Could a brain pacemaker help stroke survivors move again?

NCT ID NCT05701280

Recruiting now Disease control Sponsor: Enspire DBS Therapy, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 21, 2026 · Updated 3 times

Summary

This study tests whether deep brain stimulation (DBS) combined with physical therapy can improve arm weakness in people who had a stroke 1 to 6 years ago. About 202 participants will receive either DBS plus rehab or rehab alone. The goal is to see if the treatment safely restores arm movement and function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Deep brain stimulation (DBS) device
What this could lead to: If successful, this could offer a new way to improve arm movement and daily function for people with long-term weakness after a stroke.
What could go wrong: This is an early pivotal study with 202 participants, so results may not apply to everyone. DBS surgery carries risks like infection or bleeding, and the treatment may not work for all.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ischemic stroke Paresis stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STROKE UPPER EXTREMITY PARESIS

Contacts and locations

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Locations

Barrow Neurological Institute (BNI)
RECRUITING

Phoenix, Arizona, 85013, United States

Contact Email: •••••@•••••
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Johns Hopkins School of Medicine
RECRUITING

Baltimore, Maryland, 21218, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55906, United States
Mayo Clinic Florida
RECRUITING

Jacksonville, Florida, 32224, United States
Medical University of South Carolina (MUSC)
TERMINATED

Charleston, South Carolina, 29425, United States
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

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