HEALTHY

This early-stage study is testing a new vaccine called V118E to see if it is safe and well-tolerated in healthy adults. The vaccine aims to protect against infections caused by Streptococcus pneumoniae bacteria, which can cause pneumonia and other serious illnesses. Around 126 he…

This study tests a vaccine given to pregnant women to see if it can protect their babies from group B streptococcus (GBS) infection, a serious illness in newborns. Healthy pregnant women aged 49 or younger, between 24 and 36 weeks of pregnancy, can join. Participants receive one …

This study tests a new dengue vaccine called V181 in 12,000 healthy children aged 2 to 17. The goal is to see if the vaccine is safe, triggers a strong immune response, and reduces cases of dengue fever caused by any of the four dengue virus types. Participants will receive eithe…

This early-stage study is testing two new vaccines (V350A and V350B) designed to prevent diseases caused by the Epstein-Barr virus (EBV), which can cause infectious mononucleosis and is linked to certain cancers and multiple sclerosis. The study will enroll 250 healthy adults and…

This study compares a new intranasal (nose spray) COVID-19 booster vaccine, LVT-001, with the standard mRNA booster shot in 238 healthy adults. The goal is to see if the nasal vaccine is safe and triggers a strong immune response, especially in the nose and throat where the virus…

This early-stage study tests a new drug called LY4213663 in healthy volunteers and people with rheumatoid arthritis (RA). The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the body processes the drug. The study lasts…

This early-stage study tests an experimental drug called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check safety and how the body handles the drug. Participants will receive either the drug or a placebo, and the study lasts …

This study is testing whether two different versions of the drug survodutide are equally effective in the body. It involves 80 healthy overweight or obese adults who will receive both formulations in a crossover design. The goal is to see if the new formulation matches the origin…

This early-stage study tests a new drug called LY3971297 in healthy volunteers, people with obesity and high blood pressure, and those with reduced kidney function. The main goal is to check for side effects and measure how the drug moves through the body. The study involves up t…

This phase 2 trial is testing whether a daily dose of tocotrienol, a form of vitamin E from palm oil, can reduce markers of aging in healthy adults aged 35 to 64. Over 6 months, 220 participants will take either tocotrienol or a placebo. Researchers will measure changes in cellul…

This early-stage study tests a new drug called LY4006895 in healthy volunteers and people with early symptomatic Alzheimer's disease. The main goal is to check if the drug is safe and how the body processes it. The study has two parts: a single dose in healthy people and multiple…

This early-phase trial is testing a new biologic drug called XmAb657 in 60 people, including healthy volunteers and those with autoimmune diseases like scleroderma, Sjögren's disease, and idiopathic inflammatory myopathies. The main goal is to check safety and how the body handle…

This study tests fisetin, a natural compound found in strawberries and apples, in healthy young adults and older people with multiple chronic diseases. Participants take fisetin or a placebo for two days and are followed for up to three months. The goal is to see if fisetin safel…

This early-stage trial tests a new drug called IBI3013, which blocks a protein (IL-15) involved in immune attacks. It includes 160 people: healthy volunteers first, then people with active vitiligo or severe alopecia areata. The main goal is to check safety and how the drug moves…

This study tests whether a weekly dose of everolimus (a drug similar to rapamycin), resistance training three times a week, or both together can improve bone formation in women aged 60-75 with low bone mass. Researchers will measure bone markers, density, and muscle function over…

This early-stage trial is testing a new experimental antibiotic, BAL2420, in 136 healthy adults. The goal is to check if it is safe and how the body processes it. Researchers will give single or multiple doses and watch for side effects. This is a first step toward possibly using…

This study tests whether fecal microbiota transplantation (FMT) can help children and young adults with autism who also have stomach issues. FMT involves transferring healthy donor stool into the patient's gut via colonoscopy. Researchers will track changes in gut and autism symp…

This early-stage study tests an experimental drug called LY3938577 in healthy volunteers and people with type 1 diabetes. The main goals are to see how the body processes the drug and whether it can safely lower blood sugar. The study has four parts, comparing the drug to insulin…

This study tests a new rehabilitation program for people with recent spinal cord injuries (within 1-5 months). Participants walk on a downhill treadmill while receiving electrical stimulation to their leg and trunk muscles. The goal is to improve walking and movement. Researchers…

This early-stage trial tests an experimental weight loss pill called BGM0504 in 75 healthy and overweight or obese Chinese adults. Participants will receive either the drug or a placebo to check for side effects and measure weight changes over 8 weeks. The goal is to see if the d…

This study tests whether adding lactase enzyme drops to breast milk or formula helps premature babies (born at 28-34 weeks) gain weight. Many preemies lack enough lactase to digest lactose, which can cause diarrhea and slow growth. In this double-blind trial, 100 newborns will re…

This early-stage study tests a new injection called [18F]LY4214835 to see if it is safe and how it spreads in the body. It includes healthy volunteers and people with cancer. The goal is to improve how doctors see tumors using imaging scans.

This study looks at how stable certain biomarkers (like RNA and proteins) are in healthy volunteers. Researchers want to see if things like age, gender, or eating affect these markers. The goal is to make future diagnostic tests more reliable. The study involves 60 healthy adults…

This study is testing a device called Inflammacheck that measures chemicals in a person's breath to see if it can help tell the difference between lung cancer, other lung diseases, and healthy lungs. Researchers will collect breath samples from 140 adults and use AI to build a di…

This study is testing whether special light-based scans (photoacoustic imaging and diffuse reflectance spectroscopy) can tell the difference between healthy, benign, and malignant breast tissue. Researchers will scan 90 women with known breast lumps and compare the scan results t…

This study is testing a new automated MRI method to see if it can take clearer pictures of the liver. It will include up to 200 adults (and some children age 7+) who are healthy, have known or suspected liver disease, or have iron overload. Participants will have one MRI scan, an…

This study explores a new blood test that looks for DNA fragments from damaged heart cells to detect active heart inflammation in people with sarcoidosis. Researchers will compare results from 120 participants, including healthy volunteers and those with known heart conditions. I…

This pilot study tests a new device called the Retro-TCE capsule, which is a small camera attached to a string that is inserted into the lower gut to take pictures without needing sedation. The study will enroll 30 people, including healthy volunteers and those with Lynch syndrom…

This study is testing a portable ultrasound device called POROUS R4C that measures bone in the lower leg without radiation. Researchers want to see if it can estimate bone mineral density as accurately as the standard X-ray method (DXA). The study will include 350 healthy men and…

This study compares a new wrist-worn device (ViTrack) that measures blood pressure without a cuff to traditional arm-cuff devices. About 91 healthy volunteers with normal or high blood pressure will have their readings compared. The goal is to see if the wrist wearable is accurat…

This study is looking at whether it's safe and effective to give the Tdap vaccine (for whooping cough) and the RSV vaccine at the same doctor's visit during pregnancy, or if they should be given separately. The researchers will recruit 60 healthy pregnant individuals and randomly…

This study tests a 9-month program called NE+ for American Indian youth aged 12-18. The program includes educational modules and cultural teachings to encourage abstinence, condom use, and avoid substance use. It also involves parents and school staff. The goal is to see if the p…

This study is testing a program to help Latinx caregivers supervise their young children more closely to prevent accidental injuries. Researchers will work with 100 families in Southwest Michigan, using group sessions and videos to teach supervision skills. The goal is to see if …

This study tests whether a chatbot that uses motivational interviewing can help college students with anhedonia (loss of interest or pleasure) feel more emotional arousal. Eighty participants will interact with the chatbot or a control version, and their brain activity will be sc…

This study tests whether a chatbot that uses motivational interviewing can help college students with anhedonia (loss of interest or pleasure) update their beliefs in a more positive way. 80 participants will interact with the chatbot or a control version over several sessions. T…

This study tests whether a chatbot that uses motivational interviewing can improve how people with anhedonia (loss of interest or pleasure) respond to social rewards. Eighty college students with elevated depression and anhedonia will interact with the chatbot regularly over a pe…

This study tests whether a friendly chatbot that uses motivational interviewing can change brain activity in people with anhedonia (loss of pleasure). Eighty college students with high anhedonia and depression symptoms will chat with the bot regularly for a few weeks. Brain scans…

