HEALTHY

This study tests a new vaccine called V118E that aims to prevent diseases caused by Streptococcus pneumoniae bacteria, such as pneumonia. Researchers want to see if the vaccine is safe and well-tolerated in 126 healthy adults. Participants will receive either the new vaccine or a…

This study tests a vaccine given to pregnant women to protect their babies from group B streptococcus (GBS), a bacteria that can cause serious illness in newborns. About 6,000 healthy pregnant women will receive either the GBS vaccine or a placebo (saltwater shot). Researchers wi…

This early-stage study is testing two experimental vaccines (V350A and V350B) designed to prevent diseases caused by the Epstein-Barr virus, such as mononucleosis and certain cancers. About 250 healthy adults and teens will receive either the vaccine or a placebo to check for sid…

This study tests a new dengue vaccine called V181 in 12,000 healthy children aged 2 to 17. The goal is to see if the vaccine is safe, triggers an immune response, and reduces cases of dengue fever from all four virus types. Participants will receive either the vaccine or a placeb…

This study is testing a new COVID-19 booster vaccine that is given as a nasal spray. Researchers want to see if it is safe and how well it triggers an immune response in the nose and body compared to a standard mRNA booster shot. The trial will involve healthy adults in France wh…

This study tests whether a weekly dose of everolimus (a drug similar to rapamycin), resistance training three times a week, or both together can improve bone and muscle health in women aged 60-75 who have lower-than-normal bone density. Participants will be randomly assigned to o…

This early-phase study is testing a new medicine called LY3938577 in healthy volunteers and people with type 1 diabetes. The main goals are to see how the drug moves through the body, how safe it is, and whether it can lower blood sugar. The study has four parts and compares the …

This early-stage study tests the safety and how the body handles a new drug called LY3549492 in 120 healthy adults who are overweight or have obesity. Participants will receive multiple doses of the drug and be monitored for about 8 weeks. The goal is to see if the drug is safe a…

This early-stage study tests a new drug called IBI3013 in healthy people and those with active vitiligo or severe alopecia areata. The goal is to check if the drug is safe and how the body processes it. The study involves up to 160 participants and lasts up to 48 weeks for those …

This study tests whether adding lactase drops to milk helps premature babies (born at 28-34 weeks) digest lactose better and gain weight faster. About 100 newborns will receive either lactase-fortified milk or regular milk, and their weight, length, and head growth will be tracke…

This early-stage study tests a new medicine called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check if the drug is safe and how well the body handles it. Participants will be followed for up to a year, and the study also loo…

This early-stage study tests a new drug called LY4006895 in healthy people and those with early Alzheimer's. The main goal is to check if the drug is safe and how the body handles it. The study has two parts: one with a single dose in healthy volunteers, and another with multiple…

This early-stage study tests a new imaging agent called NeuCaVis in 12 healthy volunteers. NeuCaVis is a radioactive tracer used in PET scans that targets fructose use, which may highlight inflammation better than standard tracers. The goal is to check safety and how the tracer s…

This study tests two light-based techniques (diffuse reflectance spectroscopy and photoacoustic imaging) to see if they can accurately tell the difference between healthy breast tissue, benign lumps, and malignant tumors. About 90 adults with a biopsy-confirmed tumor larger than …

This study is testing a new automated MRI method to see if it can take better pictures of the liver. It includes healthy adults and people with known or suspected liver disease or iron overload. Participants will have one MRI scan and be in the study for just one day.

This early-stage study tests a new radioactive tracer called [18F]LY4214835 to see if it is safe and how it spreads through the body. About 41 healthy volunteers and cancer patients will receive one injection and be followed for about 35 days. The goal is to improve cancer detect…

This study is testing a new blood test that looks for DNA from damaged heart cells to detect inflammation in people with sarcoidosis, a disease that can affect the heart. The goal is to find a simpler, safer way to diagnose heart involvement without the need for radiation-heavy s…

This study tests a new capsule camera attached to a string that takes pictures of the lower gut without needing sedation. About 30 healthy adults and people with Lynch syndrome or inflammatory bowel disease will try it. The goal is to see if the device can get clear images and be…

This study compares a new cuff-less wrist wearable (ViTrack) to standard cuff-based blood pressure monitors. It involves 91 healthy volunteers with normal or high blood pressure. The goal is to see if the wrist device measures blood pressure accurately and check for any skin irri…

This study tests if adding technology (a website and virtual coaching) to basic education and goal-setting helps older adults who live alone and have mild memory concerns become more physically active. Participants wear a fitness tracker, set weekly step goals, and complete surve…

This study aims to create and test a home supervision program for Latinx families to prevent injuries in children ages 2 to 5. Researchers will work with 100 Spanish-speaking caregivers to see if the program improves how they watch their kids and reduces minor injuries. The progr…

This study looks at whether it's better to give the RSV and Tdap vaccines together at one visit or separately during pregnancy. Researchers will check safety, immune response, and how well the study runs. About 60 healthy pregnant people will take part.

This study tests whether a krill oil supplement called Lysoveta can improve memory in healthy adults aged 50 to 75 who feel their memory is slipping. Participants take either Lysoveta or a placebo daily for 112 days and complete computer-based memory tests and mood questionnaires…

This early-stage study tests a new medicine called LY4086940 in healthy people and those who are overweight or have obesity, with or without type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will take part in differ…

This study tests a new inhaled medication called Optate for people with mild COVID-19. About 40 adults will receive either Optate or a placebo spray. Researchers will measure virus levels in the nose and track symptom changes using a quality-of-life survey.

This study tests whether taking citicoline, a natural supplement, can improve mood in healthy adults who are experiencing moderate mood disturbances. About 90 men and women aged 21 to 65 will take either citicoline or a placebo daily, and researchers will measure mood, sleep qual…

This early-stage study tests an experimental pill called BGM0504 in healthy and non-diabetic overweight or obese Chinese adults. The main goal is to check safety and how the body processes the drug. Researchers will also measure weight changes after 8 weeks. The study involves 75…

This study looks at whether a special vacuum dressing (closed incision negative pressure therapy) helps wounds heal better after breast reduction surgery compared to a standard bandage. About 92 women having the surgery will have one breast treated with the special dressing and t…

This early-stage study tests a new drug called LY4057996 in 124 healthy volunteers and people with type 1 or type 2 diabetes. The main goal is to see if the drug is safe and what side effects it may cause. Participants receive the drug as a shot under the skin or into a vein, and…

This study tests whether a new type of laser (DFG laser) causes less pain and helps skin heal faster than the standard CO2 laser. About 23 healthy adults will receive both lasers on small skin areas and report their pain levels. Researchers will also track healing time and blood …

This early-stage study tests a new drug called LY4064912 in healthy volunteers and people with overweight or obesity. The main goal is to check if the drug is safe and what side effects it may cause. Researchers will also measure how the body processes the drug and track any chan…

This early-stage study tests a new drug called LY4213663 in healthy volunteers and people with rheumatoid arthritis (RA). The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the body processes the drug. The study lasts…

This study looks at whether eating grapes rich in natural compounds called flavonoids can protect brain function, blood flow, and mood during mental stress in healthy young adults aged 18-40. Participants will consume either a high-flavonoid grape powder or a low-flavonoid contro…

This study tests whether training the muscles you use to breathe in can improve strength and performance in amateur CrossFit athletes. 94 healthy adults aged 18-60 who do CrossFit will either do breathing exercises with a special device or use a fake device. Researchers will meas…

