors who live at home become more active. Researchers will compare a group receiving this program plus usual care to a group receiving only usual care. …

This study tests a new system that combines virtual reality with a walking robot to help people who have had a stroke walk with a more natural, balanced stride. The robot gives real-time feedback to encourage using the weaker leg more. Researchers will compare 15 stroke survivors…

This study tests a new low-cost shoe that changes friction to help people with foot drop after stroke walk more easily. About 50 adults who are at least 3 months past their stroke will try the shoe at home. The goal is to see if it improves walking speed and balance.

This study tests a smart wearable device called gaitQ that uses cues to help people with long-term movement conditions like Parkinson's disease, stroke, multiple sclerosis, and arthritis walk better. Researchers will measure walking improvements in 150 participants, including hea…

This study tests whether a gentle brain stimulation technique called tDCS, combined with health education and aerobic exercise, can reduce severe tiredness after a stroke. About 54 adults who had a stroke within the last 45 days and feel very fatigued will take part. The goal is …

This study tests a program where stroke survivors coach other recent stroke survivors. The goal is to see if this peer support can improve mental well-being, hope, and quality of life. The study involves 20 participants and uses surveys to measure changes over 8 weeks.

This study tests a wearable device that gives feedback on swallowing muscle activity to help people with swallowing problems from stroke or Parkinson's disease. About 120 adults aged 50-90 will do a 12-week therapy program either in-person or at home via telehealth. The goal is t…

This study tests whether a gentle, non-invasive tongue stimulation device can boost arm recovery in people who had a stroke at least 6 months ago. 74 participants will receive either real or fake tongue stimulation while doing arm exercises for 4 weeks. Researchers will measure c…

This study tests a soft robotic glove designed to help people who have had a stroke regain movement in their wrist and hand. Sixty participants will use the glove during 20 training sessions, and the glove uses muscle signals to assist with tasks. The goal is to see if this robot…

This study tests whether using mild brain stimulation before walking therapy can help people who have had a stroke walk better. About 100 adults who had a stroke at least 3 months ago and still have trouble walking will take part. The goal is to see if this approach improves walk…

This study is testing a wearable suit called Neuro20 that uses mild electrical pulses to help muscles work. Researchers want to see if it can improve walking, muscle strength, and heart rate in 30 people who have had a spinal cord injury, stroke, or amputation. Participants will …

This study tests whether adding sensory training to standard Constraint-Induced Movement (CI) therapy can help stroke survivors with mild-to-severe arm and hand weakness. Researchers will enroll 15 adults who are at least 6 months post-stroke. Participants will receive intensive …

This study tests whether adding one hour of arm-hand exercises daily (5 days a week for 4 weeks) to standard care helps stroke patients regain arm and hand function. 80 people who had a stroke will be randomly assigned to either the extra arm-hand therapy or a lower-body exercise…

This study compares three treatments—mirror therapy, brain stimulation (rTMS), and robotic hand therapy—added to standard rehab for stroke survivors. It aims to see which best improves arm movement, quality of life, and pain. About 120 adults aged 40-80 who had a stroke at least …

This small pilot study tests whether a home-based cognitive strategy program (PRPP-I) can help adults with chronic stroke become more independent in daily activities like dressing, cooking, and bathing. Researchers will enroll 18 participants to see if the program is feasible and…

This study tests a small-group, video-based program that helps people who had a stroke learn skills to manage their own recovery. It is for adults aged 45-85 who are less than 6 months post-stroke and living at home. The program focuses on improving confidence, daily activity per…

This study tests whether a smartphone app powered by artificial intelligence can improve thinking and memory in people who have had a stroke. Forty adults aged 45 to 60 with lasting cognitive problems will use the app as part of their recovery. The goal is to see if the AI traini…

This small study looks at whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis pay better attention and feel less tired. Researchers will use EEG to watch brain activity during hypnosis sessions. The goal is to see if this approach is practi…

This study looks at whether doing aerobic exercise (like walking or cycling) right before physical therapy can help stroke survivors recover better. The goal is to improve arm movement, thinking skills, and mood. About 40 Veterans who had a stroke at least 6 months ago will take …

This early-stage study at Johns Hopkins University is testing whether psilocybin, a psychedelic compound, is safe for people who had a stroke at least one year ago. The study will enroll 20 adults and closely monitor their blood pressure and any psychiatric changes. The goal is t…

This study is testing a mobile app called MAYA that offers cognitive behavioral therapy (CBT) to help with anxiety and depression in adults who have had a stroke. Researchers want to see if the app is easy to use and acceptable to stroke survivors. Ten participants aged 40-79 wil…

This study tests whether applying kinesio tape (a stretchy, therapeutic tape) to the neck muscles can improve swallowing safety in people who have trouble swallowing after a stroke. Researchers will measure changes using video X-rays before and right after taping. The study enrol…

This study tests a wearable hand orthosis called MyHand 2 for stroke survivors who have weakness on one side. The goal is to improve hand function and daily activities. Researchers will refine the device based on feedback from 60 adult participants who had a stroke at least six m…

This study tests a special mouth exercise program using a device to help people who still have trouble swallowing 12 weeks after a stroke. About 60 participants will be randomly assigned to the program or standard care. The goal is to see if the exercises improve swallowing funct…

This study tests a device called SSMD to see if it can improve arm movement in adults who have had a stroke or traumatic brain injury within the past year. About 150 participants will either use the SSMD device or standard electrical stimulation, along with usual rehab, for 5-6 w…

This study aims to treat shoulder pain that often occurs after a stroke. The researchers believe that a buildup of a natural substance called hyaluronic acid in the muscles causes stiffness and pain. They will test an injection to break down this buildup in 68 stroke survivors, u…

This study tests a gentle ultrasound technique called LIFUS to see if it can improve arm movement and motor learning in people who had a stroke at least 6 months ago. Researchers will try different power levels and timing patterns to find the best settings. 24 adults with arm wea…

This study explores whether listening to music for one hour each day can improve emotional well-being, thinking, and memory in people who have had a stroke. Sixty adults aged 50 to 90 who had a stroke at least six months ago will be randomly assigned to listen to music or an audi…

This study tests whether using a virtual reality (VR) treadmill for 12 weeks is practical and helpful for people who had a stroke at least 6 months ago. 30 participants will either use the VR treadmill or do traditional exercises. The goal is to see if VR training improves walkin…

This study tests a 10-week power training program for people who had a stroke at least 6 months ago. The goal is to see if fast, explosive exercises can improve walking, strength, and balance better than standard slow strength training. Sixty participants will be randomly assigne…

This study tests whether a robotic leg brace (exoskeleton) can improve walking and daily function in 50 stroke survivors during inpatient rehab. Participants will use the device in therapy sessions, and researchers will measure changes in mobility, muscle stiffness, and independe…

This study tests whether a non-invasive brain stimulation technique called TMS, combined with speech therapy, can improve language recovery in people who had a stroke 2 to 6 weeks earlier. 63 participants will receive either real or fake TMS alongside therapy. The goal is to see …

This study tests whether robot-assisted Tai Chi can improve arm function in people who have had a stroke. 120 adults with arm weakness will be randomly assigned to either robot Tai Chi or standard rehab exercises for 4 weeks. The goal is to see which approach leads to better moto…

This study tests whether combining a gentle nerve stimulation (taVNS) with robot-assisted arm training can improve arm movement, breathing strength, and quality of life in people who had a stroke at least six months ago. Thirty adults with moderate to severe arm weakness will be …

This study tests a 12-week dance and movement program for stroke survivors who have weakness on one side of the body. The goal is to see if it helps them take part in daily and social activities more easily, and improves balance, walking, confidence, and quality of life. About 16…

This study tests whether a small electrical device placed on the spinal cord can help people who have had a stroke move their arm and hand better. The device is implanted in the neck to stimulate nerves and muscles. The study will include 20 adults who had a stroke and have weakn…

This study tests three types of non-invasive brain stimulation combined with hand therapy to see which best helps stroke survivors regain hand movement. About 63 adults who had a stroke 6 to 24 months ago will participate. The goal is to improve their ability to pick up and move …

This study is testing a wearable suit called Mollii that uses mild electrical pulses to improve movement and quality of life in people who have had a stroke or have multiple sclerosis. About 40 participants will wear either the active suit or a placebo version to see if it helps …

This study tests whether numbing a nerve in the arm or leg can reduce the hard-to-treat pain some people feel after a stroke. About 36 adults who have had stroke-related pain for at least 6 months will receive either lidocaine, levobupivacaine, or a saltwater injection twice, two…

This study tests a new way to improve balance for people who had a stroke at least 6 months ago. The method uses small, painless vibrations on the skin to give the brain extra sensory cues about body position. Researchers will enroll 36 adults to see if this approach helps them s…

