ISCHEMIC STROKE

This study tests whether starting a special exercise program soon after a stroke can protect the brain from memory loss and dementia. Researchers will enroll 120 people who had a stroke in the past 6 months. Participants will do a mix of exercises, and the study will measure chan…

This study tests a new device and technique (ADAPT 2.0) for removing blood clots in people having an acute ischemic stroke. The goal is to see if it can restore blood flow more completely and safely than current methods. About 750 adults who are already scheduled for clot removal…

This study compares a new 'virtual stroke unit' approach to standard stroke unit care for people with a stroke who are not eligible for a clot removal procedure. The virtual unit uses video calls and monitoring equipment to let a specialist team at a main hospital help guide care…

This study tests whether closing a small pouch in the heart (left atrial appendage) with a device, along with blood thinners, can prevent another stroke better than blood thinners alone. It includes 482 adults with atrial fibrillation who had a recent stroke despite taking antico…

This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care o…

This study tests whether implanting small filters in the carotid arteries (the main neck arteries) can prevent repeat strokes in people with atrial fibrillation who have already had a stroke. Participants will receive the filters plus standard blood thinners, or blood thinners al…

This study tests a nurse-led program called BEST CARE ICTUS_HC for adults hospitalized with acute stroke in hospitals without specialized stroke units. The program includes staff training, swallowing tests, and environmental adaptations to help with attention and safety. Research…

This study tests a new device called the Adaptive Tip Catheter for removing blood clots in people having a severe stroke. About 74 adults will receive the catheter procedure within 24 hours of stroke symptoms. The goal is to see if the device can restore blood flow in the brain w…

This study looks at people over 65 who recently had a stroke with no clear cause. Doctors suspect they may have hidden atrial fibrillation (an irregular heartbeat) not caught in the hospital. The trial compares two treatments: a blood thinner (apixaban) or aspirin, to see which b…

This study compares two treatments for small ischemic strokes (lacunar strokes): a combination of antiplatelet drugs (pills) versus the standard clot-busting drug tPA given through an IV. The goal is to see if the pill combo works just as well but causes fewer bleeding problems. …

This study tests a new drug called TS23, an antibody that may help people recover from ischemic strokes by lowering the chance of bleeding in the brain. The trial involves 300 adults who have had a stroke and will receive either the drug or a placebo. Researchers will check for b…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study tests a tool called Savvy, which includes phone exercises, a weekly pill organizer, and text reminders, to help stroke survivors take their blood pressure medication as prescribed. Researchers will compare medication adherence and blood pressure control between those u…

This study tests whether a procedure called hemoadsorption, which filters the blood, can help people with severe ischemic stroke. Researchers will compare standard care plus hemoadsorption to standard care alone in 116 adults. The goal is to see if the procedure reduces the chanc…

This study is testing a drug called Mexidol in people who have had an ischemic stroke (a stroke caused by a blocked blood vessel in the brain). The goal is to see if Mexidol can reduce the size of the brain injury and improve recovery. The trial will involve 120 adults aged 18 to…

This study tests whether a custom 3D-printed external skull cap can prevent Sunken Flap Syndrome, a condition where the brain sinks after part of the skull is removed. 72 patients who had decompressive craniectomy will either wear the cap or not, and researchers will compare brai…

This study looks at how well and how safely the Tigertriever device works to remove blood clots from large brain vessels in people having an ischemic stroke. About 150 adults will be treated within 8 hours of their first symptoms. The goal is to restore blood flow and improve rec…

This Phase 2 trial tests whether a low dose of albumin, a natural blood protein, can protect brain tissue after an ischemic stroke. One hundred participants will receive either albumin or a placebo during a standard procedure to restore blood flow. The goal is to see if albumin r…

This phase 3 trial tests whether adding tocilizumab, an anti-inflammatory drug, to standard emergency stroke treatment improves outcomes for people with a severe stroke in the back of the brain. About 348 adults will receive either tocilizumab or a placebo by IV right before a pr…

This study tests a device called GORE® CARDIOFORM Septal Occluder to close a small hole in the heart (PFO) in people who have had a stroke with no clear cause. About 636 participants will get the device plus blood-thinning medicine. The goal is to see if this reduces the chance o…

This study tests a clot-busting drug called tenecteplase, given directly into the brain artery, for people having a medium-sized stroke. About 488 adults will be randomly assigned to get the drug or standard care. The goal is to see if the drug helps more people recover with litt…

