ISCHEMIC STROKE

This large phase 3 trial tests whether newer blood thinner combinations (ticagrelor plus aspirin or rivaroxaban plus aspirin) are better than the standard clopidogrel plus aspirin at preventing stroke, brain bleeding, or death from blood vessel disease. Over 1,600 participants wi…

This study tests a wireless device that stimulates the vagus nerve during rehabilitation exercises to help people who have had a stroke recover arm and hand function. The approach, called targeted plasticity therapy, aims to enhance the brain's ability to rewire itself. The trial…

This pilot study tests a new device called OsciPulse that rapidly compresses the calves to improve blood flow and reduce the risk of blood clots in people hospitalized after a stroke. About 40 adults with leg weakness will be randomly assigned to receive either OsciPulse or stand…

This study looks at whether genetic testing can help doctors pick the right antiplatelet medicine for people who have had a stroke or mini-stroke. About 350 patients will be randomly assigned to either standard care or a genetic test that checks if a common drug, clopidogrel, is …

This study tests whether a very low blood pressure target (below 120 mmHg) can prevent major heart problems in people who have had a stroke or mini-stroke. About 4,300 participants are randomly assigned to either intensive or standard blood pressure control and followed for about…

This study compares two ways to help stroke survivors control their blood pressure using telehealth. About 86 participants will receive either enhanced remote monitoring or standard care. The goal is to see which approach better helps people reach a safe blood pressure target and…

This pilot study tests whether a blend of in-person therapy and home-based digital rehab (video calls and apps) works as well as traditional full in-person rehab for people recovering from stroke, brain bleeding, or head injury. Thirty participants will each try both approaches i…

This study tests whether adding spironolactone to standard blood pressure treatment helps lower blood pressure more effectively in people who have had a stroke. About 160 adults who had a bleeding or clot-caused stroke are taking spironolactone or continuing their usual care. Res…

This study looks at a device called the AMPLATZER PFO Occluder, which is implanted to close a hole in the heart (PFO) in people who have had a stroke. Over 1,200 participants are being followed for up to 5 years to see if the device prevents another stroke and is safe. The goal i…

This early-phase trial tests a combination of umbilical cord stem cells (injected into the brain) and a liquid called conditioned medium (given as nose drops) in 15 people who recently had a stroke. The goal is to see if this approach is safe and can help the brain grow new cells…

This study compares two ways to perform carotid artery stenting—a procedure that opens narrowed neck arteries to prevent stroke. The standard method uses an artery in the groin, while the experimental method uses an artery in the wrist. Researchers will enroll 3000 adults with si…

This study tests whether using a CPAP machine to treat sleep apnea shortly after an ischemic stroke can reduce the risk of another stroke, heart attack, or death within 6 months. It also looks at whether CPAP improves overall recovery and brain function. Over 3,000 participants a…

This trial tests a device called Tigertriever 13 to treat distal ischemic strokes, where a blood clot blocks a small artery deep in the brain. About 168 patients with disabling symptoms will receive either the device or standard medical care within 24 hours of stroke onset. The g…

This study looks at whether stroke survivors can get effective arm rehabilitation at home using a device that stimulates the vagus nerve during therapy. About 50 people who already have the Vivistim implant will receive up to 36 hours of in-home therapy paired with nerve stimulat…

This early-phase trial tests whether a new drug called NCS-01 is safe for people who have had a stroke. Sixteen patients will receive the drug within 48 hours of their stroke. The main goal is to check for side effects, not to see if the drug works. This is a first step to see if…

This study planned to test whether donated umbilical cord blood could help adults with stroke or spinal cord injury. However, the trial was withdrawn before enrolling any participants, so no data or results are available.

This study tests whether a video-based telehealth program, including an iPad and remote blood pressure monitoring, can help stroke survivors better control their blood pressure after leaving the hospital. The program also aims to reduce racial disparities in post-stroke care. Abo…

This pilot study tests whether temporarily raising blood pressure with drugs like phenylephrine or norepinephrine can reduce brain damage in people having a major stroke. About 40 adults with large-vessel blockage strokes will receive the blood pressure boost during standard clot…

This study looks at better ways to find hidden atrial fibrillation (an irregular heartbeat) in people who have had a stroke. About 337 participants will use either a wearable patch for 72 hours or a handheld device three times a day to monitor their heart rhythm. The goal is to s…

This study tests whether smartwatches can detect atrial fibrillation (AF) in people who recently had a stroke. Participants already have an implanted heart monitor (the gold standard) and will also wear a smartwatch for 12 weeks. The goal is to see how well the smartwatch catches…