This study tests if a mild electrical pulse to the ear (called taVNS) can improve arm and hand movement in people who had a stroke. Thirty adults with arm weakness from a stroke will get either real taVNS or a fake version during daily physical therapy for two weeks. Researchers …

This study is testing whether a robotic device called Pablo Tyromotion can help improve arm and hand movement in people who have had a stroke. The study will include 120 participants aged 45-80 who have some arm weakness but can still grip. The goal is to see if this technology c…

This study tests a new approach to help people who have lost part of their vision after a stroke. It combines eye movement exercises with sound cues and mild brain stimulation to encourage the brain to adapt and possibly restore some sight. The trial enrolls 48 adults within 3 mo…

This study is testing whether a safe, non-invasive brain stimulation device can help people recover arm and hand movement after a recent stroke. 50 participants with severe arm weakness will receive either real or fake stimulation alongside their normal rehab therapy. The goal is…

This study tests whether combining two non-invasive therapies can help stroke survivors regain hand control. Participants will receive brain stimulation (tDCS) and muscle stimulation (FES) while practicing hand tasks. The goal is to see if these treatments improve movement and br…

This study tests whether adding a vibrating device (Vibramoov®) to robotic walking training helps stroke patients walk better than robotic training alone. Forty adults who had a stroke at least 3 months ago will take part in a 4-week rehab program. The goal is to see if the combi…

This study looks at whether moderate or high-intensity walking exercise is better for improving walking in people who had a stroke at least 6 months ago. About 156 participants will be randomly assigned to one of two exercise programs, each done with a physical therapist three ti…

This study tests whether a hands-on ankle adjustment (called talocrural joint manipulation) can improve ankle awareness and balance in people who have had a stroke. Researchers will measure how well participants sense their ankle position before and after the treatment. The study…

This study tests a non-invasive brain stimulation technique called iTBS to see if it can improve balance and leg movement in people who had a stroke more than six months ago. Researchers will use MRI scans to understand how the brain changes. The study involves 56 adults with las…

This study tests whether adding mindfulness exercises to standard neuromuscular stimulation can improve lung function, physical abilities, and stress levels in stroke survivors. Researchers will enroll 60 adults aged 50-65 who have had a stroke. One group will receive both treatm…

This study tests a new virtual reality therapy that combines mirror therapy with cooperative tasks to improve arm function in stroke survivors. Researchers will compare this new approach to standard VR mirror therapy in 44 adults who had a stroke at least 6 months ago. The goal i…

This study tests whether a biofeedback device that shows real-time visuals of swallowing can help stroke survivors with swallowing problems recover better than standard therapy. One hundred participants will be split into two groups: one using biofeedback and the other using only…

This study compares three rehabilitation approaches for people who have had a stroke: mirror therapy, cognitive orientation to daily occupational performance (CO-OP), and conventional occupational therapy. 45 adults with subacute or chronic stroke will receive 4 weeks of therapy …

This study looks at whether adding intensive virtual reality-based balance and gait training to standard physical therapy helps people who had a stroke within the last six months. About 48 adults with stroke-related weakness on one side will be randomly assigned to either standar…

This study tests whether combining virtual reality training with a gentle brain stimulation technique (tDCS) can improve arm and hand movement in people who have had a stroke. Researchers will enroll 100 adults who are at least 3 months post-stroke and have moderate arm weakness.…

This study tests a new therapy for people with aphasia, a language disorder often caused by stroke that makes it hard to find words. The therapy uses timed naming exercises to balance effort and accuracy, aiming to improve long-term word recall. About 30 adults with chronic aphas…

This study tests whether high-intensity interval training (HIIT) can help reduce severe tiredness in people who had a stroke 6 months to 5 years ago. Sixty adults aged 40-80 will be split into three groups: HIIT, moderate exercise, or stretching. They will exercise three times a …

This study tests whether combining prism adaptation training (PAT) with a mild electrical stimulation (TENS) helps stroke survivors pay better attention to their neglected side. About 20 participants will be randomly assigned to receive either PAT alone or PAT plus TENS. Research…

This study tests whether mild electrical stimulation to the cerebellum can boost language therapy for people with aphasia after a stroke. About 60 adults who had a stroke at least 6 months ago and have trouble naming objects will receive either real or fake stimulation during spe…

This pilot study tests whether combining a mild electrical stimulation of the spinal cord with balance training can improve postural control and reduce fall risk in people who had a stroke over a year ago. Sixteen community-dwelling adults will be randomly assigned to receive eit…

This study compares two treatments—Botox injections and dry needling—for reducing leg stiffness (spasticity) after a stroke. About 90 people who had a first stroke within the past year will be randomly assigned to receive either one Botox session or 12 weekly dry needling session…

This study looks at whether Vojta therapy, a type of physical therapy that uses gentle pressure on specific body areas to trigger natural movement patterns, can help people who had a stroke improve their posture and trunk control. Researchers will compare standard physical therap…

This study tests whether virtual reality (VR) and mixed reality (MR) games can help people who had a stroke move their arms and hands better. 45 adults aged 20 to 80 with arm weakness will try these high-tech mirror therapy systems or standard therapy. The goal is to see if the g…

This study tests a wearable device that sends gentle, low-frequency electromagnetic fields to the brain to help people who had a stroke more than 6 months ago recover arm movement and reduce disability. About 25 adults with chronic stroke will use the device in a clinic setting. …

This study tests if watching swallowing actions—either on video or in real life—can improve swallowing function in stroke patients with difficulty swallowing (dysphagia). 90 participants will be split into three groups, all receiving standard training, with two groups also practi…

This study tests if a freezing technique (cryoneurotomy) works as well as surgery to relax a stiff, twisted foot in people who had a stroke. About 114 adults with chronic stroke will receive one of the two treatments. The goal is to reduce muscle tightness and improve walking, wi…

This study tests a new way to help people who have had a stroke regain arm movement. It uses a virtual reality system that reads muscle signals and helps the person move a virtual hand, gradually reducing assistance to retrain the brain. The study also adds mild brain stimulation…

This study tests whether combining synergy-based motor therapy with neuromuscular electrical stimulation can improve arm and hand function in people who had a stroke 3 to 6 months ago. About 40 adults aged 50 to 65 with mild to moderate arm weakness will participate. The goal is …

This study tests a new exercise called CUped for stroke survivors who have weakness on one side. The exercise uses a special machine to help retrain leg movement while sitting, aiming to improve walking. About 12 adults who had a single stroke will try it to see if it is safe, to…

This study tests a home-based telerehabilitation program for stroke survivors who have trouble using their arms and hands but cannot access outpatient therapy. About 200 participants across Alberta will use a system of game-like exercises with wearable sensors, guided remotely by…

This study compares two robotic devices—the Lokomat exoskeleton and the C-Mill treadmill—to see which one helps stroke survivors walk better and feel better. About 40 adults who have had a stroke will use one of the machines during rehab. Researchers will check their walking, bal…

This study tests if sound wave therapy (ESWT) can reduce muscle stiffness in the wrist of people who had a stroke. Researchers will use ultrasound to measure changes more precisely than standard exams. The goal is to find a non-invasive, drug-free way to improve movement and qual…

This study tests a program of intense, repetitive hand and arm exercises in 15 children aged 7 to 12 who had a stroke. The goal is to improve their ability to use their affected arm in daily activities. Researchers will measure changes using a questionnaire called ABILHAND-Kids. …

This study tests a home-based robotic device combined with mild electrical stimulation to help stroke survivors improve leg movement and walking. About 60 adults who had a stroke at least 6 months ago will use the robot alone or with stimulation during home training sessions. The…

This study is testing whether using robotic exoskeletons and virtual or augmented reality during treadmill training can help people who have had a stroke improve their walking and daily independence. Researchers will compare different training methods in 80 participants to see wh…

This study tests whether a gentle spinal manipulation (like a chiropractic adjustment) can improve balance, reduce fall risk, and increase chest mobility in people who have had a stroke. About 52 adults with chronic stroke will receive both the real treatment and a sham procedure…

This study tests whether a special brain-training tool called HEG Neurofeedback can help people who had a stroke regain hand movement. About 30 people who had a stroke within the last 3 months will either do standard hand therapy or standard therapy plus the neurofeedback trainin…

This study tests a new walking training method for people who have had a stroke. It uses a special treadmill and feedback (like sounds or visuals) to help improve leg movement and make walking more balanced. The study involves 15 stroke survivors and 15 healthy adults, each atten…

This study tests whether special core and pelvic exercises can improve trunk control and balance in people who have had a stroke within the last 6 months. 38 adults aged 45-60 will be assigned to either core strengthening with pelvic exercises or standard trunk exercises. The goa…

