Eli Lilly And Company

This large research program is testing several different experimental treatments for chronic pain conditions including knee arthritis, low back pain, and diabetic nerve pain. The study will enroll up to 10,000 participants to compare new pain interventions against placebo treatme…

This study is testing a weekly injection called eloralintide in adults who have painful knee osteoarthritis and are overweight or have obesity. The main goals are to see if the treatment helps reduce knee pain and leads to weight loss. About 900 participants will be in the study …

This study is testing two new investigational drugs, macupatide and eloralintide, to see if they help with weight loss in adults who have type 2 diabetes and are overweight or have obesity. About 200 participants will receive the drugs alone, in combination, or a placebo for near…

This large Phase 3 trial is testing whether an oral drug called muvalaplin can reduce the risk of serious heart problems like heart attacks and strokes in people with high levels of a specific cholesterol particle called lipoprotein(a). The study will enroll over 10,000 adults wh…

This study is testing a new oral medication called pirtobrutinib for adults with immune thrombocytopenia (ITP), a condition where the immune system attacks blood platelets. The first part checks the drug's safety and side effects, while the second part compares different doses to…

This study is testing several different weight management treatments for adults with obesity or overweight. The trial will evaluate how safe and effective these new interventions are for long-term weight control. Participants will be assigned to different treatment groups based o…

This is an early-stage study to check the safety and side effects of a new drug called LY4057996 in healthy volunteers and people with Type 1 or Type 2 diabetes. Researchers will give the drug as an injection under the skin or into a vein and measure how the body processes it. Th…

This study is testing whether adding a weight-loss drug (tirzepatide) to a standard ulcerative colitis drug (mirikizumab) works better than the colitis drug alone. It's for adults who have active ulcerative colitis and are also overweight or have obesity. The main goals are to se…

This study is testing whether a weekly injection called tirzepatide, combined with healthy eating and exercise, helps adolescents with obesity lose weight and improve related health conditions like high blood pressure and prediabetes. About 300 teens aged 12-17 with obesity and a…

This early-stage study is testing a new radioactive cancer drug called LY4337713 in adults with advanced solid tumors that have spread. The drug is designed to seek out and deliver radiation directly to cancer cells that have a specific protein marker called FAP. Researchers will…

This study is testing whether a new weekly injection called eloralintide helps people with obesity or overweight lose more weight when added to their current weekly weight-loss medication. It will involve about 900 adults, some with type 2 diabetes and some without, over roughly …

This is an early-stage trial testing a new drug called LY3962673 in people with advanced pancreatic, lung, or colorectal cancer that has a specific genetic change called KRAS G12D. The main goals are to find a safe dose and see if the drug, given alone or with other chemotherapie…

This large, 5-year study is testing how well the weekly medication tirzepatide works for weight loss in a real-world setting compared to standard care. It will involve 3000 adults with obesity who do not have diabetes, aiming to see how much weight they lose and if the drug helps…

This study is testing if adding the weight-loss medication tirzepatide to an existing psoriasis treatment (ixekizumab) works better for people who have both conditions. It will involve about 200 adults with moderate-to-severe plaque psoriasis who are also overweight or have obesi…

This study is testing whether adding a new drug called LY4268989 to an existing UC treatment (mirikizumab) works better than the existing drug alone. It's for adults with moderate to severe ulcerative colitis who haven't gotten enough relief from other standard medications. The m…

This global Phase 3 study is testing whether adding an experimental drug called LY3537982 (olomorasib) to standard cancer treatments works better than standard treatments alone for people with untreated advanced non-small cell lung cancer. The trial is specifically for patients w…

This study is testing a once-daily pill called orforglipron to see if it can safely lower high blood pressure in adults who are also overweight or have obesity. It's a large, late-stage trial comparing the pill to a placebo. The goal is to see if this medication can help control …

This study is for people who have already been taking the drug pirtobrutinib for chronic lymphocytic leukemia or non-Hodgkin lymphoma in a previous trial. Its main purpose is to monitor the long-term safety of the drug and track how long patients live. It allows participants from…

This is the first study in humans to test the safety and side effects of a new drug called LY4298445. It will involve both healthy volunteers and people with systemic lupus erythematosus or rheumatoid arthritis. The main goal is to see how the body handles the drug and to find a …

