ISCHEMIC STROKE

This study tests whether two drugs—colchicine (anti-inflammatory) and low-dose rivaroxaban (blood thinner)—can reduce the risk of another stroke, heart attack, or death in people who recently had a stroke. About 4,500 adults who had a stroke in the last 14 days and do not need st…

This study tests whether semaglutide, a drug used for diabetes and obesity, can help people recover better after a stroke. Researchers will give weekly injections for 12 weeks to 100 stroke patients who had a clot-removal procedure. The goal is to see if the drug can limit brain …

This study tests whether a procedure to reopen a blocked brain artery, combined with medication, is better than medication alone at preventing another stroke or death. About 286 adults aged 18-80 who have had a stroke or mini-stroke from a blocked artery will be randomly assigned…

This study tests whether a drug called butylphthalide can help people who have had a minor stroke recover better over the long term. About 1,200 adults aged 40-80 will take either the drug or a placebo daily for 12 months. Researchers will track survival, stroke recurrence, disab…

This study tests whether lying flat (0 degrees) or with the head elevated (30 degrees or more) after a stroke clot removal procedure helps patients recover better. About 2,240 adults who had a stroke from a large blood vessel blockage will be randomly assigned to one of the two h…

This study tests whether a common diabetes drug (a DPP4 inhibitor) can help prevent or improve memory and thinking problems that often occur after a mild stroke. Researchers will give the drug or a placebo for 180 days to 312 adults aged 40-75 who have had a mild stroke and have …

This early study tests whether a nasal spray made from tiny particles of stem cells is safe and can help people recover from a stroke. Nine adults who had a stroke within the past two weeks will receive the spray. The main goal is to check for side effects, but researchers will a…

This study tests whether a single dose of stem cells from donated umbilical cords can help people recover motor function after an ischemic stroke. 86 adults who had a stroke 2 weeks to 3 months ago will receive either the stem cells or a placebo. The main goal is to see if the tr…

This study tests two devices, Supernova and Neutron, that are threaded through blood vessels to remove clots in people having a severe stroke. The goal is to restore blood flow to the brain within 24 hours of symptoms starting. About 3,000 participants will be followed for 90 day…

This study tests whether sending people with a suspected major stroke directly to the angiography suite (a special X-ray room) for treatment is better than the usual approach of doing a CT or MRI scan first. About 568 adults with severe stroke symptoms within 6 hours of onset wil…

This study looks at two treatments for a severe type of stroke where a large clot blocks the main artery at the back of the brain. About 518 adults will be grouped based on whether they received a procedure to remove the clot or standard medication. The goal is to see which appro…

This study tests whether giving a low dose of albumin (a natural protein) during stroke treatment can limit brain damage. About 100 adults with ischemic stroke who need a procedure to restore blood flow will receive either albumin or a saltwater placebo. Researchers will measure …

This study tests whether filtering harmful substances from the blood (hemoadsorption) can help people with severe ischemic stroke. About 116 adults who had a stroke within the last 48 hours will be randomly assigned to receive either standard care or standard care plus hemoadsorp…

This study tests whether a combination of two blood thinners (rivaroxaban and aspirin) works better than the standard two-drug combo (clopidogrel and aspirin) to prevent another stroke in people who have had a stroke due to narrowed arteries inside the brain. About 1,172 adults o…

This study tests whether adding cilostazol to aspirin or clopidogrel can prevent another stroke or heart attack in people who have already had a stroke or mini-stroke. About 2,000 adults will take part, and researchers will track major events like stroke, heart attack, or death. …

This study tests whether a personalized form of brain stimulation, called IAF-based rTMS, can improve arm and leg movement in people who have had a first ischemic stroke. Thirty-four adults will receive either active or sham (fake) stimulation for two weeks each, in a crossover d…

This study will test if a gentler form of exercise, which uses a blood pressure cuff to limit blood flow, can improve leg strength and balance as well as traditional resistance training in people who have had a stroke. About 80 adults aged 30-40 who had a stroke 3-12 months ago w…