This study looks at two different ways to help people who have had a stroke improve the use of their affected arm and hand. One method uses exercises with just the affected arm, while the other uses both arms together. Thirty-two adults who had a stroke 6 to 24 months ago will ta…

This study tests whether a gentle electrical stimulation on the ear (taVNS) combined with robot-assisted arm training can improve arm and hand function in people who had a stroke at least 6 months ago. 30 adults with moderate to severe arm weakness will receive either real or sha…

This study tests whether follow-up care for stroke survivors can be done effectively through video or phone calls with a nurse, instead of in-person clinic visits. About 196 adults who recently had a stroke and own a smartphone will take part. The goal is to see if telecare impro…

This study looks at whether combining or switching attention-focus instructions during arm exercises helps recent stroke survivors regain better arm function. About 36 adults aged 40-80 who had a stroke within the past 6 months will participate. Researchers will compare two train…

This study tests whether wearing a ring sensor and seeing your arm activity on a smartphone app can encourage stroke survivors to use their affected arm more during everyday tasks. About 50 chronic stroke survivors (more than a year after their stroke) will wear the sensors and u…

This study tests whether targeted practice in a driving simulator can improve driving skills for veteran stroke survivors. One hundred participants will each receive both active training (focusing on speed, lane position, collision avoidance, and dashboard attention) and a contro…

This study looks at whether adding music training and group leisure activities to standard hospital rehab helps people recover better after a stroke. About 90 adults who recently had a stroke will be split into three groups: usual rehab alone, usual rehab plus individual music tr…

This study tests whether using a mobile breathing trainer (AiroFit PRO™) for 15 minutes a day, 5 days a week over 6 weeks can improve lung function, muscle strength, and quality of life in people who have had a stroke and have weakness on one side of the body (hemiplegia). About …

This study is for people with aphasia, a language problem that often happens after a stroke. It makes it hard to find the right words. The study will test a new way of scheduling therapy sessions to see if it helps people remember words better and use them in everyday life. About…

This study tests a home-based, web program that helps stroke survivors and their family caregivers work together on arm exercises. The goal is to improve the survivor's arm function and daily activity while also reducing caregiver stress. About 220 participants (survivors and the…

This study tests a 6-month nurse-led rehabilitation program for stroke patients in Bangladesh after they leave the hospital. The program includes a team of nurses, physical therapists, and occupational therapists to help with self-care and using assistive devices. Researchers wil…

This study tests a non-invasive treatment that sends mild electrical pulses to the spinal cord to improve walking and balance in people who have weakness on one side of the body due to a stroke. Researchers will enroll 115 adults who are at least 6 months past their stroke and ca…

This study tests a home-based rehabilitation program called TASSRET for stroke survivors who have limited access to physical therapy. Fifty participants will use either a video or a manual guide to practice specific tasks aimed at improving arm and leg function, balance, and walk…

This study tests a non-invasive technique called focused ultrasound to see if it can improve arm movement in people who recently had a stroke. About 50 participants will receive the ultrasound treatment, and researchers will check for side effects and measure changes in brain act…

This study tests a program that uses storytelling and skills-building to help young adults (ages 18-64) who have had a stroke feel more connected and independent in their communities. 208 participants will be randomly assigned to the program or usual care. The goal is to improve …

This study tests a new rehabilitation method called NICE for people who have had a stroke and have lasting arm weakness. About 48 adults aged 21 to 80 will use a machine that shows them how to activate specific muscle groups, helping improve coordination and movement. The goal is…

This study tests a new virtual reality system that combines mirror therapy with fun games to help stroke patients improve arm movement. Researchers will check how comfortable and easy the system is to use in 172 healthy volunteers and stroke survivors. The goal is to see if this …

This study tests whether adding visual biofeedback to standard swallowing exercises and electrical stimulation helps stroke survivors with swallowing problems. About 34 adults who had a stroke in the last 6 months will be split into two groups: one gets visual biofeedback exercis…

This study tests whether a non-invasive magnetic brain stimulation technique called rTMS can reduce fatigue in people who had a stroke more than six months ago. Fatigue is a common and disabling symptom after stroke. The trial will enroll 60 participants and measure changes in fa…

This study tests a robotic exoskeleton that limits arm and trunk movement to help people recovering from a stroke regain better arm control. The goal is to reduce the use of compensatory movements and improve natural arm function. The trial will enroll 44 adults who had a stroke …

This study tests whether a 12-week sitting Tai Chi program can improve thinking, arm movement, balance, and mood in people who have had a stroke and still have memory or thinking problems. About 176 participants (88 stroke survivors and their caregivers) will either do the Tai Ch…

This study tests a wearable robotic glove that reads brain signals to help move the hand. It is for adults who had a stroke at least 16 weeks ago and still have trouble using their arm. The goal is to see if this brain-computer interface glove improves hand function and strength …

This study looks at whether a gentle nerve stimulation (tVNS) combined with a special hand therapy (mCIMT) can help people who had a stroke more than 6 months ago improve arm movement, thinking, and quality of life. Fifty participants will be split into two groups: one gets both …

This study tests a wearable device that helps stroke survivors improve arm movement by retraining how muscles work together. The device gives feedback on individual muscle activity to reduce abnormal co-contraction. The study will enroll 96 people who have had a stroke, either re…

This study tests a digital speech therapy app called Zenicom for people who have trouble speaking after a stroke. Twenty adults with aphasia (language difficulty) will either do standard speech therapy alone or add the app for two weeks. The goal is to see if the app safely impro…

This study tests whether a special virtual reality program that stimulates multiple senses can help stroke patients improve their leg movement and thinking skills. About 40 adults who have had a stroke will be randomly assigned to either the VR therapy or standard care. The goal …

This study tests whether adding visual-motor training to standard physiotherapy helps people who had a stroke regain better use of their arm and hand. Researchers will compare the combination therapy to physiotherapy alone in 38 adults aged 18-75 who are at least 6 months past th…

This study tests a wrist-worn sensor system called StrokeWear to help chronic stroke survivors use their weaker arm more in daily life. 32 participants will either use the sensor with a home exercise program or follow standard home exercises alone. The goal is to see if the senso…

This study looks at whether using a soft robotic hand device together with electrical stimulation can help stroke survivors regain hand function better than either therapy alone. About 64 people who had a stroke 3 to 6 months ago will take part. They will receive the combined tre…

This study tests whether adding augmented reality (AR) or virtual reality (VR) to treadmill training helps people who have had a stroke improve their balance and walking. Sixty-six adults who can walk with some help will be split into three groups: one using VR, one using AR, and…

This study tests if a gentle, non-invasive brain stimulation method called iTBS can improve arm and hand movement in people who had a stroke more than six months ago. Researchers will enroll 48 adults with lasting weakness on one side. Participants will receive iTBS alongside reh…

This study tests a special exercise program called Task-Oriented Circuit Training (TOCT) for people who have had a stroke. The program uses 15 different exercise stations to help improve arm and hand movement. Researchers want to see if this approach can improve dexterity, coordi…

This study tests a new type of stroke rehabilitation that combines mirror therapy with other techniques to help people who have had a stroke regain movement in their arm and hand. About 81 adults who had a stroke at least 3 months ago will participate. The goal is to see if this …

This study tests whether a gentle electrical treatment called NESA microcurrents can help people who had a stroke 6 months to 6 years ago. It aims to reduce muscle tightness, pain, and balance problems, and improve sleep, daily activities, and quality of life. About 30 participan…

This study tests whether watching videos of functional actions (like walking) combined with rhythmic music can improve balance and walking in stroke survivors. Forty adults who had a stroke 6 months to 2 years ago will be split into two groups: one gets standard therapy, the othe…

This study tests whether special balance (vestibular) exercises can help reduce fatigue in people who have had a stroke. Thirty adults who had a stroke at least 6 months ago will either do these exercises or standard rehab three times a week for one hour. Researchers will measure…

This study looks at whether escitalopram, a common antidepressant, can make language therapy work better for people who have trouble speaking after a stroke. About 88 adults who had a stroke within the past three months will take the drug or a placebo while doing language exercis…

This study tests whether adding a vibrating sensation to the arm can help stroke survivors who have lost some sense of where their arm is. Thirty people who had a stroke at least six months ago will try reaching for objects and drinking from a glass while wearing a device that bu…

This study is testing a powered ankle exoskeleton to help people who have had a stroke walk more easily. Fifteen stroke survivors will wear the robotic brace while walking on a treadmill, over ground, and on stairs and ramps. The goal is to see if the device reduces the energy ne…

This study looks at how different amounts and types of walking therapy affect people who had a stroke 1 to 6 months ago. Researchers want to see if more intense or more task-specific walking practice helps improve how far people can walk, how often they walk in daily life, and th…