This study explores whether an 8-week virtual mindful self-compassion program is practical and well-received by transgender and nonbinary young adults. Participants attend weekly 2.5-hour online classes plus a 4-hour retreat, practice daily exercises, and complete surveys over se…

This study looks at whether drinking beetroot juice every day for 12 weeks can help postmenopausal women get more heart and blood vessel benefits from exercise. The researchers will compare two groups of women doing the same exercise program—one group gets real beetroot juice, th…

This study tests whether a drink containing caprylic acid and omega-3 fatty acids can help muscles recover strength after a tough workout. Twenty-eight healthy young men will take the supplement for seven days and do a muscle-damaging exercise. Researchers will measure muscle str…

This study tests whether adding polyphenol-rich beans and lentils to the daily diet can improve skin health in women aged 45-65. Over 12 weeks, 50 women will eat either pulses or white rice, and researchers will measure skin sensitivity to UV light, moisture loss, and redness. Th…

This study tests if a new type of laser (DFG laser) causes less pain and helps skin heal faster than the standard CO2 laser. About 23 healthy adults will receive both lasers on small skin areas and report their pain levels. Researchers will also take photos and use imaging to tra…

This early-stage study is testing an experimental drug called LY4064912 in 144 healthy volunteers and people with overweight or obesity. The main goal is to check safety and how the body handles the drug, not yet to prove it works for weight loss. Participants will receive either…

This study tests whether offering a prize after a medical procedure can reduce anxiety in children aged 6-17. About 187 kids will get standard support from a child life specialist, and some will also be offered a prize if they meet a coping goal. Researchers will compare anxiety …

This study looks at whether drinking an olive extract (OliPhenolia) for eight days can increase how much fat people burn during cycling. It also tests if adding caffeine before exercise boosts that effect. The trial involves 40 healthy, recreationally active adults and compares t…

This study tests a 16-week group exercise program called the Ideomotor Program in 158 healthy adults aged 50 and older. The program combines physical and mental exercises to see if it improves thinking, movement, and overall well-being. Participants will be compared to a group do…

This early-stage study tests a new drug called LY4057996 in 124 healthy volunteers and people with type 1 or type 2 diabetes. The main goal is to see if the drug is safe and what side effects it may cause. Participants receive the drug as a shot under the skin or into a vein, and…

This study tests whether taking Bragg apple cider vinegar before a high-carb meal can lower blood sugar spikes in healthy adults aged 20-50. Participants will drink either vinegar or water, then have blood drawn to measure glucose and insulin. The goal is to see if vinegar helps …

This study tests a new virtual reality system that combines mirror therapy with interactive games to help people recover arm movement after a stroke. Researchers will enroll 172 participants, including both healthy individuals and stroke survivors, to see if the system is comfort…

This study tests whether training the muscles you use to breathe in can improve strength and exercise performance in amateur CrossFit athletes. 94 healthy adults aged 18-60 who do CrossFit will either do breathing training with a special device plus their usual workouts, or use a…

This pilot study is testing whether a multi-strain probiotic supplement called Smile Probio 45B is easy for healthy adults to take and whether it helps with digestion, fatigue, and quality of life. Forty healthy adults will take the probiotic daily for 30 days, starting with one …

This study tests whether a krill oil supplement called Lysoveta can improve memory in healthy adults aged 50 to 75 who feel their memory is slipping. Participants take either Lysoveta or a placebo daily for 112 days and complete computer-based memory tests and mood questionnaires…

This study looks at whether being mobile during labor helps first-time mothers have better birth outcomes, like fewer unplanned C-sections. About 714 low-risk women will either get standard care or use a special mobility system. Researchers will track labor length, pain medicatio…

This study tests whether eating grapes rich in flavonoids can protect brain blood flow, thinking, and blood vessel health during mental stress. 44 healthy young adults will consume either a high-flavonoid grape powder or a low-flavonoid placebo before a stress task. The goal is t…

This study tests whether a closed incision negative pressure wound therapy (ciNPWT) device can reduce wound complications after breast reduction surgery. 92 women will have one breast treated with the device and the other with standard adhesive strips. The goal is to see if the d…

This study is testing whether a dietary supplement called citicoline can improve mood in healthy adults who are experiencing moderate mood disturbances. Researchers will give 90 participants either citicoline or a placebo daily and measure changes in mood, sleep quality, stress, …

This early-stage study will give 30 healthy volunteers single doses of two experimental drugs, MK-7262 and enlicitide, to see how they affect each other's levels in the blood. The goal is purely to understand how the drugs interact, not to treat any disease. Results will guide fu…

This study tests a new radioactive tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. Researchers will compare scans from 90 volunteers (patients and healthy older adults) to understand how inflammation relates to m…

This study looks at whether a teacher-led program called the Early Childhood Friendship Project can help preschoolers be less aggressive and more kind. About 600 children from diverse backgrounds will take part. Researchers will measure changes in behavior, thinking skills, and e…

This study investigates why a low-carb, high-fat (ketogenic) diet raises 'bad' cholesterol in some people but not others, and how it affects blood sugar. Twenty healthy adults will follow both a ketogenic diet and a standard diet for 24 hours, repeating each three times. The goal…

This study tests a new radioactive tracer called [11C]ZTP-1 to see if it can measure a protein called PDE4B in the brain and body. PDE4B helps control inflammation and brain signals. Forty healthy adults will get the tracer and have PET/CT scans. The goal is to see if this tracer…

This study looks at whether adding a website and virtual coaching to basic activity tracking can help older adults who live alone, have mild memory concerns, and are not very active. 86 participants will wear a Garmin device, set step goals, and get weekly texts. Half will also g…

This study looks at how being overweight or obese changes blood pressure during different breathing tasks and exercise. Researchers at Florida State University will measure blood pressure in 80 healthy adults at rest and during aerobic and breathing muscle tests. The goal is to b…

This study compares kidney blood flow during exercise in healthy young African American and White adults. Researchers want to see if African Americans have a larger drop in kidney blood flow during physical activity, which could help explain higher rates of heart and kidney disea…

This early-phase study tests a new radioactive tracer called [18F]-fluoromannitol in 10 healthy adults. The tracer is designed to light up infections on PET scans. Researchers will check its safety and how it spreads through the body. If all goes well, it may later be tested in p…

This study at the University of Michigan is recruiting 500 incoming freshmen to understand why some people are more vulnerable to stress while others bounce back easily. Participants will use a mindfulness app called Maya for 6 weeks, wear a Fitbit for a year, and provide samples…

This early-stage study tests a new drug called LY4088044 in healthy adults to see if it is safe and how the body handles it. About 104 participants will receive the drug or a placebo, either as a shot under the skin or into a vein. The study lasts up to 92 weeks and focuses on si…

This study explores whether a specific type of acupuncture, called electroacupuncture, can increase bowel activity in healthy volunteers. Researchers will use a digital stethoscope to listen to bowel sounds before, during, and after the procedure. The goal is to see if stimulatin…

This early-stage study will test how eltrekibart, an experimental drug, is absorbed when injected under the skin compared to when given through a vein. Sixty healthy adults will receive a single dose and be monitored for about 17 weeks. The goal is to gather safety and absorption…

This study uses a homemade device with electrodes placed on the belly to record electrical signals from the stomach and intestines. Researchers will compare these signals in healthy volunteers, people with Crohn's disease (with or without fibrosis), and people with functional gas…

This study aims to improve how MRI scans are done by testing new imaging techniques on up to 1,000 healthy volunteers and people with cardiac risk factors. Participants will have one or more MRI scans over a few years, with some receiving a contrast dye. The goal is to refine cur…

This early-phase trial is testing a new drug called LY4515100 in 40 healthy adults to see if it is safe and how the body handles it. Participants will receive either the drug or a placebo and stay overnight for monitoring. The study does not aim to treat any disease, but to gathe…

This study aims to discover what factors help keep the brain healthy as we age. It will follow up to 100,000 generally healthy adults over time, using online tests and surveys twice a year. Participants also get access to brain-training modules and optional coaching. The goal is …

