New stroke drug aims to help patients missed by standard treatments
NCT ID NCT05065216
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a drug called DM199 in about 728 people who have had a moderate stroke and cannot get clot-removing treatments. The drug is given through a vein and then as shots under the skin for three weeks. Researchers want to see if it helps patients recover better than a placebo, measured by their ability to do daily activities 90 days later.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- DM199 (rinvecalinase alfa), a lab-made version of a human protein that may help repair blood flow after stroke
- What this could lead to
- If it works, this could offer a new treatment option for people with moderate stroke who cannot get standard therapies like clot removal.
- What could go wrong
- This is an early-to-mid-stage trial, so success is not guaranteed. The drug may not improve recovery or could cause side effects like bleeding.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ACUTE STROKE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
AZ Groeninge
RECRUITINGKortrijk, Belgium, 8500, Belgium
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Abbott Northwestern Hospital
RECRUITINGMinneapolis, Minnesota, 55407, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Addenbrooke's Hospital
RECRUITINGCambridge, United Kingdom, CB2 0QQ, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Ascension St. John
ACTIVE_NOT_RECRUITINGTulsa, Oklahoma, 74104, United States
-
Ascension Via Christi Hospitals Wichita Inc.
RECRUITINGWichita, Kansas, 67214, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
B.-A.-Z. County Central Hospital
RECRUITINGMiskolc, Hungary, 3526, Hungary
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Bajcsy-Zsilinszky Hospital
RECRUITINGBudapest, Hungary, 1106, Hungary
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Boca Raton Regional Hospital Marcus Neuroscience Institute
RECRUITINGBoca Raton, Florida, 33486, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
CHU Pontchaillou /Hopital Sud Service de Neurologie
RECRUITINGRennes, Brittany Region, 35033, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Chattanooga Center for Neurologic Research
RECRUITINGChattanooga, Tennessee, 37404-1163, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Clinique St Pierre
RECRUITINGOttignies, Belgium, 1340, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Elias Emergency University Hospital
RECRUITINGBucharest, Romania, 011461, Romania
Contact Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Erlanger Hospital
RECRUITINGChattanooga, Tennessee, 37403, United States
Contact Email: •••••@•••••
-
Fundeni Clinical Institute
RECRUITINGBucharest, Bucharest (Sector 2), 022328, Romania
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Glendale Adventist Medical Center d/b/a Adventist Health Glendale
RECRUITINGGlendale, California, 91206-4152, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Gulf Health Hospitals d/b/a Thomas Hospital
RECRUITINGFairhope, Alabama, 36532, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
HCA Florida - JFK Medical Center
RECRUITINGAtlantis, Florida, 33462-1149, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Hamilton Health Sciences - Hamilton General Hospital
RECRUITINGHamilton, Ontario, L8L8E7, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Health Sciences North
RECRUITINGHamilton, Ontario, L8L2X2, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Holy Cross Health
RECRUITINGFort Lauderdale, Florida, 33308, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Hospital Clínico Universitario de Santiago
RECRUITINGSantiago de Compostela, Spain, 15706, Spain
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Hospital Universitari Vall d'Hebron-Institut de Recerca
RECRUITINGBarcelona, Spain, 8035, Spain
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Hospital Universitario Germans Trias i Pujol
RECRUITINGBadalona, Spain, 8916, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Houston Methodist Neurological Institute
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Imeldaziekenhuis (Imelda Hospital)
RECRUITINGBonheiden, Belgium, 015 50 50 11, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Instituto de Investigacion Biomedica de A Coruna (INIBIC)
RECRUITINGA Coruña, Spain, 15006, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Israel-Georgia Medical Research Clinic-Healthycore LTD
RECRUITINGTbilisi, Georgia, 0112, Georgia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
JSC K. Eristavi National Center of Experimental and Clinical Surgery
RECRUITINGTbilisi, Georgia, 0159, Georgia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Jessa Ziekenhuis
RECRUITINGHasselt, Belgium, 3500, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Kaiser Permanente Los Angeles Medical Center