This study is testing an investigational drug called LY3871801 for adults with moderate-to-severe rheumatoid arthritis (RA) who haven't gotten enough relief from standard treatments. About 380 participants will receive either the drug or a placebo to see if it safely reduces dise…

This is the first human trial of a new experimental cancer drug called LY4175408. It is designed to target and deliver a toxic payload specifically to cancer cells that have a certain marker (PTK7). The study will test the drug's safety, side effects, and early signs of effective…

This study is testing whether adding lebrikizumab, an injectable medication, to standard nasal sprays helps people with chronic sinusitis and nasal polyps. It will involve about 510 participants and last around 18 months. The main goals are to see if the treatment reduces feeling…

This large, real-world study aims to see if adding the drug donanemab to usual care helps people with early Alzheimer's disease maintain their independence longer than usual care alone. It will follow about 6,250 participants for over five years, tracking how long they can live a…

This study is testing whether the medication mirikizumab can help control Crohn's disease in children and teenagers. About 90 participants with moderate to severe Crohn's disease who haven't responded well to other treatments will receive the drug for about 74 weeks. Researchers …

This study is testing a new weekly injection called eloralintide to see if it helps adults with obesity and type 2 diabetes lose weight. Over 1,000 participants will receive either the real injection or a placebo (dummy shot) for about 75 weeks. Researchers will measure changes i…

This study is testing a once-daily oral medication called orforglipron to see if it helps adolescents with obesity or overweight with related health conditions manage their weight. It will compare the drug to a placebo (a pill with no medicine) in about 125 participants over 18 m…

This study is testing two new drugs, eltrekibart and mirikizumab, alone and together, for adults with moderate to severe ulcerative colitis. The goal is to see if these treatments can safely bring the disease under control and help patients achieve remission. It is for people who…

This study is testing a once-daily pill called orforglipron to see if it helps people with obesity or overweight and type 2 diabetes lose weight and better control their blood sugar. It will compare the pill's effects to a placebo (a dummy pill) in about 600 participants over 18 …

This study is testing a once-daily pill called orforglipron to see if it can reduce episodes of stress urinary incontinence (leaking urine during activities like coughing or exercise) and help with weight loss. It will involve about 1,000 adult women who have this type of inconti…

This early-stage study is testing a new targeted cancer drug called STX-478, both alone and in combination with other approved cancer therapies. It aims to find a safe dose and see if it can help control advanced solid tumors, particularly breast cancer, that have a specific gene…

This large, late-stage study is testing whether an investigational medication called brenipatide helps adults with alcohol use disorder reduce their drinking compared to a placebo. About 1,100 participants will self-inject the study drug or a dummy shot for about a year while res…

This study is testing whether an investigational medication called brenipatide can help adults who have recently quit smoking avoid relapsing back to cigarettes. About 222 participants will receive either brenipatide or a placebo (inactive substance) via self-injection for 24 wee…

This study is testing a once-daily pill called orforglipron to see if it can help lower high blood pressure and reduce body weight. It will involve about 487 adults who have both hypertension and are overweight or have obesity. Participants will be randomly assigned to receive ei…

This 5-year study is testing whether a medication called orforglipron can reduce the risk of major heart problems and death in people who already have heart or kidney disease. It will involve over 7,000 participants, who will be randomly assigned to receive either the real drug o…

This study is testing a new weekly injection called LY3457263 to see if it can help lower blood sugar in people with type 2 diabetes. It is for people whose blood sugar is still too high even though they are already taking stable doses of the medications semaglutide or tirzepatid…

This study is testing a new drug called LY3938577 to see if it works as well as or better than a common long-acting insulin (degludec) for controlling blood sugar in people with type 2 diabetes. It will involve about 100 people who are already using insulin and will last about 6 …

This study is testing how well the injectable medication lebrikizumab works for people with moderate eczema covering 10-25% of their body who experience severe daily itching. About 200 adults and teenagers will receive the medication for 6 months to see if it reduces their eczema…

This study is testing a new targeted radiation treatment called LY4257496 for people with advanced cancers that have a specific protein (GRPR). The main goals are to find a safe dose and see if the treatment helps shrink tumors. It is for adults with certain advanced breast, pros…