This study looks at how the drug mirdametinib is absorbed and removed from the body in people with moderate or severe liver problems compared to those with normal liver function. It involves 32 adults and is for research only, not to treat any condition. The goal is to understand…

This study looks at whether brain scans can detect when a person is about to make a mistake during a typing task, up to one second in advance. Researchers will use MRI and MEG to record brain activity in 40 healthy right-handed adults aged 18 to 35. The goal is to understand how …

This study tests whether a gentle brain stimulation technique called transcranial electrical stimulation (TES) can help people quickly reach a meditative state—normally achieved only after years of training. 48 healthy adults who have never meditated will wear an EEG cap and rece…

This study tests whether a virtual reality (VR) program can help nursing students learn how to counsel day surgery patients. Sixty nursing students will either receive the VR training or standard education. The goal is to see if the VR approach is feasible and acceptable, not yet…

This study will test whether using essential oils (by smelling, applying to skin, or swallowing capsules) can improve immune health in healthy adults aged 18 to 45. Forty participants will use either the oils or a placebo for 30 days. Researchers will measure changes in blood, sa…

This study tests a new radioactive tracer called 11C-JMJ-129 to see how well it can image a protein called PDE4D in the brain and body of healthy volunteers. PDE4D is linked to thinking and mood, and may play a role in disorders like Alzheimer's and depression. Researchers will a…

This study is testing new methods and technologies to improve the quality and comfort of MRI scans. It involves 720 healthy volunteers and people with various medical conditions. Researchers will compare images from the new techniques to standard MRI to see if they are clearer an…

This study at Mayo Clinic compares 50 people who have had SCAD (a tear in a heart artery) with healthy volunteers. Researchers measure artery stiffness, thickness, and how the 'fight or flight' nervous system responds to stress. The goal is to understand what might cause SCAD, no…

This study aims to improve MRI technology for imaging the brain. Researchers will test new scanning methods on 1,100 healthy adults aged 18 and older. Participants will have yearly MRI scans and may perform simple tasks like listening to sounds or tapping fingers. The goal is to …

This study uses a special real-time MRI technique to watch how the jaw joint moves in healthy people and in those with temporomandibular joint (TMJ) disorders. By comparing the motion patterns, researchers hope to better understand what goes wrong in TMJ disorders. The study invo…

This early-stage trial is testing a new drug, LH-001, in 56 healthy adults aged 18 to 60. The goal is to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and measure drug levels …

This early-phase trial is testing the safety and tolerability of a new drug called LY4302814 in 150 healthy volunteers. Participants will receive either the drug or a placebo, and researchers will monitor side effects and how the body processes the drug. The study lasts about 6 m…

This study looks at how the experimental drug PF-08049820 is absorbed in healthy adults. It tests three different forms of the drug, taken with or without food, and also with another drug that reduces stomach acid. The goal is to understand the best way to give the drug in future…

This research study examines how brain activity changes during emotional and thinking tasks in people with depression and healthy volunteers. Using brain scans (EEG, fMRI) and mild brain stimulation (TMS), researchers aim to understand the brain circuits involved in mood and suic…

This study looks at whether the amount of melanin in your skin changes how much nicotine from thirdhand smoke gets into your body. Researchers will measure nicotine in blood and urine after skin exposure. The goal is to understand how skin pigment affects chemical uptake, not to …

This study looks at how the antifungal drug itraconazole changes the way the body handles an experimental drug called LY4395089. Fourteen healthy adults will stay at a research unit for 15 visits over about 2 weeks, and blood tests will measure drug levels. The results will help …

This early-phase study tests three different forms of the experimental drug LY4065967—a tablet and two types of capsules—in 36 healthy adults. The goal is to measure how much and how fast each form gets into the bloodstream and to check for side effects. Participants will stay at…

This study looks at how secondhand cannabis smoke affects healthy nonsmokers. Researchers will measure cannabis byproducts in urine before and after exposure in public places. The goal is to understand how much of the smoke's chemicals enter the body. This is a small pilot study …

This early-stage trial is testing a new drug called BI 3776528 in healthy men aged 18 to 50. The main goal is to see if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo. This study does not aim to treat any disease.

This study looks at how differences in personality, brain activity, and behavior may make some young adults more likely to use substances like cannabis. Researchers will track eye movements and brain scans in 294 people aged 18-22. No treatment or medication is involved—the goal …

This study looks at the bacteria living on the skin and in the gut of 100 adults with and without vitiligo. Researchers want to see if people with active or stable vitiligo have different bacteria compared to healthy volunteers. No treatments or drugs are given—just samples colle…

This early-stage trial enrolls 20 healthy adults to compare how two different capsule forms of the drug varegacestat are absorbed by the body. Participants will receive both forms in a random order under fasting conditions. The study measures drug levels in the blood and checks f…

This study looks at how eating cloudberries and lingonberries affects tiny particles called extracellular vesicles, which cells use to communicate. Sixty healthy adults will eat these berries daily for a week. Researchers will check changes in gut bacteria, immune cells, and bloo…

This study looks at how a single dose of the experimental drug BI 1291583 behaves in the blood of people with and without liver problems. The drug is being developed for bronchiectasis, a chronic lung disease. About 32 adults aged 18–80 will take part, divided into groups based o…

This study is for 60 healthy adults to see how the body processes two medicines—enlicitide and rosuvastatin—when taken as separate pills versus combined into one tablet. Researchers will measure drug levels in the blood over time and check for any side effects. The goal is to und…

This study collects blood or apheresis samples from 24 people with solid tumors and healthy volunteers. Researchers will analyze immune cells to see how they respond to a neoantigen vaccine, which is designed to help the immune system recognize cancer. The goal is to learn how to…

This early-stage study is testing an inhaled drug called RB042 for the first time in humans. Researchers want to see if it is safe and how the body handles it. The study includes 90 healthy adults, some of whom are smokers. Participants will receive either RB042 or a placebo thro…

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This pilot study looks at how heat stress and fatigue affect a person's ability to perform two tasks at once, like walking while doing math. Ten healthy adults will walk in a heat chamber until their body temperature reaches 39°C, then complete balance and memory tests. The goal …

This study looks at how smoking cigarettes and the time of day change a type of white blood cell called eosinophils. Researchers will compare chronic smokers (who smoke at least 8 cigarettes daily) with non-smokers, all healthy adults aged 18-50. Smokers will have blood tests on …

This early-stage study tests how a single dose of MK-8527 changes the way methadone moves through the body. It involves 14 healthy adults and aims to measure methadone levels over 24 hours. The results will help understand if MK-8527 affects methadone, which is important for futu…

This early-stage study is testing an experimental oral drug called LY3867070 in 196 healthy volunteers. The main goal is to see if the drug is safe and what side effects it might cause. Researchers will also measure how the body processes the drug. This is a first step to see if …

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. Researchers want to see if those with pain and fatigue have higher levels of brain inflammation. The study does not …

This study aims to develop a method to adjust the strength of transcranial focused ultrasound (tFUS) for each person. Researchers will test how tFUS affects vision in 30 healthy adults aged 18-70. The goal is to find the right dose for each individual to make future treatments mo…

This study aims to find out if people who get calcium oxalate kidney stones produce more oxalate in their bodies than healthy people. Researchers will compare 80 adults—some with a history of stones and some without—after they eat a special low-oxalate diet and take small amounts…

This study aims to find out if people who get calcium oxalate kidney stones absorb more oxalate from food than healthy people. Researchers will compare stone formers and healthy volunteers by having them eat special diets and measuring oxalate in urine, blood, and stool. The goal…

This study tests whether taking a monosaccharide powder (a type of sugar) can change how immune system proteins are modified in healthy adults. Researchers will analyze blood samples from 44 participants to look for changes in antibody structure. The study is placebo-controlled, …

This study aims to understand how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 healthy volunteers and those at higher risk for type 2 diabetes. Participants receive medi…

This early-stage study tests a new medicine, PF-08057418, in healthy adults to see if it is safe and how the body processes it. Eight participants will receive single doses (as a solution or tablet) once a week for 5 weeks. The study is not intended to treat any disease, but to g…

This study investigates whether abnormal insulin action in the brain contributes to cognitive and metabolic problems in schizophrenia. Twenty participants (some with schizophrenia, some healthy) will receive either intranasal insulin or a placebo before a PET scan that measures b…

This early-stage trial is testing a new drug called BI 3814916 in 136 healthy adults to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and measure drug levels in the blood. Thi…

This study explores whether a non-invasive brain stimulation technique can help people quickly achieve a deep meditative state, normally only reached after years of training. About 22 healthy adults who already meditate will wear an EEG cap and receive brain stimulation while per…

This early-stage study by Pfizer looks at how different levels of liver function affect the processing of a new drug called PF-07328948. About 26 adults with and without liver impairment will take a single tablet and stay at the clinic for 6 days for monitoring and blood tests. T…

This early-stage study is testing a new drug called BI 3031185 in 100 healthy adults to see if it is safe and how the body handles it. Participants will take multiple doses of the drug or a placebo. The goal is to gather safety information, not to treat any disease.

