ISCHEMIC STROKE

This study compares same-day outpatient stroke care to standard hospital care in 400 patients aged 60 or older who have had a mild stroke or transient ischemic attack (TIA). The goal is to see if the outpatient approach is just as good at helping patients recover without major co…

This study tests whether a computer-based decision-support system helps doctors manage cholesterol-lowering treatment (evolocumab) more effectively in people who recently had a stroke or mini-stroke. About 4000 participants in China will be followed for one year to see if more pa…

This study tests whether giving a second dose of the clot-busting drug tenecteplase can help people having a stroke caused by a medium or large blood clot. Participants will be adults who did not improve much one hour after the standard first dose. The goal is to see if the extra…

This study tests whether a telerehabilitation coaching program (TeleSCoP) can help people who have had an ischemic stroke feel more confident managing their health, lower their blood pressure and cholesterol, and avoid going back to the hospital. Sixty adults aged 45 and older wi…

This study looks at 600 adults who had their first small vessel stroke. They all get clopidogrel and aspirin, and some also get atorvastatin or rosuvastatin within 24 hours. The goal is to see if adding a statin lowers the chance of another stroke in 90 days. Participants are fol…

This study tests a new medicine called TS23 for people having a stroke caused by a blood clot. The goal is to see if it can safely improve recovery by preventing bleeding in the brain. About 300 adults with moderate to severe stroke will receive either TS23 or a placebo, and thei…

This study tests a device called OsciPulse that gently pulses the legs to prevent dangerous blood clots in people hospitalized after a stroke. About 40 participants will either get the OsciPulse or standard compression therapy. The main goal is to see if OsciPulse lowers a clot m…

This study is for people having a stroke caused by a large or medium blood clot in the brain. It compares different methods of removing the clot to see which leads to the best recovery and least disability. The goal is to find the safest and most effective approach for each patie…

This study tests if the drug Dimephosphon can improve recovery in people who have had an acute ischemic stroke (a stroke caused by a blood clot). The trial involves 184 adults aged 35-80 who will receive either Dimephosphon or a placebo within 24-72 hours of their stroke. The mai…

This study tests whether giving a clot-busting drug (tenecteplase) directly into the brain artery after mechanical clot removal can improve recovery in people with severe stroke. About 132 adults aged 18-85 with large artery blockages will be enrolled. The goal is to see if the d…

This study compares two antiplatelet drug combinations—aspirin plus ticagrelor versus aspirin plus clopidogrel—in people who recently had a minor stroke or transient ischemic attack (TIA) caused by a large blood vessel blockage. About 900 adults aged 18–75 will receive treatment …

This study looks at the best time to start blood thinners after emergency stroke treatment in people with atrial fibrillation (an irregular heartbeat). About 438 adults who had a stroke caused by a blocked large artery and received emergency clot removal will be randomly assigned…

This study tests whether briefly stopping and restarting blood flow in the neck right after a stroke procedure can help the brain recover better. About 120 adults who had a major stroke and received emergency treatment to reopen a blocked artery will be included. The goal is to s…

This study tracks 800 stroke patients to see how quickly and effectively high-dose statins lower their cholesterol. Researchers aim to find out why some people respond better than others, so treatment can be tailored to each patient. Participants must start intensive statin thera…

This study tests whether taking atorvastatin (a cholesterol-lowering drug) before a brain stent procedure can prevent strokes and other serious events. About 354 adults with brain aneurysms will receive either the drug or a placebo before and after stent placement. Researchers wi…

This study looks at giving a second dose of the clot-busting drug tenecteplase to people having an ischemic stroke who don't get better within an hour after the first dose. The goal is to see if this extra dose is safe and helps open blocked blood vessels in the brain. About 120 …

This study tests whether a medication (edaravone dexborneol) taken as a tablet under the tongue can help people recover from a stroke caused by small vessel disease. About 600 adults aged 30–80 who had a recent small stroke will receive either the drug or a placebo for 24 weeks, …

