ISCHEMIC STROKE

This trial is testing if a common emergency clot-busting treatment for stroke is safe and effective for people who take a specific type of blood thinner (Factor Xa inhibitors). Currently, guidelines often prevent these patients from receiving this treatment due to bleeding concer…

This study is testing if an intravenous drug called Dimephosphon can help people recover better after a recent ischemic stroke. About 184 adults who had a stroke within the last 24-72 hours will receive either the drug or a placebo. Researchers will measure how well people recove…

This study is testing a new medical device and technique called ADAPT 2.0 to remove blood clots from the brain during acute ischemic stroke. The trial will enroll 750 adult stroke patients to see if this approach can restore blood flow to the brain more effectively and safely tha…

This study tests whether repeatedly squeezing the arms with a blood pressure cuff can prevent stroke symptoms from getting worse. Researchers will enroll 910 people who recently had a small, deep brain stroke. Half will receive real arm pressure training, while half get a fake tr…

This study is testing whether adding an experimental drug called TBO-309 improves outcomes for stroke patients undergoing a specific procedure. The drug is given during surgery to open blocked arteries in the neck and brain, with the goal of preventing new clots from forming in t…

This study is testing if starting two cholesterol-lowering drugs together works better than one alone for people who recently had a stroke. The goal is to quickly get 'bad' cholesterol to a very low level to help prevent another stroke. About 300 patients in Taiwan who had a stro…

This early-stage study is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' is safe for people who had a stroke over a year ago. Researchers believe psilocybin might temporarily reopen a critical learning period in the brain, potentially makin…

This study is testing if using a positive airway pressure (PAP) machine to treat sleep apnea can help people recover better after a stroke. Researchers will compare recovery in 180 stroke patients who use the PAP machine to 180 who receive usual care. The main goal is to see if t…

This large national trial aims to find the best ways to treat stroke patients who have blocked brain arteries. It will test different emergency procedures, devices, and care methods to help patients recover better. The study is enrolling 1,600 stroke patients at 38 major hospital…

This study is testing a new medical device called the Supernova stent retriever for treating acute ischemic strokes caused by large blood clots. The device is designed to physically remove clots from blocked brain arteries to restore blood flow. Researchers will enroll 100 stroke…

This study is testing a new wireless device designed to help people regain movement after a stroke. The device gently stimulates a nerve in the neck during physical therapy exercises, aiming to help the brain re-learn how to control the arm and hand. Researchers want to see if th…

This small pilot study is testing a new medical device worn around the neck to carefully control body temperature in people who have just had a stroke. The goal is to see if keeping a normal body temperature for 72 hours can protect the brain from further damage and improve recov…

This study is testing if giving patients extra oxygen (normobaric hyperoxia) while they are being transferred to a hospital for a stroke clot-removal procedure (thrombectomy) can protect the brain and lead to better recovery. It will involve 1,500 adults who have had a severe isc…

This study aims to find the safest time to start blood-thinning medication for stroke patients who have an irregular heartbeat (atrial fibrillation) and develop a specific type of brain bleed after a clot-removal procedure. It will compare starting the medication early versus lat…

This study is testing a new computer-based support system designed to help doctors manage cholesterol levels in patients who have had a stroke or mini-stroke (TIA). It will involve 4000 patients in China who are already taking a specific cholesterol-lowering drug called Evolocuma…

This study is testing if a tiny, dissolvable film containing a chili pepper compound (capsaicin) is safe for people who just had a stroke. The film is placed in the mouth and aims to stimulate nerves that may improve blood flow to the brain. About 46 participants will be randomly…

This study tests whether a remote coaching program can help people recover from an ischemic stroke. For three months, 60 participants will receive phone calls, videos, and support to build confidence in managing their health, improve lifestyle factors like diet and blood pressure…

This study aims to see if adding either atorvastatin or rosuvastatin (two common cholesterol-lowering drugs) to standard blood-thinning medication in the first day after a stroke better prevents a second stroke. It will involve 600 adults who have just had their first moderate-to…

This study is testing if placing a patient with a major stroke in a head-down position before a surgical procedure to remove a blood clot can lead to better recovery. Researchers believe this simple positioning might protect more brain tissue while waiting for surgery, potentiall…

This study is testing whether a new antibody drug called TS23 can help people who recently had a stroke. Researchers want to see if TS23 is safe and if it can reduce stroke damage when given within 4.5 to 24 hours after symptoms begin. The trial will include about 300 stroke pati…

This study is testing whether a gentle, non-invasive brain stimulation technique, when combined with standard thinking-skills therapy, can help improve memory and thinking in people who have had a recent stroke. About 70 participants who are having trouble with thinking after a s…

This study is testing whether a new tablet placed under the tongue can help people recover better after a specific type of stroke. It will involve 600 adults in China who recently had a small stroke linked to underlying blood vessel disease in the brain. Participants will take ei…

This study aims to find the best and safest time to restart blood-thinning medication for stroke patients who also have an irregular heartbeat called atrial fibrillation. Researchers will compare starting the medication early versus delaying it after patients have a procedure to …