This study looks at how difficult childhood experiences might affect memory and brain function in people with opioid use disorder. Researchers will use brain scans and memory tests to compare three groups: people with opioid use disorder on buprenorphine, people without the disor…

This study tests whether a low-dose fisetin supplement (100 mg daily for 7 weeks) is safe and can reduce signs of inflammation and aging in healthy adults aged 50 and older. Researchers will measure changes in blood markers and track side effects. The goal is to see if this suppl…

This early-stage study tests the safety and how the body handles a new drug called AZD1613. About 136 healthy adults, including those of Japanese and Chinese descent, will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels in the b…

This early-stage study in 450 healthy volunteers checks if a single injection of mirikizumab works as well as two separate shots. The main goal is to see how the body handles the drug and to ensure safety. Participants will be monitored for about 15 weeks with blood tests and che…

This study looks at whether carbon fiber insoles can improve vertical jump and sprint speed in healthy, moderately active men aged 18-30. Participants will perform tests with and without the insoles to compare results. The goal is to gather data on performance, not to treat or cu…

This early-stage study is recruiting 44 adults aged 18 to 80, including both healthy people and those with liver problems. All participants will take a single tablet of the drug BI 3000202. Researchers will measure how the drug moves through the body and check for side effects ov…

This study uses EEG (a non-invasive brain wave test) to find patterns in the brain that might predict how chronic low back pain changes over time. Researchers will track 130 adults with chronic low back pain and healthy volunteers for up to 5 months. The goal is to develop better…

This study tests whether two different injector pens deliver the same amount of Genotropin (a growth hormone) into the blood. About 26 healthy adults aged 18 to 60 will receive a single shot with each pen and have blood samples taken. The goal is to see if the pens work equally w…

This study looks at how growth hormone affects beta-cells, which make insulin, in people with a family history of type 2 diabetes. Researchers will compare 30 obese adults with and without a family history of diabetes. The goal is to better understand why some people develop diab…

This early-phase study is testing the safety and how the body handles a new oral drug called AS-S603, which is being developed to treat Alzheimer's disease. The trial involves 88 healthy volunteers, including Korean and Caucasian adults and Korean elderly people. Participants wil…

This study looks at how growth hormone affects beta-cells, which make insulin to control blood sugar, in women who had gestational diabetes. Researchers will compare women with and without a history of gestational diabetes to better understand risk factors. The goal is to learn m…

This study looks at how the medicine PF-07328948 moves through the body in adults with different levels of kidney function. About 28 people aged 18 to 80, with either normal kidneys or moderate-to-severe kidney problems, will take a single tablet. Researchers will check safety an…

This early-stage trial checks whether a single dose of vicadrostat changes heart rhythm in 45 healthy adults. Participants receive vicadrostat, placebo, and moxifloxacin (a known heart-rate-affecting drug) in random order. The goal is to see if vicadrostat is safe for the heart b…

This study looks at how well healthy adults can stick out and lift their tongues. Researchers will measure tongue strength and how long people can hold the position. They will also check if these tongue skills are linked to handgrip strength, breathing muscles, and risk for sleep…

This study is collecting health information, lifestyle data, and biological samples from up to 100,000 adults to help researchers better understand diseases like lupus, celiac disease, and kidney disease. Participants provide data and samples through a direct-to-patient platform.…

This study tests a new portable CPAP device designed to help people with sudden breathing failure before they reach the hospital. Researchers want to see if the device is easy enough for non-medical people to use correctly. The study involves 50 participants: healthy older adults…

This study tests whether intermittent fasting—fasting for 16 hours and eating within an 8-hour window—can help healthy adults lose body fat and feel better. Researchers will measure body fat percentage and visceral fat, and track quality of life. The study involves 70 healthy par…

This early-stage study tests the safety of a new drug called CAY001 in 24 healthy adults aged 18-50. Participants receive a single dose of the drug or a placebo by IV, and researchers monitor them for 28 days for side effects and how the drug moves through the body. The goal is s…

Researchers at the University of Pittsburgh are testing whether a short, non-invasive brain stimulation technique called continuous theta burst stimulation (cTBS) can alter emotional and physical responses to stress. Fifty-five healthy adults will receive both real and sham stimu…

This study at Mayo Clinic enrolls 50 healthy adults to provide comparison data for the Adult Congenital Heart Disease Registry. Participants undergo an MRI and a test measuring blood pressure in the lungs during exercise. The goal is to better understand heart and lung function i…

This study is for healthy men aged 18-64 to see how the experimental drug PF-07328948 is absorbed and removed from the body. Participants will take the drug by mouth and by injection, and provide blood, urine, and stool samples. The study does not aim to treat any disease, just t…

This study tests whether telemedicine can effectively educate and counsel people considering living kidney donation. Researchers will compare standard in-person care with live video visits. The goal is to see if telemedicine is practical and helps donors make better decisions.

This study looks at how healthy adults' brains keep track of both the emotional content and the duration of emotional events. Researchers will use brain scans (fMRI) and a technique called TMS to understand which brain regions handle this information and help guide decisions. The…

This study aims to collect normal measurements of tongue strength and movement in 300 healthy children aged 4 to 17. Researchers will use a simple device to measure tongue pressure and check for tongue-tie restrictions. The results will help doctors better understand what is typi…

This study aims to understand whether blood flow in fat tissue changes as we age. Researchers will compare healthy younger adults (18-35) with older adults (65-80) by measuring blood flow and taking small fat samples. Participants will also drink a sugary drink to see how the bod…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders, such as spinal cord injury or stroke, control assistive devices using their thoughts. Researchers will record brain signals with EEG and use machine learning to interpr…

This study uses a special type of MRI called hyperpolarized xenon MRI to take detailed pictures of the lungs in 260 healthy young adults. The goal is to find early signs of lung damage that could lead to chronic lung disease later in life. Participants are already part of a large…

This study looks at whether listening to music while running changes the forces your feet exert on the ground. Forty healthy adults aged 18-35 will run on a special treadmill at different speeds, once with music and once with traffic noise. Researchers will measure foot pressure …

This study aims to better understand how many calories a person needs to eat to stay in energy balance, meaning their weight stays the same. Researchers will use a whole-room calorimeter, a special room that measures the energy your body burns, to get more accurate results than u…

This study tests whether a nasal spray containing oxytocin (the 'love hormone') can help healthy adults better control a brain region called the anterior insula, which is involved in body awareness and emotions. Participants will use real-time brain scans (fMRI) to learn to regul…

This early-phase trial is testing a new drug called BI 3821001 in 72 healthy men to see if it is safe and how the body processes it. Participants receive either a single rising dose of the drug or a placebo. The study focuses on side effects and drug levels in the blood, not on t…

This study collects small tissue samples from the abdomen of children and adults undergoing peritoneal dialysis (a type of kidney treatment). The goal is to learn how the lining of the belly changes over time with dialysis. Researchers will also take samples from healthy people h…

This early-stage study is testing whether a new drug called BLKR201 is safe for people. About 128 healthy adults will take either the drug or a placebo and stay at a research clinic for several days. Researchers will monitor side effects, measure how the drug moves through the bo…

This study looks at how physiotherapy students and their teachers rate non-technical skills like teamwork, leadership, and communication during clinical simulations. About 100 second-year students with no real patient experience will take part in nine simulation sessions. The goa…

This study looks at whether doing sprint interval training during different phases of the menstrual cycle (follicular vs. luteal) changes how well your body adapts. Researchers will measure endurance performance and muscle changes in 24 healthy women who exercise regularly. The g…

This study recruits 360 healthy young people aged 6-20 to measure how many steps per minute match different walking intensities. Researchers will use this data to create clear, step-based guidelines for physical activity that kids, parents, and doctors can easily understand and u…

This study aims to find early signs of Parkinson's disease in people who carry a change in the GBA1 gene, which puts them at higher risk. Researchers will use simple, non-invasive tests to check for subtle changes in movement, thinking, sleep, and other functions that can appear …

This early-phase trial is testing a new drug called M5542 in 49 healthy adults to see if it is safe and how the body processes it. Participants receive a single injection of either M5542 or a placebo. The study is currently recruiting.