This study is testing whether transplanting healthy bacteria from donor stool can improve gut problems, autism symptoms, and emotional behavior in people with autism spectrum disorder (ASD) who also have stomach issues. About 60 participants aged 7 to 30 will receive the treatmen…

This early-stage study is testing a new injectable drug called LY3971297 to see if it is safe and how the body processes it. The trial includes healthy volunteers, people with obesity and high blood pressure, and those with reduced kidney function. Researchers will monitor side e…

This study looks at how well healthy adults tolerate a probiotic supplement called Smile Probio 45B and whether it helps with bloating, fatigue, and quality of life. About 40 participants will take the probiotic daily for 30 days, track their bowel habits, and fill out questionna…

This early-stage study tests MK-4082, a new weight loss pill, in 120 healthy overweight or obese adults. Unlike current injectable weight loss drugs, this medicine is taken as a pill. The main goal is to check safety and how the body processes different doses, not yet to measure …

This study looks at whether giving children a small incentive (like a prize) after a medical procedure helps reduce their anxiety. About 187 children aged 6 to 17 who are having a procedure will be supported by a child life specialist and may receive a prize. Researchers will com…

This study looks at whether eating dinner earlier in the day helps people with obesity and prediabetes burn more fat and control blood sugar better. Researchers will compare early and late dinner times in 32 adults. The goal is to understand how meal timing affects metabolism, no…

This early-stage study tests the safety of a single dose of IBI3032 in 32 healthy adults. Participants are randomly assigned to receive either the drug or a placebo. The study is for research only and does not aim to treat any disease.

This study looks at whether a bile acid supplement called 7-keto lithocholic acid (7-KLCA) can change the types of bacteria in the gut and improve health markers like blood sugar and cholesterol. Researchers will give the supplement to 40 healthy adults aged 18-65 for 12 weeks an…

This study watches how babies and toddlers aged 6 to 24 months chew infant cereals with different textures. Researchers want to see if certain textures help children learn to chew better at different ages. About 153 healthy children will take part, and their chewing will be recor…

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 adults with and without metabolic syndrome. The goal is to find biological markers that predict disease progression and help design personalized prevention or treatment strategies. Part…

This study looks at how kidney blood flow changes during exercise in healthy young African American adults compared to White adults. Researchers want to understand why African Americans face higher risks of heart and kidney problems. Participants will do cycling, cold hand tests,…

This study looks at how two natural compounds in food—oxalate and citrate—interact in the body and affect kidney stone risk. Researchers will give potassium citrate to 24 adults (some with a history of kidney stones, some without) and measure changes in their urine over six hours…

This early-stage study tests whether an inhaled drug called RB042 is safe and how it moves through the body. About 90 healthy adults, including some who smoke, will receive either the drug or a placebo. The goal is to check for side effects, not to treat any disease.

This study collects small tissue samples from the abdomen of people (ages 0 to 90) who are on peritoneal dialysis, a type of kidney treatment. The goal is to learn how the lining of the abdomen changes over time with dialysis, which can affect how well the treatment works. By stu…

This study tests whether a brain-training technique called real-time fMRI neurofeedback can help healthy adults reduce the spontaneous return of learned fear responses. Participants will receive feedback based on brain connections between the prefrontal cortex and hippocampus whi…

This study looks at how a drug called pimavanserin, which blocks a specific serotonin receptor in the brain, affects memory, emotional processing, and decision-making in healthy adults aged 18-45. Researchers will compare the drug to a placebo to learn more about how this recepto…

This study looks at how healthy adults who regularly drink caffeine feel and how their bodies respond after consuming different caffeinated beverages. About 75 participants will rate their feelings and have their physical responses measured. The goal is to understand the effects …

This study looks at how the brain, memory, thinking, and movement change over time in people with Lewy body disease, Alzheimer disease, and healthy volunteers. Researchers will use brain scans and brain-wave tests to learn more about these disorders. The goal is to better underst…

This study looks at whether salbutamol, a common asthma medication, can improve exercise performance in non-asthmatic endurance athletes. Researchers will test if a select group of athletes with breathing limitations might benefit from the drug. The study involves 64 healthy, hig…

This early-stage study tests a new drug, CM383, in 30 healthy adult men. The goal is to see how the drug moves through the body and whether it is safe when given as a single dose by IV or injection. Participants must be non-smokers and avoid alcohol during the study.

This study aims to understand how healthy bone marrow plasma cells use a nutrient called glutamine. Researchers will give a special labeled form of glutamine to 20 healthy adults and then take a small bone marrow sample to measure how it's processed. This is a pilot study to test…

This study tests whether a gentle ear stimulation device (taVNS) can help people remember insights from a single psilocybin experience for longer. 108 healthy adults with mild emotional struggles will receive psilocybin plus real or fake stimulation. Researchers will measure memo…

This early-stage study tests the safety and tolerability of a new drug, HY8931, in 60 healthy adults aged 18 to 45. Participants receive either the drug or a placebo, and researchers monitor side effects and how the drug moves through the body. This study does not aim to treat an…

This study looks at how well physiotherapy students and their teachers agree on the students' non-technical skills—like teamwork, leadership, and communication—during clinical simulations. About 100 second-year students and their teachers will take part. The goal is to improve tr…

This study looks at how people's natural ability to control their thoughts and actions affects their success in a brain-training technique called neurofeedback. Forty healthy adults will learn to regulate a brain region linked to body awareness while inside an MRI scanner. The go…

This study tests a new imaging tracer to see if it can measure an enzyme linked to brain inflammation in people with Alzheimer's disease or mild cognitive impairment. About 90 volunteers aged 50 and older, including healthy individuals, will receive PET and MRI scans. The goal is…

This study looks at how a gentle electrical current applied to the brain (called tACS) affects movement in people who had a stroke more than 6 months ago. Researchers will test two different frequencies and a placebo to see which works best. They will use brain scans (MRI) and br…

This study creates and tests a training program for Care Food Specialists—workers who focus on food preparation and oral health in long-term care. About 150 healthy students in Taiwan will take the course, and researchers will measure changes in their knowledge, attitudes, and be…

This study looks at whether giving mirikizumab as one shot under the skin works the same as giving it as two shots. About 450 healthy adults will take part, and researchers will check safety and how the body handles the drug. The study lasts about 15 weeks per person.

