HEALTHY

This study tests a new dengue vaccine called V181 in 12,000 healthy children aged 2 to 17. The goal is to see if the vaccine is safe, triggers a good immune response, and lowers the number of dengue cases caused by any of the four dengue virus types. Participants will receive eit…

This study compares a new nasal spray COVID-19 booster vaccine (LVT-001) to a standard mRNA booster shot in 238 healthy adults. The goal is to see if the nasal vaccine is safe and triggers a strong immune response, especially in the nose where the virus enters. It's an early-stag…

This study tests a vaccine given to pregnant women to protect their babies from group B streptococcus (GBS), a bacteria that can cause serious illness in newborns. About 6,000 healthy pregnant women will receive either the vaccine or a placebo (saltwater shot). Researchers will m…

This study tests a new vaccine called V118E that aims to prevent diseases caused by Streptococcus pneumoniae bacteria, such as pneumonia. Researchers want to see if the vaccine is safe and well-tolerated in 126 healthy adults. Participants will receive either the new vaccine or a…

This early-stage study is testing two experimental vaccines (V350A and V350B) designed to prevent diseases caused by the Epstein-Barr virus, such as mononucleosis and certain cancers. About 250 healthy adults and teens will receive either the vaccine or a placebo to check for sid…

This early-stage study tests a new drug called LY4006895 in healthy volunteers and people with early Alzheimer's. The main goal is to check if the drug is safe and how the body processes it. About 128 participants will take either the drug or a placebo, and the study lasts up to …

This early-phase study tests whether fecal microbiota transplantation (FMT) can improve both gastrointestinal and autism-related symptoms in 60 people aged 7–30 with autism and gut issues. FMT aims to restore healthy gut bacteria, which may reduce digestive discomfort, autistic b…

This study looks at whether a weekly dose of everolimus (a rapamycin-like drug), resistance training, or both can help build bone and muscle in women aged 60-75 who have lower bone density but not full osteoporosis. About 148 women will be randomly assigned to take the drug, a pl…

This early-stage study tests a new drug called XmAb657 in healthy volunteers and people with autoimmune diseases like scleroderma, Sjögren's, and inflammatory myopathies. The main goal is to see if the drug is safe and tolerable when given as an injection under the skin. Up to 60…

This early-stage study tests a new drug called IBI3013. First, healthy adults receive a single dose to check safety and how the body processes it. Then, people with active vitiligo (white patches on skin) or severe alopecia areata (patchy hair loss) receive multiple doses. The go…

This early-phase study is testing a new medicine called LY3938577 in healthy volunteers and people with type 1 diabetes. The main goals are to see how the drug moves through the body, how safe it is, and whether it can lower blood sugar. The study has four parts and compares the …

This early-stage study tests the safety and how the body handles a new drug called LY3549492 in 120 healthy adults who are overweight or have obesity. Participants will receive multiple doses of the drug and be monitored for about 8 weeks. The goal is to see if the drug is safe a…

This study tests whether adding lactase drops to milk helps premature babies (born at 28-34 weeks) digest lactose better and gain weight faster. About 100 newborns will receive either lactase-fortified milk or regular milk, and their weight, length, and head growth will be tracke…

This early-stage study tests a new medicine called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check if the drug is safe and how well the body handles it. Participants will be followed for up to a year, and the study also loo…

This study is testing a device called Inflammacheck that measures certain chemicals in your breath to see if it can help doctors tell the difference between lung cancer, other lung diseases, and healthy lungs. About 140 adults will take part, including people with lung cancer, pn…

This study tests two light-based techniques (diffuse reflectance spectroscopy and photoacoustic imaging) to see if they can tell the difference between healthy, benign, and malignant breast tissue. About 90 adults with a breast tumor larger than 1 cm will be scanned, and the resu…

This study tests a new tool: a capsule about the size of a fish oil pill attached to a string that takes pictures inside the lower gut. It is inserted without sedation and moves slowly upward using a motor. The goal is to see if it can get clear images of the lower GI tract in 30…

This study explores a new blood test that may detect active heart inflammation in people with sarcoidosis, a disease that can cause serious heart problems. Researchers will measure DNA fragments released from damaged heart cells in 120 participants, including healthy volunteers a…

This study tests a new injection called [18F]LY4214835 to see if it is safe and can help detect cancer in the body. About 41 healthy volunteers and people with cancer will receive the injection and be monitored for side effects and how the substance spreads. The goal is to improv…

This early-stage study tests a new imaging agent called NeuCaVis in 12 healthy volunteers. NeuCaVis is a radioactive tracer used in PET scans that targets fructose use, which may highlight inflammation better than standard tracers. The goal is to check safety and how the tracer s…

This study is testing a new automated MRI method to see if it can take better pictures of the liver. It includes healthy adults and people with known or suspected liver disease or iron overload. Participants will have one MRI scan and be in the study for just one day.