This study tests whether a balloon angioplasty procedure can prevent early neurological decline in people who have had a minor stroke due to a narrowed brain artery. The trial will enroll 100 adults who have already received standard medication but still show fluctuating or worse…

This study tests a drug called DM199 in about 728 people who have had a moderate stroke and cannot get clot-removing treatments. The drug is given through a vein and then as shots under the skin for three weeks. Researchers want to see if it helps patients recover better than a p…

This study tests if briefly stopping and restarting blood flow in the neck after a stroke procedure can help the brain heal better. About 120 adults who had a major stroke and received emergency treatment to reopen a blocked artery will be randomly assigned to get this extra ther…

This study tests whether a simple, non-invasive treatment called remote ischemic conditioning (RIC) can help people recover better after a moderate stroke in the back part of the brain. RIC involves briefly inflating a blood pressure cuff on the arm to restrict blood flow, then r…

This study looks at whether adding a statin (atorvastatin or rosuvastatin) within 24 hours of a first small vessel stroke, alongside standard blood thinners (clopidogrel and aspirin), can reduce the risk of having another stroke within 90 days. About 600 adults aged 18-75 who had…

This study is testing whether giving a clot-busting drug (tenecteplase) directly into the blocked brain artery can improve outcomes for people having a stroke caused by a medium-sized vessel blockage. About 282 participants will be randomly assigned to receive either the intra-ar…

This study tests whether a single procedure that combines two heart treatments—pulmonary vein isolation (to correct irregular heartbeat) and left atrial appendage occlusion (to block a clot-prone area)—can prevent future strokes and major bleeding better than standard blood thinn…

This study tests whether a team of community health workers, social workers, and nurses can help stroke survivors who face social challenges like food or housing insecurity. The team visits participants at home starting within 72 hours of hospital discharge, offering referrals, c…

This study looks at giving a second dose of the clot-busting drug tenecteplase to people having a stroke caused by a medium or large blocked artery. Participants must receive the first dose within 4.5 hours of symptoms and show little improvement after one hour. The goal is to se…

This study compares a new ambulatory (same-day) stroke care model to standard hospital care for patients aged 60 and older who have had a mild stroke or transient ischemic attack (TIA). Participants receive a full neurological assessment and treatment plan on the same day and the…

This study tests whether giving a second dose of the clot-busting drug tenecteplase can help stroke patients who don't get better within an hour of the first dose. About 120 adults with acute ischemic stroke will receive either a second dose or standard care. The goal is to see i…

This study looks at whether people aged 60 or younger who had a stroke caused by a hole in the heart (PFO) can safely stop taking blood thinners one year after the hole is closed. The goal is to see if stopping these drugs reduces the risk of bleeding without increasing the chanc…

This study looks at two ways to prevent another stroke in older adults who have a hole in the heart (PFO) and had a stroke from an unknown cause. One option is a procedure to close the hole, plus lifelong blood thinners. The other is taking blood thinners alone. Researchers will …

This study tests whether taking atorvastatin (a cholesterol-lowering drug) before and after a brain stent procedure can prevent strokes and other serious events. About 354 adults with brain aneurysms will be randomly assigned to receive either atorvastatin or a placebo. The goal …

This study tests whether removing a blood clot from a smaller brain vessel (distal medium vessel) using a catheter-based procedure helps people recover better from a stroke than standard medical therapy alone. About 584 adults who had a stroke within the last 12 hours and cannot …

This study tests whether stimulating the vagus nerve with a magnet, while doing walking exercises, can help people who had a stroke at least 6 months ago walk better. Twenty participants will do 6 weeks of in-clinic therapy followed by 6 weeks of home exercises. The main goals ar…

This study tests two programs for people recovering from a stroke who are leaving inpatient rehab to go home. Half of the 520 participants will get a standard stroke education program, while the other half will get a program that helps modify their home environment. The goal is t…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and emergency treatment to open a blocked artery. About 438 participants will be randomly assigned to start blood thinners within 4 days or between 5-14 days after the st…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and then emergency treatment to remove a clot. Some patients develop bleeding in the brain after the procedure, and doctors want to know if starting blood thinners early …

This study tests a safe, non-drug treatment called remote ischemic preconditioning (RIC) to see if it can stop early neurological decline in people who have had a mild stroke caused by a blocked small artery. The treatment involves briefly inflating a blood pressure cuff on the a…