This study is testing whether a daily pill called orforglipron helps people with obesity or overweight lose weight. It will involve about 600 adults who have not succeeded with diet alone and have at least one other weight-related health issue. The study will compare the pill's e…

This large study is testing whether an investigational medication called brenipatide can help adults with moderate-to-severe alcohol use disorder reduce their drinking and cravings. About 1,100 participants will receive either brenipatide or a placebo injection for approximately …

This study is testing whether a new drug called brenipatide can help adults whose moderate-to-severe asthma is not well controlled by current medications. Over 500 participants will receive either the drug or a placebo for a year to see if it safely reduces the number of serious …

This study is testing a drug called mirikizumab to see if it can help control ulcerative colitis in children and teenagers aged 2 to 18. It is for kids whose disease is moderate to severe and who haven't gotten enough help from other standard treatments. The main goal is to see i…

This early-stage study is testing a new drug called LY4213663 to see if it's safe and how the body handles it. The research involves both healthy volunteers and people with rheumatoid arthritis to check for side effects and measure drug levels in the blood. This is the first step…

This study is testing an experimental pill called LY3537982 for people with advanced cancers that have a specific genetic change called KRAS G12C. The research aims to find the safest and most effective dose, both alone and combined with other cancer drugs, for patients with lung…

This is an early safety study to test a new drug called LY4256984 for people with sporadic ALS. The drug is injected into the spine. Researchers will check for side effects and measure how much of the drug gets into the blood and spinal fluid.

This large study is testing whether two investigational drugs, retatrutide and tirzepatide, can prevent serious liver complications in people with advanced fatty liver disease (MASLD). About 4,500 adults with high-risk liver scarring will be randomly assigned to receive one of th…

This trial is a flexible 'master protocol' designed to test multiple new cancer drugs for children and young adults more efficiently. It will enroll about 105 participants with various cancers. As new promising drugs emerge, they can be added to the trial for testing, allowing re…

This study is testing a once-daily pill called orforglipron to see if it can safely lower high blood pressure and reduce body weight. It will involve about 500 adults who have both hypertension and are overweight or have obesity. Participants will be randomly assigned to receive …

This study is testing whether the drug donanemab is safe and effective at slowing the progression of early Alzheimer's disease. It will involve about 1,500 people who have mild memory problems and confirmed Alzheimer's-related brain changes. Participants will receive either the d…

This study is testing whether a new weekly injection called retatrutide is safe and effective for weight loss. It will involve about 250 adults who have obesity or are overweight but do not have type 2 diabetes. Participants will receive either the real injection or a placebo (a …

This study tracks the long-term safety and survival of people with chronic lymphocytic leukemia or non-Hodgkin lymphoma who have already taken pirtobrutinib in earlier clinical trials. It allows participants from completed Lilly-sponsored studies to continue receiving the drug or…

This study is testing whether adding an investigational medication called brenipatide to a person's current bipolar disorder treatment can help delay the return or worsening of symptoms. It will involve about 400 adults with bipolar disorder who will receive either brenipatide or…

This study is testing whether adding a weight-loss drug (tirzepatide) to a Crohn's disease drug (mirikizumab) works better than the Crohn's drug alone. It's for adults who have active Crohn's disease and are also overweight or have obesity. The main goal is to see if the combinat…

This is an early-stage study to check the safety and how the body processes a new drug called LY4006896. It will involve about 127 healthy volunteers and people with Parkinson's disease. The main goal is to see how well the drug is tolerated and to measure its levels in the body …

This study is testing whether adding a new oral drug called olomorasib to standard immunotherapy works better than immunotherapy alone for people with a specific genetic change (KRAS G12C) in their non-small cell lung cancer. It will enroll about 700 people whose cancer was remov…

This study is testing whether adding an experimental drug called Tersolisib to standard breast cancer medications works better for people with advanced hormone-positive breast cancer that has a specific genetic change called PIK3CA mutation. The trial will involve about 920 adult…

This study is testing a new drug called LY4050784 for people with advanced solid tumors that have a specific genetic change called a SMARCA4/BRG1 alteration. The main goals are to find a safe dose of the drug, given alone or with other cancer treatments, and to see if it helps sh…

This study is testing whether a medication called baricitinib can help preserve the body's own insulin-producing cells in people recently diagnosed with type 1 diabetes. The trial will involve 300 participants aged 1 to 36 years who were diagnosed within the last 100 days. Partic…