This study compares two ways of doing physical activity for people who had a stroke at least 6 months ago and still have some weakness on one side. It will test if a structured program in a special facility works better than a self-guided program at home. The main goal is to see …

This study tests whether a technique called biofeedback can improve arm and hand function in people who have had a stroke. Researchers will enroll 120 adults aged 45 to 80 who have some arm weakness but can still grip. Participants will undergo rehabilitation that uses biofeedbac…

This study compares two exercise programs—high intensity interval training and intermittent functional training—to see which better improves heart health, physical function, and thinking in people who have had a stroke. About 52 adults aged 50-75 who had a stroke more than 6 mont…

This study tests a digital mirror therapy using augmented reality to help people who had a stroke more than 6 months ago improve arm movement. 44 participants will get either digital or standard mirror therapy for 10 sessions over 3 weeks. The goal is to see if the digital versio…

This study tests a new rehab method for people who lost part of their vision after a stroke. It combines gentle electrical brain stimulation with moving visual exercises, sometimes using virtual reality, to try to speed up recovery. The goal is to see if this approach can shrink …

This study tests whether adding action observation (watching movements) and motor imagery (imagining movements) to standard physical therapy can improve balance, daily function, and quality of life in people who had a stroke within the last year. About 56 participants will be ass…

This study tests whether a special virtual reality (VR) training program can help stroke survivors improve their balance and walking. Thirty-eight adults who had a stroke at least six months ago will be randomly assigned to either a real VR training with specific visual and balan…

This study tests whether a non-invasive nerve stimulation (tVNS) applied to the ear or neck, combined with task-specific training, can improve arm movement, thinking skills, and quality of life in people who had a stroke 3–6 months ago. 54 participants will be randomly assigned t…

This study tests a new speech therapy technique for people with aphasia (trouble speaking) after a stroke. Instead of copying a therapist's voice, participants will use an AI-cloned version of their own voice to practice speaking. The goal is to see if this personalized approach …

This study looks at whether doing high-intensity walking training more often helps people who had a stroke over 6 months ago walk better. About 40 adults aged 18-85 will be assigned to different training frequencies and given a home walking program. The goal is to see if more ses…

This pilot study tests Constraint-Induced Movement Therapy for adults who had a stroke at least 6 months ago and have mild weakness in one arm. The therapy involves daily training over consecutive weekdays to improve how much and how well they use their weaker arm in everyday act…

This study looks at whether task-based mirror therapy can ease pain, swelling, and improve arm movement in stroke survivors who develop shoulder-hand syndrome. About 34 people aged 45-75 will be split into two groups: one gets mirror therapy plus standard care, the other gets sta…

This study compares two walking therapies for people recovering from a stroke: one uses a harness to support body weight while walking forward and backward, and the other uses virtual reality games during walking. The goal is to see which approach better improves walking speed, b…

This study compares two ways of using a robot to help people with chronic stroke improve arm movement. About 72 participants will receive 18 sessions of robotic therapy over 6 weeks, focusing either on the shoulder first or the hand first. Researchers will measure arm function, m…

This study tests an implanted stimulator to help stroke survivors walk better. It involves screening to find good candidates, then implanting the device and creating custom controllers for home use. The goal is to see if the device can improve walking speed and ease. About 6 peop…

This study tests whether a gentle brain stimulation technique called TMS, combined with word-finding therapy, can improve speaking ability in people who have trouble finding words after a stroke. About 50 adults who had a left-hemisphere stroke at least one month ago will receive…

This study tests whether early brain-training feedback (EEG neurofeedback) can help people recover arm movement after a stroke. About 40 adults who had a stroke within the past 3 weeks will receive either real or fake (sham) neurofeedback along with standard rehabilitation. The g…

This study tests a new type of therapy for people who have had a stroke and have trouble moving their arm or hand. It uses a virtual reality system that lets patients see a 3D reflection of their good arm moving, which may help rewire the brain. Researchers will compare this VR a…

This study tests whether using a special visual device that creates the illusion of movement can help people who had a stroke regain better use of their arm and hand. About 66 participants, 4 to 10 weeks after their stroke, will either get standard therapy or add sessions with th…

This study looks at whether a twice-weekly exercise program can improve sleep quality in people who had a stroke at least a year ago and currently have poor sleep. About 62 adults aged 55 and older will take part in a 6-month program. The goal is to see if exercise helps them fal…

This study tests if doing tongue endurance exercises at home for 8 weeks can improve swallowing in adults who had a stroke 3-6 months ago. 70 participants will be randomly assigned to either the real exercise or a sham therapy. The goal is to see if the exercises strengthen tongu…

This study tests whether adding mild electrical stimulation to arm cycling exercise helps people recovering from a stroke improve their fitness and arm function. About 24 participants with subacute stroke will receive standard rehab plus either arm cycling alone or arm cycling wi…

This study tests whether a smartphone app, used alongside standard care, can help people who have had a stroke recover their ability to swallow. The app provides information and tracks progress. Researchers will compare recovery, complications like pneumonia, and quality of life …

This study compares doing rehabilitation exercises at home via video (tele-rehabilitation) versus going to a clinic, to see which better improves thinking and memory after a stroke. About 32 adults aged 50-80 who have had a stroke and have mild to moderate thinking problems will …

This study tests whether virtual reality exercises can help people with brain injuries (from stroke, trauma, or tumor) improve their attention and thinking skills. About 135 adults with recent brain injury and attention problems will use gamified VR exercises. The goal is to see …

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve arm and hand recovery in people who had a stroke within the last 6 months. About 48 participants will receive either real or placebo stimulation during their regular rehab session…

This study tests whether virtual reality (VR) training that mimics real home settings can improve arm and hand function in people who have had a stroke. About 86 participants will be split into three groups: VR-based task training, standard task training, or traditional occupatio…

This study tests whether a non-invasive brain stimulation technique called high-frequency rTMS can improve cognitive problems that occur after a stroke. Researchers will use brain imaging to see how the treatment affects brain activity. The study involves 40 adults aged 35-75 who…

This study tests whether adding rhythmic music cues to treadmill walking with thinking tasks improves walking ability and social participation in people who had a stroke at least 6 months ago. About 90 participants will be randomly assigned to one of three training groups. The go…

This study looks at whether injecting Xeomin® into the arm can improve walking in adults who have had a stroke. Twenty people with arm and leg stiffness will be tested before and 4-6 weeks after the injection using simple walking tests. The goal is to see if treating arm spastici…

This study tests whether combining a gentle brain stimulation technique (TMS) with speech therapy can improve language in people who have mild aphasia after a stroke. About 24 adults who had a stroke at least 6 months ago will receive 10 sessions of either real or fake TMS along …

This study tests whether a digital program called Sleepio, which uses cognitive behavioral therapy for insomnia, can improve sleep in stroke survivors. Researchers will also see if better sleep helps with learning motor skills during rehabilitation. About 100 adults who have had …

This study compares two exercise programs for people who have had a stroke: trunk training exercises and lateral truncal tilt balance training. The goal is to see which one better improves trunk control, balance, and the ability to perform daily activities. The study will include…

This study looks at whether playing music during routine care, like bed baths, can help stroke patients feel more comfortable in the intensive care unit. About 102 adults who recently had a stroke will take part. After care, patients will rate their comfort using a simple picture…

This study tests whether adding virtual reality (VR) to brain-computer interface (BCI) training helps stroke survivors regain arm and hand movement. Twelve adults who had a stroke 6 to 24 months ago will try both BCI with VR and BCI alone, in random order, for 6 weeks each. Resea…

This study tests whether adding a home-based telerehabilitation program to usual care helps people with arm weakness after a stroke. About 202 participants who had a stroke 90-150 days ago will be randomly assigned to either receive telerehabilitation plus usual care or usual car…

This study tests whether special knee strengthening exercises can improve balance and body awareness (proprioception) in people who had a stroke. About 34 adults, 3 months to 1 year after their stroke, will do these exercises on a machine. The goal is to see if this helps them mo…

This study tests a new rehabilitation program called ACES, which combines acceptance and commitment therapy with strategy training, to help people who have had a stroke rejoin social activities. About 54 chronic stroke survivors living in the community will take part. The program…

This study compares robot-assisted training to standard physical therapy for people who had a stroke 6-24 months ago and still have moderate to severe movement problems. The goal is to see if robot training improves leg function, daily activities, fatigue, and quality of life. Fo…

This study tests whether adding neuromuscular electrical stimulation (NMES) to standard facial exercises helps people who have facial weakness after a first-time stroke. Researchers will measure changes in facial symmetry using video recordings. The trial aims to recruit 130 adul…

