Can a Cholesterol-Lowering drug stop brain arteries from narrowing further?
NCT ID NCT07562178
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care or standard care alone for 12 months. The main goal is to see if the drug reduces further artery narrowing, which could lower the risk of another stroke.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pemafibrate
What this could lead to
If it works, this could offer a new way to lower the risk of recurrent stroke or TIA in patients with high triglycerides and narrowed brain arteries.
What could go wrong
This is a relatively small, open-label trial (Phase not specified), so results may not be definitive. The drug may not prevent artery progression or could cause side effects like liver or kidney issues.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Dokkyo Medical University Hospital
RECRUITINGMibu, Tochigi, 321-0293, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Iwate Medical University Hospital
RECRUITINGHizume, Iwate, 028-3695, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Japanese Red Cross Kyoto Daini Hospital
RECRUITINGKyoto, Kyoto, 602-8026, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Japanese Red Cross Saitama Hospital
NOT_YET_RECRUITINGSaitama, Saitama, 330-8553, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jichi Medical University Hospital
RECRUITINGShimotsuke, Tochigi, 329-0498, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kagoshima Medical Center
RECRUITINGKagoshima, Kagoshima-ken, 892-0853, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kansai Medical University Hospital
RECRUITINGHirakata, Osaka, 573-1191, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kawasaki Medical School Hospital
RECRUITINGKurashiki, Okayama-ken, 701-0192, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kumamoto University Hospital
RECRUITINGKumamoto, Kumamoto, 860-8556, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kyorin University Hospital
NOT_YET_RECRUITINGMitaka, Tokyo, 181-8611, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nagasaki University Hospital
NOT_YET_RECRUITINGNagasaki, Nagasaki, 852-8501, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Osaka General Medical Center
RECRUITINGOsaka, Osaka, 558-8558, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Osaka National Hospital
RECRUITINGOsaka, Osaka, 540-0006, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Saitama Medical University International Medical Center
NOT_YET_RECRUITINGHidaka, Saitama, 350-1298, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Showa General Hospital
RECRUITINGKodaira, Tokyo, 187-8510, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tokyo Medical University Hospital
NOT_YET_RECRUITINGShinjuku-Ku, Tokyo, 160-0023, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tokyo Women's Medical University Hospital
RECRUITINGShinjuku-Ku, Tokyo, 162-8666, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital Kyoto Prefectural University of Medicine
RECRUITINGKyoto, Kyoto, 602-8566, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Yamanashi Hospital
NOT_YET_RECRUITINGChūō, Yamanashi, 409-3898, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••