This study looks at how well and how safely the Tigertriever device works to remove blood clots from large brain blood vessels in people having a stroke. About 150 adults will be treated within 8 hours of their first symptoms. The goal is to restore blood flow and reduce disabili…

This study tests an experimental drug called DM199 in people who have had a moderate stroke and cannot receive standard clot-removal treatments. About 728 participants will receive either DM199 or a placebo within 24 hours of their stroke. The goal is to see if the drug improves …

This study tests a new catheter designed to remove blood clots from the brain in people having a severe stroke. About 74 adults aged 18 to 90 who can be treated within 24 hours of symptoms will take part. The goal is to see if the device can restore blood flow in up to three atte…

This study tests whether adding a statin (atorvastatin or rosuvastatin) to the blood thinner clopidogrel within 24 hours of a first large-vessel ischemic stroke can lower the risk of another stroke. Researchers will follow 600 adults aged 18-75 for three months, tracking new stro…

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover from a moderate stroke that affects the back part of the brain. RIC involves briefly inflating a blood pressure cuff on the arm to restrict blood flow, then releasi…

This study tests whether adding an anti-inflammatory drug (tocilizumab) to standard emergency stroke treatment helps people recover better after a severe stroke in the back part of the brain. About 348 adults who need emergency vessel-opening treatment will be randomly assigned t…

This study tests a new drug called TBO-309 in people having a severe stroke caused by a blockage in two neck arteries (tandem occlusion). The drug is given through a vein during standard clot-removal procedures to help keep the treated artery open and reduce the risk of bleeding …

This study tests whether lying with the head down before a procedure to remove a blood clot in the brain can improve recovery in people having a severe stroke. About 210 adults with a large blocked artery will be randomly assigned to either a head-down position or usual care befo…

This study tests whether a procedure to remove a blood clot from a medium-sized brain artery helps people recover better than standard medicines alone. About 584 adults who have had a moderate stroke within the past 12 hours will be randomly assigned to either get the clot remova…

This study tests whether wearing a custom-made external skull prosthetic can prevent Sunken Flap Syndrome, a condition where the brain sinks after a large piece of skull is removed to relieve pressure. About 72 adults who had this surgery will either wear the prosthetic or receiv…

This study tests whether using a PAP machine (a device that helps keep your airway open during sleep) can improve recovery after a stroke. Researchers will enroll 360 people who have had an ischemic stroke and also have moderate to severe obstructive sleep apnea. Participants are…

This study tests whether closing a small heart pouch (left atrial appendage) with a device, along with continuing blood thinners, can reduce the risk of another stroke in people with atrial fibrillation who already had a stroke while on blood thinners. About 482 participants will…

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain's arteries can help people recover better after a stroke caused by a medium-sized blockage. About 488 adults who have had a stroke within the last 24 hours will be randomly assigned to…

This study tests whether a balloon procedure (angioplasty) can prevent early worsening in people who have had a minor stroke due to narrowed arteries in the brain. About 100 adults whose symptoms are not controlled by medication will be enrolled. The goal is to see if opening the…

This study tests whether adding a drug called urinary kallidinogenase (HUK) to the standard clot-busting drug tenecteplase helps people recover better after a stroke. About 200 adults who have had a moderate to severe stroke within the last 4.5 hours will receive either the combi…

This study looks at whether young patients (60 or younger) who had a stroke caused by a hole in the heart (PFO) can safely stop taking blood thinners one year after the hole is closed. The goal is to see if stopping these drugs reduces bleeding risks without increasing the chance…

This study tests whether doing two heart procedures at once—fixing faulty electrical signals and closing a small heart pouch—can prevent strokes better than standard blood thinners or closing the pouch alone. About 240 people who recently had a stroke and have atrial fibrillation…