This study tests whether a music-based program done at home can help stroke survivors recover thinking, speech, movement, and mood. One hundred adults who had a stroke at least 3 months ago will either do music exercises 5 times a week for 10 weeks plus usual care, or just usual …

This early study tests whether combining simple passive robots with noninvasive muscle stimulation can help people who have had a stroke regain arm function. Only 4 participants will be enrolled to give feedback on how practical and helpful the device is. The goal is to see if th…

This study compares two ways to boost mirror therapy for stroke survivors who have leg weakness. One group gets mirror therapy with mild electrical muscle stimulation; the other gets mirror therapy with special sound beats. The goal is to see which combo improves leg movement and…

This study tests a wrist-worn sensor system called StrokeWear to help people who have had a stroke use their weaker arm more in daily life. About 88 participants who had a stroke 1 to 6 months ago will either use the sensor with a home exercise program or follow standard care. Th…

This study tests whether a 4-week program combining virtual reality (VR) and real-world walking practice can help stroke survivors walk more confidently in places like shopping malls and streets. Forty adults who had a stroke 9-24 months ago will use VR goggles and game controlle…

This study tests if combining two types of nerve stimulation can improve arm and hand function in people who had a stroke at least 6 months ago. Researchers will enroll 120 adults aged 55-75. Participants receive either the combined stimulation or a placebo, and their motor skill…

This study is testing whether a special vibration system can help older adults and stroke survivors improve muscle strength, balance, and movement, while also reducing pain. Researchers will recruit 80 participants to try the vibration exercises and measure changes in strength, w…

This study tests whether adding gentle vibration to hand exercises helps stroke survivors regain hand function, feeling, and muscle control. 38 participants who had a stroke at least 3 months ago will be randomly assigned to either vibration-enhanced training or standard exercise…

This study tests whether a fast form of brain stimulation (accelerated rTMS) can safely improve apathy—loss of motivation and withdrawal—in people who had a stroke at least 6 months ago. About 40 adults aged 40+ will receive either real or fake stimulation to a brain area linked …

This study looks at two different technology-based therapies—robot-assisted walking training and visual feedback balance training—to see which one helps people who have had a stroke improve their balance and walking. The trial will include 60 adults aged 21-85 who are at least ab…

This study compares two ways of making ankle-foot braces (AFOs) for people with leg weakness from conditions like cerebral palsy, stroke, or spinal cord injury. The traditional method uses a plaster cast, while the newer method uses 3D scanning and printing. Researchers want to s…

This study tests a new robot that helps people who had a stroke 6 months to 3 years ago improve their walking. The robot has a special mode that encourages patients to actively move their legs, rather than just being moved by the machine. 60 participants will receive 15 training …

This study tests a special thinking strategy for stroke survivors who have trouble paying attention to one side of their body or space, a condition called spatial neglect. The training helps people become more aware of their neglect and learn ways to cope. Researchers want to see…

This study tests whether a high-dose, high-intensity neurorehabilitation program is feasible for stroke patients. About 120 adults with stroke will receive 300 minutes of technology-supported training per week across inpatient, outpatient, and home settings. The goal is to see if…

This study tests a procedure called cryoneurolysis, which uses cold to freeze specific nerves in the shoulder, to see if it can reduce pain and improve movement in people with spasticity (muscle tightness) after a stroke, brain injury, or other conditions. Half of the 50 particip…

This early study tests whether a device that sends mild electrical pulses to the spinal cord and muscles can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend up to 5 sessions per …

This study compares two modern therapies—mirror therapy and virtual reality (VR)—to see which one better improves arm function in people who have weakness on one side after a stroke. About 42 adults, aged 18 to 75, who had a stroke 6 to 12 months ago will be randomly assigned to …

This study tests whether adding virtual reality therapy to standard rehabilitation and action observation therapy can improve arm and hand function in people who had a stroke 6 weeks to 6 months ago. About 38 adults will be randomly assigned to two groups: one gets standard care …

This study looks at whether high-intensity interval training (HIIT) on a stepper machine can improve muscle power in people who had a stroke 1-5 years ago. 66 participants will be split into three groups: HIIT, moderate exercise, or stretching, all training three times a week for…

This study is for people who had a stroke at least 6 months ago and now have depression and trouble with focus or planning. Researchers want to see if using an iPad-based brain training program, along with learning new thinking strategies, can improve mood, memory, and daily life…

This study compares robotic gait training to standard physical therapy for people recovering from a stroke. Researchers want to see if using a robotic exoskeleton early in rehab improves walking speed and ability. The study involves 54 adults aged 18-85 who are in inpatient rehab…

This study looks at whether fun activities like dance and virtual reality gaming can help people who have had a stroke improve their balance, movement, and daily function. Researchers will compare these alternative therapies to standard rehabilitation in 120 adults aged 18 to 90.…

This study tests a non-invasive brain stimulation technique called high-definition tDCS to reduce arm stiffness and improve movement in people who have had a stroke. Researchers will enroll 30 adults with arm weakness on one side. The goal is to see if stimulating specific brain …

This study tests whether forced aerobic exercise (using a stationary bike that helps move your legs) can improve arm and leg recovery in people who had a stroke 3-9 months ago. Researchers will measure movement, brain activity, and blood markers of healing, and compare costs to s…

This study tests whether a gentle brain stimulation technique (rTMS) can make walking and thinking training more effective for people who had a stroke at least 6 months ago. About 184 adults aged 50+ will get either real or fake stimulation before each training session, 12 times …

This study tests whether adding musical sound cues to standard walking therapy helps people with Parkinson's disease, stroke, or multiple sclerosis walk better and feel less tired. About 120 adults will either get standard rehab or rehab with these sound cues. The goal is to see …

This study tests whether adding a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to standard rehab can improve heart rate control, arm strength, and quality of life in stroke survivors. About 44 adults aged 35-80 who had a stro…

This study tests whether a home-based e-rehabilitation program (OTHER) helps older adults who have had a stroke improve their ability to perform daily activities, compared to standard occupational therapy. About 171 people aged 60 and older will receive either the OTHER program—w…

This study tests whether personalized exercise plans, created using data from wearable sensors, can help people who had a stroke walk better. Fifty-two adults aged 45-75 who had a stroke at least six months ago will take part. They will do 12 supervised exercise sessions over six…

This study tests whether a non-invasive treatment called extracorporeal shockwave therapy can improve arm and hand function in people who had a stroke six months ago. Researchers will measure movement speed and muscle activity in 50 adults aged 25 to 65. The goal is to find a saf…

This study is testing whether a gentle, non-invasive brain stimulation technique, combined with computer-based brain training games, can help improve memory, focus, and thinking speed in people who have had a minor stroke. Researchers at Johns Hopkins will enroll about 60 stroke …

This study is testing two different speech therapy programs delivered via telemedicine to see which is better at improving conversation skills in people who have trouble speaking after a stroke (aphasia). Researchers will compare a new therapy designed to engage the right side of…

This study is testing whether combining two non-drug treatments—electroacupuncture and a brain stimulation technique called rTMS—helps people recover movement after a stroke better than brain stimulation alone. About 180 adults who had a stroke within the last 6 months will be ra…

This study is testing if a new type of physical therapy using robotic arms and video game-like exercises can help improve both thinking skills and arm movement in adults with Parkinson's disease, multiple sclerosis, or who have had a stroke. Researchers want to see if this high-t…

This study is collecting movement, daily activity, and genetic data from 70 stroke patients to create a 'digital twin' — a computer model that mirrors each patient. The goal is to better predict how someone will recover after a stroke. No new treatments are being tested; this is …

This study checks if a hand laterality task (judging whether a pictured hand is left or right) is a valid tool for stroke patients. About 30 adults who have had a stroke will complete reaction time and hand judgment tasks. The goal is to see how well this test measures thinking a…

This study looks at how the diaphragm (the main breathing muscle) changes after a stroke and how that relates to breathing strength. Researchers will measure diaphragm movement and thickness using ultrasound, and test breathing muscle strength in 38 adults who had a stroke 1-6 mo…

This study looks at how a single session of exercise can temporarily reduce sensitivity to pain in both healthy adults and stroke survivors who do not currently have pain. Researchers will measure pain thresholds before and after a cardiovascular workout to understand the body's …

This study looks at whether people who have a blood clot in the lungs (pulmonary embolism) are more likely to have a stroke if they also have a small hole in the heart, called a PFO. About 1 in 4 people have this hole, which can let a clot travel to the brain. Researchers will us…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders (like spinal cord injury, stroke, or multiple sclerosis) control assistive devices just by thinking about moving. Researchers will use EEG to read brain signals and comb…

This study looks at why stroke survivors' leg muscles get tired faster than normal. Researchers will measure blood flow to the leg during exercise and test a safe, non-invasive technique called ischemic conditioning to see if it can improve blood flow and reduce muscle fatigue. T…

This study looks at how using arm support (like a cane or walker) changes the way people who have had a stroke walk. About 34 adults with stroke will walk on a special treadmill with no support, one-arm support, and two-arm support. The goal is to help physical therapists create …

This pilot study looks at how botulinum toxin (Botox) injections affect the muscles, tendons, and nerves in the legs of people who have had a first stroke and developed a stiff, twisted foot (equinovarus). Researchers will use 3D ultrasound and special movement tests to track cha…

This study is building a large registry of people who have had a stroke and still have symptoms. The goal is to connect them with researchers working on new ways to improve recovery. Anyone 18 or older with a past stroke and ongoing symptoms can join.