This study is testing if a new support tool called 'Savvy' can help people who have had a stroke remember to take their blood pressure medicine. The tool includes a weekly pill organizer, text message reminders, and short phone exercises. Researchers will compare 150 stroke survi…

This large study is testing if a surgical procedure to remove a blood clot from the brain works better than standard medication alone for a specific type of stroke. It will involve about 584 adults who have had a stroke caused by a blockage in a smaller brain artery within the la…

This study aims to find the best medicine to prevent a second stroke in people who just had a minor stroke or a TIA (a 'warning stroke'). Researchers are comparing two different drug combinations, each taken with aspirin, over 90 days. They will check which one is more effective …

This study aims to find the better blood-thinner combination to prevent a second stroke in people who just had a minor stroke or TIA. It will compare two different drug pairs, both taken with aspirin, over 90 days in 900 participants. The main goal is to see which combination is …

This study is testing whether a combination of gentle brain stimulation and special walking exercises can help people recover movement and thinking skills after a stroke. Researchers will compare two types of brain stimulation (tDCS and tACS) when paired with physical therapy and…

This study is testing a new rehabilitation technique for stroke survivors who have trouble moving their arm. Researchers are using gentle electrical stimulation to help the brain better sense the arm's position, aiming to improve movement control and recovery. The study involves …

This study is testing whether personalized brain stimulation can help people recover arm movement after a stroke. Researchers will use a gentle electrical current on the scalp during occupational therapy sessions. The study includes 80 people who had a stroke more than 3 months a…

This study is observing 800 people who recently had a stroke or have significant artery narrowing. All participants are receiving a short, high-dose course of common cholesterol-lowering drugs (statins) to see how much it lowers their 'bad' cholesterol and other blood fats. The g…

This study is testing if taking two antiplatelet pills (like aspirin plus another) works as well as the standard intravenous clot-busting medicine for treating a small type of stroke, called a lacunar stroke, if given within 4.5 hours. Researchers want to see if the pill combinat…

This study is testing whether a small device that stimulates a nerve in the neck, used during walking therapy, can help people walk better after a stroke. Researchers want to see if this combination is safe and can improve walking speed and leg function for adults who had a strok…

This is the first human study testing a new oral medication called LWP779, which is being developed to treat ischemic stroke. Researchers are giving the drug to 76 healthy volunteers to check if it's safe, how the body processes it, and what side effects might occur. The study wi…

This study is testing if taking the cholesterol-lowering drug atorvastatin before a brain aneurysm procedure can prevent strokes and artery narrowing. It will involve 354 patients in China who are getting a special stent called a flow diverter. Patients will be randomly assigned …

This study is testing a smartphone app designed to help people who have had a stroke or mini-stroke (TIA) manage their health after leaving the hospital. The app connects to home blood pressure and glucose monitors and uses AI to give personalized advice. Researchers want to see …

This study is testing whether a new drug called DM199 can help people recover better after a moderate stroke. It is for adults who have had a stroke within the last 24 hours and are not eligible for the most common clot-removal procedures. Participants will receive either the stu…

This study aims to see if adding one of two cholesterol-lowering drugs (atorvastatin or rosuvastatin) to the blood thinner clopidogrel is better at preventing a second stroke in people who just had their first major ischemic stroke. It will enroll 600 adults and compare which dru…

This study is testing a new medical device called the Adaptive Tip Catheter for treating stroke caused by blood clots. The device is designed to remove clots from brain arteries more effectively during emergency procedures. Researchers will measure how quickly blood flow is resto…

This study is testing whether adding a drug made from human urine proteins (urinary kallidinogenase) to the standard clot-busting medicine (tenecteplase) helps people recover better from a stroke. It will involve 200 adults who have just had a stroke and received the standard clo…

This early-stage trial is testing the safety and initial effectiveness of an experimental treatment called NouvSoma001 for people who recently had an ischemic stroke. The treatment involves intravenous administration of tiny particles derived from human neural stem cells. The stu…

This study is for people with atrial fibrillation (AFib) who have had a stroke despite taking blood thinners. It tests if adding a heart procedure to close a small pouch in the heart (called the left atrial appendage) is better than just continuing blood thinners alone. The goal …

This study is testing whether adding a clot-busting medication directly into the blocked artery after mechanical clot removal improves recovery from severe stroke. The trial involves 132 adults who have had a major stroke caused by a large blocked artery in the brain. Researchers…

This study is testing if smartwatches can find irregular heartbeats (atrial fibrillation) in people who recently had a stroke. Researchers will compare two different smartwatches to a small implanted heart monitor, which is the current best method. The goal is to see if these com…

This study is testing a new type of combined PET/MR scan to see if it can better identify which carotid artery plaques are unstable and likely to cause a stroke. It will enroll 100 people who have been diagnosed with carotid plaque. The goal is to see if this scan can provide cle…

This study aims to develop an early warning system for a dangerous complication called delayed cerebral ischemia, which can cause more brain damage after a stroke. Researchers will use machine learning to analyze brain signals and test blood for specific proteins to see if they c…