This study looks at whether teaching healthy young adults to eat more potassium-rich foods is easier and better for their blood vessels than telling them to cut back on salt. Researchers will compare the two approaches in 32 people who currently eat too much salt and not enough p…

This study uses a special type of MRI (called hyperpolarized xenon MRI) to look at the lungs of 260 young adults who are already part of a larger lung health study. The goal is to find early signs of lung damage that could lead to chronic lung disease later in life. Participants …

This early-stage trial tests a new drug called BI 3804379 in healthy adults aged 18 to 65. The goal is to check if the drug is safe and how the body processes it. Participants receive either the drug or a placebo as a shot under the skin. The study does not aim to treat any disea…

This study looks at how HIV affects the brain even when the virus is controlled with medication. Researchers will use special PET and MRI scans to measure brain cell connections in 70 people with HIV and healthy volunteers. The goal is to understand why some people with HIV still…

This study explores whether a brain-computer interface (BCI) can help people with motor disorders control assistive devices just by thinking about moving. Researchers will test 100 healthy volunteers and people with conditions like spinal cord injury or stroke. The goal is to imp…

This early-stage study tests an experimental drug called LY3867070 in 196 healthy adults to see if it is safe and how the body handles it. Participants take the drug by mouth and have blood tests to measure side effects and drug levels. The study does not aim to treat any disease…

This study looks at whether the brain's synaptic density (connections between nerve cells) improves after at least 4 weeks of not using cannabis. Researchers will use PET scans to measure these changes in people with cannabis use disorder and compare them to healthy volunteers. T…

This early-stage study tests whether a new drug called IMP761 is safe in healthy adults aged 18 to 55. Participants receive either the drug or a placebo and are monitored for side effects and how the drug moves through the body. The study does not aim to treat any disease, but to…

This study checks if an experimental medicine for heart failure, MK-2828, changes how the body handles two other drugs: rosuvastatin (for cholesterol) and furosemide (a water pill). About 39 healthy adults will take MK-2828 along with these drugs to see if there are any interacti…

This study tests a program called the Early Childhood Friendship Project (ECFP) in 600 preschool children. The program is led by teachers and aims to reduce physical and relational aggression, increase kindness, and improve social and academic skills. Researchers will also measur…

This study looks at how different types of strength training affect the brain and muscles. Sixty healthy adults aged 18 to 40 will do leg exercises paced by a metronome—either with a steady beat, a variable (fractal) beat, or no beat at all. Researchers will use brain stimulation…

This study looks at how blind people use a white cane to sense the world around them, like feeling for curbs or obstacles. Researchers will test touch perception on a rod and measure brain activity with EEG and MRI. The goal is to understand how the brain treats the cane as an ex…

This study tests a new radioactive tracer called 11C-JMJ-129 to see how well it can highlight a protein called PDE4D in the brain and body of healthy volunteers. PDE4D is linked to thinking and mood, and may play a role in disorders like Alzheimer's and depression. Researchers wi…

This observational study looks at how gut bacteria relate to brain structure and function in healthy aging and in people with early Alzheimer's, Parkinson's, or multiple sclerosis. Researchers will analyze stool and blood samples, brain scans, and thinking skills in 200 participa…

This study takes small tissue samples from the rectum of people with Irritable Bowel Syndrome (IBS) and healthy volunteers. Researchers will measure how the nerves in these samples react to different substances and look at genetic markers. The goal is to better understand what ca…

This study tests a new neck-strengthening device called TopSpin360 in 60 junior hockey players. Researchers want to see if it improves neck strength and brain function, measured by reaction time and brain waves. The goal is to understand if stronger necks can help protect players…

This study looks at whether taking a daily carotenoid supplement (like those found in carrots) can improve eye health in healthy adults aged 18-75. Over 3 months, researchers will measure changes in the retina's protective pigment, blood flow, and vision sharpness. Participants w…

This study looks at how quickly the body turns EPA (an omega-3 found in fish oil) into DHA (another important omega-3). Researchers want to see if a person's sex and specific genes affect this process. Healthy adults will take EPA supplements for 12 weeks and give blood samples t…

This study tests whether a nasal spray of oxytocin (the 'love hormone') can help healthy adults learn to control a brain area called the anterior insula, which is involved in body awareness and empathy. Participants will use real-time brain scans (fMRI) to try to increase activit…

This study follows 10,000 healthy adults for up to 20 years to learn how to detect cancer earlier. Participants give blood samples and answer questionnaires during routine medical visits. The goal is to find changes in proteins, RNA, and DNA that signal cancer long before symptom…

This early-stage study tests whether a new drug, AZD1613, is safe and how the body processes it. About 136 healthy adults, including people of Japanese and Chinese descent, will receive either the drug or a placebo. The goal is to gather safety data, not to treat any disease.

This early-stage study is testing whether a new drug, SRK-439, is safe in healthy adults aged 18 to 55. Researchers will give single or multiple doses and monitor for side effects, changes in lab tests, and how the drug moves through the body. The goal is to gather safety informa…

This study looks at how a gentle, noninvasive nerve stimulation (applied to the ear) changes activity in the brain and stomach. Researchers will use MRI scans and heart/stomach monitors to measure these effects in healthy adults and people with functional dyspepsia. The goal is t…

This study looks at how short (10 minutes) and longer (30 minutes) exercise sessions change appetite, hunger-related hormones, and how much food healthy men eat after a meal. Researchers will compare these effects to a no-exercise control group. The goal is to better understand t…

This study looks at how certain dietary supplements change proteins in the immune system of healthy adults. Researchers will give supplements or a placebo to 44 volunteers aged 18-45 and take blood samples to measure changes. The goal is to understand, not to treat any disease.

This study aims to understand how the body's immune cells respond to a new type of cancer vaccine called a neoantigen vaccine. Researchers will collect blood samples from 24 people, including those with solid tumors and healthy volunteers, to analyze immune reactions. The goal is…

This study looks at how the brain's memory and reasoning areas develop in healthy teenagers (13–18) compared to adults (19–25). Participants will do memory tasks during brain scans (fMRI) over three visits, spaced 1.5 years apart. The goal is to understand how the brain changes w…

This study compares heart and lung blood pressure in healthy adults and those with congenital heart disease. Researchers will measure how the heart's blood vessels respond to exercise using MRI and a small tube in the heart. The goal is to collect data that helps doctors better u…

This study looks at how the brain processes optimistic and pessimistic signals in healthy people and those with Parkinson's disease. Researchers will use MRI scans while participants play a game to see if Parkinson's affects these signals. The goal is to better understand why cer…

This study aims to improve how MRI scans work by testing new techniques and settings. Healthy adults and current NIH participants aged 18 and older can join. Participants will have one or more MRI scans, possibly with a contrast agent, and blood samples may be taken. The goal is …

This study looks at whether a specific type of acupuncture (electroacupuncture) at two points on the body can affect how often the bowels move. Thirty healthy adults will have their bowel sounds recorded before, during, and after the treatment using a special digital stethoscope.…

This study looks at how drinking milk or eating yogurt affects thinking and memory in healthy children aged 9 to 14. Researchers want to see if different types of dairy (like full-fat vs. low-fat) can improve attention, learning, and mood through signals from the gut to the brain…

This study looks at how the body absorbs a new drug called LY4064809. Eight healthy adults will receive the drug by mouth and by IV to compare how much enters the bloodstream. Participants stay at a research center for 14 days, and the whole study lasts about 21 days. The results…

This study looks at whether training the muscles you use to breathe can also make your tongue stronger and more enduring. Researchers will measure tongue strength and endurance in 60 healthy adults before and after a breathing muscle training program. The goal is to understand if…

This study translates and tests health questionnaires about pain, movement, and daily life for Albanian-speaking people. About 300 adults with muscle or joint pain, back pain, or other musculoskeletal issues will fill out the translated forms. The goal is to make sure these tools…

This early-stage study tests a new drug called BI 3821001 in healthy men aged 18 to 55. The goal is to check if the drug is safe and how the body processes it. Participants receive a single dose and are monitored for side effects. No direct health benefit is expected, but results…

This study looks at how common topical medications—like antifungal creams, mild steroid ointments, and moisturizers—change the community of bacteria living on healthy skin. Researchers will track these changes over short-term use in 24 adults. The goal is to understand how these …

This study tests whether a home-based mobile app can help parents of 3-4 year olds improve their child's daily physical activity, sleep, and screen time. About 80 children who currently meet few or no movement guidelines will wear activity trackers and have motor skills tested. P…

