Hypertriglyceridemia

This phase 3 trial tests a drug called plozasiran in 288 adults with severe hypertriglyceridemia (very high blood fats) who have had at least two pancreatitis attacks. Participants receive either the drug or a placebo every three months. The main goal is to see if the drug can pr…

This phase 2 trial tests an injectable drug called ION775 in 72 adults with high or severely high triglycerides. The goal is to see if it safely lowers fasting triglyceride levels. Participants continue standard care while receiving the study drug.

This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care o…

This study tests a new medicine called SHR-1918 for people with high triglycerides, a type of blood fat that can raise heart risk. About 360 adults will get either the drug or a placebo for 48 weeks to see if it safely lowers fat levels. The goal is to control the condition, not …

This study tests the long-term safety and effectiveness of a drug called plozasiran in adults with very high triglycerides (a type of fat in the blood). About 869 people who completed earlier studies will receive injections every 3 months for 2 years. The goal is to see if the dr…

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This Phase 2 trial tests two experimental injections, HRS-7249 and SHR-1918, in 108 adults with severely high triglycerides who are at high risk of acute pancreatitis. The study aims to see if these drugs can safely lower fat levels in the blood and reduce the chance of a pancrea…

This early-stage trial tests a new CRISPR-based treatment called CTX310 for people with severe cholesterol and triglyceride problems that don't improve with standard therapies. The treatment uses a tiny fat bubble to deliver gene-editing tools that turn off a gene linked to high …

This Phase 2 trial tests whether the drug RBD5044 can safely lower high triglyceride levels in adults. About 40 Chinese participants with high triglycerides will receive either RBD5044 or a placebo twice over 84 days. The main goal is to see if RBD5044 reduces triglyceride levels…

This early-stage study tests a single dose of VERVE-201, a gene-editing therapy, in 36 adults with dangerously high cholesterol and triglycerides that don't respond to standard treatments. The treatment aims to permanently turn off a liver gene (ANGPTL3) to lower blood fats. The …

This study tests an injectable drug called solbinsiran in 60 adults with severe hypertriglyceridemia (very high blood fats). Participants receive two shots of either the drug or a placebo. The goal is to see if solbinsiran safely lowers triglycerides and related fats better than …

This study tests whether adding chia and pumpkin seeds to a standard healthy diet can lower triglyceride levels in people with hypertriglyceridemia. 375 adults with moderately high triglycerides will follow a balanced diet for 4 weeks, with half also eating seeds. The goal is to …

This program gives adults and adolescents with familial chylomicronemia syndrome (FCS) and adults with severe hypertriglyceridemia (SHTG) access to an experimental drug called plozasiran. Participants receive injections every 3 months for 15 to 21 months. The goal is to lower dan…

This small pilot study is testing whether eating Greek bottarga (grey mullet fish roe) every day can improve blood sugar, cholesterol, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 participants will compare the effects of bottarga against a dairy pro…

This early-stage trial tests a single infusion of CS-121, a gene editing therapy, in 15 adults with familial chylomicronemia syndrome (FCS), a rare condition causing extremely high blood fat levels. The therapy targets the APOC3 gene to lower triglycerides and reduce disease burd…

This study tests a new injection called JMT202 in 48 Chinese adults with very high triglycerides (a type of fat in the blood). The goal is to see if it is safe and can lower triglyceride levels. Participants will receive either the drug or a placebo over several doses, and resear…

This Phase 2 study tests whether the drug MAR001 can lower blood fat levels after a meal in adults with high triglycerides. Thirty participants will receive either MAR001 or a placebo injection. The main goal is to see if MAR001 reduces the rise in triglycerides and remnant chole…

This study compares low-glycemic index (GI) bakery foods like pasta and pizza to standard wholegrain versions in 40 adults with high triglycerides. The goal is to see if low-GI carbs improve a key marker of metabolic and heart risk more than wholegrain carbs. Participants follow …

This study looks at children with suspected or confirmed genetic and metabolic disorders to find new disease-causing gene mutations. Researchers will analyze blood samples for DNA and metabolites, and in some cases take a small skin sample. The goal is to better understand these …

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk together about stem cell transplant or cellular therapy decisions. The goal is to see if the tool is easy to use and helpful for families. About 60 …

This study is a registry that gathers information from up to 500 people in Russia who have extremely high triglyceride levels (a type of fat in the blood). The goal is to learn more about their health, genetics, and current treatments. No new drugs or procedures are tested—just o…

This study uses MRI scans to look for brain differences in people with metabolic diseases compared to healthy volunteers. Researchers will track changes over time and link them to body fat and other health measures. About 126 adults will take part at Ulm University Hospital. No d…

This study looks at how different types of insulin resistance (in fat or muscle) affect the liver's production of fats called triglycerides. Researchers will measure fat production after a meal, with and without exercise beforehand. The goal is to understand why some people have …

The SMILE study is tracking 10,000 adults aged 18 and older to see how sarcopenia (age-related muscle loss) and metabolic diseases like diabetes influence overall health and lifespan. Researchers will collect data from medical records, tests, and surveys over time. This is an obs…

This early study is testing two types of fish oil—EPA and DHA—to see how they affect blood clotting and cholesterol in people with high triglycerides. Eighty participants will take one of the two oils for a month and have their blood tested. The goal is to learn which oil might b…

This study tests whether spinning blood samples at very high speed can remove fat particles that interfere with a key test for blood thinners. Researchers will add fat to routine blood samples from 150 adults on anti-Xa medications and see if the spinning method clears the fat wi…

This study follows 100 children under 18 who are already on a ketogenic diet for conditions like drug-resistant epilepsy, autism, chronic migraine, or brain tumors. Researchers want to see if the diet supports healthy growth, improves symptoms, and boosts quality of life. The die…