This study tests whether closing a small pouch in the heart (the left atrial appendage) during heart surgery can prevent strokes and blood clots. About 6,500 adults at risk for atrial fibrillation and stroke are taking part. The goal is to see if this simple addition to surgery i…

This study looks at whether clopidogrel, a blood thinner, can prevent new silent brain infarctions (small, unnoticed strokes) in people who recently had a stroke or mini-stroke. Researchers will track 134 participants over 24 months using MRI scans and cognitive tests. The goal i…

This phase 3 trial tests whether adding regular, personalized exercise to standard medical care can prevent new strokes in 1300 people with symptomatic intracranial arterial stenosis (narrowed arteries in the brain). Participants are randomly assigned to either standard care or s…

This study tests whether a special arm brace that reads muscle signals can help stroke survivors with severe arm weakness recover better during early rehabilitation. Three veterans who had a stroke within the past 6 months will use the device alongside standard therapy. The goal …

This study compares two types of exercise programs to see which one better improves balance and leg movement in people who have had a stroke. The study includes 52 adults aged 45 to 65 who had a stroke 6 to 10 months ago and have mild to moderate leg weakness. Participants will d…

This study tests whether taking vitamin K2 supplements for one year can improve muscle strength and brain function in people who recently had an ischemic stroke. 190 participants will receive either vitamin K2 or a placebo daily. Researchers will measure handgrip strength and oth…

This study tests a new program called PA-ChatS that helps people increase physical activity in the first 6 weeks after a stroke. Participants wear a Fitbit to track steps and have weekly phone meetings with an occupational therapist for 6 weeks. The study includes 25 stroke survi…

This pilot study is testing whether memantine, a drug already used for Alzheimer's, can improve arm and leg function after an ischemic stroke. Twenty participants with arm weakness will receive either memantine or a placebo for several weeks. The study measures motor skills and t…

This observational study tracks 5,000 people taking common blood thinners (like rivaroxaban or apixaban) or antiplatelet drugs (like aspirin). Researchers regularly measure drug levels in the blood to see how they relate to clots or bleeding events. The goal is to find the best d…

This study looks at how blood flow in the feet changes during a 12-week heart and blood vessel rehab program for people with narrowed arteries. Researchers will track 80 adults with conditions like peripheral artery disease or coronary artery disease. The goal is to better unders…

This study looks at whether having a rehabilitation doctor see stroke patients early in their hospital stay can shorten how long they stay and reduce the chance of coming back. Researchers are tracking 3,000 stroke patients to see if this coordinated care approach improves recove…

This study is creating a statewide collection of blood samples and medical information from people with various brain blood vessel diseases, such as stroke and dementia. The goal is to build a resource that scientists can use in future research to better understand and potentiall…

This study follows over 2,400 adults in Korea who have had their first stroke. Researchers will track their recovery, daily activities, and quality of life for 10 years. The goal is to learn what factors help or hinder long-term recovery after a stroke.

This study looks at whether short bursts of breathing air with less oxygen (like at high altitude) can improve arm and hand function in people who had a stroke at least six months ago. Twenty participants will undergo 15 cycles of one-minute low-oxygen breathing followed by norma…

This study looks at whether a heart ultrasound (called TTE) can help prevent another stroke in people who have already had one. About 2,000 stroke patients who received a TTE will be followed to see if the test helped doctors change treatment and reduce the chance of a second str…

This study looks at whether custom-made videos can help people who had a stroke 1 to 10 years ago better understand their condition and feel more satisfied with their care. About 100 participants will use a video app and answer surveys after 7 and 90 days. The goal is to see if t…

This study follows about 300 children who had seizures shortly after birth to see if their genes influence whether they develop epilepsy later in childhood. Researchers will combine genetic information with brain scans and EEG results to create a risk score. No new treatments are…

This study looks at whether bacteria in the gut and mouth are linked to a higher risk of stroke in people with narrowed neck arteries. Researchers will measure certain waste products from these bacteria in the blood and see if they relate to stroke or worsening artery blockages. …

This study looks at whether a lighter sedation (sedoanalgesia) or full general anesthesia leads to better early recovery in people having emergency clot removal after a stroke. Researchers will track 62 patients' neurological scores and vital signs during and after the procedure.…

This study looks at whether modern medicines (like statins and newer blood thinners) can keep the one-year stroke rate below 5% in people with narrowed neck arteries who have already had a minor stroke or warning signs. About 114 participants are being followed to see how well th…