This study looks at brain MRI scans and genetic information from up to 2000 children (healthy and with developmental delays) to create computer models that can better predict and explain developmental disorders. The goal is to learn more about how the brain grows and changes, not…

This study aims to uncover whether eczema (atopic dermatitis) and food allergies share unique genetic or biochemical markers. Researchers will collect blood and skin samples from 200 participants, including those with food allergies, eczema, or neither. The goal is to create a mo…

This study aims to learn more about the bacteria and other microbes living in the vagina and mouth of women. Researchers will collect swab samples from 520 participants who visit certain clinics in Finland. The goal is to see how these microbes differ between healthy women and th…

This early-stage study tests the safety of a new drug called SYNT-101 in healthy adults and those who are overweight or have obesity. Researchers will monitor for side effects and measure how the drug moves through the body. No treatment benefit is expected; the goal is to gather…

This early-stage study tests the safety of an experimental eye drop called BT01001 in 32 healthy adults aged 18 to 50. Participants receive either the eye drop or a placebo to check for side effects and how the drug moves through the body. No treatment benefit is expected; the go…

This study checks if people can collect their own blood samples at home to measure levels of urolithin A, a compound in Mitopure. About 250 healthy adults aged 18-80 will take Mitopure and use a kit to provide dried blood spots. The goal is to see if the home method is reliable e…

This study looks at whether listening to music while running changes the forces your feet put on the ground and your overall running form. Researchers will have 40 healthy adults (ages 18-35) run on a treadmill with and without music to measure impact. The goal is to understand i…

This study tests a new portable CPAP device designed to help people with sudden breathing problems before they reach the hospital. Researchers will check how easy it is to use and how well it works in 50 healthy volunteers and hospitalized patients with low oxygen levels. The goa…

This study is testing a device called Electrical Impedance Tomography (EIT) that creates images of the lungs without using radiation. Researchers want to see if it can provide useful information about breathing and blood flow in children with chronic lung diseases, neuromuscular …

This study tests whether a non-invasive brain stimulation technique called HD-tDCS can improve hand control in healthy older adults. Forty right-handed participants will receive either a standard or a personalized dose of stimulation while performing hand tasks. The goal is to se…

This early-stage study tests whether a new topical cream called JW0061 is safe and well-tolerated on the skin of healthy adults. About 104 Korean and Caucasian volunteers will receive either the cream or a placebo. The goal is to check for side effects and skin reactions, not to …

This study looks at how certain drinks change amino acid levels and appetite hormones after a meal in healthy adults aged 20 to 50. About 24 participants will try different beverages in a random order. The goal is to understand the body's short-term response, not to treat any dis…

This study tests whether a non-invasive brain stimulation technique can help people quickly reach a deep meditative state, normally achieved only after years of practice. Twelve healthy adults who already meditate will undergo brain stimulation while wearing an EEG cap and perfor…

This study looks at whether blood flow in fat tissue changes as we age. Healthy adults aged 18-35 or 65-80 will have their fat blood flow measured, provide two small fat samples, and drink a sugary drink. The goal is to understand basic aging processes, not to treat any disease.

This early-stage study is testing a new injection called ZT003 in healthy volunteers and people who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it. About 76 participants will receive either the drug or a placebo to gather impo…

This study checks how well the Owlet OSS 3.0-M1 sensor measures pulse rate and blood oxygen levels in healthy children aged 19 months to 5 years. About 90 kids will wear the sensor while their readings are compared to a standard medical device. The goal is to see if the sensor is…

This study aims to accurately measure how many calories healthy Chinese people burn each day using a special water test called doubly labelled water. Researchers will track 240 volunteers across China, collecting data on body measurements, blood tests, and activity levels. The re…

This study looks at how a new drug called LY3537031 moves through the body in people with mild, moderate, or severe liver problems compared to healthy volunteers. About 32 adults will receive a single injection under the skin. The goal is to measure drug levels and check for side…

This study gathers detailed eye scans from 180 adults with healthy eyes or conditions like retinal disease, glaucoma, or corneal disease. The goal is to collect data that may help doctors better understand and diagnose these conditions in the future. Participants will have their …

This study looks at two ways of giving people real-time feedback on their brain activity using fMRI. 90 healthy adults will try either continuous or intermittent feedback to see which helps them better control a brain region called the anterior insula. The goal is to understand h…

This study looks at how healthy hearts function at rest and during exercise in people of different ages. Researchers will measure heart pressures and fuel use in 80 volunteers. The goal is to understand normal heart aging, not to test a treatment.

This early-stage study aims to see if a new drug called LY4515100 is safe and how it moves through the body. About 40 healthy adults will receive either the drug or a placebo. The study involves blood tests and overnight stays, but does not offer any treatment for a disease.

This study looks at whether a nasal spray of oxytocin (the 'love hormone') changes how people react to threats in a video game-like setting. 80 healthy adults will try to escape from virtual predators while their brain activity and decisions are measured. The goal is to understan…

This study looks at how different levels of breathing exercises change oxygen levels in the rib muscles of healthy people. About 27 physically active adults will do breathing training at various intensities while their muscle oxygen is measured. The goal is simply to learn more a…

This early-stage study is testing a new drug called LY4066708 in 104 healthy volunteers to see if it is safe and what side effects it might cause. Researchers will also measure how much of the drug enters the blood and brain, and how quickly the body gets rid of it. The study las…

This study aims to develop a simple decision tool that helps physical therapists decide when to check vital signs like heart rate and blood pressure during outpatient therapy. Researchers will survey a panel of experienced physical therapists over three rounds to agree on which s…

This study follows 120 college freshmen to see how a vegan, vegetarian, or omnivore diet changes their body weight and the bacteria in their mouth and gut. Participants will provide saliva, stool, and urine samples over their first year at university. The goal is to understand ho…

This study looks at whether brain signals can predict when someone is about to make a mistake during a typing task, up to one second in advance. Researchers will scan the brains of 40 healthy, right-handed adults aged 18-35 using MRI and MEG while they perform keyboard tasks. The…

This study looks at whether doing the "Xuong tan lac than" exercise for 12 weeks can improve joint flexibility and muscle endurance in healthy adults. About 34 volunteers will do the exercise daily and get their joints and muscles tested every few weeks. The goal is to learn more…

This study looks at whether eating grapes can help improve muscle strength and thinking skills in healthy women aged 65 and older. Participants will visit the campus four times for strength tests, thinking tests, and blood draws. The goal is to see if a simple dietary change can …

This study is looking for 2000 healthy adults who have a close family member with a blood cancer like multiple myeloma. The goal is to find early warning signs of the disease by collecting blood samples and health data over time. Researchers hope this will lead to better ways to …

This study tests whether the Q-Collar, a device worn around the neck, changes how the brain controls blood flow during rest and exercise. Twenty healthy adults aged 18 to 30 will complete two sessions—one with the collar and one without—while doing standing, breathing, and biking…

This study looks at whether moving around during labor helps first-time mothers have better birth outcomes. About 714 women will either receive standard care or use a special mobility system. The main goal is to see if the system reduces the need for unplanned C-sections.