This early-phase study tests the safety and tolerability of a new drug called SYNT-101 in healthy adults and those who are overweight or have obesity. About 64 participants will receive either the drug or a placebo. The main goal is to check for side effects and how the drug move…

This study follows healthy women who are trying to get pregnant, as well as women who are not, to collect samples and learn about the molecular signals between mother and embryo during the first two weeks after fertilization. Researchers will compare cycles that lead to a full-te…

This study follows 120 college freshmen to see how a vegan, vegetarian, or omnivore diet affects their body weight, body fat, and the bacteria in their mouth and gut. Researchers will also check changes in saliva, urine, and blood markers. The goal is to understand how diet shape…

This study tests whether training your breathing muscles can also strengthen your tongue. Sixty healthy adults will use a breathing device for several weeks. Researchers will measure tongue strength and endurance before and after training. The goal is to see if there is a connect…

Researchers at the University of Oxford are studying how pimavanserin, a drug used for Parkinson's disease, affects memory, emotional processing, and decision-making in 80 healthy adults aged 18-45. By blocking a specific serotonin receptor, the study aims to better understand br…

This study aims to understand how the brain responds to magnetic stimulation when it is timed with natural brain waves. Researchers will test healthy adults and people who had a stroke at least 6 months ago. The goal is to find ways to make brain stimulation more effective for im…

This early-stage study is testing an investigational drug called PF-08653944 in 26 adults, some with healthy livers and others with mild to severe liver impairment. Researchers want to see how liver function affects the way the body processes the drug and whether it is safe. Part…

This early-stage study tests whether a new topical cream called JW0061 is safe for healthy adults. About 104 Korean and Caucasian volunteers will apply the cream or a placebo. Researchers will check for skin irritation, changes in blood pressure, heart rate, and lab results. This…

This pilot study is testing how different protein beverages affect amino acid levels and appetite hormones in healthy adults. Twenty-four participants will try several drinks in a random order. The goal is to see which drink leads to the best changes in appetite-related signals.

This early-phase trial tests whether a new drug called IMP761 is safe and tolerable in 79 healthy adults aged 18-55. Participants receive either IMP761 or a placebo intravenously, along with a harmless immune challenge (KLH) to see how the drug affects immune responses. The study…

This study tests whether teaching young adults to eat more potassium is easier and better for their blood vessels than telling them to cut back on salt. Researchers will compare two groups: one gets advice on boosting potassium-rich foods, the other on reducing sodium. They'll tr…

This study looks at whether breathing slowly (6 breaths per minute) lowers stress more than breathing at a normal pace or just resting. Healthy adults will practice a breathing method, then take a stress test involving cold water and math. Researchers will measure heart rate, str…

This study looks at how genetic differences in the CYP2C9 enzyme affect the way healthy volunteers process warfarin and similar drugs. Researchers will give participants single doses of one or more of these drugs and measure how their bodies break them down. The goal is to better…

This study aims to see if newly developed wearable sensors are comfortable and safe for healthy adults aged 18 to 99. Researchers will also check if these sensors accurately measure vital signs like heart rate and breathing compared to approved medical devices. The goal is to gat…

This study looks at how social media addiction might be linked to compulsive exercise in healthy university students aged 18-24. Researchers will use questionnaires to measure social media use and exercise behaviors. No treatment is given—this is purely observational.

This study tests whether a gentle electrical current applied to the brain (tACS) can improve hand movement in people who had a stroke more than 6 months ago. Researchers will use brain scans and EEG to see how the stimulation changes brain activity. 45 participants (including hea…

This study looks at whether eating dinner earlier in the evening, in sync with your body's internal clock, helps burn more fat and control blood sugar. Researchers will compare early versus late dinner in 32 adults—some healthy weight, some with obesity and prediabetes. Participa…

This study looks at whether doing the "Xuong tan lac than" exercise for 12 weeks can improve joint flexibility and muscle endurance in healthy adults. About 34 volunteers will do the exercise daily and get their movement and nerve function tested regularly. The goal is to underst…

This study is testing a new, smaller minitablet version of the drug obefazimod in 44 healthy adults aged 18 to 55. The goal is to see how the body absorbs the minitablet compared to the current capsule and to check if the minitablet tastes okay. Participants will take a single do…

This study uses special PET scans to look at two types of brain cells involved in inflammation in Alzheimer's disease. Researchers will give participants two different tracers to see microglia and astrocytes separately. The goal is to develop a method that can tell these cells ap…

This study explores whether combining a single dose of psilocybin (the active ingredient in magic mushrooms) with a gentle ear stimulation device can help people remember the insights they gain during the psychedelic experience for longer. Researchers will enroll 108 healthy adul…

This study is testing whether a bile acid supplement called 7-keto lithocholic acid (7-KLCA) can change the types of bacteria living in the gut and improve health markers like blood sugar and cholesterol. Researchers will give the supplement to 40 healthy adults aged 18 to 65 for…

This study looks at how the female sex hormone estradiol might change the way the spinal cord adapts. Researchers will use mild electrical stimulation to test nerve responses in 50 healthy young adults. The goal is to understand basic biology, not to treat any disease.

This early-stage study tests a new drug, DF5112, in 48 healthy adults to see if it is safe and how the body handles it. Participants receive a single dose of the drug or a placebo and are monitored for about a week in a clinic, with follow-up visits for a month. The goal is to ga…

This early-stage trial is testing a new drug called BI 3804379 in healthy adults to see if it is safe and how the body processes it. About 106 healthy men and women aged 18 to 65 will receive either the drug or a placebo as a shot under the skin. The study focuses on side effects…

This study looks at whether taking the blood pressure drug losartan changes how the antibiotic cephalexin works in the body. Twelve healthy volunteers will take both drugs at the same time, three hours apart, or cephalexin alone. Researchers will measure drug levels in blood and …

This study looks at how two drugs interact in healthy adults. In Part 1, researchers measure how itraconazole changes the levels of MK-2828 in the body. In Part 2, they see if taking MK-2828 multiple times affects how the body handles a single dose of midazolam. The goal is to ga…

This study looks at how blind people use a white cane to sense the world around them, not just to move. Researchers will test how well users can feel where a touch happens on the cane and measure brain activity during these tasks. The goal is to understand how the cane becomes an…

This study aims to improve diagnosis for people with rare genetic diseases whose standard genetic tests came back negative. Researchers will take a small skin sample and analyze RNA to find hidden genetic changes. The study involves 105 participants, including healthy volunteers …

This study takes small tissue samples from the rectum of people with irritable bowel syndrome (IBS) and healthy volunteers to measure how the nerves in the gut are working. Researchers will use special imaging and other lab techniques to see how these nerves respond to different …

This early-stage study tests a new medicine called PF-07985631, which may one day treat a kidney disease called IgA nephropathy. About 92 healthy adults will receive either the study drug or a placebo as an injection or IV. The main goal is to check safety and how the body proces…

This early-stage trial is testing how the body absorbs a single dose of aramchol, a drug being studied for liver disease. Researchers will give 32 healthy volunteers two different single doses of aramchol meglumine tablets and measure drug levels in their blood. The goal is to un…

