ISCHEMIC STROKE

This study tested whether Mongolian medicine ZhenBao Pills help people recover arm function after an ischemic stroke. 216 adults who had a stroke within the past 30 days took either the pills or a placebo twice daily for 90 days. The main goal was to see if arm movement improved …

This study tests whether using a blood test to guide antiplatelet medication can reduce the risk of a second stroke. People who have had a non-cardioembolic ischemic stroke and are already taking aspirin will be assigned to either continue standard aspirin or switch to a differen…

This study looked at whether a therapeutic education program, added to standard medical care, helps people who have had a heart attack or stroke better control their risk factors over one year. About 202 adults aged 18-75 took part. The goal was to see if the program improves phy…

This study tested whether the drug rivaroxaban works as well as warfarin to prevent further brain damage in people who have had a stroke due to antiphospholipid syndrome (APS), a condition that causes abnormal blood clotting. About 40 participants took either rivaroxaban or warfa…

This completed study tested a new device called the Supernova stent retriever in 55 people with severe stroke caused by a large blood clot in the brain. The device is threaded through blood vessels to grab and remove the clot, restoring blood flow. Researchers measured how often …

This study tested whether adding dornase alfa (a drug used for cystic fibrosis) to standard clot-busting treatment could improve blood flow before a clot removal procedure in people having a major stroke. 330 adults with acute ischemic stroke and a large vessel blockage were enro…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study tested whether a 40-hour, 8-week cognitive telerehabilitation program could reduce the risk of memory and thinking problems after a stroke. 86 adults who recently had a stroke were randomly assigned to either the home-based brain training or standard care. The program …

This study tested whether using a special tongue brush (Orabrush) can lower the chance of aspiration pneumonia and improve swallowing in people who had a stroke. Researchers enrolled 252 stroke patients and compared those who used the brush to those who did not. The goal was to s…

This early-stage study tested whether a single intravenous infusion of stem cells from human umbilical cord tissue is safe for people who had an ischemic stroke 3 to 6 months earlier. 18 participants were monitored for side effects and any improvement in daily function. The goal …

This phase 3 trial tested whether giving a clot-dissolving drug called tenecteplase directly into the brain artery can improve blood flow in stroke patients who still have blockages after standard mechanical clot removal. 156 adults with acute ischemic stroke were randomly assign…

This study tested a brain-computer interface (BCI) combined with functional electrical stimulation (FES) to help stroke survivors with foot weakness walk better. 62 adults who had a stroke at least 6 months prior and had trouble walking participated. The therapy used brain signal…

This study tested a program to help people with heart disease, stroke, or heart failure in India. The program used non-physician health workers, text messages about healthy living, and a computer tool to help doctors make decisions. 410 adults took part to see if the program impr…

This study tested whether a drug called dornase alfa (Pulmozyme) can help restore full blood flow to the brain after a stroke. The trial included 39 people who had a stroke and were already receiving standard clot-busting medication and a mechanical clot removal procedure. The go…

This study tested whether adding Mexidol to standard stroke care helps people recover better after a first ischemic stroke. 304 adults who had a stroke within 48 hours were given either Mexidol or a placebo for about 10 weeks. Researchers measured disability, neurological symptom…

This study tested whether Enhanced External Counterpulsation (EECP) therapy, a non-invasive treatment using leg cuffs to boost blood flow, can improve brain circulation in people with severe narrowing of key brain arteries. The 130 participants had recently experienced a stroke o…

This study looked at whether a medication called Renexin CR can help people who have had a certain type of stroke (non-cardioembolic ischemic stroke) within the last 72 hours. The goal was to see if it reduces the chance of getting worse in the hospital or having another stroke w…

This study looked at 1,424 veterans at high risk for heart problems who had major surgery. It compared two approaches to blood transfusion: a liberal strategy (transfusing when hemoglobin drops below 10) versus a restrictive strategy (transfusing only when hemoglobin drops below …