This study looks for brain signals that can predict how chronic low back pain changes over time. Researchers will use EEG (a non-invasive brain wave test) to measure brain activity in 130 adults with and without chronic low back pain. Participants will be followed for 5 months to…

This early-stage study tests a new medicine, PF-07985631, in healthy adults to see if it is safe and how the body processes it. The drug is being developed for a kidney disease called IgA nephropathy. Participants receive either the drug or a placebo as a single injection and are…

This study looks at how the drug mirdametinib is absorbed and removed from the body in people with moderate or severe liver problems compared to healthy volunteers. About 32 adults aged 18 to 80 will take part. The goal is to gather information only, not to treat any condition.

This study tests how the body processes a new prostate cancer drug (opevesostat) when taken with or without another drug (itraconazole). It involves 14 healthy adult men and measures drug levels in the blood. The goal is to gather safety and drug interaction data, not to treat an…

This study collects blood samples from 400 healthy adults aged 18 to 65 to build a biorepository for research. The goal is to discover new ways platelets become active and cause inflammation and blood clots in diseases. Participants must not have taken blood thinners in the past …

This study looks at how the brain works during tasks involving emotions, attention, and memory in both healthy volunteers and people with depression. Researchers use brain scans and gentle brain stimulation to measure activity. The goal is to gather information that could lead to…

This study looks at how a gentle brain stimulation technique called tDCS affects attention and thinking. Researchers will test healthy adults and people with schizophrenia using computer tasks and brain wave recordings. The goal is to understand brain function better, not to trea…

This study looks at how kidney blood flow changes during exercise in healthy older African American adults compared to White adults. Researchers want to understand why African Americans face higher rates of heart and kidney problems. Participants will do cycling, a cold hand test…

This early-stage study tests whether a new drug, HY6725, is safe and how it behaves in the body. About 74 healthy adults aged 18 to 55 will receive either the drug or a placebo once or twice, with follow-up for up to 150 days. The goal is to check for side effects and measure dru…

This study looks at how well healthy adults can stick out their tongues with force and for how long. Researchers will measure tongue pressure and endurance using a special device, and compare these results with handgrip and breathing muscle strength. The goal is to understand nor…

This study tests whether a probiotic called Saccharomyces boulardii can improve the gut's ability to control what passes into the body. Researchers will give the probiotic or a placebo to 56 healthy adults and measure changes in gut permeability, inflammation, and digestive sympt…

This study will measure how fast 360 healthy young people (ages 6-20) need to walk to get health benefits. Researchers will track steps per minute and heart rate to create simple, personalized walking guidelines. The goal is to replace vague advice like 'walk briskly' with clear …

This study looks at how tiny changes in your genes might affect natural molecules that help turn off inflammation. By studying 200 healthy volunteers and people with inflammatory conditions, researchers hope to understand why some people develop chronic diseases like arthritis or…

This study aims to uncover how Visual Snow Syndrome (VSS) arises in the brain. Researchers will use advanced MRI scans and visual tests to compare brain activity in people with VSS, migraine, and healthy volunteers. The goal is to identify which brain pathways cause the constant …

This study aims to better understand how many calories a person needs to eat to stay at the same weight. Researchers will use a whole-room indirect calorimeter, a special room that measures the energy your body burns, to find a more accurate way to calculate energy balance. 34 he…

This study looks at how growth hormone, with or without liraglutide, changes appetite-related signals, energy use, and blood sugar in healthy adults and those with growth hormone deficiency. Participants will take each treatment for 21 days and have blood tests and body measureme…

This study looks at whether breathing slowly (6 breaths per minute) can lower physical and mental stress more than breathing at a normal pace or just resting. Researchers will compare three groups of healthy adults to see if the specific rhythm or just the act of focusing on brea…

This study is testing a new portable ultrasound device that uses sound waves to measure bone density in the lower leg, without radiation. Researchers will compare its results to standard DXA X-ray scans in 350 healthy men and women aged 21 to 55. The goal is to see if the ultraso…

This early-stage study is testing a single dose of an experimental medicine called PF-08653944 in 54 overweight or obese adults. The goal is to see how the drug is absorbed when injected into the thigh, upper arm, or abdomen. Researchers will also monitor safety through blood tes…

This study tests a 21-day self-guided digital program designed to prepare healthy volunteers for a supervised psilocybin session. Forty participants will be randomly assigned to either a daily meditation or music-listening routine. The main goal is to see if the program is practi…

This study looks at how the drug tulisokibart behaves in the body when given through two different autoinjectors. About 330 healthy adults will receive a single injection, and researchers will measure drug levels in the blood and check for side effects. The goal is to see if both…

This study tests whether a safe, mild electrical current applied to the scalp can change brain activity and thinking speed in healthy adults. About 196 younger (20-40) and older (60-80) adults will do computer tasks while receiving real or fake stimulation, with brain scans to se…

This study compares a 9-week group cycling program to a one-time training session for adults who rarely cycle. Researchers want to see which approach gets more people biking regularly and improves health and well-being. About 268 participants will be tracked for a year to measure…

This study looks at how stroke changes the way people move their arms when walking. Researchers will measure brain activity and muscle patterns in 84 people (some who had a stroke and some healthy) to understand why arm swing is different after a stroke. The goal is to gather kno…

This study aims to collect normal measurements of tongue strength and movement in 300 healthy children aged 4 to 17. Participants will perform simple tongue tasks using a pressure-measuring device. The results will help doctors better understand what is typical for children, whic…

This study checks how well a new algorithm can detect irregular heartbeats using sensors on the finger and wrist. It involves 120 healthy adults aged 18 to 80. The goal is to see if the device works accurately compared to a standard ECG. No treatment or medication is given.

This study aims to find out if children with primary ciliary dyskinesia (PCD) also have a condition called bronchial hyperresponsiveness, which makes airways overly sensitive. Researchers will compare 40 participants (those with PCD and healthy volunteers) using breathing tests. …

This study tests a new wireless pill that measures temperature inside the gut. The goal is to see if it can help detect diseases like Crohn's disease. Ten healthy adults will swallow the capsule and researchers will check if it sends accurate temperature readings.

This early-stage study is testing a new drug called BI 3776528 in healthy male volunteers. The main goal is to see if the drug is safe and how the body processes it. About 142 men aged 18 to 50 will take part. This study does not aim to treat any disease.

This study looks at healthy Somali Americans to find out if they have hidden sleep problems and how those problems might be linked to higher blood pressure. Researchers will measure sleep quality and blood pressure in 240 adults. The goal is to understand why this group may be at…

This study looks at how a 30-minute exercise session changes appetite and hunger-related hormones when healthy men are on a low-calorie diet. Researchers will compare three groups: one with no diet changes, one on a strict diet, and one on a strict diet plus exercise. The goal is…

This study looks at whether drinking beetroot juice (which contains nitrate) before sleep can improve sleep quality and how well your brain and blood vessels work at night. Researchers will study 60 healthy adults, both young (18-35) and older (65-80). Participants will have thei…

This study checks if two different versions of the drug survodutide are absorbed the same way in the body. It involves 80 healthy adults who are overweight or obese. Participants will receive both formulations at different times to compare drug levels in the blood.

