ISCHEMIC STROKE

This study is testing two medical devices called Supernova and Neutron that are designed to remove blood clots from brain arteries during a stroke. The goal is to restore blood flow quickly to minimize brain damage and help patients recover better. Researchers will track 3,000 st…

This study is testing whether a widely used diabetes medication (a DPP4 inhibitor) can help protect memory and thinking skills in people who have had a mild stroke and also have type 2 diabetes. Researchers will give the drug or a placebo to over 300 participants for six months t…

This study is testing whether a medication called butylphthalide, taken for a full year, can help people who have just had a minor stroke. Researchers want to see if it prevents another stroke, reduces disability, and protects memory and thinking skills. About 1,200 participants …

This study is testing whether an injection of stem cells from umbilical cords can help people recover movement and independence after a stroke. Researchers will compare the stem cell treatment to a placebo (dummy treatment) in 86 adults who had a stroke 2 weeks to 3 months ago. T…

This study aims to find the safest and most effective time to begin physical therapy after a major stroke. It will test if waiting until at least the third day after the stroke is better for the brain than starting therapy within the first two days. The goal is to prevent further…

This study aims to find the most effective medication combination to prevent a second stroke in people who recently had one caused by narrowed arteries in the brain. It will compare two different blood-thinning drug regimens over 90 days, followed by aspirin. The trial will enrol…

This large study aims to see if two existing drugs, taken at low doses, can help people who recently had a stroke avoid having another major heart or blood vessel problem. It will enroll up to 4,500 recent stroke survivors who are not on blood thinners. Participants will be rando…

This study aims to determine whether putting stroke patients fully to sleep (general anesthesia) or keeping them lightly sedated (procedural sedation) during emergency clot removal surgery leads to better recovery. Researchers will compare these two common anesthesia approaches i…

This is a very early safety study testing a new nasal spray for people who have had an ischemic stroke. The spray contains tiny particles from human umbilical cord stem cells, which researchers hope may help the brain heal. The study will enroll 9 patients to check if the treatme…

This study is testing whether giving a second dose of a clot-busting drug helps stroke patients who don't show improvement after the first standard dose. Researchers will enroll 120 adults who had a stroke within 3 hours and received the initial medication but didn't get better. …

This study aims to see if a gentler leg exercise method is as good as traditional strength training for people recovering from a stroke. It will compare how both methods affect leg muscle power and balance. The research will involve 80 stroke survivors who are 3 to 12 months post…

This study is testing whether a non-invasive brain stimulation technique, called rTMS, can boost the benefits of standard physical therapy for people recovering from a stroke. It will compare real magnetic stimulation to a fake (sham) version in 66 patients who have had a first s…

This study is testing if taking patients suspected of having a major stroke directly to the procedure room (angiography suite) for treatment, instead of first stopping for a CT or MRI scan, leads to better recovery. It will involve 568 adults who arrive at the hospital within 6 h…

This study is collecting information on how well and how safely a device called the Tigertriever works to remove blood clots from brain arteries in people having a stroke. It will follow 150 patients who receive this standard clot-removal procedure within 8 hours of their stroke …

This study tests whether same-day outpatient stroke care works as well as traditional hospital stays for older adults who have mild strokes or mini-strokes. Researchers will compare recovery and safety outcomes between 400 participants randomly assigned to either outpatient or in…

This study is testing if a blood filtering treatment, called hemoadsorption, can help people who have just had a severe stroke. It will compare standard stroke care alone to standard care plus the blood filtering treatment. The main goal is to see if adding this treatment helps m…

This study is testing if delivering a clot-busting drug directly into a blocked brain artery is better than standard care for a specific type of stroke. It will involve 488 adults who have had a stroke caused by a blockage in a medium-sized brain vessel. The main goal is to see i…

This study aims to find out if the angle of a patient's bed after a major stroke procedure affects their recovery. It will compare lying completely flat (0 degrees) with having the head raised (30 degrees or more) in over 2,200 adults who have had a clot physically removed from t…

This study is testing if starting a specific type of physical therapy very soon after a stroke helps people recover better. It compares 'task-oriented' therapy, which focuses on practicing everyday activities like walking or buttoning a shirt, to standard physical therapy. About …

This study is testing if giving a low dose of albumin, a natural protein, can help protect brain tissue from further damage after an ischemic stroke. It will involve 100 patients who have had a stroke and need a procedure to open a blocked blood vessel. Researchers will check if …

This study is testing whether delivering a clot-busting drug directly into a blocked brain artery can help people who have had a stroke caused by a blockage in a medium-sized vessel. About 282 adults who have had this specific type of stroke will be randomly assigned to receive e…

This study aims to find the best amount of protein to give to critically ill brain injury and stroke patients through a feeding tube. Researchers will compare three different protein doses to see which one most helps patients regain consciousness, survive, and leave the hospital …

This study looks back at medical records to compare two approaches for treating severe strokes caused by a blocked artery in the brainstem. It aims to see whether a surgical procedure to remove the clot or standard medication leads to better recovery for 518 patients. The main go…

This study is testing if giving a second dose of a clot-busting drug (tenecteplase) helps stroke patients who don't show significant improvement one hour after the first standard dose. It will involve 198 adults who have had an ischemic stroke caused by a blocked blood vessel in …

This study aims to see if adding the drug cilostazol to a standard blood thinner (aspirin or clopidogrel) is better at preventing another stroke or heart attack in people who recently had a stroke or mini-stroke. It will enroll 2000 participants who have had a stroke or TIA withi…

This large national trial aims to test if a public education and awareness campaign can get people having a stroke to the hospital much faster. It will involve over 1.6 million people across 16 communities in China. The goal is to see if faster arrival leads to more effective eme…

This research study aims to understand the makeup of blood clots that cause strokes. Researchers will analyze clots removed from 500 stroke patients during standard medical procedures and study related blood biomarkers. The goal is to learn how clot composition relates to how wel…

This study aims to understand if a specific measurement from a standard brain scan can predict how well stroke patients recover after receiving clot-busting medication. Researchers will look back at medical records and brain scans from 200 stroke patients who received this standa…

This study aims to collect detailed information from 200 adults with severe brain injuries at a Swedish hospital. Researchers will track patients' recovery over 12 months to better understand how these injuries progress and what factors affect outcomes. No experimental treatments…

This study aims to understand how the body's immune and inflammatory systems respond during and after stroke treatment. Researchers will measure specific blood markers in 300 stroke patients receiving standard clot-busting treatments at multiple time points over one year. The goa…

This study aims to understand if strokes progress differently in Afro-Caribbean patients compared to patients in mainland France. Researchers will compare brain imaging data from 135 stroke patients in Guadeloupe with data from a national French registry. The goal is to identify …

This study aims to find out how often a major type of stroke, caused by a large blockage in a brain artery, occurs at a hospital in Egypt. Researchers will observe 300 stroke patients over a year, collecting their medical and scan data. The goal is to understand how common these …

This study aims to understand why stroke recovery varies so much, even after successful treatment. Researchers will monitor 180 patients who have had a clot removed, tracking their brain and nerve signals during the first week. The goal is to find patterns in these signals that c…

This study aims to understand how a combination of gentle electrical brain stimulation and physical therapy affects blood flow in the brains of people recovering from a stroke. Researchers will measure brain activity in 60 stroke survivors to see if this combined approach helps t…