This study tested whether lying in a head-down position (10 degrees) after successful stroke treatment improves recovery. 90 adults with large-vessel stroke were randomly assigned to head-down or standard care. Researchers measured changes in stroke severity and functional outcom…

This completed study tested a new device designed to remove blood clots from the brain in people having a severe stroke. Eight patients were treated within 8 hours of symptoms starting. Researchers measured how well the device restored blood flow and tracked any serious side effe…

This study tested whether a special CT scan done in the procedure room can accurately detect bleeding in the brain of stroke patients. The goal is to speed up diagnosis and treatment by avoiding extra trips to the regular CT scanner. 252 adults with stroke symptoms were enrolled …

This study combined data from nearly 4,000 stroke patients to see how often a heart CT scan finds blood clots that standard ultrasound might miss. Researchers looked at how well this quick scan, done during the initial stroke workup, detects clot sources in the heart. The goal is…

This study tested whether adding augmented cues—like visual and auditory feedback from a sensor-based glove—to standard physical therapy could improve hand function in people recovering from a stroke. Fifty patients with subacute ischemic stroke were randomly assigned to receive …

This study tested a treatment that shines a laser light inside a vein to help people recover after an ischemic stroke. 22 adults with mild to moderate stroke symptoms received the laser therapy. Researchers measured their disability and stroke symptoms before treatment, and again…

This study tested whether task-oriented gait training combined with core stabilization exercises can improve mobility, balance, and walking in people who had a stroke. Fifty-four adults aged 45-75 with left-side weakness took part in an 8-week program. The goal was to see if thes…

This study looked at whether electroacupuncture (a type of acupuncture with mild electric pulses) can lower inflammation and help people recover after a stroke. 17 adults who had their first ischemic stroke took part. Researchers measured changes in symptoms and blood markers to …

This study tested whether a chin tuck against resistance (CTAR) exercise can improve swallowing in stroke patients with dysphagia. 112 participants did the exercise daily for two weeks alongside standard rehab. Researchers measured swallowing ability with a water test and a quali…

This completed trial looked at how two different feeding tubes affect the mental health of 156 stroke patients with swallowing problems. One group used a standard nasogastric tube, the other an intermittent oro-esophageal tube. Researchers measured anxiety, depression, and feelin…

This study tested whether chewing real food (like candies and dumplings) before meals can improve swallowing and quality of life in stroke patients who have trouble swallowing. 120 patients were split into two groups: both got standard rehab and tube feeding, but one group also c…

This study tested whether adding a drug called Cytoflavin to standard physical rehab helps stroke survivors recover better. Cytoflavin is an antioxidant that may protect brain cells and improve learning of new skills. The trial involved 240 adults aged 40-80 who had a stroke 2 we…

This study tested whether combining a drug called galantamine with a specific cognitive training program could improve thinking skills in adults aged 35-70 who had a first stroke 3 months earlier. 47 participants received either the drug or a placebo, plus brain training, and wer…

This study tested whether a gentle electrical current applied to the scalp (tES) can improve movement and thinking in people who had a stroke. Sixty adults who had a stroke between 2 weeks and 2 years ago received real or fake stimulation while doing physical therapy. Researchers…

This study tested whether adding art therapy to standard speech rehab could help people who recently had a stroke and now have trouble speaking (aphasia). Fifteen participants received 12 art therapy sessions alongside their usual therapy. Researchers used brain scans to see if a…

This study tested a therapy called cognitive multi-sensory rehabilitation (CMR) in 40 people who had a stroke 6 to 18 months earlier. The therapy uses movement awareness and discrimination exercises to help the brain and arm work together. Participants received 12 sessions over f…

This study tested whether adding mirror therapy to Botox injections can better reduce arm spasticity in stroke survivors. Thirty patients who had a stroke at least three months earlier received Botox injections and then either mirror therapy or a sham treatment. Researchers measu…