This study looks at how different levels of liver function affect the way the body processes a study medicine called PF-07328948. Researchers will give a single tablet to 26 adults, some with liver problems and some healthy, and monitor them for about 6 days. The goal is to see i…

This study looks at how lepodisiran enters the blood and leaves the body in people with mild, moderate, or severe liver issues compared to those with healthy livers. About 33 adults will receive a single injection and be monitored for up to 9 weeks. The goal is to understand how …

This study looks at whether eating white potatoes at breakfast or dinner changes how your body handles blood sugar, hunger, and how many calories you eat later. Researchers will track blood sugar continuously and measure appetite and food intake in 30 healthy adults. The goal is …

This study tests whether a low-dose fisetin supplement (100 mg daily for 7 weeks) is safe and can reduce signs of inflammation and aging in healthy adults aged 50 and older. Researchers will compare changes in blood markers between the supplement and placebo groups. The goal is t…

This study looks at how taking sialic acid by mouth changes the types and amounts of bacteria in the gut, especially harmful ones like E. coli. It involves 42 healthy adults aged 18 to 75. No treatment or cure is being tested—the goal is simply to learn more about how sialic acid…

This study tests whether a new tablet form of tafamidis works the same as the current capsule. About 24 healthy adults will take a single dose of each form under fed conditions. The main goal is to measure drug levels in the blood, not to treat any disease.

This study tests a new substance called [18F]-fluoromannitol, used in PET scans to help detect infections. Ten healthy adults will receive the tracer to see how it spreads through the body and if it is safe. The goal is to gather information that could help diagnose infections in…

This study is the first time BAL2420 is being tested in humans. It aims to check the safety and how the body processes the drug in 136 healthy adults. Participants receive either the drug or a placebo, and researchers monitor for side effects. The goal is to gather essential safe…

This study looks at whether a computer-animated character that explains medical illustrations helps people understand them better and feel less anxious. About 300 healthy adults who speak English or Spanish will take part. Some will see the character on a computer screen, some in…

This 10-year study aims to understand what keeps the brain healthy as we age. It will track 100,000 generally healthy adults through online tests, training, and optional brain scans. Participants complete assessments twice a year and get access to coaching and tips to improve bra…

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. The goal is to see if those with pain and fatigue have higher levels of brain inflammation. Researchers will compare…

This early-stage study tests the safety of a new drug called HB0056 in 46 healthy adults aged 18 to 55. Participants receive a single dose of either the drug or a placebo. The main goal is to see if the drug causes any side effects and how the body processes it.

This study looks at how a new medicine called PF-07328948 is absorbed, spread, and removed from the body. It involves 8 healthy men aged 18 to 64. Participants take the drug by mouth and by injection, and provide blood, urine, and stool samples. The goal is to learn how the body …

This study looks at how two drugs interact in healthy adults. In Part 1, researchers measure how itraconazole changes the amount of MK-2828 in the body. In Part 2, they see if taking MK-2828 multiple times affects how the body processes a single dose of midazolam. The goal is to …

This study looks at whether taking a probiotic called Lactobacillus rhamnosus GG can help prevent changes to gut bacteria caused by proton pump inhibitors (PPIs), which are common acid reflux medicines. Researchers at Mayo Clinic will give healthy adults either a probiotic or a p…

This study tests whether using an AI chatbot (like ChatGPT) can improve how physical therapy students learn to diagnose and treat patients. About 60 healthy students will be split into two groups: one uses AI to practice with virtual patient cases for 8 weeks, while the other fol…

This study looks at how physical fitness changes the bacteria in your gut. Researchers will compare gut microbes from inactive people to elite athletes to see if exercise boosts gut health. The goal is to understand which bacteria are linked to better fitness and create a sample …

This study looks at whether taking the blood pressure drug losartan changes how the antibiotic cephalexin is absorbed and removed from the body. 12 healthy adults will take cephalexin alone, with losartan, or three hours after losartan. The goal is to see if there is an interacti…

This early-stage study is testing a new drug called BLKR201 in 128 healthy adults to see if it is safe and how the body handles it. Participants will take the drug or a placebo and stay at a research clinic for several days. The study also checks if food changes how the drug is a…

This study collects health information, lifestyle details, and biological samples from up to 100,000 adults aged 18 to 90. The goal is to help researchers better understand conditions like lupus, celiac disease, and kidney disease, and to develop improved tests and treatments. Pa…

This study tests a new imaging tool that gives surgeons live, 3D views inside the eye during surgery. It includes up to 262 people with various eye conditions like retinal detachment, macular holes, or cataracts, as well as healthy volunteers. The goal is to see if this technolog…

This study looks at how the experimental drug PF-07328948 is handled by the body in people with normal or reduced kidney function. About 28 adults aged 18 to 80 will receive a single dose and be monitored for safety and drug levels. Results will help determine if kidney problems …

This study looks at how the drug BI 1291583, being developed for the lung disease bronchiectasis, behaves in people with and without liver problems. About 32 adults aged 18 to 80 will take a single dose of the drug. Researchers will measure drug levels in the blood and check for …

This early-stage study tests a new drug called CAY001 in healthy adults for the first time. The main goal is to check its safety and how the body processes it. About 24 volunteers will receive either a single dose of CAY001 or a placebo, and researchers will monitor them for 28 d…

This study looks at whether a 16-week ideomotor group exercise program can improve thinking, movement, and overall well-being in healthy adults aged 50 and older. About 158 participants will be compared to a group doing standard cognitive training. The goal is to see if this gent…

This study looks at how an experimental medicine, PF-08653944, is processed by the body and whether it is safe. About 26 adults with normal or impaired liver function will receive a single injection. Researchers will compare results across groups to guide future use in people wit…

This study is testing a new rehabilitation program for people with spinal cord injury (SCI) that combines walking downhill on a treadmill with mild electrical stimulation to activate weak muscles. Researchers will also check blood and spinal fluid for biomarkers to decide whether…

This study looks at how focusing your attention differently during calf-strength exercises might change the way you walk. Researchers will compare two types of external focus (like thinking about moving a marker) with an internal focus (thinking about your own muscles) in healthy…

This study looks at how natural changes in the female hormone estradiol might change the way the spinal cord adapts. Researchers will use mild electrical stimulation to test spinal responses in 50 healthy young adults. The goal is to understand basic biology, not to treat any dis…

This study aims to develop better MRI techniques for looking at the brain's structure and activity. Healthy adults aged 18 and older will have yearly MRI scans, sometimes while doing simple tasks like listening or tapping a finger. The information gathered will help improve imagi…

This study is testing whether wearable devices like smartwatches can accurately track movement problems in people with Huntington's disease. About 100 participants, including those with Huntington's and healthy volunteers, will wear devices and complete surveys and interviews at …

This pilot study aims to see if a new sensor technique can reliably measure how cooling the thigh muscle changes the way nerves control movement. Researchers will test 24 healthy adults aged 18-35, comparing muscle signals under normal and cooled conditions. The goal is to gather…

This study looks at people with a specific gene change (GBA1) who are at higher risk for Parkinson's disease. Researchers will use simple, non-invasive tests to find very early signs of Parkinson's, which can appear up to 20 years before symptoms. The goal is to create a model to…

This study looks at how people with temporal lobe epilepsy (TLE) remember spatial information, like routes or locations, compared to healthy volunteers. Researchers want to understand why some patients forget these details faster than usual, even within weeks. The study involves …

This study looks at how eating berries, like cloudberries and lingonberries, changes tiny particles called extracellular vesicles that cells use to talk to each other. Researchers want to see if these berries affect the body's immune signals and gut bacteria. The study involves 6…

This study is testing a new minitablet form of the drug obefazimod in healthy adults aged 18 to 55. The goal is to see how the body absorbs the minitablet compared to the current capsule and to check if the minitablet tastes okay. About 44 participants will take a single dose of …

