New drug takes aim at autoimmune diseases in early human test
NCT ID NCT07276958
First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time
Summary
This early-stage study tests an experimental drug called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check safety and how the body handles the drug. Participants will receive either the drug or a placebo, and the study lasts up to about a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- LY4298445 (an experimental drug given as an injection)
- What this could lead to
- If successful, this could point toward a new treatment option for lupus and rheumatoid arthritis by targeting immune cells.
- What could go wrong
- This is a very early Phase 1 trial with only 63 participants, so safety and effectiveness are not yet known. The drug may cause side effects or fail to show benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Anhui Provincial Hospital
NOT_YET_RECRUITINGHefei, 230036, China
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Nucleus Network
RECRUITINGBrisbane, 4006, Australia
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Nucleus Network
RECRUITINGMelbourne, VIC 3004, Australia
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Peking University First Hospital
NOT_YET_RECRUITINGBeijing, 100034, China
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Peking University Third Hospital
NOT_YET_RECRUITINGBeijing, 100191, China
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Renji Hospital, Shanghai Jiaotong University School of Medicine
NOT_YET_RECRUITINGShanghai, 200127, China
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The First Affiliated Hospital of Wenzhou Medical University
NOT_YET_RECRUITINGWenzhou, 325000, China
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
NOT_YET_RECRUITINGWuhan, 430022, China
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Xiangya Hospital of Central South University
NOT_YET_RECRUITINGChangsha, 410008, China
Contact Phone: •••-•••-••••
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