This study is testing whether using two non-invasive stimulation methods together (one on the brain, one on the spinal cord) can improve movement, feeling, and thinking in people who have had a stroke or spinal cord injury. Researchers will also use MRI and other tests to underst…

This study aims to see if a personalized form of brain stimulation, called TMS, can help people who have had a stroke regain hand function. Researchers will compare personalized TMS to standard TMS in 37 participants who have had a stroke at least 6 months ago. The goal is to und…

This study tests a 6-week online program that combines personal skill-building with inclusive volunteering to help young stroke survivors (ages 18-64) improve their ability to work. 160 participants will be randomly assigned to either the program plus usual care or usual care alo…

This study tests how much walking practice on a special treadmill (split-belt treadmill with virtual reality) stroke survivors can handle in early recovery. About 72 people who had their first stroke within the past week to three months will take part. The goal is to find the rig…

This study tests a camera system that watches how stroke survivors move their arms during robot-assisted therapy. The camera uses smart software to detect bad posture and give feedback. Researchers want to see if this setup works as well in small groups as it does in one-on-one s…

This study explores whether a brain imaging technique called fMRI neurofeedback can help people who have had a stroke improve their reading. Participants will practice controlling their own brain activity using real-time feedback from an MRI scanner. The goal is to retrain the le…

This study looks at a layer of tissue in the lower back (thoracolumbar fascia) in people who had a stroke at least 6 months ago. Researchers want to see if its thickness is related to balance, trunk control, flexibility, and daily independence. About 70 participants aged 40-70 wi…

This study tests whether vibrating certain muscles can help the brain recover after a stroke or traumatic brain injury. Researchers will measure changes in nerve and brain activity in 56 people with leg weakness. The goal is to understand how this therapy might promote brain rewi…

This study aims to learn how the brain and spinal cord change after a stroke. Researchers will use MRI scans to look at the structure and function of the brain in 35 stroke patients and compare them to healthy volunteers. The goal is to find markers that can predict recovery and …

This study looks at whether giving magnetic pulses to the brain at the right moment in your natural brain wave cycle can make movement training more effective. Researchers will test healthy adults and people who had a stroke at least 6 months ago. The goal is to understand how th…

This study looks at how swelling around a brain bleed affects recovery. Researchers will follow 500 adults who had a spontaneous hemorrhagic stroke to see if the swelling is linked to long-term disability. The goal is to better understand this swelling so future treatments can ta…

This study looks at how stroke changes the way the spinal cord processes sensory signals. Researchers will stimulate nerve roots in the neck during surgery and measure muscle and brain responses in 15 people (some with stroke, some without). The goal is to better understand spina…

This study enrolls 500 people with brain small vessel disease (CSVD) to see how genetics influence their condition. Participants get genetic testing for five key genes and are followed for at least two years. The goal is to track strokes and dementia, not to test a new treatment.

This study tests a new ultrasound technology that can continuously monitor blood flow in the brains of sick and premature infants. Researchers will enroll 180 babies, including healthy preterm and term infants as well as those with conditions like heart defects, infections, or st…

This study is tracking 350 adults with severe stroke caused by a blocked large artery in the brain. Researchers want to see how well a procedure called endovascular thrombectomy (which removes the clot) works in real-world hospitals across Asia-Pacific, not just in controlled cli…

This study looks at how a non-invasive brain stimulation technique called cortical priming affects the ability to learn leg movements in healthy adults and people who had a stroke at least six months ago. Researchers will measure changes in stepping speed and brain activity after…

This study is creating a large collection of blood and DNA samples from 1,000 people with atrial fibrillation (an irregular heartbeat) and stroke. Researchers will use these samples to investigate the genetic causes of these conditions and find better treatment targets. Participa…

This study looks at whether a modified cardiac rehabilitation program can improve physical and emotional recovery in people who have had a stroke. Researchers will enroll 76 adults aged 18-80 who had a stroke at least 6 months ago and have some leg weakness. The goal is to see if…

This study checks if a pressure-sensitive smart insole (Ceriter Stride One) can accurately measure walking patterns in people recovering from stroke, brain injury, or spinal cord injury. About 30 participants will wear the insoles while walking on a high-tech treadmill (GRAIL) to…

This study looks at how quickly people with stroke or memory problems can move. Researchers want to see if new, short tests can help diagnose diseases like Alzheimer's or predict recovery after a stroke. About 129 adults aged 40-85 will take these tests, and the results will be c…

This study looks at whether low magnesium in the blood is linked to memory and thinking problems after a stroke. Researchers will measure magnesium levels and cognitive skills in 80 stroke patients over time. The goal is to understand if magnesium deficiency plays a role in post-…

This study looks at how the brain controls arm movement after a stroke and how rehabilitation therapy changes those brain pathways. Fifty people who had a stroke 3 to 6 months ago and have moderate to severe arm weakness will either receive 30 hours of specialized arm training or…

This study aims to develop a non-invasive way to measure pressure inside the skull (intracranial pressure or ICP), which is currently done by drilling a hole in the head. Researchers will collect data from 581 patients who already have the standard surgical monitor, while also us…

This study tests a non-invasive wrist monitor that continuously checks for stroke by detecting arm weakness. It aims to catch strokes faster in 1,200 high-risk hospital patients, while keeping false alarms low. The goal is to improve treatment and outcomes without any drugs or su…

This study involves up to 100 young adults (ages 18-55) who have had a stroke. Researchers will collect detailed health information and samples to better understand recovery. The goal is to test how practical this approach is and explore factors like age, lifestyle, and biology t…

This study compares two types of speech therapy for people with aphasia (trouble speaking or understanding language) after a stroke. One therapy is done remotely via video, and the other is done in a clinic. The goal is to see if remote therapy works as well as in-person therapy.…

This study looks at better ways to measure and treat 'neglect' — a condition where stroke survivors ignore one side of their world. Researchers will test a treatment that combines repetitive task practice with mild brain stimulation. The goal is to see if this approach can improv…

This study looks at whether a simple ECG test can tell which patients are at risk of forming dangerous blood clots that lead to stroke. Researchers will study the heart's small pouch (left atrial appendage) and blood samples from 1000 people having open-heart surgery. The goal is…

This study explores how targeted brain stimulation can improve movement speed in people who have had a stroke. Researchers will first map brain circuits in healthy volunteers, then test a specific stimulation pattern in stroke patients. The goal is to understand which brain areas…

This study looks at how a treatment that pairs mild brain stimulation (tDCS) with watching hand movement videos (action observation therapy) helps stroke survivors regain hand control. Researchers will measure brain and muscle activity changes in 60 adults who had a stroke 6-24 m…

This study looks at how stroke changes the way people move their arms when walking. Researchers will measure brain activity and muscle patterns in 84 people (some who had a stroke and some healthy) to understand why arm swing is different after a stroke. The goal is to use these …

This study is testing whether brain scans and a technique called transcranial magnetic stimulation can predict how well someone will recover arm movement after a stroke. Researchers will collect data from 657 adults who recently had a stroke and have arm weakness. The goal is to …

This study looks at how the brain changes after a stroke and how those changes affect arm and hand movement. Researchers will use brain scans and movement tests to find early signs that predict recovery. The goal is to better understand why some people develop movement problems a…

This study tests whether temporarily stimulating a specific part of the brain can improve hand, arm, and speech function in people who had a stroke at least 6 months ago. Ten participants will have a thin wire placed in the brain for less than 30 days to deliver mild electrical p…

This study looks at a small leg muscle called the plantaris and its role in treating tight ankles (ankle equinus) in children aged 4-17. About 42 kids having surgery for this condition will have the plantaris and larger calf muscles lengthened in a random order. The goal is to se…

This study aims to find biological markers that can predict which stroke survivors will improve their walking speed with high-intensity interval training (HIIT). Researchers will measure blood lactate, brain chemicals, and blood flow in 55 veterans with chronic stroke. The goal i…

This study looks at how the brain talks to muscles in people who have had a stroke. Researchers will use a cap and stickers to measure brain and muscle activity while participants squeeze a hand grip. They will also test two types of gentle brain stimulation to see if it helps im…

This study looks at whether a fast genetic test can help doctors choose the best antiplatelet medication for people who have had a minor stroke or a high-risk transient ischemic attack (TIA). About 200 adults admitted to the hospital will provide a cheek swab for genetic testing.…

This study looks at whether certain genetic changes in the ANXA2 gene are more common in people who have had a stroke without a clear cause. Researchers will compare blood samples from 240 adults who have had such a stroke to see if these gene variants increase risk. The goal is …

This study aims to understand if COVID-19 vaccines have any impact on brain health. Researchers will use MRI scans to look at the brains of 500 healthy adults in Hong Kong, comparing scans taken before and after vaccination. The goal is to provide clear, evidence-based informatio…

This study tracks 5,000 people who have had a brain aneurysm treated with new medical devices. Researchers want to learn what makes aneurysms come back, like smoking. The goal is to improve future treatments, not to test a new drug or cure.