This study looks at how the antifungal drug fluconazole changes the amount of olomorasib in the blood and how fast the body clears it. Fifteen healthy adults will take both drugs and stay overnight at the research center 12 times over about 7 weeks. The goal is to gather safety a…

This study aims to develop a new way to stimulate the brain using focused ultrasound, guided by real-time brain wave monitoring (EEG). Researchers will test this system in 80 healthy adults aged 18-64 to find the best settings for future treatments. The goal is to create a closed…

This study looks at how a low-methionine diet affects gut bacteria and inflammation in 40 healthy adults aged 20-50. Participants follow their usual diet, then a special diet, and some take methionine supplements or a placebo. The goal is to see if this diet can shift gut bacteri…

This study looks at how insulin-making cells in the pancreas respond to growth hormone in women who had gestational diabetes. Researchers want to understand why some women develop type 2 diabetes later. The study involves 30 women with a history of gestational diabetes or healthy…

This study looks at whether brain activity tests can predict if a person with depression can safely stop taking antidepressants without relapsing. About 204 people will have their brain waves measured and give blood samples over time. Researchers hope to find biological signs tha…

This study uses a special brain scan (PET) with a new tracer called [11C]APP311 to measure synaptic density—the connections between brain cells—in people with psychotic disorders or cannabis use disorder, compared to healthy volunteers. Researchers aim to understand how these con…

This study is translating and testing a questionnaire called the Cervical Cancer Screening Uptake Questionnaire (CCSTQ) for Turkish women. The goal is to understand the psychological and social reasons that influence whether women aged 21 to 65 get screened for cervical cancer. A…

This study looks at how personality, brain activity, and behavior differ among young adults aged 18-22. Researchers want to see if certain patterns of attention and reward processing are linked to cannabis use. Participants will complete tasks and brain scans. The goal is to bett…

This study aims to learn how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 healthy volunteers and those at higher risk for type 2 diabetes. Participants receive medicatio…

This study looks at how different areas of the brain communicate in healthy adults. Researchers use safe, non-invasive methods like magnetic pulses and brain wave recordings to measure these connections. The goal is to better understand normal brain function, not to treat any dis…

This early-stage study is testing a natural compound called fisetin in 60 healthy younger adults and older patients with multiple chronic conditions. Participants take fisetin or a placebo for two days and are followed for up to three months. The goal is to see if fisetin is safe…

This study aims to understand how being overweight or obese changes the way your heart and blood vessels respond during different breathing exercises and physical activity. Researchers will measure blood pressure in 80 healthy adults while they rest, exercise, and perform special…

This study explores whether healthy adults can learn to calm a brain region linked to worrying about future events. Using real-time brain scans, participants get feedback to help control activity in that area. The goal is to see if this training reduces anxious feelings about wha…

This study looks at whether the phase of a woman's menstrual cycle (follicular vs. luteal) changes how her body adapts to sprint interval training. Researchers will measure endurance performance and muscle changes in 24 healthy women after two weeks of training. The goal is to un…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography and CT scans in up to 4,000 adults, including healthy volunte…

This study is testing a new method called RNA sequencing to find genetic causes of rare diseases that standard DNA tests miss. Researchers will take skin samples from 105 people, including healthy volunteers and patients with known or suspected genetic conditions. The goal is to …

This study looks at whether university students who spend a lot of time on social media are more likely to have unhealthy exercise habits. Researchers will survey 187 healthy students aged 18-24 who use social media at least 4 hours daily. The goal is to understand the connection…

This study is for healthy adults aged 18 and older. It aims to see if taking a supplement called palmitoylethanolamide (PEA) every day for a year is safe. Participants will be randomly assigned to receive either PEA or a placebo, and neither they nor the researchers will know whi…

This study looks at how people who speak two languages or a spoken and a signed language manage to switch between them. Healthy adults who are fluent in Mandarin and English or American Sign Language and English will do tasks like naming pictures or sorting words. The goal is to …

This study looks at a little-known part of the brain called the reticulospinal system, which helps control movements like walking and reaching. Researchers will use loud sounds to trigger fast reactions and measure how this system changes in people with spinal cord injury over 6 …

This study looks at whether giving magnetic brain stimulation at the right moment in your natural brain rhythm can make it work better for improving arm and hand movement. Researchers will test healthy adults and people who had a stroke at least six months ago. The goal is to lea…

This study looks at how much flavanols (natural compounds found in foods like apples, berries, and tea) people consume as part of their normal diet. Researchers will collect urine samples from 200 healthy adults aged 25-75 to measure specific breakdown products. The goal is to be…

This study checks if special sensors can accurately measure the forces inside a carbon-fiber leg brace. Researchers will test the brace on healthy adults, people who use braces regularly, and those with nerve damage in their feet. The goal is to improve how braces are designed an…

This study looks at how difficult childhood experiences might change the way people learn and remember things, and how that relates to opioid use disorder. Researchers will compare brain scans and memory tests in 185 adults: those with opioid use disorder on buprenorphine, those …

This early-stage study is testing a new drug called BI 3031185 in 60 healthy men aged 18 to 50. The goal is to see if the drug is safe and how the body processes it when taken as multiple doses. Participants will receive either the drug or a placebo, and no direct health benefit …

This study looks at whether using video calls (telemedicine) can effectively educate and counsel people who are thinking about donating a kidney. Researchers will compare standard in-person care to a telemedicine approach. The goal is to see if telemedicine helps donor candidates…

This early-stage study is testing a new drug, NSHO-101, in 24 healthy adults. The main goal is to see how the drug moves through the body and whether it is safe. Participants will be closely monitored for side effects. This research helps determine if the drug can move into futur…

This study looks at how quickly and how much the gut bacteria change when healthy adults take a fiber called native chicory inulin. Researchers will compare it to a placebo (maltodextrin) to see if the fiber directly causes changes in gut bacteria, bowel habits, mood, and appetit…

This early-phase study tests the safety and how the body processes a new drug called FZ008-145 in 190 healthy adults aged 18 to 65. Researchers will also measure pain tolerance using a cold water test. The goal is to gather safety data, not to treat any disease.

This study gives healthy volunteers psilocybin (the active ingredient in magic mushrooms) and uses brain scans and computer tasks to measure changes in thoughts and brain activity. The goal is to understand how the drug works, not to treat any disease. About 30 adults aged 18-75 …

This observational study compares how prosocial behaviors and brain networks develop in 100 infants at high and low risk of autism spectrum disorder (ASD). Researchers will use developmental assessments, EEG, and MRI scans during natural sleep to track differences. The goal is to…

This early-stage study tests whether a new inhaled drug, CPD704, is safe and how it moves through the body. About 90 healthy Chinese adults will receive single or multiple doses. The goal is to check for side effects and measure drug levels in the blood, not to treat any disease.