This study tests whether adding a protein from human urine (human urinary kallidinogenase) to the standard clot-busting drug tenecteplase helps people recover better after an acute ischemic stroke. The trial will enroll 200 adults who arrive at the hospital within 4.5 hours of st…

This study tests whether giving the clot-busting drug tenecteplase directly into the brain artery after mechanical clot removal can improve outcomes for people with acute ischemic stroke. About 132 adults aged 18-85 with large vessel blockages will be randomly assigned to receive…

This early-stage trial is testing a new treatment called NouvSoma001 for people who have had an ischemic stroke within the past week. The treatment uses tiny particles from stem cells, given through an IV, to see if it is safe and might help the brain recover. About 69 participan…

This study tests whether deep brain stimulation (DBS) combined with physical therapy can improve arm weakness in people who had a stroke 1 to 6 years ago. About 202 participants will receive either DBS plus rehab or rehab alone. The goal is to see if the treatment safely restores…

This study tests a smart management system that uses a WeChat app and home devices like blood pressure monitors to help people who have had a stroke or mini-stroke avoid another one. About 4,490 participants will either get usual care or use the system after leaving the hospital.…

This study tests whether a computer-based decision-support tool can help more people who have had a stroke or mini-stroke reach their LDL cholesterol goal of less than 1.8 mmol/L after one year of treatment with evolocumab. About 4,000 adults in China who recently had a non-cardi…

This study tests whether combining a statin with ezetimibe (another cholesterol-lowering drug) works better than a statin alone in people who recently had a stroke. Researchers will enroll 300 adults aged 20 or older who had a stroke or TIA within the past 30 days and have high L…

This study tests whether adding inclisiran (a twice-yearly injection) to standard care lowers LDL cholesterol more than standard care alone in 520 patients who recently had a heart attack, stroke, or urgent heart procedure. Participants are randomly assigned to receive inclisiran…

This study tests whether giving patients 100% oxygen (normobaric hyperoxia) before a clot-removal procedure can improve their recovery three months after a severe stroke. About 1,500 adults with acute ischemic stroke will be randomly assigned to receive either the extra oxygen or…

This study is for people having a stroke caused by a blocked artery in the brain. It compares different methods of removing the clot (thrombectomy) to find which works best. About 1600 adults will take part, and the goal is to reduce long-term disability.

This study tests a new drug called TBO-309 in 78 people having a stroke caused by a blocked artery in the neck and brain. The drug is given through a vein during standard clot-removal and stenting procedures. The goal is to see if TBO-309 can keep the stent open without causing d…

This study tests whether a sublingual tablet (edaravone dexborneol) can improve outcomes for people who recently had a stroke due to small vessel disease. About 600 adults aged 30–80 will receive either the tablet or a placebo for 24 weeks, with follow-up for one year. The goal i…

This study compares two ways to help stroke survivors control their blood pressure: home monitoring alone versus home monitoring plus group medical visits. High blood pressure is the leading cause of a second stroke, so the goal is to find a better method to keep blood pressure i…

This study compares two antiplatelet drug combinations—ticagrelor plus aspirin versus cilostazol plus aspirin—given within 24 hours of a minor stroke or TIA. The goal is to see which combination better prevents new strokes over 90 days while keeping bleeding complications low. Ab…

This pilot study tests whether a device called CB240_Aurora, which monitors and adjusts body temperature, can help people recovering from a severe ischemic stroke. Twenty-two adults who have had a stroke within the last 48 hours will wear the device for 72 hours. Half will receiv…

This study is testing whether placing stroke patients in a head-down position (Trendelenburg) before a clot-removal procedure can improve their recovery. Researchers will enroll 210 adults with a severe stroke caused by a large blocked artery. The goal is to see if this simple po…

This Phase 3 trial tests whether the drug Dimephosphon can improve recovery in people who have had an acute ischemic stroke. About 184 adults aged 35-80 will receive either Dimephosphon or a placebo within 24-72 hours of their stroke. The main goal is to see if more patients achi…

This phase 3 trial compares atorvastatin versus rosuvastatin, both given with clopidogrel, in 600 adults who had a first large-vessel ischemic stroke. The goal is to see which combination better prevents new strokes within 90 days. Participants receive either 40 mg atorvastatin o…