This early-stage study tests a new medicine, PF-07985631, in healthy adults to check its safety and how the body processes it. The medicine is being developed for a kidney disease called IgA nephropathy. Participants receive either the drug or a placebo as a single injection and …

This study follows 100 infants and toddlers with either a high or low family risk of autism spectrum disorder (ASD). Researchers will track how prosocial behaviors—like helping and understanding others—develop, along with brain network changes measured by EEG and MRI. The goal is…

This study collects blood, tissue, and other samples from up to 10,000 people to create a biobank for research. The goal is to help scientists study the causes of diseases like cancer, heart disease, and diabetes. Participants provide samples and basic health data, but no treatme…

This study looks at how much harmful chemicals from fire smoke get into firefighters' bodies. Researchers will collect urine and cheek cell samples from 60 firefighters before and after they fight a structural fire. The goal is to measure changes in exposure levels and understand…

This early-phase trial is testing an experimental drug called HY6725 in 74 healthy adults to see if it is safe and how the body processes it. Participants receive either the drug or a placebo as a single injection or two injections one month apart. The study does not aim to treat…

This study examines how adults who carry the gene for phenylketonuria (PKU) but do not have the disease handle phenylalanine, a common amino acid. Researchers will give participants phenylalanine or a placebo and then use MRI scans and cognitive tests to measure brain activity, t…

This study looks at whether salbutamol, a common asthma medication, can improve exercise performance in non-asthmatic endurance athletes. Researchers will test if a select group of athletes with breathing limitations might benefit from the drug. The study involves 64 healthy, hig…

This study looks at brain changes in people who use cannabis heavily and want to quit. Researchers will use brain scans to measure a protein linked to brain cell connections, both before and after at least 4 weeks of not using cannabis. They will also test memory to see if brain …

This study tests a workshop called I CAN that teaches people how to work together to reduce cancer in their community. About 200 adults in Western New York will join to see if the program is practical and well-liked. The goal is to empower local action, not to treat or cure cance…

This early-stage study tests whether a new drug, HY8931, is safe and how the body processes it. Sixty healthy adults aged 18 to 45 will receive either the drug or a placebo. Participants will be monitored for up to 90 days after dosing.

This study looks at how the drug MK-1084 (calderasib) moves through the body in people with and without liver problems. Researchers will measure drug levels in the blood and check for side effects. About 58 adults will take a single dose and be monitored. The goal is to understan…

This study looks at how the heart works in healthy adults of different ages, both at rest and during exercise. Researchers will use a thin tube inserted into the heart to measure pressures and blood flow. The goal is to understand what is normal, which can help doctors better dia…

This study tests whether a mild electrical stimulation behind the ear (taVNS) can temporarily change insulin, C-peptide, and blood sugar levels in 30 healthy adults. Half will get real stimulation, half a sham. Researchers want to see if this nerve trick could one day lead to new…

This study is testing how growth hormone and liraglutide (a diabetes drug) affect appetite, energy use, and blood sugar in healthy adults and those with growth hormone deficiency. Forty participants will receive each treatment or placebo for 21 days, with blood tests and body mea…

This Phase 1 trial is testing the safety and tolerability of a new drug called SRK-439 in 76 healthy adults aged 18 to 55. Participants receive either a single or multiple doses of the drug or a placebo by injection. The study measures side effects, lab tests, and how the drug mo…

This early-stage study tests the safety of a new drug called LY4066708 in 104 healthy people. Researchers will measure how much drug enters the blood and brain, and how fast the body clears it. The study lasts up to 24 weeks and does not aim to treat any disease, but will help gu…

This study gives healthy adults a single dose of psilocybin (the active ingredient in magic mushrooms) or a placebo, then uses brain scans and thinking tasks to measure changes in thoughts and brain activity. The goal is to understand how the drug works, not to treat any disease.…

This study looks at how fast healthy adults convert EPA (an omega-3) into DHA, and whether biological sex or a specific gene (ELOVL2) influences this process. Participants take EPA supplements for 12 weeks and give blood samples. The goal is to understand individual differences i…

This study looks at how cooling the thigh muscle changes the way nerves control it. Researchers will use special sensors to measure muscle signals in 24 healthy adults aged 18-35. The goal is to see if this method works well, so they can plan larger studies later. No treatment is…

This study aims to find ways to detect cancer earlier by following 10,000 healthy adults for up to 20 years. Researchers will collect lifestyle data and blood samples to identify changes that happen before a cancer diagnosis. The goal is to improve early detection, when treatment…

This pilot study aims to see if a new method can measure how healthy bone marrow plasma cells use glutamine, an important nutrient. Twenty healthy adults will receive an intravenous infusion of a special labeled glutamine, followed by a bone marrow aspiration. The goal is to comp…

This study tests whether real-time brain imaging feedback can help healthy adults reduce the spontaneous return of fear memories. Forty participants will receive either active or sham neurofeedback while undergoing fMRI. The goal is to strengthen memory control by targeting conne…

This study is testing whether two common topical medications—a steroid (desonide) and an antifungal (ketoconazole)—change the types and amounts of bacteria living on healthy skin. Twenty-four adults will apply the creams twice daily for two weeks, and researchers will compare ski…

This study tests whether a non-invasive brain stimulation technique called HD-tDCS can improve hand movement in healthy older adults. Forty right-handed participants will receive either standard or personalized stimulation, plus brain scans. The goal is to see if customizing the …

This study looks at how healthy adults who regularly drink sweetened, caffeinated beverages feel after trying different versions. Participants will rate their feelings and have their body's responses measured. The goal is to understand the effects of these drinks, not to treat an…

This study looks at how the brain processes optimistic and pessimistic signals related to dopamine, a chemical that helps control movement and mood. Researchers will compare 70 people with Parkinson's disease and 70 healthy volunteers using brain scans while they play a reward-ba…

This early-stage study is testing a new drug called NSHO-101 in 24 healthy adults to see how the body handles it and whether it is safe. Participants will receive the drug and have their blood levels and any side effects monitored closely. This is a first step in human testing an…

This study gathers eye scan images from 180 people with healthy eyes or eye diseases like glaucoma and retinal disease. The goal is to collect data using a new optical coherence tomography (OCT) device called A10900. No treatment or medication is given. The information will help …

This study looks at whether measuring big toe strength can help doctors understand nerve damage caused by chemotherapy (called CIPN). Researchers will compare 30 people with CIPN to healthy adults using a special device called ToeScale. Participants will also answer questionnaire…

This study looks at how much protein male cyclists aged 65 and older need after a cycling workout. Researchers will use a safe, non-invasive method to measure protein needs. The goal is to improve dietary advice for active older adults. Eight healthy, experienced cyclists will ta…

This study tests whether continuous or intermittent real-time fMRI neurofeedback is better at helping healthy adults control a brain region called the anterior insula, which is involved in emotions and body awareness. Ninety participants will undergo either real or sham neurofeed…

This study looks at how small genetic changes influence molecules that naturally resolve inflammation. Researchers will analyze blood samples from 200 volunteers of Bangladeshi and Pakistani origin to understand why some people develop chronic inflammatory diseases like arthritis…

This study looks at how the brain, memory, thinking, and movement change over time in people with Lewy body disease, Alzheimer disease, and healthy volunteers. Researchers will use brain scans and brain-wave tests to learn more about these disorders. The goal is to better underst…

This study tests a 20-hour training course designed to improve how healthcare aides help elderly people eat safely. Researchers will enroll 150 students in long-term care programs in Taiwan and measure changes in their knowledge, attitudes, and behaviors before and after the trai…

This study is looking for 2,000 people who have a close family member with a blood cancer like multiple myeloma. The goal is to find early warning signs of the disease by collecting blood samples and health information over time. Participants will not receive any treatment, but t…

This study explores whether a training program that mixes cognitive tasks (like memory and attention exercises) with physical therapy can improve recovery in people with post-stroke cognitive impairment or Moyamoya disease. Researchers will also use brain imaging to see how think…

This early-stage study tests the safety and tolerability of an investigational drug called ZT003 in healthy adults and those who are overweight or obese. About 76 participants will receive either the drug or a placebo to check for side effects and how the drug moves through the b…

This study uses a special brain scan (PET) to measure the density of connections between brain cells in people with psychotic disorders (like schizophrenia) or cannabis use disorder, compared to healthy volunteers. The goal is to understand how brain connection changes relate to …

This study tests whether healthy adults can learn to control a part of their brain linked to worrying about future events. Participants will receive real-time feedback from an MRI scanner to try to change their brain activity. The goal is to see if this training can reduce feelin…

This study is testing whether wearable devices like smartwatches can accurately track movement problems in people with Huntington's disease. About 100 participants, including those with Huntington's and healthy volunteers, will wear sensors and complete surveys and interviews at …

This early-stage study tests a new drug, CM383, in 30 healthy adult men. The goal is to see how the drug moves through the body and check for side effects. Participants receive a single dose either by injection under the skin or into a vein. This study does not aim to treat any d…

This study looks at how different caffeinated drinks change how you feel and your body's responses. About 150 healthy adults who regularly drink caffeine will try their usual drink and a test drink. They'll rate their feelings and use a wearable device to track body signals.