This study aims to see how well and how safely the drug mirikizumab works over a long period (about 3 years) in children and adolescents with moderate-to-severe ulcerative colitis or Crohn's disease. It is an extension study for about 150 young people who have already been taking…

This is an early-stage study to check the safety and how the body processes a new drug called LY4086940. It will involve about 201 healthy people and people who are overweight, have obesity, or have type 2 diabetes. The main goal is to see if the drug is safe and well-tolerated a…

This large, Phase 3 study aims to test the safety and effectiveness of different weight management medications for children and teenagers with obesity or overweight. It will enroll 125 young participants aged 12 to under 18 who have previously tried lifestyle programs without eno…

This is the first human study to test the safety and basic effects of a new drug called LY4167586 for weight management. It will involve 84 otherwise healthy adults with obesity or overweight. Researchers will give single doses to see how the body handles the drug and monitor for…

This is a first-in-human study to test the safety and find the right dose of a new investigational drug called LY4052031 for people with advanced or metastatic solid tumors. The drug is designed to target a specific protein found on many cancer cells, delivering its medicine dire…

This early-stage study is testing a new drug called LOXO-435 for people with advanced solid tumors, including bladder cancer, that have a specific genetic change (FGFR3). The main goals are to find a safe dose, understand side effects, and see if the drug can shrink tumors. The s…

This study aims to monitor the long-term safety of the drug pirtobrutinib in people with previously treated blood cancers like chronic lymphocytic leukemia and lymphoma. It is only open to a small group of 13 people who are already benefiting from the drug in a previous trial. Pa…

This study is testing whether a new drug called solbinsiran, given as two injections, can safely lower very high levels of triglycerides (a type of fat in the blood) better than a placebo. It will involve 60 adults with a history of severely elevated triglycerides. The main goal …

This study is testing a medication called baricitinib to see if it can safely control the symptoms of a severe form of childhood arthritis called systemic JIA. Children aged 1 to 18 with active arthritis will take either baricitinib or a standard treatment (tocilizumab) to compar…

This study is testing a new weekly injection called eloralintide to see if it helps adults with obesity or overweight lose weight and improve their health. It will involve nearly 2,000 people who do not have type 2 diabetes. Participants will receive either the real injection or …

This study aims to understand how a new investigational drug for Type 2 diabetes, called LY3209590, is processed by the body in children and teenagers. It involves giving a single dose to about 22 young participants and tracking the drug levels in their blood over approximately 1…

This study is testing if higher doses of the diabetes medication dulaglutide are safe and effective for teenagers aged 10-17 with type 2 diabetes. It will involve about 55 teens and last around 8 months. Researchers will check if the medicine helps control blood sugar and body we…

This study is testing whether adding the weight-loss medication tirzepatide to the standard arthritis drug ixekizumab helps people with psoriatic arthritis who are also overweight or obese. About 200 adults who have been on ixekizumab for about 3 months will take tirzepatide for …

This early-stage study aims to check the safety and how the body processes a new drug called LY3549492 in healthy adults who are overweight or have obesity. About 120 participants will receive multiple doses over approximately 8 weeks while researchers monitor for side effects an…

This study is testing whether a pill called baricitinib can help regrow hair in children and teenagers with severe alopecia areata, a condition that causes sudden hair loss. About 595 participants aged 6 to 18 will take the pill or a placebo for 36 weeks to see if it's safe and e…

This study is testing whether a new injectable medicine called brenipatide, when added to standard buprenorphine treatment, can help people with opioid addiction stay off drugs. About 465 participants will receive either the new medicine or a placebo injection alongside their usu…

This study allows cancer patients who benefited from previous Eli Lilly drug trials to continue receiving the study medication after those trials conclude. It focuses on monitoring the long-term safety of these treatments. Only patients who were already receiving the drug in a co…

This is an early-stage study to check the safety and basic effects of a new investigational drug, LY3938577, for Type 1 Diabetes. It will involve healthy volunteers and people with well-controlled Type 1 Diabetes. Researchers will measure how the drug moves through the body and c…

This is the first human study of an experimental cancer drug called LY4101174. Researchers want to find a safe dose and see if it can help control advanced cancers that have spread or returned after other treatments. The study will enroll about 490 people with various solid tumor…