This study tests a 9-month program called NE+ for American Indian youth ages 12-18. The program includes educational modules, cultural teachings, and caregiver involvement to promote healthy relationships, prevent substance use, and improve mental health. Researchers will compare…

This study looks at whether adding technology (a website and virtual coaching) to basic education and step tracking can help older adults who live alone and have mild memory concerns become more physically active. The goal is to see if increased activity, social support, and stre…

This study aims to create and test a home supervision program for Latinx families to prevent injuries in children ages 2 to 5. Researchers will work with 100 Spanish-speaking caregivers to see if the program improves how they watch their kids and reduces minor injuries. The progr…

This study looks at whether it's better to give the RSV and Tdap vaccines together at one visit or separately at different visits during pregnancy. Researchers want to see if this kind of trial is possible and how safe and effective each approach is. About 60 healthy pregnant peo…

This study tests whether a krill oil supplement called Lysoveta can improve memory in healthy adults aged 50 to 75 who feel their memory isn't as sharp as it used to be. Participants will take either Lysoveta or a placebo pill daily for about 4 months and complete computer-based …

This early-stage study tests a new drug called LY4064912 in healthy volunteers and people with overweight or obesity. The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the body processes the drug and track any change…

This early-stage study is testing a new weight loss medicine called MK-4082, taken as a pill rather than an injection. Researchers want to see if it is safe and how the body handles different doses. The study involves 120 healthy adults with a body mass index (BMI) between 25 and…

This study looks at whether Bragg apple cider vinegar can help control blood sugar after a meal in healthy adults aged 20-50. Participants will drink either vinegar or water with a carbohydrate-rich meal, then have their blood sugar measured. The goal is to see if vinegar reduces…

This early-phase study tests a new drug called LY4057996 in healthy volunteers and people with type 1 or type 2 diabetes. The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the drug moves through the body and its effe…

This study looks at whether giving children a small prize after a medical procedure helps lower their anxiety. About 187 children aged 6 to 17 will be observed and asked to rate their fear. A child life specialist will support them before and during the procedure. Researchers wil…

This study looks at whether letting first-time mothers move freely during labor can reduce the chance of an unplanned C-section. About 714 low-risk women will either get standard care or use a special mobility system. Researchers will track labor length, pain relief use, and how …

This study looks at how well healthy adults tolerate a probiotic called Smile Probio 45B and whether it helps with digestion, fatigue, and quality of life. Forty participants will take the supplement for 30 days, track their bowel habits, and complete surveys. The goal is to see …

This study tests whether citicoline, a natural supplement, can improve mood in healthy adults who have moderate mood issues. About 90 people will take either citicoline or a placebo for a set time. Researchers will measure mood, sleep quality, and stress levels to see if the supp…

This study tests a drink containing caprylic acid and omega-3 fatty acids to see if it helps muscles recover strength and reduce fatigue after intense exercise. Researchers will enroll 28 healthy young men who exercise regularly. Participants will do a muscle-damaging workout and…

This study tests whether a science-based mobile app called Flourish can improve well-being in college students. About 2,500 students will be randomly assigned to use the app alone, use it with a buddy, or continue with their usual resources. Over 6 weeks, they will complete surve…

This study tests whether training the muscles you use to breathe in can improve strength and performance in amateur CrossFit athletes. 94 healthy adults aged 18-60 who do CrossFit will either do breathing exercises with a special device or use a fake device. Researchers will meas…

This study looks at whether eating grapes can help improve muscle strength and cognitive function in healthy women aged 65 and older. Participants will attend four sessions on campus for strength tests, thinking assessments, and blood draws. The goal is to see if a simple dietary…

This early-stage study tests an experimental drug called SP-624 in 36 adults—some healthy and some with major depression. Participants take the drug or a placebo daily for two weeks. Researchers use EEG brain scans and AI to see if SP-624 changes brain activity and improves memor…

This study tests a new virtual reality system that combines mirror therapy with fun games to help stroke patients improve arm movement. Researchers will check how comfortable and easy the system is to use in 172 healthy volunteers and stroke survivors. The goal is to see if this …