This phase 3 trial compares two anti-clotting drug combinations—aspirin plus ticagrelor versus aspirin plus clopidogrel—in 900 adults who recently had a minor stroke or transient ischemic attack (TIA) caused by a large artery blockage. Participants receive the drugs within 24 hou…

This study looks at whether using a positive airway pressure (PAP) machine to treat obstructive sleep apnea can help people recover better after an ischemic stroke. About 360 participants who have had a stroke and have moderate to severe sleep apnea will be randomly assigned to r…

This study tests whether clot-busting drugs (alteplase or tenecteplase) are safe and effective for stroke patients who have taken a blood thinner (FXa inhibitor) in the last 48 hours. Current guidelines avoid this treatment due to bleeding concerns, but new evidence suggests it m…

This study tests whether a special PET/MR scan can tell which fatty deposits in the neck arteries are likely to cause a stroke. About 100 adults with known carotid plaque will get two types of PET tracers along with MRI to measure inflammation and scarring inside the plaque. Rese…

This study compares a new wireless heart sensor patch to standard hospital monitoring for detecting atrial fibrillation (an irregular heartbeat) in people who recently had a stroke. About 450 adults will be randomly assigned to wear the patch for up to 14 days or receive usual ca…

This study is testing whether machine learning and special brain injury markers in blood and spinal fluid can warn doctors early when a patient with a brain bleed is developing delayed cerebral ischemia (lack of oxygen to the brain). Researchers will monitor 1,500 adults in inten…

This study tests a portable EEG device called StrokePointer that ambulance crews can use to detect severe strokes caused by large vessel blockages. Currently, over half of these patients are taken to hospitals that cannot perform the needed clot-removal procedure, causing an aver…

This study tests whether a gentle, non-invasive nerve stimulation (called tVNS) applied to the ear or neck can improve arm movement, thinking, and quality of life when paired with standard therapy in people who had a stroke 3–6 months ago. About 54 adults who had their first isch…

This study looks at whether a regular exercise program can improve the benefits of botulinum toxin (Botox) injections for arm stiffness after a stroke. About 70 stroke survivors with arm spasticity will receive Botox and then be randomly assigned to either a prescribed exercise r…

This study tests whether adding telerehabilitation (home-based, supervised and independent arm exercises) to usual care improves arm function and reduces disability after a stroke. Twenty adults in Brazil who had a stroke about 4 months ago will participate. The goal is to see if…

This study tests whether vagus nerve stimulation (VNS) paired with rehabilitation can improve leg and walking function in people who have had an ischemic stroke. Researchers will enroll 24 adults who are already approved for VNS therapy for arm problems. The goal is to see if thi…

This study is testing whether combining a special movement therapy with mild electrical stimulation can help people who had a stroke regain arm function. Forty participants who had an ischemic stroke 3 to 6 months ago will receive either the combo therapy or standard rehab. The g…

This study tests a new virtual reality system that uses motion-tracking games to help stroke survivors improve arm and hand function. 56 people who had a stroke within the last 2 to 6 months will either get this VR therapy or standard rehab for 8 weeks. Researchers will measure a…

This study tests whether a special brain-training game can help people who have had a stroke regain movement in their hand. The game uses a headband to measure brain activity and rewards concentration by moving a virtual hand. The study will include 30 people who had a stroke wit…

This pilot study tests whether a low-cost virtual reality (VR) system can help people recovering from a first-time stroke improve their arm movement. Researchers will compare VR therapy to standard care in 40 adults with moderate to severe arm weakness. Participants will use a Me…

This study tests a new rehabilitation method for people who lost part of their vision after a stroke. It combines gentle electrical brain stimulation with visual exercises, sometimes using virtual reality, to try to speed up recovery of sight in the blind area. The study involves…

This study tests whether a personalized form of brain stimulation (tDCS) can help people who had a stroke more than 3 months ago regain arm movement. Researchers will use brain scans to tailor the stimulation to each person and measure changes in brain connectivity and motor func…

This study tests whether a non-invasive nerve stimulation (taVNS) combined with occupational therapy can improve arm movement in people who had a stroke at least 6 months ago. 60 participants will receive the stimulation during therapy sessions. The goal is to see if this approac…

This study tests whether a gentle electrical current applied to the brain, combined with walking and thinking exercises, can improve movement and thinking in people who have had a stroke. Sixty adults who had a stroke between 2 weeks and 5 years ago will participate. The goal is …