RECRUITINGLos Angeles, California, 90027-5209, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Memorial Hermann Hospital, Texas Medical Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Memorialcare Long Beach Medical Center
RECRUITINGTorrance, California, 90806, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Mercy Health - St. Vincent Medical Center
RECRUITINGToledo, Ohio, 43608, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
New Hospitals LTD
RECRUITINGTbilisi, Georgia, 0114, Georgia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Northwell Health Physician Partners - Neurology at Lenox Hill
RECRUITINGNew York, New York, 10075, United States
Contact Email: •••••@•••••
-
OSF HealthCare Saint Francis Medical Center
RECRUITINGPeoria, Illinois, 61637, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Ochsner Clinic Foundation
RECRUITINGNew Orleans, Louisiana, 70121, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Oregon Health & Science University
RECRUITINGPortland, Oregon, 97239, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Petz Aladár County Teaching Hospital
RECRUITINGGyőr, Vasvári Pál U. 2-4, 9024, Hungary
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Pineo Medical Ecosystem LTD
RECRUITINGTbilisi, Georgia, 0114, Georgia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Prisma Health-Greenville Memorial Hospital
RECRUITINGGreenville, South Carolina, 29605, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Ronald Reagan UCLA Medical Center
RECRUITINGLos Angeles, California, 90095, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Royal Devon and Exeter Hospital
RECRUITINGExeter, Devon, EX25DW, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Royal Stoke University Hospital
RECRUITINGStoke-on-Trent, United Kingdom, ST4 6QG, United Kingdom
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Sarasota Memorial Hospital
RECRUITINGSarasota, Florida, 34239-2617, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
St George's Hospital
RECRUITINGLondon, United Kingdom, SW17 0QT, United Kingdom
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
St. Damjan Greek Catholic Hospital
RECRUITINGKisvárda, Hungary, 4600, Hungary
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Stanford Health Care
RECRUITINGStanford, California, 94305, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Summa Health Clinical Research Center
RECRUITINGAkron, Ohio, 44304, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Sunnybrook Research Institute
RECRUITINGNorth York, Ontario, M4N 3M5, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Tampa General Hospital (TGH) - The Stroke Center
RECRUITINGTampa, Florida, 33606-3603, United States
Contact Email: •••••@•••••
Contact
-
The Clinical Neuroscience Institute
ACTIVE_NOT_RECRUITINGDayton, Ohio, 45431, United States
-
The Hospital of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
The Lundquist Institute at Harbor UCLA Medical Center
RECRUITINGTorrance, California, 90502, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
The Newcastle upon Tyne Hospitals NHS Foundation Trust - Royal Victoria Infirmary (RVI)
RECRUITINGNewcastle upon Tyne, England, NE1 4LP, United Kingdom
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
The University of New Mexico - School of Medicine
RECRUITINGAlbuquerque, New Mexico, 87131, United States
Contact Email: •••••@•••••
-
The University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Trinity Health Grand Rapids Hospital
RECRUITINGGrand Rapids, Michigan, 49503, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
UMASS Chan Medical School
RECRUITINGWorcester, Massachusetts, 01655, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
USC Arcadia Hospital
RECRUITINGArcadia, California, 91007, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
UZ Gent
RECRUITINGGhent, Belgium, 9000, Belgium
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University Medical Center of Southern Nevada
RECRUITINGLas Vegas, Nevada, 89102, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Alberta Hospital
RECRUITINGEdmonton, Alberta, T6G 2G3 7802481660, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Florida Jacksonville
RECRUITINGJacksonville, Florida, 32209, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Vancouver General Hospital
RECRUITINGVancouver, British Columbia, V5Z1M9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
West Georgia Medical Center LTD
RECRUITINGKutaisi, Georgia, 4600, Georgia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a metronome beat retrain the brain after a stroke?
- Digital peer support may ease long-term stroke recovery for younger survivors
- Can juggling two tasks at once help stroke survivors walk better?
- Slow breaths, faster recovery? a trial tests breathing and neck release after stroke
- Robots vs. therapists: a head-to-head trial for stroke recovery
- Stroke recovery from home: can video-based motor training outperform standard physical therapy?