This study is testing whether a small, wireless heart monitor patch worn on the chest for up to 14 days is as good as or better than standard hospital equipment at finding an irregular heartbeat called atrial fibrillation (AF) after someone has had a stroke. About 450 adults who …

This study is testing a portable, headset-like device that measures brain waves (EEG) to help ambulance crews quickly identify if a patient is having a severe type of stroke. The goal is to get these patients directly to the right specialized hospital for urgent treatment, avoidi…

This study is testing whether a simple, 8-week program of tongue-strengthening exercises done at home can improve swallowing difficulties in adults who have had a stroke. Researchers will compare the exercise program to a sham therapy to see which is better at helping people swal…

This study is testing whether robot-assisted training is better than standard physical therapy for improving movement and walking in people recovering from a stroke. It will involve 40 participants who are 6 to 24 months post-stroke and have moderate to severe movement difficulti…

This study is testing whether a medication called acetyl-leucine can improve balance and reduce unsteadiness (ataxia) in people who have had a specific type of stroke affecting the back of the brain. It will involve 200 participants who will take either the real medication or a p…

This study aims to understand how the body's immune system reacts in the first day after a stroke is treated with a clot-removal procedure. Researchers will track 1200 patients to see if specific immune system patterns can predict recovery at 3 and 12 months. The goal is to gathe…

This study aims to understand how the community of bacteria in our gut (the microbiome) might influence recovery after a stroke. Researchers will compare stool and blood samples from 100 people who recently had a stroke with 100 healthy people. The goal is to learn how gut bacter…

This study aims to understand why some people experience thinking and memory problems after a stroke, while others recover better. Researchers will follow 8,000 stroke patients over time, using brain scans, blood tests, and memory assessments. The goal is to identify early signs …

This study aims to better understand which fatty deposits (plaques) in brain arteries are most likely to break off and cause a stroke. Researchers will compare detailed brain scans from 140 people who have had a stroke with scans from people who have similar plaques but no sympto…

This study aims to gather detailed information from 500 people who have had an ischemic stroke. Researchers will collect blood samples and brain/heart scans to look for new markers that can predict how well someone recovers and their risk of future heart problems. The goal is to …

This study aims to understand how small vessel disease in the brain develops and progresses, which can lead to memory problems and dementia. Researchers will follow 50 people who have had a stroke and have risk factors like high blood pressure or diabetes. Participants will have …

This study aims to discover biological markers in blood and other samples that could help identify people at high risk for stroke before it happens. Researchers will follow 7,000 participants—both stroke patients and healthy individuals—for up to four years, tracking their health…

This study is looking back at the medical records of 100 stroke patients at a hospital in Villavicencio, Colombia. Researchers are not testing a new treatment; instead, they are analyzing how care was provided to understand where delays happen and if guidelines were followed. The…

This study aims to understand how well a proven emergency stroke treatment works in everyday hospital practice across the Asia-Pacific region. Researchers will follow 350 adult stroke patients to see what factors help or hinder successful treatment in real-world settings, compare…

This study is observing 1,300 people who previously completed a 1-year exercise program for stroke prevention. The goal is to see if the benefits of that exercise program last for a total of 3 years by tracking their health. It is an observational study, meaning no new treatment …

This study aims to understand how certain substances in the blood relate to brain injury from strokes or bleeding. Researchers will compare blood samples from 200 patients who have had a major stroke or brain bleed with those who had a minor, temporary event. The goal is to see i…

This study aims to understand why some people with atrial fibrillation (AF, an irregular heartbeat) still have a stroke even while taking blood-thinning medication. Researchers will follow 500 stroke patients with AF for about a year, collecting blood samples and heart scan data.…

This study is collecting real-world information on how well approved medical devices work for treating brain aneurysms and strokes. It will follow 1,000 patients who have already been treated with these devices as part of their standard care. The goal is to gather safety and effe…

This study aims to understand a condition called 'augmented renal clearance,' where the kidneys work faster than normal, in patients with severe brain injuries, strokes, or infections. Researchers will measure kidney function and drug levels in over 500 adult ICU patients to see …

This study is creating a detailed registry of 15,000 people in Shanghai who have had an ischemic stroke. Its main goal is to understand why strokes are happening in younger adults, including the roles of traditional risks like high blood pressure and newer factors like air pollut…

This study aims to understand how plaque inside the brain's arteries changes shape and size over one year in people who have had a stroke. Researchers will use a detailed 3D imaging scan at the start and after 12 months to closely measure these changes. The goal is to learn more …

This study aims to understand why some stroke survivors experience memory and thinking problems afterward. Researchers will follow 150 stroke patients for 3 years to see if damage to the brain's protective barrier during the stroke predicts future cognitive decline. The study use…

This is a national registry that connects people who have had a stroke with researchers. The goal is to build a large pool of potential participants to help scientists develop and test new treatments for stroke recovery. Anyone 18 or older who has had a stroke can join by complet…