This study tests a dissolvable oral film with a tiny dose of capsaicin (the hot part of chili peppers) in adults who had a stroke within the last 24 hours. The film aims to stimulate nerves in the mouth that may boost blood flow to the brain. 46 participants will receive either t…

This study tests whether psilocybin, a psychedelic substance, is safe for people who had a stroke at least a year ago. Researchers will monitor blood pressure and other vital signs in 20 participants. The goal is to see if psilocybin can help with lingering symptoms like weakness…

This study tests whether a virtual reality system that helps move a virtual hand using muscle signals, combined with mild brain stimulation, can improve arm function in stroke survivors. 45 people who had a mild to moderate stroke will try this approach. The goal is to see if thi…

This study is testing whether adding robotic exoskeletons and virtual or augmented reality to treadmill training can help people who have had a stroke walk better and feel more independent. Researchers will compare different training methods in 80 participants to see which works …

This study tests whether a painless brain stimulation technique called tDCS, combined with cognitive therapy, can improve thinking and memory in people who recently had a stroke. About 70 adults who had a stroke within the past month and have trouble thinking will receive either …

This study tests whether a telerehabilitation coaching program can help people who have had an ischemic stroke feel more confident managing their health, lower risk factors like high blood pressure and cholesterol, and avoid going back to the hospital. Sixty participants will eit…

This study tests whether a tongue endurance exercise program can improve swallowing in adults who have had a stroke. Seventy participants will be randomly assigned to either the tongue exercise group or a sham therapy group. They will do home-based exercises for 8 weeks and have …

This study tests two rehabilitation methods—mirror therapy (sensory augmentation) and mild brain stimulation (tDCS)—to improve arm and hand movement in stroke survivors. 36 adults aged 45-65 with chronic stroke will be split into three groups, each receiving different combination…

This study tests whether a daily dose of acetyl-leucine (a modified amino acid) can improve balance and coordination in people who have had a stroke affecting the back part of the brain. Two hundred adults who recently had a stroke and have trouble walking or staying steady will …

This study tests a wrist-worn sensor system called StrokeWear that gives feedback and encourages stroke survivors to use their weaker arm more during daily activities. 88 people who had a stroke 1-6 months ago will either use the system plus a home exercise plan, or just the exer…

This study compares two types of exercise programs—trunk training and lateral balance training—to see which better improves trunk control, balance, and daily activities in people who have had a stroke. Researchers will enroll 44 participants aged 40-75 who are at least six months…

This study compares robot-assisted training to standard physical therapy for people who have had a stroke and still have moderate-to-severe movement problems. Forty participants who are 6-24 months post-stroke will be randomly assigned to one of two training programs. The goal is…

This study looks at how social and lifestyle factors—like education, race, and income—affect a person's thinking and memory after a stroke. Researchers will interview 450 adults who had a stroke and review their brain scans and medical records. The goal is to understand why some …

This study tests how Tizanidine, a drug used for muscle stiffness, changes arm movement in people who have had a stroke. Researchers will measure brain activity, muscle responses, and movement patterns in 64 participants. The goal is to understand what limits movement after strok…

This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give…

This observational study is looking at 250 people who have had a stroke or mini-stroke due to narrowing of arteries in the brain. Researchers want to see if a specific platelet protein (FcγRIIa) and blood flow patterns on MRI can help predict who will have another stroke within a…

This early-stage study tests a technique that uses electrical stimulation to help stroke survivors improve arm movement. The idea is to correct mismatched sensory signals between vision and body awareness, which can interfere with motor learning. Only 3 people with chronic stroke…

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study aims to find early warning signs for major chronic diseases like stroke, heart disease, and cancer by following 4,500 healthy adults aged 30-80 in Lishui. Participants will receive regular check-ups and long-term monitoring. The goal is to improve prevention and care a…

This pilot study tests whether a special wire can safely measure blood flow in the brain's smallest blood vessels right after a stroke clot is removed. The goal is to understand why some patients still have disability even when the main artery is reopened. Fifteen adults who had …

This study looks at sleep problems like sleep apnea and insomnia in 226 people who have had a stroke. Researchers want to see how these sleep issues affect recovery, daily activities, and quality of life. Participants will use a home sleep test and a smartwatch to track sleep and…