This study compares early task-oriented rehabilitation (practicing meaningful daily activities) with traditional physiotherapy in 158 adults who had a stroke within the past 48 hours. The goal is to see which approach leads to better motor function and quality of life after 3 mon…

This study will test a new type of rehabilitation robot for people who have had a stroke and have trouble moving one arm. The robot uses a non-invasive brain-computer interface and mirror therapy, where the patient moves their healthy arm and the robot helps move the affected arm…

This study tests whether adding a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to standard motor rehabilitation can improve movement and daily function in people who have had a first ischemic stroke. Sixty-six adults aged 18 …

This study will collect detailed information from 200 adults with severe brain injuries treated at Örebro University Hospital. Researchers will track their recovery over 12 months using medical records and follow-up data. The goal is to better understand how brain injuries progre…

This study watches how the brain heals in the first week after a stroke clot is removed. Researchers will monitor 180 adults to see if early brain activity patterns can predict recovery at 90 days. The goal is to create a tool that helps doctors personalize rehabilitation.

This study looks at how the immune system and inflammation change in people having a stroke who receive clot-busting treatment or mechanical clot removal. Researchers will measure inflammatory markers in the blood at several time points over a year. The goal is to see if these ma…

This study tests whether a public health campaign can help people having a stroke get to the hospital within the critical 4.5-hour window. Researchers will compare two groups of communities in China—one receiving the campaign and one not—to see if the campaign speeds up hospital …

This study will compare how quickly brain damage from a stroke worsens in Afro-Caribbean patients in Guadeloupe versus patients in Nantes, France. Researchers will look at 135 adults who have had a stroke caused by a blocked large artery. The goal is to understand if there are di…

This study looks at whether a simple CT scan measurement, called net water uptake, can help predict recovery in people who receive clot-busting treatment for stroke. Researchers will review the medical records of 200 stroke patients from multiple hospitals. The goal is to see if …

This study follows 30 adults who had a stroke causing severe arm weakness. Researchers will use brain scans (fMRI) to see how the brain changes and rewires over time. The goal is to better understand why some people recover more movement than others, which could help design bette…

This study looks at 958 adults with severe stroke who need a procedure to remove a blood clot from their brain. Researchers want to find out if being fully asleep (general anesthesia) or lightly sedated (procedural sedation) leads to better recovery and less disability three mont…

This study tests whether adding gentle electrical brain stimulation to standard physical therapy can improve brain function in people who have had a stroke. Researchers will measure changes in brain blood flow using a special light-based scanner. The goal is to understand how com…

This study will look at 300 adults who had an ischemic stroke (a type of stroke caused by a blood clot) to find out how often a large blood vessel in the brain is blocked. Researchers will use CT or MRI scans to check for blockages and track patients' recovery. The goal is to bet…

This study looks at blood clots removed from stroke patients during a procedure called mechanical thrombectomy. Researchers want to see if the clot's makeup is linked to how well treatment works, what caused the stroke, and how patients recover. 500 adults with ischemic stroke or…

This study will follow about 12,750 adults and children who have had a stroke (either from a clot or bleeding in the brain). Researchers will collect information on their care from the moment they arrive at the hospital through recovery and long-term follow-up. The goal is to lea…

This study aims to find brain activity markers that can predict how well people recover after a stroke. Researchers will first study healthy volunteers to understand normal brain patterns. Then, 120 stroke patients will receive either real or fake brain stimulation alongside stan…

This study looks at whether giving different amounts of protein early on can help people with serious brain conditions like traumatic brain injury or stroke recover better. About 216 adults in the ICU will be randomly assigned to one of three protein dose groups. Researchers will…

This study looks at whether waiting until day 3 after a stroke to start physical therapy is better for patients with persistent artery blockages. Researchers will test if delayed mobilization is safe and helps reduce brain damage and improve recovery. The study involves 50 adults…