This study tests an 8-week online program designed to help working-age stroke survivors start their own business. Researchers want to see if the program increases self-employment rates, confidence, and life satisfaction. About 156 participants who have been out of paid work for a…

This study looks at how genes and brain scans can help predict recovery from aphasia, a language disorder that often follows a stroke. Researchers will study 90 adults aged 40-90 who have had a stroke, using MRI and genetic tests to understand why some people recover better than …

This study is testing whether a new digital test battery, Mindmore Distance, can accurately assess thinking and memory skills in people with brain conditions like stroke, Parkinson's, or multiple sclerosis. Researchers will compare results from home-based tests with standard in-p…

This study is for adults with psoriasis who want to help researchers understand the link between psoriasis and heart disease. The goal is to see if certain heart tests and blood markers can predict future heart problems. Participants will be followed over time to track heart heal…

This study looks at better ways to invite people with stroke into research, especially women and those with language problems after stroke. Researchers will compare a new recruitment method to the usual one across several hospitals. The goal is to make sure study results reflect …

This study tests whether combining prism adaptation training with electrical stimulation can improve spatial neglect (a condition where stroke survivors ignore one side of space) and walking problems. Researchers will measure changes in pointing behavior, brain activity, and walk…

This study tests whether adding virtual reality (VR) walking exercises to standard therapy is practical and well-liked by stroke patients and their therapists. About 40 adults who had a stroke will do personalized VR training twice a week for 4 weeks. The goal is to see if this a…

This study enrolls 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Researchers want to understand why some strokes happen even when patients take blood thinners. They will collect blood samples and heart ultrasound images, then follow …

This study aims to understand why many people feel extreme tiredness after a stroke, known as post-stroke fatigue. Researchers will monitor 250 stroke patients' heart rate, blood pressure, and heart function to see if problems with the body's automatic nervous system play a role.…

This study tests whether a live video call between a neurologist and emergency medical technicians (EMTs) can improve the accuracy of stroke detection in the ambulance. About 512 adults with suspected stroke will be included. The goal is to see if video assistance helps diagnose …

This study tests whether a computer model can predict which reading therapy works best for people who developed dyslexia after a stroke. Twelve participants will each try two different therapies—phonomotor treatment and semantic feature analysis—for 60 hours each. The goal is to …

This study checks if new guidelines for placing sticky electrodes on the calf muscles give more accurate readings in people who have had a stroke. Twenty participants will have electrodes placed using both the new and standard methods, and ultrasound will confirm their positions.…

This study tests whether high-density brain recordings can decode Mandarin Chinese speech features, including tone, from imagined speech. About 50 adults with brain conditions like epilepsy or tumors will have temporary electrodes placed during surgery, and 10 people with severe …

This study looks at how placebos (fake treatments) work in the brains of people who have had a stroke. Researchers want to see if knowing you are getting a placebo changes brain activity and helps with recovery. About 56 adults with arm weakness from a chronic stroke will take pa…

This study is a registry that gathers medical information from up to 40,000 people who had surgery for brain conditions like stroke, aneurysm, or abnormal blood vessels. Researchers will use this data to better predict outcomes and compare different surgical techniques and device…

This study looks at whether thinking about an external target (like a spot on the wall) or focusing on your own body movements helps people who had a stroke stand up from a chair more evenly. Twenty adults who had a stroke at least 6 months ago will try both approaches. The goal …

This study tests whether a noninvasive technique called transcutaneous spinal cord stimulation can improve arm and hand function in 30 adults with either a spinal cord injury or stroke. Participants will receive electrical stimulation through electrodes placed on the skin over th…

This study is testing a smartphone app that creates a "digital twin" of you to help manage your health after a stroke or related condition. Researchers want to see if people find the app useful and easy to use for preventing future problems. About 20 adults will use the app along…

This study tests whether a smartphone app called ICanWALK can teach people to use walking aids like crutches, canes, and walkers more safely. Researchers will enroll 52 adults who use a walking aid most of the time due to a leg injury, stroke, or multiple sclerosis. Participants …

This study looks at whether combining ultrasound with artificial intelligence can help doctors quickly identify bleeding strokes. About 500 adults with stroke symptoms will get a non-invasive ultrasound scan within 48 hours. Researchers will compare the AI's reading of the ultras…

This study looks at why people who had a stroke have trouble coordinating their legs while walking. Researchers will measure brain and nerve signals in 50 adults with chronic stroke to find the root causes. The goal is to gather knowledge that could lead to better walking therapi…

This study looks at why some people with muscle, bone, or joint problems follow their home exercise programs while others don't. Researchers will track 252 adults with conditions like arthritis, back problems, or stroke recovery. The goal is to find out what factors—like pain, mo…

This study tests whether personalized transcranial direct current stimulation (tDCS) can help people recover from a stroke. Researchers will measure brain connectivity changes in 80 adults who had a stroke at least 3 months ago. The goal is to see if this tailored brain stimulati…

This study watches and analyzes video recordings of real occupational therapy sessions for adults recovering from stroke or spinal cord injury. Researchers want to identify the key techniques therapists use to improve arm and hand function. The goal is to create a toolkit that he…

This study looks at how small vessel disease in the brain affects thinking skills. Researchers will measure brain activity with EEG in 80 older adults and test whether personalized computer training or gentle brain stimulation can help. The goal is to find better ways to detect a…

This study follows 130 patients with severe brain injuries (from stroke, trauma, or lack of oxygen) who are in a coma or minimally conscious state. Researchers will use brain scans, EEGs, and other tests to find clues that might predict if and when a patient will regain conscious…

This study looks at how stroke affects walking efficiency. Researchers will test a new method to measure the energy used during walking in 18 people who have had a stroke. Participants will walk on a treadmill for three short sessions. The goal is to see if this new measure can h…

This study looks at how memory and thinking problems after a stroke affect a person's ability to relearn walking. Researchers will use walking tests, brain scans, and thinking assessments in 65 older adults who had a stroke at least 6 months ago. The goal is to find better ways t…

This study follows 213 adults who had a stroke caused by atrial fibrillation and are in inpatient rehab. Researchers want to see if patients with this type of stroke have different recovery needs and if more intense rehab (3-5 sessions daily) leads to better function at six month…

This study tests a wearable device called Neuralert that monitors hospital patients at high risk for stroke. The device is worn on both arms and sends alerts if it detects signs of a stroke. The goal is to see if it can identify strokes faster than current methods. About 50 adult…

This study looks at how muscles work together after a stroke and whether a special exercise guided by muscle signals can improve arm movement. Researchers will test this in 74 people, including stroke survivors and healthy adults. The goal is to find new ways to help people regai…

This study is testing a wearable exoskeleton to help improve walking balance in people who have had a stroke. Researchers will measure how the device affects balance during walking on a treadmill. About 21 adults who had a stroke at least 6 months ago and have trouble with balanc…

This study looks at how deep brain stimulation (DBS) changes brain activity and movement in people with conditions like Parkinson's disease and essential tremor. About 60 people scheduled for DBS surgery will have temporary brain recordings during their procedure. The goal is to …

After a stroke, using both hands together is often hard, but current tests only look at one-handed tasks. This study enrolls 32 stroke survivors to see if a new test called the Ad-AHA Stroke matches real-world hand use measured by wrist-worn sensors over three days. The goal is t…

This study is looking for brain signals, called biomarkers, that can help doctors track and predict how well stroke patients recover their ability to walk. Researchers will use a mobile brain/body imaging device while patients use a robotic walking aid. The goal is to find better…