This study tests a fast genetic test done in the hospital to see if it helps doctors pick the best blood thinner for stroke patients. Some people have a gene variation that makes the common drug clopidogrel less effective. The test checks for 11 known gene variants and alerts the…

This study tests a new brain scanning method called fNIRS to see if it can predict recovery in unconscious ICU patients with severe stroke or brain injury. Researchers will compare fNIRS results with standard tests in 30 patients and healthy volunteers. If successful, fNIRS could…

This study follows 1,875 people who have had an ischemic stroke and are taking blood thinners to prevent another one. Researchers use MRI scans to see if these medications increase the risk of tiny brain bleeds or major bleeding. The goal is to help doctors choose safer treatment…

This study compares a standardized swallow test (MASA) with the usual non-standardized test to see which better detects swallowing problems and risk of food or liquid entering the lungs in stroke patients. Researchers will test 50 adults recently hospitalized after an ischemic st…

This study looks at whether an imbalance in gut bacteria is linked to stroke risk and recovery in young adults (ages 18-45). Researchers will analyze stool and blood samples from 60 stroke patients to find patterns that could help predict strokes earlier. The goal is to understan…

This study looks at whether low magnesium in the blood is linked to memory, attention, and other thinking problems after a stroke. Researchers will measure magnesium levels and give cognitive tests to 80 stroke patients over several weeks. The goal is to understand if magnesium d…

This study tests whether a gentle electrical current applied to the brain (tACS) can improve hand movement in people who had a stroke more than 6 months ago. Researchers will use brain scans and EEG to see how the stimulation changes brain activity. 45 participants (including hea…

This study is analyzing blood samples from 500 people who recently had a stroke and comparing them to healthy volunteers. Researchers are looking for specific RNA molecules that could serve as biomarkers to detect stroke and predict how well patients will recover. The goal is to …

This study is collecting information from 5,000 people hospitalized for ischemic stroke to see how different treatments affect their recovery. Researchers will track outcomes like disability and stroke recurrence over up to 24 months. The goal is to build models that help predict…

This early-stage study tests a new drug called LWP779 in 76 healthy adults to see if it is safe and how the body processes it. The drug is being developed for future use in people who have had an ischemic stroke. Participants will receive either the drug or a placebo, and researc…

This study tracks 350 stroke patients across the Asia-Pacific to see how well a proven clot-removal procedure (endovascular thrombectomy) works in everyday hospitals, not just in controlled trials. Researchers will analyze patient outcomes, imaging, and even the removed clots to …

This study at Johns Hopkins University will follow 50 people who have had a stroke and have risk factors like high blood pressure, high cholesterol, or diabetes. Researchers will use repeated MRI scans over about 15 months to track changes in the brain's white matter. The goal is…

This study is following 500 adults who had an ischemic stroke (a clot blocking blood flow in the brain). Researchers are collecting blood samples, brain scans, and health data to find new markers that can predict how well someone will recover and whether they will develop heart p…

This study aims to see if blood markers for Alzheimer's and brain injury can help predict death and hospital readmission in older patients. Researchers will follow 400 hospitalized seniors, including those with neurological issues or dementia. The goal is to develop a tool that u…

This study looks at whether caregivers' expectations for stroke patients' recovery match what physical therapists think is achievable. Researchers will compare goals set by caregivers and therapists for 58 subacute stroke patients. The aim is to improve how rehabilitation goals a…

This study uses advanced 3D-rotational angiography to track how fatty plaques in brain arteries change over one year in 140 people who have had a stroke or mini-stroke. Participants will have two scans 12 months apart while managing heart risk factors. The goal is to understand p…

This study compares bone density in 84 stroke patients at different recovery stages (1 week to 6 months, or over 1 year) to understand osteoporosis risk. Researchers will also look at factors like muscle strength and vitamin D levels. The goal is to identify high-risk patients wh…

This study looks at fatty buildup in brain arteries that can break off and cause strokes. Researchers want to see if high-risk plaques look different from harmless ones. They will use special imaging to compare plaques in 140 people who have had a stroke with those who have not.

