ISCHEMIC STROKE

This study looks at whether stroke survivors with lasting arm weakness can get effective therapy at home using a device that stimulates the vagus nerve during rehab exercises. About 50 participants who already have the Vivistim implant will receive up to 36 hours of in-home thera…

This study tests whether lowering blood pressure more aggressively than current guidelines can prevent major heart problems and strokes in people who have already had a stroke or mini-stroke. About 4,368 participants will be randomly assigned to either intensive blood pressure co…

This study looks at whether genetic testing can help doctors pick the right blood thinner for people who have had a stroke or mini-stroke. About 350 patients will be randomly assigned to either standard care or a genetic test that checks if a common drug, clopidogrel, will work f…

This study tests whether adding the drug spironolactone to standard blood pressure treatment is more effective than standard treatment alone for stroke survivors. About 160 adults who had a stroke will participate. The main goal is to see if spironolactone leads to lower home blo…

This study looks at whether treating obstructive sleep apnea with a CPAP machine, starting soon after a stroke, can lower the chance of having another stroke, a heart attack, or dying within 6 months. Over 3,000 people who had a stroke are taking part. The goal is to see if sleep…

This study compares two ways to perform carotid artery stenting—a procedure to open narrowed neck arteries and prevent strokes. One method uses an artery in the wrist (radial), the other in the groin (femoral). The trial will enroll 3000 adults with significant carotid narrowing …

This study tests a new device, the Tigertriever 13, to remove blood clots in small brain vessels in people who have had a stroke within the last 24 hours. The goal is to see if the device can safely restore blood flow better than standard medical care. About 168 adults aged 18-85…

This early-stage study tests a new drug called NCS-01 in 16 people who have had a stroke. The goal is to see if the drug is safe and tolerable when given within 48 hours of stroke onset. Researchers will monitor side effects and changes in neurological function.

This study tests a new treatment for people who recently had an ischemic stroke. It combines a nasal spray of conditioned medium with a direct injection of umbilical cord stem cells into the brain. The goal is to see if this helps the brain repair itself and improve recovery. The…

This early study tests whether briefly raising blood pressure during emergency stroke treatment can slow brain damage. About 40 adults having a clot-removal procedure will take part. The goal is to see if this approach is safe and possible, not yet to prove it works.

This study tests if regular physical exercise can help prevent future strokes in people who have narrowing of the arteries inside the brain (symptomatic intracranial arterial stenosis). About 1300 adults aged 40-80 who recently had a stroke or mini-stroke are taking part. Partici…

This study tests whether closing the left atrial appendage (a small pouch in the heart) during heart surgery can prevent strokes in people who have risk factors for atrial fibrillation and stroke. Over 6,500 adults are taking part. The main goal is to see if this procedure reduce…

This study tests a new wireless device that uses mild nerve stimulation during physical therapy to help people who had a stroke at least a year ago. The goal is to see if it is safe and can improve arm and hand movement. About 42 adults aged 22 to 79 with moderate arm weakness wi…

This study tests whether taking vitamin K2 supplements for one year can improve muscle strength, muscle mass, and brain function in people who recently had an ischemic stroke. About 190 participants will receive either vitamin K2 or a placebo daily. Researchers will track their p…

This early-stage study tests whether memantine, a drug used for Alzheimer's, can improve arm and leg movement after a stroke. Twenty adults who had an ischemic stroke and have arm weakness will receive either memantine or a placebo. Researchers will measure motor function and tra…

This study explores whether a new program can help people increase physical activity within the first 6 weeks after a stroke. About 25 participants will wear a Fitbit to track steps, meet weekly with an occupational therapist, and complete surveys. The goal is to see if the progr…

This study looks at whether newer medications (like statins and modern blood thinners) can keep stroke risk below 5% in people with narrowed carotid arteries who have already had a mini-stroke or stroke. Researchers are tracking 114 participants for one year to see how well curre…

This study tests whether a smartwatch (Apple Watch or PulseOn) can detect hidden atrial fibrillation (AF) in 84 stroke survivors who already have an implanted heart monitor. Participants wear the watch for 12 weeks, and the watch alerts them if it senses an irregular pulse. The g…

This study looks at whether bacteria in the gut and mouth are linked to a higher risk of stroke in people with narrowed neck arteries. Researchers will measure certain waste products from bacteria in the blood and track who has a stroke over time. No new treatments are being test…

This study is creating a statewide collection of blood samples and medical information from 72 people with various brain blood vessel diseases, such as stroke, mini-stroke, and vascular dementia. The goal is to provide a resource for future research to better understand these con…

This study looks at whether a lighter sedation (sedoanalgesia) or full general anesthesia leads to better early brain recovery in people having emergency clot removal after a severe stroke. About 62 participants with large artery blockages will be monitored for neurological score…