This study tests whether combining a statin with ezetimibe works better than a statin alone to lower LDL cholesterol below 70 mg/dL in people who recently had a stroke. About 300 adults with evidence of artery hardening and high cholesterol will be randomly assigned to one of the…

This study tests a new technique called ADAPT 2.0 that uses a special suction device to remove blood clots from the brain during a stroke. The goal is to see if it can safely and effectively restore blood flow better than current methods. About 750 adults having a stroke will tak…

This study tests a treatment called remote ischemic preconditioning (RIC) to see if it can prevent early worsening of symptoms in people who have had a mild stroke caused by a blocked small artery. The treatment involves briefly inflating a blood pressure cuff on the arm to restr…

This study tests whether injecting a clot-dissolving medicine directly into the brain's arteries can improve recovery for people having a stroke caused by a medium-sized blood vessel blockage. About 282 adults with this type of stroke will be randomly assigned to receive either t…

This study tests whether adding ticagrelor or cilostazol to aspirin can better prevent a second stroke in people who recently had a minor stroke or TIA. About 900 adults aged 18-75 will receive one of the two drug combinations within 24 hours of their first event. The goal is to …

This study tests whether a WeChat-based intelligent management system can help people who have had a stroke or mini-stroke avoid another one. About 4,490 participants will either get usual care or use the app after leaving the hospital. After one year, researchers will check for …

This study tests whether giving extra oxygen (normobaric hyperoxia) to people having a major stroke, before they undergo a clot-removal procedure (thrombectomy), can improve their recovery and reduce disability. About 1500 adults with acute ischemic stroke will be randomly assign…

This study compares two treatments for people having a small type of stroke called a lacunar stroke. One group gets a standard clot-busting medicine through an IV, while the other takes a combination of antiplatelet pills (similar to aspirin). The goal is to see if the pills work…

This study tests whether stroke patients who take blood thinners (FXa inhibitors) can safely receive a standard clot-busting drug (IVT). Current guidelines deny IVT to these patients due to bleeding fears, but new evidence suggests it may be safe. The trial will compare recovery …

This early-stage trial tests a new treatment called NouvSoma001 for people who have had an ischemic stroke within the past week. The treatment uses tiny particles from stem cells, given through a vein, to see if it is safe and might help the brain heal. About 69 adults aged 18 to…

This study looks at 240 adults with atrial fibrillation who had a stroke and then a procedure to remove a clot. Some will start blood thinners early (within 3 days) and others later (after 7-14 days) to see which timing is safer and prevents another stroke. The goal is to find th…

This study tests a tool called Savvy that combines phone exercises, a weekly pill organizer, and text reminders to help stroke survivors take their medication as prescribed. The goal is to see if it improves medication adherence and blood pressure control. The study involves 150 …

This study is testing a new medical device worn around the neck to see if carefully controlling body temperature can protect the brain after a stroke. It will compare patients who receive active temperature control with those who are only monitored. The goal is to see if this app…

This study tests a portable EEG device called StrokePointer that ambulance crews can use to quickly identify stroke patients who need a specialized hospital. About 275 adults with suspected stroke will have their brain waves measured in the ambulance. The goal is to see if the de…

This study looks at whether a small, wireless heart sensor patch worn for up to 14 days can find an irregular heartbeat (atrial fibrillation) better than the usual 24-48 hour hospital monitor in people who recently had a stroke. About 450 adults who had a stroke or mini-stroke in…

This study aims to develop a machine learning system that can detect delayed cerebral ischemia (reduced blood flow to the brain) early in patients with subarachnoid hemorrhage. Researchers will analyze heart rate, brain waves, and blood markers from 1,500 intensive care patients.…

This study tests whether a special PET/MR scan can better identify unstable plaque in the carotid artery that may cause a stroke. About 100 adults with carotid plaque will receive two types of PET tracers along with MRI to measure inflammation and fibrosis in the plaque. Research…