This small study in 12 healthy volunteers aims to see if biological sex influences how quickly people recover from a sedative called dexmedetomidine. Researchers will also test whether a brain measurement technique (TMS-EEG) can safely track brain activity during sedation without…

This study aims to understand what causes Visual Snow Syndrome (VSS), a condition where people see constant flickering dots across their vision. Researchers will use brain scans and visual tests to find which brain pathways are involved. About 100 adults with VSS, migraine, or he…

This study investigates whether adding natural variability (fractal-like patterns) to metronome-paced strength training leads to faster and better brain adaptations compared to standard pacing. Sixty healthy adults aged 18-40 will perform leg extension exercises three times a wee…

This study looks at whether brain activity tests can tell if it's safe for people with depression to stop taking antidepressants. About 204 people will have brain scans, sleep tests, and blood draws to see if their brains return to normal with treatment. The goal is to find a way…

This observational study looks at how gut bacteria relate to brain structure and function in healthy aging and in people with early Alzheimer's, Parkinson's, or multiple sclerosis. Researchers will use brain scans, stool samples, blood tests, and cognitive assessments in 200 part…

This study tests whether taking the probiotic Lactobacillus rhamnosus GG (found in Culturelle) can prevent or reverse changes in gut bacteria caused by the acid reflux drug omeprazole. Researchers will give 30 healthy adults omeprazole plus either the probiotic or a placebo for s…

This study looks at how a 30-minute exercise session changes hunger and appetite-related hormones in healthy men who are also eating fewer calories. Researchers will compare three groups: one with normal eating, one with severe calorie restriction, and one with severe calorie res…

This study tests whether adding different textures to infant rice cereal helps babies aged 6 to 24 months develop better chewing and mouth movements. About 153 healthy infants will be split into groups, each receiving cereal with specific textures suited to their age. Researchers…

This study tests new MRI software to see if it can make image-guided tumor ablation procedures more precise. Researchers will compare the new sequences to standard ones in 100 healthy volunteers and patients already scheduled for ablation. The goal is to improve targeting, treatm…

This study aims to find the best way to record electrical signals from the stomach to the brain using a non-invasive technique called transcranial magnetic stimulation (TMS). Researchers will test different stimulation settings in 155 healthy adults to see what works best. The go…

This study is testing whether taking a daily carotenoid supplement for 3 months can improve retinal health in healthy adults aged 18-75. Researchers will measure changes in macular pigment, retinal thickness, blood flow, and vision, as well as cognitive function. Participants are…

This study looks at how short (10 minutes) and longer (30 minutes) exercise sessions affect appetite, hunger-related hormones, and how much food healthy men eat after a meal. Researchers will compare these exercise sessions to a no-exercise control group. The goal is to understan…

This study is checking how well the Owlet OSS 3.0-M1 sensor measures pulse rate and blood oxygen levels in 90 healthy children aged 19 months to 5 years. The sensor readings will be compared to a standard hospital monitor. The goal is to see if the Owlet device is accurate enough…

This early-stage study is testing a new eye drop called BT01001 in 32 healthy adults to see if it is safe and how the body processes it. Participants will receive either the eye drop or a placebo (inactive drop) and be monitored for side effects. Since this is a Phase 1 trial in …

This study checks if special sensors can reliably measure forces inside carbon fiber ankle-foot braces (orthoses). Researchers will test healthy volunteers and people with or without neuropathy who already use such braces. Participants will walk, sit, and stand while sensors reco…

This study looks at whether current protein recommendations for children ages 8-10 are too low, especially for those who are very active and fit. Researchers will measure how the body uses protein in 30 healthy kids with different activity levels. The goal is to better understand…

This early-stage study tests whether a new inhaled drug called CPD704 is safe and how the body processes it. It involves 90 healthy Chinese adults aged 18-55. Participants receive single or multiple doses via inhalation and are monitored for side effects and drug levels in the bl…

This study looks at how a single session of moderate or high-intensity exercise changes blood vessel function in healthy people and those with slightly high blood pressure. 45 adults will do three separate sessions: rest, moderate exercise, and high-intensity interval exercise. R…

This study tests whether a low-methionine diet can change the gut microbiome and reduce inflammation in 40 healthy adults. Participants follow a plant-based, low-methionine diet for several weeks, with some also taking methionine supplements or a placebo. Researchers will measure…

This study aims to see if healthy older African American adults have a larger drop in kidney blood flow during exercise compared to White adults. Twelve participants will do cycling, a cold hand test, and mental math while researchers measure kidney blood flow. The goal is to und…

This study looks at how breathing exercises at different effort levels affect oxygen in the chest muscles of healthy adults. About 27 physically active volunteers will do breathing training sessions while their muscle oxygen is measured. The goal is to understand the body's respo…

This study is testing whether a mobile app called Flourish can improve well-being in college students. About 2,500 students will either use the app, use it with a buddy, or continue with their usual resources. Researchers will measure changes in mood, loneliness, and belonging th…

This study is checking if taking a supplement called palmitoylethanolamide (PEA) every day for a year is safe for healthy adults. About 200 volunteers aged 18 and older will take either PEA or a placebo pill. Researchers will track side effects, vital signs, and blood tests over …

This study aims to find out if children with primary ciliary dyskinesia (PCD) also have a condition called bronchial hyperresponsiveness, which makes airways overly sensitive. Researchers will compare 40 participants (those with PCD and healthy volunteers) using breathing tests. …

This study looks at how two natural compounds in food, oxalate and citrate, interact in the body and affect kidney stone formation. Researchers will measure changes in urine levels of these compounds after participants consume potassium citrate. The study includes 24 adults, some…

This study collects blood samples from 400 healthy adults aged 18 to 65 to understand how platelets work and cause inflammation and blood clots. Participants must not have taken blood thinners in the past 10 days and must not have blood diseases. The goal is to build a blood bank…

This study is testing whether taking oral sialic acid can change the types of bacteria living in the gut. Researchers will collect stool samples from 42 healthy volunteers before and after they take the supplement. The goal is to see if sialic acid can reduce harmful bacteria and…

This study looks at how a prebiotic fiber from chicory root (inulin) changes gut bacteria in healthy adults aged 18-45. Over 13 weeks, participants take either inulin or a placebo (maltodextrin) and provide stool and blood samples. Researchers track changes in Bifidobacterium and…

This study tests a 12-week mobile app program for parents of 3-4 year olds who currently meet few movement guidelines. Children wear activity trackers, and parents get weekly tips and goals through the app. The goal is to see if the app helps kids get more physical activity, bett…

This study looks at how drinking milk or eating yogurt affects thinking and memory in healthy children ages 9 to 14. Researchers will give kids different dairy snacks and test their attention, memory, and mood over two hours. The goal is to understand if dairy products can help k…

This study uses a weak electrical current applied to the scalp (tDCS) to see if it can improve attention and cognitive control in healthy adults and people with schizophrenia. Participants will perform thinking tasks while their brain activity is measured with EEG. The goal is to…

