Can a Cholesterol-Lowering drug stop brain arteries from narrowing further?

NCT ID NCT07562178

Recruiting now Disease control Sponsor: Tokyo Women's Medical University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care or standard care alone for 12 months. The main goal is to see if the drug reduces further artery narrowing, which could lower the risk of another stroke.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pemafibrate
What this could lead to: If it works, this could offer a new way to lower the risk of recurrent stroke or TIA in patients with high triglycerides and narrowed brain arteries.
What could go wrong: This is a relatively small, open-label trial (Phase not specified), so results may not be definitive. The drug may not prevent artery progression or could cause side effects like liver or kidney issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cerebral artery stenosis cerebral atherosclerosis hypertriglyceridemia intracranial arterial disease intracranial arteriosclerosis ischemic stroke stroke disorder transient ischemic attack

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTRIGLYCERIDAEMIA INTRACRANIAL ATHEROSCLEROTIC DISEASE (ICAD) STROKE (CVA) OR TIA

Contacts and locations

Locations

Brain Attack Center Ota Memorial Hospital
NOT_YET_RECRUITING

Fukuyama, Hiroshima, 720-0825, Japan
Dokkyo Medical University Hospital
RECRUITING

Mibu, Tochigi, 321-0293, Japan
Fujita Health University Hospital
NOT_YET_RECRUITING

Toyoake, Aichi-ken, 470-1192, Japan
Hiroshima City Hiroshima Citizens Hospital
NOT_YET_RECRUITING

Hiroshima, Hiroshima, 730-8518, Japan
Institute of Science Tokyo Hospital
NOT_YET_RECRUITING

Bunkyō-Ku, Tokyo, 113-8519, Japan
Iwate Medical University Hospital
RECRUITING

Hizume, Iwate, 028-3695, Japan
Japanese Red Cross Kyoto Daini Hospital
RECRUITING

Kyoto, Kyoto, 602-8026, Japan
Japanese Red Cross Saitama Hospital
RECRUITING

Saitama, Saitama, 330-8553, Japan
Jichi Medical University Hospital
RECRUITING

Shimotsuke, Tochigi, 329-0498, Japan
Kagoshima Medical Center
RECRUITING

Kagoshima, Kagoshima-ken, 892-0853, Japan
Kansai Medical University Hospital
RECRUITING

Hirakata, Osaka, 573-1191, Japan
Kawasaki Medical School Hospital
RECRUITING

Kurashiki, Okayama-ken, 701-0192, Japan
Kindai University Hopital
NOT_YET_RECRUITING

Sakai, Osaka, 590-0197, Japan
Kobe City Medical Center General Hospital
NOT_YET_RECRUITING

Kobe, Hyōgo, 650-0047, Japan
Kumamoto University Hospital
RECRUITING

Kumamoto, Kumamoto, 860-8556, Japan
Kyorin University Hospital
RECRUITING

Mitaka, Tokyo, 181-8611, Japan
Nagasaki University Hospital
RECRUITING

Nagasaki, Nagasaki, 852-8501, Japan
Nippon Medical School Hospital
NOT_YET_RECRUITING

Bunkyō-Ku, Tokyo, 113-8603, Japan
Nippon Medical School Musashikosugi Hospital
NOT_YET_RECRUITING

Kawasaki, Kanagawa, 211-8533, Japan
Nippon Medical School Tamanagayama Hospital
NOT_YET_RECRUITING

Tama, Tokyo, 206-8512, Japan
Osaka General Medical Center
RECRUITING

Osaka, Osaka, 558-8558, Japan
Osaka Keisatsu Hospital
RECRUITING

Osaka, Osaka, 543-0042, Japan
Osaka National Hospital
RECRUITING

Osaka, Osaka, 540-0006, Japan
Saitama Medical University International Medical Center
RECRUITING

Hidaka, Saitama, 350-1298, Japan
Showa General Hospital
RECRUITING

Kodaira, Tokyo, 187-8510, Japan
The Jikei University Hspital
NOT_YET_RECRUITING

Minato-Ku, Tokyo, 105-8471, Japan
The University of Osaka Hospital
NOT_YET_RECRUITING

Suita, Osaka, 565-0871, Japan
Tokai University Hopital
NOT_YET_RECRUITING

Isehara, Kanagawa, 259-1193, Japan
Tokushima University Hospital
NOT_YET_RECRUITING

Tokushima, Tokushima, 770-8503, Japan
Tokyo Medical University Hospital
RECRUITING

Shinjuku-Ku, Tokyo, 160-0023, Japan
Tokyo Saiseikai Central Hospital
NOT_YET_RECRUITING

Minato-Ku, Tokyo, 108-0073, Japan
Tokyo Women's Medical University Adachi Medical Center
NOT_YET_RECRUITING

Adachi-ku, Tokyo, 123-8558, Japan
Tokyo Women's Medical University Hospital
RECRUITING

Shinjuku-Ku, Tokyo, 162-8666, Japan
Tokyo Women's Medical University Yachiyo Medical Center
NOT_YET_RECRUITING

Yachiyo, Chiba, 276-8524, Japan
University Hospital Kyoto Prefectural University of Medicine
RECRUITING

Kyoto, Kyoto, 602-8566, Japan
University of Tsukuba Hospital
NOT_YET_RECRUITING

Tsukuba, Ibaraki, 305-8576, Japan
University of Yamanashi Hospital
RECRUITING

Chūō, Yamanashi, 409-3898, Japan

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