This early-stage study tests an experimental pill called BGM0504 in healthy and non-diabetic overweight or obese Chinese adults. The main goal is to check safety and how the body processes the drug. Researchers will also measure weight changes over 8 weeks. 75 participants will r…

This early-stage study is testing a new injectable drug called LY3971297 to see if it is safe and how the body processes it. The trial includes healthy volunteers, people with obesity and high blood pressure, and those with reduced kidney function. Researchers will monitor side e…

This study tests if a special vacuum dressing (closed incision negative pressure therapy) helps wounds heal better after breast reduction surgery compared to a standard bandage. About 92 women will each have one breast treated with the special dressing and the other with a standa…

This study tests if a new type of laser (DFG laser) causes less pain and helps skin heal faster than the standard CO2 laser. About 23 healthy adults will receive both laser treatments on small skin areas. Researchers will measure pain scores and track healing through photos and i…

This study looks at whether adding polyphenol-rich foods like beans and lentils to your daily diet can make your skin healthier. Researchers will measure how skin reacts to UV light, its moisture barrier, and redness in 50 women aged 45-65 over 12 weeks. The goal is to see if the…

This study looks at whether drinking an olive extract (OliPhenolia®) for 8 days helps healthy, active adults burn more fat during cycling. It also checks if having caffeine before exercise makes the effect stronger. About 40 volunteers will take part. The goal is to see if this n…

This study tests a new inhaled medication called Optate for people with mild COVID-19. About 40 adults will receive either Optate or a placebo spray. Researchers will measure virus levels in the nose and track symptom changes using a quality-of-life survey.

This early-stage study tests a new medicine called LY4086940 in healthy people and those who are overweight or have obesity, with or without type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will take part in differ…

This early-stage study tests a new drug called LY4213663 in healthy volunteers and people with rheumatoid arthritis (RA). The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the body processes the drug. The study lasts…

This study looks at whether eating grapes rich in natural compounds called flavonoids can protect brain function, blood flow, and mood during mental stress in healthy young adults aged 18-40. Participants will consume either a high-flavonoid grape powder or a low-flavonoid contro…

This study looks at how fluconazole, a common antifungal, changes the way the body handles olomorasib, an experimental cancer drug. Fifteen healthy adults will take both drugs and have their blood levels measured. The study lasts about 7 weeks and requires 12 overnight stays at a…

This early-stage study is testing a new drug called BI 3031185 in 60 healthy men aged 18 to 50. The goal is to see if the drug is safe and how the body processes it when taken by mouth multiple times. Participants will be randomly assigned to receive either the drug or a placebo,…

This study looks at whether a nasal spray with oxytocin (the 'love hormone') can help people better control a specific brain region during a brain-scanning task. Healthy adults will receive either oxytocin or a placebo and then practice using their thoughts to change brain activi…

This study looks at how different diets (vegan, vegetarian, or omnivore) change body weight, body fat, and the microbes in your gut and mouth. Researchers will follow 120 college freshmen for their first year, collecting saliva, stool, urine, and blood samples. The goal is to und…

This early-stage study is testing whether a new drug, HB0056, is safe and tolerable in healthy adults. About 46 volunteers will receive a single dose of the drug or a placebo. Researchers will monitor for side effects and measure how the drug moves through the body. This study do…

This study is adapting a questionnaire called the Cervical Cancer Screening Uptake Questionnaire (CCSTQ) for Turkish women. The goal is to understand the psychological and social reasons why women choose to get screened for cervical cancer. Researchers will ask 215 women aged 21-…

This study looks at how an experimental medicine, PF-08653944, is handled by the body in adults with normal liver function and those with mild to severe liver problems. Participants receive a single injection and undergo blood tests and checkups. The goal is to gather safety and …

This study looks at whether a diet low in methionine (an amino acid) can change the bacteria in your gut and lower inflammation. Forty healthy adults will follow the diet for several weeks, with some also taking methionine supplements or a placebo. Researchers will measure gut ba…

This early-stage study tests a new drug, LTG-001, in 204 healthy adults aged 18 to 55. The goal is to check its safety, side effects, and how the body processes it when taken by mouth or through a vein. No treatment is given—this is purely to gather information for future researc…

This study tests whether a mild nerve stimulation (taVNS) after a single dose of psilocybin can help people remember insights from their experience longer. 108 healthy adults with mild emotional distress will be tracked using memory tests, brain scans, and well-being surveys. The…

This study looks at how different areas of the brain connect and communicate in healthy adults. Researchers use safe, non-invasive methods like magnetic pulses and brain wave recordings to measure these connections. The goal is to better understand brain function, not to treat an…

