New shot aims to tame dangerously high blood fats

NCT ID NCT07269210

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This study tests an injectable drug called solbinsiran in 60 adults with severe hypertriglyceridemia (very high blood fats). Participants receive two shots of either the drug or a placebo. The goal is to see if solbinsiran safely lowers triglycerides and related fats better than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Solbinsiran (also called LY3561774), an injectable drug
What this could lead to: If it works, this could lead to a new treatment option for people with dangerously high triglycerides, reducing their risk of pancreatitis and heart problems.
What could go wrong: This is an early Phase 2 trial with only 60 participants, so results may not apply to everyone. The drug may not lower triglycerides enough or could have side effects not yet seen.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertriglyceridemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE HYPERTRIGLYCERIDEMIA

Contacts and locations

Locations

AB Clinical Trials
RECRUITING

Las Vegas, Nevada, 89119, United States
ARC Biosystems
RECRUITING

Vancouver, V6Z 2H2, Canada
American Research Corporation at Texas Liver Institute
RECRUITING

San Antonio, Texas, 78215, United States
Ark Clinical Research
RECRUITING

Long Beach, California, 90815, United States
Axsendo Clinical Research - Peak Heart & Vascular - Phoenix
RECRUITING

Phoenix, Arizona, 85014, United States
C.I.C. Mauricie inc.
RECRUITING

Trois-Rivières, G8T 7A1, Canada
CMR of Greater New Haven, LLC
RECRUITING

Hamden, Connecticut, 06517, United States
Cardiovascular Specialists of Willowbrook
RECRUITING

Houston, Texas, 77070, United States
Carilion Clinic
RECRUITING

Roanoke, Virginia, 24014, United States
Catalina Research Institute, LLC
RECRUITING

Montclair, California, 91763, United States
Clinical Research of Philadelphia
RECRUITING

Pennington, New Jersey, 08534, United States
Clinical Site Partners, LLC dba Flourish Research
RECRUITING

Winter Park, Florida, 32789, United States
Eastside Research Associates
RECRUITING

Redmond, Washington, 98052, United States
Ecogene-21
RECRUITING

Chicoutimi, G7H 7K9, Canada
Endeavor Clinical Trials
RECRUITING

San Antonio, Texas, 78240, United States
Flourish Research - Bowie
RECRUITING

Bowie, Maryland, 20715, United States
Great Lakes Clinical Trials - Ravenswood
RECRUITING

Chicago, Illinois, 60640, United States
Guangdong Provincial People's Hospital
RECRUITING

Guangzhou, 510000, China
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Inpatient Research Clinic
RECRUITING

Miami Lakes, Florida, 33014, United States
Investigators Research Group
RECRUITING

Brownsburg, Indiana, 46112, United States
Medical Corporation Heishinkai OCROM Clinic
RECRUITING

Suita-shi, 565-0853, Japan
National Heart Institute
RECRUITING

Beverly Hills, California, 90211, United States
Northeast Research Institute - Downtown Office
RECRUITING

Jacksonville, Florida, 32204, United States
Novera Clinical Research
RECRUITING

Miami, Florida, 33135, United States
Peking University Third Hospital
RECRUITING

Beijing, 100091, China
Saint Elizabeth Healthcare - Saint Elizabeth Covington Hospital
RECRUITING

Covington, Kentucky, 41011, United States
Sichuan Provincial People's Hospital
RECRUITING

Chengdu, 610072, China
Southern Endocrinology Associates
RECRUITING

Mesquite, Texas, 75149, United States
Stroobants Cardiovascular Center
RECRUITING

Lynchburg, Virginia, 24501, United States
Synexus Clinical Research US, Inc./Orange Grove Family Practice
RECRUITING

Tucson, Arizona, 85741, United States
TPMG (Tidewater Physicians Multispecialty Group) Clinical Research
RECRUITING

Newport News, Virginia, 23606, United States
Takai Internal Medicine Clinic
RECRUITING

Kamakura-shi, 247-0056, Japan
The Affiliated Hospital of Xuzhou Medical College
RECRUITING

Xuzhou, 221006, China
The First Affiliated Hospital of Henan University of Science &Technology
RECRUITING

Luoyang Shi, 471003, China
The Institute of Medical Science, Asahi Life Foundation
RECRUITING

Chūōku, 103-0002, Japan
UW Medicine Diabetes Institute
RECRUITING

Seattle, Washington, 98109, United States
University of Massachusetts Chan Medical School
RECRUITING

Worcester, Massachusetts, 01655, United States
Valley Clinical Trials, LLC dba Flourish Research
RECRUITING

Northridge, California, 91325, United States
Weill Cornell Medical College
RECRUITING

New York, New York, 10021, United States
Zhongshan Hospital,Fudan University
RECRUITING

Shanghai, 200032, China

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