This study tests whether a mild electrical pulse behind the ear (taVNS) can change insulin, C-peptide, and blood sugar levels in 30 healthy adults aged 18-70. Researchers will compare active stimulation to a control group and measure heart rate changes. The goal is to learn how t…

This study looks at how much harmful chemicals firefighters are exposed to when fighting structural fires. Researchers will collect urine and cheek cell samples from 60 firefighters before and after a fire call. The goal is to measure changes in biomarker levels to better underst…

This early-stage study tests a new medicine, PF-07985631, in healthy adults to see if it is safe and how the body handles it. The medicine is being developed for a kidney disease called IgA nephropathy. Participants receive either the drug or a placebo as an injection or IV, and …

This study tests new MRI software to see if it can make image-guided ablation procedures safer and more precise. Researchers will compare the new technology to standard methods in 100 healthy volunteers and patients. The goal is to improve targeting, treatment monitoring, and out…

This early-stage study tests the safety of a new drug, DF5112, in 48 healthy adults aged 18 to 55. Participants receive either the drug or a placebo by injection and are monitored for about a week in a clinic, with follow-up visits over 29 days. The goal is to check for side effe…

This study looks at how one session of moderate or high-intensity exercise changes blood vessel function in healthy people and those with slightly high blood pressure (prehypertension). Researchers will measure artery stiffness and other markers before and after exercise in 45 ad…

This study looks at how your gut and brain work together to control hunger and fullness. Researchers will use MRI scans and different food-related tests to see which brain areas respond. The goal is to better understand appetite regulation in healthy adults.

This study follows healthy women who are trying to get pregnant, as well as women who are not, to collect samples and learn about the molecular signals between mother and embryo during the first two weeks after fertilization. The goal is to better understand what leads to a healt…

This study looks at whether a training program that mixes mental tasks with physical exercises can improve thinking and movement in people who have had a stroke or have Moyamoya disease. Researchers will measure brain activity during these tasks using a special light-based scanne…

This study aims to see if newly developed wearable sensors are comfortable and safe for healthy adults aged 18 to 99. Researchers will compare the sensors' readings of heart rate, breathing, and blood flow to those from approved medical devices. The goal is to gather information …

This study looks at whether drinking an olive extract (OliPhenolia®) for 8 days can help healthy, active adults burn more fat while cycling. It also checks if having caffeine before exercise boosts that effect. Forty volunteers will be randomly assigned to receive the drink or a …

This early-stage study enrolls 32 healthy adults to see how a drug called aramchol enters the bloodstream after taking two different doses. Participants will give blood samples to measure drug levels. The goal is to understand the drug's exposure, not to treat any disease.

This early-stage study tests an experimental drug called LY4088044 in healthy people to see if it is safe and how the body processes it. About 104 participants will receive the drug or a placebo, either as a shot under the skin or into a vein. The study lasts up to 92 weeks and i…

This study tests whether a science-based app called Flourish can improve well-being in college students. 2500 students will be randomly assigned to use the app alone, with a buddy, or continue with usual resources. Over 6 weeks, they will complete surveys measuring mood, loneline…

This study follows 800 mothers and their babies to see if how much a pregnant woman sits, sleeps, and moves affects her child's weight and heart health up to age 2. Researchers will track activity with monitors and measure baby growth. No treatments are tested—only observation to…

This study measures how much of the drug olomorasib gets into the blood and how fast the body clears it. About 120 healthy adults will take the drug by mouth in three different sequences. The study lasts about 7 weeks and includes 10 overnight stays at a research center.

This study from Stanford University looks at why people's blood sugar levels react differently to the same foods. Using continuous glucose monitors, researchers will track 100 healthy adults, people with prediabetes, and those with type 2 diabetes after eating specific meals. The…

This study aims to improve how we see inflammation in the brains of people with Alzheimer's disease. Current scans can't tell which brain cells are inflamed, but this new method uses two different tracers and math to separately track microglia and astrocytes. Researchers will sca…

This early-stage study tests a new drug, LTG-001, in healthy adults aged 18 to 55. The goal is to check its safety, how the body processes it, and whether it can be taken by mouth or through a vein. About 204 participants will receive either the drug or a placebo. This study does…

This early-stage study tests whether the experimental drug SP-624 changes brain electrical activity in 36 healthy adults and people with major depression. Participants take SP-624 or a placebo daily for two weeks. Researchers use EEG and AI to measure brain network changes and al…

This study is testing a workshop called I CAN that teaches people how to work together to reduce cancer in their community. About 200 healthy adults in Western New York will take part. The goal is to see if the program is practical and well-liked, not to directly treat or prevent…

This study looks at how the drug MK-1084 (calderasib) behaves in people with liver problems compared to healthy people. Researchers will measure drug levels in the blood and check for side effects. About 58 adults will take a single dose of the drug. The goal is to understand if …

This study aims to find the best way to record electrical signals from the stomach using a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS). Researchers will test different stimulation settings and locations in healthy adults to see what tri…

This study looks at two different ways to give oxygen to healthy volunteers before anesthesia. One method uses a breathing mask plus high-flow oxygen through the nose, while the other uses the mask alone. The goal is to see which technique raises oxygen levels faster and higher, …

This study looks at adults who carry the gene for phenylketonuria (PKU) but do not have the disease. Researchers want to see if their brains handle the amino acid phenylalanine differently than people without the gene. Participants will take phenylalanine or a placebo, then under…

This study looks at how genetic differences in the CYP2C9 enzyme affect the way healthy adults process the blood thinner warfarin. Researchers will give single doses of warfarin and other drugs to 1,000 volunteers aged 20-50. The goal is to better understand why warfarin's effect…

This study looks at how caffeinated drinks affect your mood and body. It involves 150 healthy adults aged 18 to 55 who already drink caffeine regularly. Participants will swap their usual drink for a test beverage and report how they feel using simple rating scales.

This study tests a new virtual reality system that combines mirror therapy with fun, game-like activities to help people recover arm movement after a stroke. Researchers will enroll 172 participants, including both healthy volunteers and stroke survivors, to see if the system is …

This study looks at whether measuring big toe strength can help doctors understand nerve damage caused by chemotherapy. Researchers will test 30 adults—some with nerve problems from chemo and some healthy—using a special device called ToeScale. Participants will also answer quest…

This study is testing a new 3D-printed pill that people swallow to collect bacteria samples from the gut, including the small intestine. Ten healthy adults aged 18-65 will take the pill and provide stool samples for comparison. The goal is to see if the pill is safe and can accur…

This study explores whether brain stimulation can help people quickly achieve a meditative state without years of practice. Researchers will have 48 healthy adults wear an EEG cap and receive brain stimulation while doing a guided meditation task. The goal is to see if this helps…

This early-stage study tests a new drug called M5542 in 49 healthy adults. Participants receive a single injection and are monitored for side effects and how the drug moves through the body. The goal is to gather safety information, not to treat any disease.

This study is an early test of a new drug called LY3981314 in healthy people. The goal is to see if it is safe and how the body handles it. About 76 participants will receive a single dose under the skin and be monitored for up to 25 weeks.

This study is building a large collection of human biological samples and health data to help scientists understand diseases better. It will collect samples from up to 10,000 people, including both healthy individuals and those with conditions like cancer, heart disease, and diab…

This small pilot study aims to understand if men and women wake up differently from a common anesthesia drug called dexmedetomidine. Researchers will recruit 12 healthy volunteers to measure how long it takes them to become responsive after the drug is stopped. They will also tes…

This study aims to find out exactly how much protein older, highly-trained cyclists need to eat after a training session to best support their bodies. Researchers will measure this in men aged 65 and older who cycle over 60 miles a week. They will use a special, non-invasive brea…

This study aims to see if drinking Bragg apple cider vinegar helps control blood sugar levels after a high-carb meal, compared to drinking water. Researchers will recruit 24 healthy adults who have slightly elevated blood sugar or related metabolic markers. Participants will take…

This study aims to find out if current protein recommendations for children are too low, especially for those who are very physically active. Researchers will measure protein needs in 30 healthy children aged 8-10, comparing kids who are very active to those who are more sedentar…