This study tested whether training one leg at a time on a treadmill improves walking and balance in stroke survivors more than standard two-legged training. 63 people who had an ischemic stroke at least 3 months prior took part. They did either unilateral step training, rhythmic …

This study tested whether a robotic device called Luna EMG, which uses muscle signals to assist movement, can improve walking and balance in people recovering from a stroke. 62 older adults with leg weakness after a stroke were randomly assigned to get either robotic training plu…

This study tested whether giving a very high dose of lovastatin (a common cholesterol drug) for 3 days after a stroke is safe. 162 stroke patients received either the high-dose drug or a placebo within 24 hours of symptoms. The main goal was to check for liver or muscle damage, w…

This study tested whether a brain-computer interface (BCI) system could help stroke survivors recover arm function. 84 participants with arm weakness after a stroke used the BCI to control muscle stimulation with their brain signals. The study measured improvements in arm movemen…

This study looked at ways to help people who had a stroke use a CPAP machine for sleep apnea during their rehab stay. Sleep apnea is common after stroke and can slow recovery. The researchers tested different approaches to improve how often patients used the CPAP machine over thr…

This study tested whether a non-invasive brain stimulation technique called tDCS, combined with balance and walking exercises, could help stroke survivors improve their mobility and thinking. Thirty adults who had a stroke participated. The results suggest tDCS may enhance rehabi…

This completed study looked at 140 stroke patients to understand what affects how long they stay in the hospital for rehabilitation. Researchers measured things like functional independence, balance, mental state, and depression in both patients and caregivers. The goal is to hel…

This study tested whether daily mood check-ins via a mobile app could help predict and prevent depression in people who recently had a stroke. Over 400 participants used the app for three months while researchers tracked their emotional symptoms. The goal was to see if this kind …

This small pilot study tested whether a non-invasive eye scan called OCTA can detect changes in the brain related to stroke and other neurological conditions. Researchers compared eye scans from 7 people with brain diseases and healthy volunteers. The goal was to gather early dat…

This completed study followed 550 people who had a stroke within the last 48 hours. Researchers wanted to understand why some patients recover better than others by looking at their medical history, lifestyle, and blood markers. The goal is to find out what factors protect the br…

This study tested a new ultrasound technique called ultrasound localization microscopy (ULM) to see very small arteries in the brain. Researchers used it on 24 people who had a stroke or Moya Moya disease. The goal was to see if ULM could find more tiny arteries than standard MRI…

This early study tested whether breathing short bursts of low oxygen (like being on a tall mountain) is safe for people who had a stroke. The idea is that this might trigger the brain to release proteins that help it recover. 16 stroke survivors took part, and the main goal was t…

This study tested whether a special type of MRI, called high-resolution vessel wall imaging, can help predict if a stroke will happen again in people with a narrowed brain artery. Researchers followed 74 patients who had a stroke or mini-stroke and received artery-opening treatme…

This study observed how breathing machines (mechanical ventilation) are used in 2,299 brain-injured patients in intensive care units worldwide. Researchers collected data on different ventilation strategies and their link to patient recovery. No new treatments were tested; the go…

This study measured levels of a brain protein called BDNF in 50 stroke patients who received a clot-busting drug. Researchers wanted to see if BDNF levels rise after treatment and if they could help predict recovery of movement, thinking, and mood three months later. The goal is …

This study looked at how small blood vessels in the brain change after a stroke caused by small vessel disease. Researchers used a special 3D X-ray technique to take detailed pictures of these vessels. The goal was to learn more about the disease process, which could help doctors…

This study looked at 91 Chinese patients with atrial fibrillation who had a stroke while taking blood thinners (NOACs). The goal was to understand why these strokes happen and whether not taking the medication as prescribed played a role. Researchers hope this knowledge will help…