This large, late-stage study is testing a weekly injection called eloralintide for adults with moderate-to-severe obstructive sleep apnea who are also overweight or have obesity. The goal is to see if the drug can help reduce the number of breathing pauses during sleep (sleep apn…

This large, late-stage study is testing a once-daily pill called orforglipron to see if it helps people lose weight and is safe. It will enroll about 1,200 adults who have obesity or are overweight, some of whom also have type 2 diabetes. The main goal is to see how well the pill…

This is an early-stage study to check the safety and side effects of a new drug called LY4064912, which is being developed for weight management. It will involve 144 healthy and overweight participants who will receive the drug as an injection under the skin or through an IV. Res…

This large, two-part study is testing a new drug called sofetabart mipitecan for people with advanced ovarian, fallopian tube, or peritoneal cancer. Part A is for people whose cancer has stopped responding to standard platinum chemotherapy. Part B is for people whose cancer still…

This early-stage study is testing the safety of a new drug called LY3954068 for people with early Alzheimer's symptoms. The drug is given as an injection into the spinal fluid. Researchers will check how the body processes the drug and look for any side effects in 48 participants…

This study is testing whether adding a new drug called vepugratinib to two existing cancer drugs works better for people with advanced bladder cancer that has spread and has a specific genetic change (FGFR3). About 450 adults who haven't had treatment for their advanced cancer wi…

This is the first study in people to test a new targeted cancer drug called LY4170156. It aims to find a safe dose and see if it can help control advanced cancers, including ovarian, lung, breast, and pancreatic cancers. The study will also test the drug in combination with other…

This study is testing whether a once-daily pill called orforglipron can help people with peripheral artery disease (PAD) walk farther with less leg pain. About 1,200 participants with PAD will take either the study drug or a placebo pill for about a year. The main goal is to see …

This study is testing different ways to increase the dose of an investigational weight loss medication called retatrutide. It aims to see which dosing plan is most effective and safe for helping people with obesity or overweight lose weight and improve related health measures. Th…

This study is checking the long-term safety and effectiveness of the drug baricitinib in children and teenagers (ages 1 to 17) with juvenile idiopathic arthritis (JIA). It is only for participants who have already been taking baricitinib in a previous related study. The main goal…

This early-stage study is testing a new drug called retatrutide to see how it affects the body's ability to produce and respond to insulin in people with type 2 diabetes. It will involve about 95 adults and compare the new drug against a placebo and another existing diabetes medi…

This early-stage study is testing the safety and side effects of a new Alzheimer's drug called LY4006895. Researchers will give the drug to healthy volunteers and people with early memory problems from Alzheimer's disease to see how their bodies handle it. The study will measure …

This study is testing whether a new blood test for an Alzheimer's-related protein (p-tau217) helps doctors manage patients with early memory complaints more effectively. It will compare two groups: one where doctors use the test results and one where they don't. The goal is to se…

This study is testing whether the drug baricitinib can delay or prevent the onset of type 1 diabetes in people who are at high risk. It will involve about 150 children and young adults (ages 1 to under 36) who show early signs of the disease but do not yet need insulin. Participa…

This study is testing how well and safely a daily pill called orforglipron works for people who have obesity or are overweight and also have painful osteoarthritis in the knee. About 800 participants will take the pill or a placebo (a dummy pill) for about 74 weeks. The main goal…

This study is testing a new drug, LY3537021, to see if it works better than a placebo at preventing nausea and vomiting caused by certain strong chemotherapy drugs. It will involve about 204 adults with cancer who are new to chemotherapy. Participants will be randomly assigned to…

This study is testing an investigational drug, LY4065967, to see if it safely reduces the chronic pain caused by nerve damage from diabetes. About 150 adults with diabetic nerve pain in their feet and legs will receive either the new drug or a placebo for several weeks. Researche…

This study is testing whether an investigational drug called lebrikizumab can safely reduce nasal symptoms and improve daily life for adults with perennial allergic rhinitis (year-round allergies). About 450 participants will be randomly assigned to receive either lebrikizumab or…

This study is testing whether a weekly injection called retatrutide can safely reduce chronic low back pain in adults who also have obesity or are overweight. Researchers will compare the injection to a placebo (a dummy treatment) in about 586 participants over 80 weeks. The main…

This study aims to understand how a new drug, LY3537982, is processed by the body in people with reduced kidney function. It will compare drug levels in 32 participants with moderate or severe kidney impairment to those with normal kidney function. The goal is to gather informati…

This is an early safety study to see how a new drug, eloralintide, is processed by the body in people with healthy livers and in people with mild, moderate, or severe liver damage. Researchers will give a single injection and then closely monitor participants for about 14 weeks t…

This is the first study testing a new oral drug called LY4515100 in humans. Researchers want to see if it's safe and how the body processes it in 40 healthy volunteers. The study involves taking the drug and staying overnight for monitoring and blood tests over about 30 days.