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study is collecting information from 1,000 people who have been treated for brain aneurysms or stroke using MicroVention devices. The goal is to see how well these treatments work in real life, not just in controlled trials. No new treatments are being tested—just data gathe…

This study follows 1,300 people who had a stroke or mini-stroke and completed a 1-year exercise program. Researchers will track them for 3 more years to see if the exercise helped prevent future strokes or improve daily function. No new treatments are given—this is purely observa…

This study looks at how the immune system and blood clotting change in the first day after a stroke treated with a clot-removal procedure called thrombectomy. Researchers will collect blood samples from 1,200 participants to find markers that might predict how well people recover…

This study looks at blood markers related to inflammation and clotting in people with brain oxygen deprivation from stroke or bleeding. Researchers will compare these markers between patients with brain hypoxia and those without. The goal is to see if these markers are linked to …

This study is looking at whether certain gene changes (variants) in a protein called annexin A2 are linked to strokes that happen for no clear reason, especially in younger adults. Researchers will compare blood samples from 240 people who have had a stroke with no known cause. T…

This study uses powerful 3T and 7T MRI scanners to create detailed maps of brain activity and connections in 100 stroke patients and 10 healthy volunteers. The goal is to understand how the brain reorganizes after a stroke and to identify patterns linked to motor deficits. Findin…

This study is observing 800 people who recently had an ischemic stroke or have significant artery narrowing. All are taking high doses of statins (atorvastatin or rosuvastatin) for at least a week. Researchers want to see how much their cholesterol drops and what factors influenc…

This study is testing whether a non-invasive ultrasound scan, combined with artificial intelligence (AI), can quickly identify bleeding in the brain (intracerebral hemorrhage) in people having a stroke. Researchers will enroll 500 adults with acute stroke and perform a standard C…

This study tests different power levels and timing of low-intensity focused ultrasound (LIFUS) to see which best improves arm movement and motor learning in stroke survivors. 24 adults who had a stroke at least 6 months ago and have arm weakness will participate. The goal is to f…

This study follows 213 adults recovering from a first ischemic stroke to see if the intensity of inpatient rehabilitation (high vs. moderate) affects their functional recovery at six months. It also compares people whose stroke was linked to atrial fibrillation with those whose s…

This study looks at how gut bacteria and their byproducts affect recovery after an ischemic stroke. Researchers will compare 100 stroke patients and 100 healthy people to understand differences in gut microbes, inflammation, and immune function. The goal is to find new ways to im…

This study is looking for biological markers (biomarkers) in blood, urine, spinal fluid, and other samples that could help predict who will have a stroke and how they will recover. Researchers will follow 7,000 people with and without ischemic cerebrovascular disease for up to 4 …

This study follows 140 working-age stroke survivors in France to find out what factors help or hinder their return to work. Researchers will look at medical details, personal beliefs, and job-related issues. The goal is to create better support plans for people recovering from a …

This study is testing a new type of CT scan (photon counting/spectral CT) to see if it can better identify the makeup of plaque in the carotid arteries of people who have had a stroke. Researchers will compare the CT results with MRI scans and, in some cases, with actual plaque t…

This study looks at how often antiphospholipid syndrome (APS) occurs in people aged 65 and older who have had a stroke or mini-stroke. Researchers will test blood for specific antibodies linked to APS, including some newer ones not yet standard. The goal is to better understand A…

This study will follow 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Some were taking blood thinners when they had their stroke, others were not. Researchers want to understand why blood thinners fail in some patients, by looking at …

This study follows 8,000 adults who have had a stroke to learn why some develop memory and thinking problems afterward. Researchers will track changes in cognition, brain scans, and blood samples over time. The goal is to help doctors identify who is at risk for dementia and pave…

This study looks at how hospitals in Villavicencio, Colombia, manage stroke cases by reviewing patient records. Researchers want to find delays in treatment and see if doctors follow best-practice guidelines. About 100 adults diagnosed with stroke will be included. No new treatme…

This study is building a large registry of people who have had a stroke and still have symptoms. The goal is to connect them with researchers studying new ways to improve recovery. No treatments or tests are given—just observation and data collection.

This study looks at whether damage to the blood-brain barrier right after a stroke can help predict who will have memory or thinking problems later. Researchers will follow 150 stroke survivors for three years, checking their thinking skills by phone. The goal is to better unders…

This observational study tests a new physical exam method to reliably find joint motion problems in healthy adults and people hospitalized with stroke or TIA. Researchers will compare motion patterns between groups and see if motion issues relate to quality of life after stroke. …

This study will follow 15,000 people in Shanghai who have had an ischemic stroke. Researchers will collect detailed information on risk factors, treatments, and recovery to better understand why strokes happen, especially in younger adults. The goal is to improve stroke preventio…