This study evaluated how aware caregivers are of secondary complications after a stroke, such as muscle stiffness, swallowing problems, and depression. Researchers surveyed 80 caregivers of stroke patients to see if education during rehabilitation improves their knowledge. The go…

This study measured the amount of common blood thinners (dabigatran, apixaban, and rivaroxaban) in the blood of 308 Chinese adults with atrial fibrillation who had been taking the medication for at least 3 months. The goal was to establish normal reference ranges for these drugs …

This study used artificial intelligence to learn the patterns of reduced blood flow to the brain during planned surgeries. 60 patients having carotid artery surgery or stroke clot removal were monitored with non-invasive devices. The goal was to teach AI to recognize these patter…

This completed study tested a program to help stroke survivors in rural Kentucky take their blood pressure medications as prescribed. Four participants received one-on-one education and tailored sessions from a pharmacy technician and community health worker. The goal was to see …

This pilot study tested a wearable robotic exoskeleton called EksoNR in 5 people with stroke, spinal cord injury, cerebellar ataxia, or spastic paraplegia. The goal was to see if using the device for gait training in an outpatient setting is safe, tolerable, and feasible. Researc…

This study tested whether emergency physicians can accurately predict stroke by interviewing witnesses who saw the symptoms start. Researchers asked 235 witnesses to describe what they observed, then compared the doctors' scores to brain scans. The goal was to see if this method …

This study looked at how well the ReVive™ SE device works to restore blood flow in the brain during a stroke. Only one patient took part, and the goal was to see if the device is useful in standard care. The main measure was how much blood flow returned after using the device.

This study looked at how fast treadmill walking, with or without a small electrical stimulation to the ankle muscles, helps people who have had a stroke walk better. Fifty-five participants who were at least six months past their stroke took part. The goal was to understand the b…

This study tested two types of non-invasive brain stimulation (called paired associative stimulation) to see if they could help improve hand movement in people who had a stroke. 81 participants (60 stroke survivors and 24 healthy volunteers) took part. The main goal was to unders…

This completed study followed 633 stroke or TIA survivors in France to understand why some stop taking their secondary prevention medications. Researchers looked at factors like age, beliefs about medicine, and healthcare access. The goal is to improve long-term adherence and pre…

This completed pilot study tested whether giving a daily multi-nutrient drink to people who recently had an ischemic stroke is practical and acceptable. Twenty-four adults were split into two groups: one received the drink plus standard care, the other standard care alone. The ma…

This study looked at whether measuring the optic nerve sheath with ultrasound can help identify which side of the brain is affected in suspected stroke patients. Researchers measured the nerve sheath in 19 adults in the emergency department and compared it to their physical exam …

This study gathered brain monitoring data from 162 patients with serious brain injuries, such as traumatic brain injury or stroke. Using a noninvasive ultrasound device, researchers recorded blood flow signals to build a database. The goal is to develop algorithms that could one …

This study looked at 55 stroke survivors to see if arm function in the first days after stroke can predict trunk (core) recovery weeks later. Researchers measured trunk impairment and arm skills using standard tests. The goal is to find simple early clues that help therapists pla…

This study tested whether a special MRI contrast agent called ferumoxytol can detect inflammation in brain arteries of people who recently had a stroke. Researchers compared it to standard gadolinium contrast in 30 participants with narrowed brain arteries. The goal was to see if…

This completed study in 600 stroke patients in the Middle East looked at what factors might predict different types of brain bleeding after treatment with the clot-busting drug alteplase. Researchers analyzed patient characteristics, how quickly the drug was given, and stroke ris…

This study used advanced MRI scans to look at how water and brain chemicals move in the brain after a stroke. Researchers scanned 24 stroke patients and 24 healthy volunteers to track changes over three months. The goal was to learn more about how brain cells are affected, which …

This completed study looked at how the brain adapts eye movements and how that relates to visual perception and attention. Researchers studied 24 people, including healthy adults and those with cerebellar disease. Participants performed specific eye movement tasks while researche…