This study uses ultra-powerful MRI machines to create detailed maps of the brain in 100 stroke patients and 10 healthy volunteers. The goal is to understand how the brain reorganizes itself after a stroke, especially for arm and hand movement. Researchers will use these maps to i…

This study uses advanced MRI scans to look at how the brain and spinal cord work together during a shoulder exercise in people who have had a stroke. Researchers want to understand which nerve pathways the brain uses to move after a stroke. The goal is to learn more about recover…

This study is looking for DNA markers that might predict brain damage in older adults having a minimally invasive heart valve replacement (TAVR). Researchers will measure DNA methylation in blood before and after the procedure and compare it to brain scans. The goal is to find ne…

This study compares two rehabilitation methods to improve finger movement in 40 people who had a stroke more than 6 months ago. Participants will do 10 days of piano training and have MRI brain scans to see how the brain changes. The goal is to find out which training method work…

This study follows 24 people who had a stroke and were recently diagnosed with atrial fibrillation (AF), a heart rhythm problem. Researchers will monitor how AF changes over 24 months using heart monitors and blood tests. The goal is to better understand AF progression in stroke …

This study compares a new, data-driven stroke transport algorithm to the current method for getting stroke patients to the right hospital. The goal is to see if the new approach reduces the time from stroke onset to treatment, especially for people in rural areas. About 360 adult…

This study follows 400 stroke patients in rehabilitation units to see how their walking and balance improve over six months. Researchers will measure walking ability and balance at different times. The goal is to better understand the natural recovery process after a stroke.

This early-stage study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will part…

This study looks at whether training that mixes mental tasks with physical exercises can improve thinking and movement in people with stroke or Moyamoya disease. Researchers will measure brain activity during these tasks using a special light-based scanner. The goal is to underst…

This study measures how touch signals move from the finger through the nervous system to the brain. Researchers will compare young adults and stroke survivors to see how stroke changes touch perception. Participants will feel different force levels on their finger while brain sca…

This study will collect information from HeartMate 3 heart pumps in 150 adults to see if pump data can predict problems like bleeding, infection, or frailty. Researchers want to understand how pump readings relate to patients' quality of life and health outcomes. The goal is to h…

This study follows 140 working-age stroke survivors in France to understand what factors help or hinder their return to work. Researchers will look at medical details, personal beliefs, and job-related issues. The goal is to create better support plans for people recovering from …

This study is testing whether wearable sensors can accurately track recovery in people recovering from a stroke during inpatient rehabilitation. Researchers will monitor 400 participants using body-worn sensors to see if the data can predict how well they will recover by the time…

This study aims to better understand the role of blood clots in different types of stroke. Researchers will use a special PET scan tracer that sticks to activated platelets, the cells that form clots, to see where clots are in the body. The study will involve 120 adults who have …

This early study tests whether a robot can help doctors perform delicate brain blood vessel procedures, such as taking images, blocking blood flow to tumors, or removing clots during a stroke. Ten people already scheduled for these standard treatments may have their procedure don…

This study looks at how hospitals in Villavicencio, Colombia, manage stroke cases. Researchers will review medical records of 100 adults diagnosed with stroke to see how quickly they get treated and if care follows best practices. The goal is to find delays and improve future str…

This study looks at why some people keep their thinking skills after a stroke while others don't. Researchers will interview 450 adults who had a stroke and had a brain scan. They want to see how things like education, race, and income affect memory and attention over time.

This study watches how stroke survivors move their arms during everyday activities. Researchers will measure hand movements, joint motion, and wrist distance over time. The goal is to link these real-world movements with standard recovery tests. No treatment is given—only observa…

This study tests whether a new wearable device that uses ultrasound and light can safely and easily monitor blood flow in the brains of people who have had a stroke. Researchers will also include healthy older adults and people with dementia, depression, or delirium to compare re…

This study is testing a new way to help people who have had a stroke regain arm movement. The method uses a brain stimulation technique called TMS, timed precisely based on brain signals measured by a special light-based sensor. The goal is to see if this approach can improve bra…

This study looks at how the brains of 25 stroke patients with weak hand muscles work when they do mirror movements. Researchers use a special brain scanner to measure activity. The goal is to learn more, not to test a treatment.

This study looks back at medical records of 2600 stroke patients who received clot-busting medication between 4.5 and 24 hours after their stroke started. The goal is to see how many had good recovery (able to live independently) despite the delayed treatment. It does not test a …

This study looks at how a gentle electrical current applied to the brain (called tACS) affects movement in people who had a stroke more than 6 months ago. Researchers will test two different frequencies and a placebo to see which works best. They will use brain scans (MRI) and br…

This study looks at how shoulder pain on the paralyzed side affects arm function, balance, fear of falling, and independence in people who have had a stroke. Researchers will measure these factors in 62 adults with stroke and shoulder pain. The goal is to better understand the re…

This study looks at whether using a 7-day heart monitor can find hidden atrial fibrillation (an irregular heartbeat) in people with higher levels of a heart stress marker called NT-proBNP. About 4,000 adults aged 40 and older without known AF will be split into two groups: one ge…

This study looks at how changes in blood flow to the brain affect breathing during sleep in healthy adults. Researchers will measure breathing responses to low oxygen and high carbon dioxide levels under normal and low-oxygen sleep conditions. The goal is to better understand bre…

This study tests a new, non-invasive wearable patch with a microphone that listens to swallowing sounds in people who have trouble swallowing after a stroke. Researchers will collect these sounds during a standard swallowing X-ray test and use machine learning to find patterns of…

This study is observing about 10,000 adults who have had a stroke and received the clot-busting drug tenecteplase as part of their normal care. Researchers will track their recovery and any side effects for 90 days to see how well the drug works in real-world settings across many…

This study is following 5,000 adults in Hong Kong who either have a brain disease (like stroke or dementia) or are at high risk. Researchers will collect medical records and survey data over time to identify what factors lead to brain diseases. The goal is to find ways to keep br…

This study is testing whether a quick, painless eye scan called OCTA can spot signs of brain diseases like stroke and bleeding. Researchers will compare scans from 50 people with brain conditions and healthy volunteers. The goal is to gather early data to support larger studies, …

This study looks at whether backward walking training can improve walking and balance in Veterans who have had a stroke. Researchers will compare two different amounts of training (18 vs. 27 sessions) and use brain scans to see how the brain changes. The goal is to find out which…

This observational study looks at whether the settings on a breathing machine (like pressure and power) are linked to how severe a person's brain injury is. It includes 19 adults with brain injuries from stroke, trauma, or bleeding who need a breathing machine. The goal is to see…

This study looks at how fear of movement (kinesiophobia), balance, and fear of falling are connected in people recovering from a stroke. Researchers will measure these factors using surveys and balance tests in 138 stroke patients. The goal is to better understand these relations…

This study looks at how taking multiple medications affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older in Shaanxi Province, China, over two years. The goal is to…

This study is testing whether a special MRI of the heart can help doctors decide which stroke patients need a small heart monitor implant. About 100 adults who had a stroke with no clear cause will get a heart MRI and a monitor. The goal is to see if scar tissue in the heart's up…

This study looks at how often fatigue occurs after a first stroke and what factors—like pain, mood, sleep, or physical ability—might make it worse. About 107 adults who had a stroke at least three months ago will answer questionnaires and do simple tests. The goal is to help doct…

This study aims to understand how a protein called BD-tau, which is released into the blood when the brain is injured, changes over time in people having a stroke. Researchers will take blood samples every hour for 48 hours from 100 adults with acute ischemic stroke. The goal is …

This early study looks at whether a non-invasive device that stimulates a nerve in the ear (taVNS) can change brain activity and certain genetic markers in people who had a stroke within the past month. About 44 participants with arm weakness will receive either real or fake stim…

This study is testing a new questionnaire called the Pressure Relief Frequency Scale (PReFS) to see if it can reliably help wheelchair users with neurologic disorders (like spinal cord injury, stroke, or traumatic brain injury) decide how often they need to relieve pressure. Rese…

This study is testing a special glove with sensors to see how well it measures touch and thinking problems in people who have had a stroke. The goal is to make sure the glove works safely and reliably, so doctors can use it to improve robotic rehab for the arm and hand. About 126…

This study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE suit affects their balance and walking over time. Participants will be followed during routine care, and research…

This study uses high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand diseases like glaucoma, macular degeneration, and diabetes-related eye problems.…

This study follows 150 people who recently had a stroke to see how their walking ability recovers over time. Researchers will measure walking speed and distance, and look at how patients develop new ways to move. The goal is to create better rules for predicting and improving rec…

This study aims to understand how two mental practice techniques—imagining movements and watching others perform movements—affect muscle activity in stroke survivors. Researchers will measure electrical signals in arm and hand muscles of 28 participants during these exercises to …