This is an early-stage study to check the safety of a new drug called LY3981314 and see how the body handles it. It involves about 76 healthy volunteers who will receive a single injection under the skin. The main goal is to identify any side effects and measure the drug's levels…

This is an early safety study to understand how a new drug, LY3537031, is processed by the body in people with different levels of liver function. It will enroll 32 people, including healthy volunteers and those with mild, moderate, or severe liver impairment. The main goal is to…

This study is testing a new imaging agent called [18F]LY4214835 to see if it is safe and to measure how much radiation it delivers to different organs. It involves both healthy volunteers and people with cancer who will receive a single injection and be followed for about 35 days…

This study aims to measure how much of an experimental drug called olomorasib gets into the bloodstream and how long it stays there after being taken as capsules. It involves 120 healthy volunteers who will take the drug and stay overnight at a research center for monitoring. The…

This early-stage study aims to see if a common antifungal medication (fluconazole) changes how much of an experimental cancer drug (olomorasib) gets into a person's blood and how long it stays there. It involves 15 healthy participants who will stay overnight at a research center…

This study aims to understand how long people should fast and what happens when they temporarily stop taking the medication tirzepatide, in terms of how quickly their stomachs empty after eating. Researchers will use ultrasound scans to measure food and liquid remaining in the st…

This is an early safety study to see how a new drug called lepodisiran behaves in people with healthy livers compared to those with mild, moderate, or severe liver problems. Researchers will give a single injection and then carefully measure how much of the drug gets into the blo…

This is the first study in humans for the experimental drug LY4088044. Researchers want to see if it's safe and how the body handles it in 104 healthy volunteers. Participants will receive injections under the skin or into a vein, and researchers will monitor them for side effect…

This is an early safety study to see how healthy Chinese adults' bodies handle a single injection of an experimental drug called remternetug. The main goal is to check for any side effects and measure how much of the drug gets into the bloodstream and how long it stays. The study…

This study aims to understand how Alzheimer's disease develops by tracking people at risk for the condition over seven years. It will follow 3,400 participants with normal memory to see if a specific blood test can predict future declines in thinking skills. The study does not te…

This is an early safety study to see how a new drug called Eloralintide moves through the body in people with severe kidney disease. Researchers will compare results from 28 participants—some with healthy kidneys and some with severe kidney impairment. The main goal is to underst…

This is a very early study to check if a new drug called LY4066708 is safe for people and to see how the body handles it. It will involve about 104 healthy volunteers who will receive the drug and be monitored for up to 24 weeks. The main goals are to identify any side effects an…

This is an early safety study to understand how healthy people tolerate a new experimental drug called LY3867070. Researchers will give the drug to 196 healthy volunteers and monitor for side effects while measuring how the body processes it. The study will also check how the dru…

This study aims to understand how three different tablet versions of an investigational drug, LY4100511, are absorbed by the body. It will involve 48 healthy volunteers to see if the drug's absorption changes when taken with common stomach acid medication. The goal is to gather d…

This is an early-stage study to check the safety and side effects of a new injectable drug called LY3971297. It will involve about 225 healthy adults and adults with obesity, high blood pressure, or reduced kidney function. The main goal is to see how the body handles the drug an…

This study aims to understand how fasting and temporarily stopping the diabetes medication dulaglutide affect how much food and liquid stays in the stomach after a meal. Researchers will use ultrasound scans to measure stomach contents in about 20 adults with type 2 diabetes. The…

This is an early safety study to understand how a new drug, LY3537031, moves through and leaves the body. It will compare people with healthy kidney function to those with severe kidney impairment or kidney failure. The main goal is to measure drug levels in the blood and check f…