This study tests whether a dissolvable oral film with a tiny amount of capsaicin (the hot part of chili peppers) is safe for people who had a stroke within the last 24 hours. The film aims to stimulate nerves that may improve blood flow to the brain. 46 adults will receive either…

This early-stage study at Johns Hopkins University is testing whether psilocybin, a psychedelic compound, is safe for people who had a stroke at least one year ago. The study will enroll 20 adults and closely monitor their blood pressure and any psychiatric changes. The goal is t…

This study tests whether pairing vagus nerve stimulation (a mild electrical pulse) with mobility training can help people who had a stroke at least 6 months ago walk faster and more safely. About 20 participants will receive the therapy in clinic. Researchers will track side effe…

This study tests whether a daily dose of acetyl-leucine (a modified amino acid) can improve balance and reduce uncoordinated movement in people who had a stroke affecting the back part of the brain. About 200 adults who recently had their first stroke and have trouble walking wil…

This study tests whether a safe, non-invasive brain stimulation technique called tDCS, combined with standard cognitive therapy, can improve memory and thinking in people who recently had a stroke. Researchers will enroll 70 adults aged 18-90 who had a stroke within the past mont…

This study tests whether a gentle electrical current applied to the brain, combined with physical therapy and exercises that mix walking with thinking tasks, can improve movement, thinking, and brain activity in people who have had a stroke. The study will include 60 adults who h…

This study tests if doing tongue endurance exercises at home for 8 weeks can improve swallowing in adults who had a stroke 3-6 months ago. 70 participants will be randomly assigned to either the real exercise or a sham therapy. The goal is to see if the exercises strengthen tongu…

This study compares robot-assisted training to standard physical therapy for people who had a stroke 6-24 months ago and still have moderate to severe movement problems. The goal is to see if robot training improves leg function, daily activities, fatigue, and quality of life. Fo…

This study is tracking 350 adults with severe stroke caused by a blocked large artery in the brain. Researchers want to see how well a procedure called endovascular thrombectomy (which removes the clot) works in real-world hospitals across Asia-Pacific, not just in controlled cli…

This study looks at the best way to prevent another stroke in older adults (over 60) who have a small hole in the heart called PFO and had a stroke from an unknown cause. Researchers will compare three treatments: closing the hole with a device, taking blood thinners, or taking a…

This study is tracking 5,000 adults hospitalized for an ischemic stroke to see how different treatment strategies affect their recovery. Researchers will collect medical records and brain scans to build models that predict outcomes. The goal is to learn which treatments work best…

This study looks at how gut bacteria and their byproducts might help people recover from a stroke. Researchers will compare 100 stroke patients with 100 healthy volunteers to understand differences in gut bacteria, immune system activity, and inflammation. The goal is to find new…

This study compares blood RNA patterns between 500 people who recently had a stroke and healthy volunteers. The goal is to find RNA molecules that can help doctors detect strokes earlier and predict how well patients will recover. No new treatments are being tested; this is a res…

This study is collecting information from 1,000 people who have been treated for brain aneurysms or stroke using MicroVention devices. The goal is to see how well these treatments work in everyday medical practice. No new treatments are being tested—just real-world data is gather…

This study is tracking 8,000 stroke survivors to understand why some develop memory and thinking problems (dementia) after a stroke. Researchers will use brain scans, blood tests, and thinking assessments to find factors that predict cognitive decline. The goal is to help doctors…

This study follows 500 adults who had an ischemic stroke to identify biological and imaging markers that predict heart complications and recovery. Participants provide blood samples and imaging data, and their health is tracked for up to three months. The goal is to better unders…

This study is building a large registry of people who have had a stroke and still have symptoms. The goal is to connect them with researchers working on new ways to improve recovery. Anyone 18 or older with a past stroke and ongoing symptoms can join.