This study explores whether using a large language model AI (like ChatGPT) can improve the clinical reasoning skills of physical therapy students. Researchers will compare students who practice with the AI on realistic patient cases to those who follow the standard curriculum. Th…

This study from Stanford University is looking for 100 volunteers to help understand why people's blood sugar levels respond differently to the same foods. Participants will wear a continuous glucose monitor and test various meals, supplements, and short exercises. The goal is to…

This study looks at how a drug called LY3537031 moves through the body in people with mild, moderate, or severe liver problems compared to healthy volunteers. About 32 adults will receive a single injection under the skin. The goal is to understand how liver function affects drug…

This study gathers expert physical therapists to agree on when it's important to check vital signs like heart rate and blood pressure during outpatient therapy. About 100 experienced therapists will complete three rounds of surveys to build consensus. The goal is to create a deci…

This study tests a 21-day digital program that uses either meditation or music to prepare healthy volunteers for a supervised psilocybin session. Forty people will be randomly assigned to one of the two preparation methods. The main goal is to see if the program is feasible and e…

This study collects blood and skin samples from 200 people with eczema, food allergies, or neither. Researchers will analyze these samples to find shared genetic or biochemical signals. The goal is to better understand how these conditions are connected, which could lead to bette…

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 people with and without metabolic syndrome. The goal is to find biological markers that predict disease progression and help create personalized prevention and treatment plans. Particip…

This study looks at how stroke changes the way people move their arms when walking. Researchers will measure brain activity and muscle patterns in 84 people (some who had a stroke and some healthy) while they walk on a treadmill. The goal is to understand why arm swing is often a…

This study looks at how eating white potatoes at breakfast versus dinner changes blood sugar levels, hunger, and how many calories people eat later. Researchers want to see if potatoes can help control appetite better than other low-sugar carbs. The study involves 30 healthy adul…

This study is testing a new way to stimulate the brain using focused ultrasound, guided by brain wave recordings (EEG). The goal is to learn how to adjust the stimulation in real time for each person. About 80 healthy adults aged 18-64 will take part. This research is not a treat…

This study is testing a device called Electrical Impedance Tomography (EIT) that uses electrodes to create images of the lungs without radiation. Researchers want to see if it can provide useful information about lung function in children with chronic respiratory diseases, includ…

This study looks at how people who speak two languages or speak one language and sign another manage to switch between them. Researchers will have 360 healthy adults complete tasks like naming pictures or classifying words in different languages. The goal is to understand the men…

This study looks at how different areas of the brain communicate in healthy adults. Researchers use a safe, non-invasive technique called transcranial magnetic stimulation (TMS) along with EEG and MRI to measure brain activity. The goal is to better understand brain connectivity,…

This study checks how well a new algorithm can detect irregular heartbeats using sensors on the finger and wrist. It involves 120 healthy adults aged 18 to 80. The goal is to see if the device works accurately compared to a standard heart monitor.

This study looks at how the Q-Collar, a device already cleared by the FDA, changes brain blood flow in healthy adults during rest and exercise. Twenty participants aged 18 to 30 will do tasks like standing up quickly, breathing against resistance, and biking while their brain blo…

This study tests a new neck strengthening device called TopSpin360 in 60 junior hockey players. Researchers want to see if using the device can improve neck strength and measures of brain function, like reaction time and brain wave activity. The goal is to learn more about how ne…

This study uses a noninvasive device to stimulate a nerve in the ear and see how it changes brain and stomach activity. Researchers will use MRI scans to measure these effects in healthy adults and people with stomach discomfort. The goal is to better understand how the brain and…

This study is testing a new device called a wireless thermal capsule, which is swallowed and measures temperature as it travels through the digestive tract. The goal is to see if it can reliably detect small temperature changes that might indicate inflammation from diseases like …

This study tests a special microscope that takes live 3D images inside the eye during surgery. It aims to help surgeons see better when treating conditions like retinal detachment, macular holes, and cataracts. About 262 people will take part, including healthy volunteers and sur…

This study tests whether a single dose of oxytocin nasal spray changes how healthy adults escape from simulated predators in a virtual environment. Researchers will measure escape success, decision timing, and brain activity. The goal is to understand how oxytocin modulates defen…

This study compares a 9-week group cycling program (Cycle Nation) to a single training session to see which gets more adults cycling regularly. Participants are healthy adults who rarely cycle. The program includes skills training, group rides, and goal-setting. Researchers will …

This study investigates the reticulospinal system, an ancient part of the brain that controls posture, walking, and reaching. Researchers will use loud sounds and brain stimulation to test how this system works in healthy people and those with spinal cord injury. The goal is to u…

This study looks at whether eating grapes can help improve muscle strength and thinking skills in healthy women aged 65 and older. Participants will attend four sessions for muscle tests, cognitive tests, and blood draws. The goal is to see if a simple dietary change can support …

This study looks at whether a person's natural ability to focus and control their thoughts can predict how well they learn to control a specific brain region using real-time brain scans (fMRI). Forty healthy adults will practice a mental strategy while seeing their own brain acti…

This study tests whether a computer-animated character that explains medical illustrations helps people understand patient education materials better than looking at the pictures alone. Researchers will compare the character on a regular screen versus in virtual reality. The goal…

This study looks at how the brain's memory systems change from adolescence to adulthood. Healthy volunteers aged 13-25 will do memory tasks during brain scans. The goal is to understand how we form and connect memories, not to treat any disease.

This study looks at whether drinking beetroot juice, which is high in natural nitrate, before bed can change sleep patterns and how the brain controls blood flow. Researchers will give 60 healthy adults either active beetroot juice or a placebo and measure sleep stages, blood pre…

This study follows 800 mothers and their babies to see if how much a pregnant person sits, moves, and sleeps affects the child's weight and heart disease risk up to age 2. Researchers will track activity with monitors and measure baby growth. The goal is to find out if changing d…

This observational study collects vaginal and oral swab samples from 520 women to explore the microbiome and its link to health and discharge. Some participants also provide a Pap smear. The goal is to gather knowledge, not to test a treatment.

This Phase 1 trial is testing the safety and tolerability of a single dose of IBI3032 in 32 healthy adults. Participants are randomly assigned to receive either the drug or a placebo. The study is for research only and is not meant to treat any medical condition.

This study looks at brain MRI scans and genetic information from 2000 children (healthy and with developmental delays) to create computer models that can predict developmental disorders. The goal is to find patterns in brain structure and genes that explain these conditions. No n…

This study looks at how your gut and brain work together to control appetite. Researchers will place a temporary balloon in the stomach and give participants tasteless and tasty meals while scanning their brains with MRI. The goal is to understand the signals that make us feel fu…

This study will measure total energy expenditure in 240 healthy Chinese children and adults using the gold-standard doubly labelled water method. Researchers will also collect data on body measurements, blood tests, physical activity, and gut bacteria. The goal is to provide accu…

This study looks at whether the way older adults focus their attention during strength training affects how they walk. Forty-five healthy older adults will do calf raises for 4 weeks, either focusing on the muscle itself or on an external cue. Researchers will measure changes in …

This study looks at sleep problems in healthy Somali Americans and how they might raise the risk of high blood pressure. Researchers will use sleep studies and 24-hour blood pressure monitors on 240 adults. The goal is to find hidden sleep issues and understand their link to bloo…

This study uses a safe, non-invasive technique called transcranial direct current stimulation (tDCS) to apply a very weak electrical current to the scalp of healthy adults. Researchers will compare how younger (20-40) and older (60-80) participants perform computer tasks and how …

This early-stage trial is testing the safety of a single dose of HB0056, a new bispecific antibody, in 46 healthy adults aged 18 to 55. Participants are randomly assigned to receive either the drug or a placebo, and researchers will monitor for side effects and how the drug moves…

This study is testing whether people can use a home kit to collect blood samples and measure levels of urolithin A, a compound found in pomegranates and some supplements. 250 healthy adults aged 18-80 will take Mitopure or pomegranate juice and collect dried blood spots at home. …

This study uses special PET scans to measure brain synapse density in people with HIV who are on effective treatment. Researchers want to understand why some still develop thinking or memory problems. They will compare 70 participants (with and without HIV) over two years using b…