This study looks at why some people have memory and thinking problems after a stroke. Researchers want to see if damage to the brain's protective barrier, seen on an MRI right after the stroke, can help predict who will have cognitive decline over the next three years. The study …

This study tracks how fatty deposits in brain arteries change shape and size over one year in 140 people who have had a stroke or mini-stroke. Using advanced 3D X-ray imaging, researchers compare scans taken 12 months apart to see how the plaques evolve under strict control of he…

This study aims to identify features of unstable brain plaques that are likely to cause strokes in people with intracranial atherosclerotic disease. Researchers will compare plaque shapes and blood flow in 140 patients who have had a stroke versus those who have not. The goal is …

This study follows 50 people who have had a stroke and at least one risk factor like high blood pressure or diabetes. Researchers use repeated MRI scans over 15 months to watch how small blood vessel damage in the brain gets worse. The goal is to learn more about how this damage …

This study enrolls 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Researchers want to understand why some strokes happen even when patients take blood thinners. They will collect blood samples and heart ultrasound images, then follow …

This study looks at whether a quick genetic test can help doctors pick the most effective blood thinner for stroke patients. Some people have a gene variation that makes a common drug, clopidogrel, less effective. The test checks for this variation so doctors can prescribe a diff…

This study follows 1,875 people who have had an ischemic stroke and already have tiny brain bleeds (microbleeds). Researchers want to see if taking blood thinners to prevent another stroke makes these bleeds worse or leads to larger brain bleeds. Participants will have MRI scans …

This study tests whether personalized transcranial direct current stimulation (tDCS) can help people recover from a stroke. Researchers will measure brain connectivity changes in 80 adults who had a stroke at least 3 months ago. The goal is to see if this tailored brain stimulati…

This study tests a technique that uses mild electrical stimulation to help stroke patients with sensory problems improve arm movement. The goal is to see if this method can help the brain learn better by correcting mismatched signals between vision and body awareness. Only 3 peop…

This study follows 1,300 people who had a stroke or mini-stroke and completed a 1-year exercise program. Researchers want to see if the benefits of regular physical activity last for 3 more years. No new treatments are given—just observation to track strokes and other health even…

This study tests if a special wire can safely measure blood flow in the tiny blood vessels of the brain right after a stroke clot is removed. Even when the main artery is cleared, many patients still have disabilities, possibly because the smallest vessels aren't getting enough b…

This study looks at specific blood markers related to inflammation and clotting in people who have lost oxygen to the brain due to stroke or bleeding. Researchers will compare these markers between affected patients and those without brain oxygen loss. The goal is to better under…

This study looks at how hospitals in Villavicencio, Colombia, manage stroke cases. Researchers will review medical records of 100 adults diagnosed with stroke to see how quickly they get treated and if care follows best practices. The goal is to find delays and improve future str…

This study looks at whether an imbalance in gut bacteria is linked to stroke risk and recovery in young adults (ages 18-45). Researchers will analyze stool and blood samples from 60 stroke patients to find patterns that might help predict strokes earlier. The goal is to understan…

This study looks at how the body's immune and inflammatory systems react in the first 24-36 hours after a stroke treated with a clot removal procedure (thrombectomy). Researchers will analyze blood samples from 1,200 participants to find patterns that might predict how well peopl…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and remove medications from the body too quickly. It focuses on adults in the intensive care unit with life-threatening brain problems like stroke, severe injury, or infection.…

This early-stage study tests the safety of a new drug called LWP779 in 76 healthy adults aged 18 to 65. Participants receive either the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. The goal is to gather safety information be…

This study aims to find new biomarkers in blood, spinal fluid, urine, and stool that can help predict who is at risk for ischemic stroke and how the disease will progress. Researchers will follow 7,000 participants—including stroke patients and healthy volunteers—for up to 4 year…

This study will follow 15,000 people in Shanghai who have had an ischemic stroke (a type of stroke caused by a blocked blood vessel). Researchers will collect information on patients' health history, lifestyle, and treatments to better understand what causes strokes in younger ad…