This study is testing a new, smaller minitablet version of the drug obefazimod in 44 healthy adults aged 18 to 55. The goal is to see how well the body absorbs the minitablet compared to the current capsule and whether the minitablet tastes acceptable. This is an early-stage stud…

This study looks at how small changes in your genes might affect the body's natural ability to control inflammation. Researchers will analyze blood samples from 200 volunteers to measure molecules that help resolve inflammation. The goal is to better understand why some people de…

This study collects small tissue samples from the belly lining of children and adults on peritoneal dialysis. The goal is to learn how dialysis changes this lining over time, which can affect treatment success. Participants include people with kidney failure on dialysis, healthy …

This study looks at how past childhood experiences might affect memory and brain function in people with opioid use disorder. Researchers will compare three groups: people with opioid use disorder on buprenorphine, people without the disorder on buprenorphine, and healthy adults.…

This study tests a new experimental HIV medicine, MK-4646, in 16 healthy adults to see how it interacts with two standard HIV treatments: BIC/FTC/TAF and dolutegravir. Researchers will measure drug levels in the blood and check for side effects. The goal is to ensure safety befor…

This study looks at how stroke changes the way people move their arms when walking. Researchers will measure brain activity and muscle patterns in 84 people (some who had a stroke and some healthy) to understand why arm swing is different after a stroke. The goal is to use these …

This study looks at whether eating white potatoes at breakfast or dinner changes how your body handles blood sugar, how full you feel, and how many calories you eat later. Researchers will track 30 healthy adults using a continuous glucose monitor and measure their food intake at…

This study looks at whether a specific combination of electroacupuncture points can affect bowel movements in 30 healthy volunteers. Participants will have their bowel sounds recorded before, during, and after a 20-minute acupuncture session using a digital stethoscope. The goal …

This early-stage study tests a new drug, CM383, in 30 healthy men to see how the body absorbs and processes it, and to check for any safety issues. Participants receive a single dose either as an IV or a shot. The goal is to gather basic information, not to treat any disease.

This early-stage study tests whether a new topical drug called JW0061 is safe for healthy adults. About 104 Korean and Caucasian volunteers will receive either the drug or a placebo cream. The goal is to check for side effects and how the body processes the drug, not to treat any…

This study aims to improve current methods and develop new techniques for magnetic resonance imaging (MRI). Researchers will test different scanning parameters on healthy volunteers and current NIH participants aged 18 and older. Participants will undergo one or more MRI scans, e…

This study looks at whether telemedicine (video visits) can effectively educate and counsel people considering living kidney donation. About 70 participants will either get standard care or telemedicine support. Researchers want to see if this approach helps donors make better de…

This early-stage study is testing a new drug called LY4515100 in 40 healthy adults to see if it is safe and how the body processes it. Participants will take either the drug or a placebo and stay overnight for monitoring. The study lasts up to 30 days and includes blood tests. It…

This study looks at how a medicine called BI 3000202 is handled by the body in people with and without liver problems. About 44 adults aged 18 to 80 will take a single tablet and have their blood tested over a month. The goal is to understand if liver impairment changes drug leve…

This study from Stanford University aims to understand why people have different blood sugar responses to the same foods. Researchers will use continuous glucose monitors (CGMs) to track how 100 adults (with prediabetes, type 2 diabetes, or healthy) react to specific meals. The g…

This study looks at how the drug itraconazole changes the amount of MK-2828 in the body, and how MK-2828 changes the amount of midazolam. It involves 28 healthy adults and is in Phase 1. The goal is to understand drug interactions, not to treat any disease.

This study looks at whether teaching healthy young adults to eat more potassium-rich foods is easier and better for their blood vessels than telling them to cut back on salt. Researchers will compare the two diet approaches over six months, checking things like blood pressure and…

This study explores whether using an AI chatbot, like ChatGPT, can improve how physical therapy students learn to diagnose and treat patients. About 60 students will either use the AI to practice with virtual patient cases or follow their usual lessons. The goal is to see if AI c…

This study looks at how kidney blood flow changes during exercise in healthy older African American adults compared to White adults. Researchers want to see if African Americans have a bigger drop in kidney blood flow during exercise, cold stress, or mental stress. The goal is to…

This study explores whether brain stimulation can help people quickly achieve a meditative state, normally requiring years of training. 48 healthy adults will undergo brain stimulation while wearing an EEG cap and performing a guided meditation task. Researchers will measure chan…

This study aims to understand what keeps the brain healthy as we age. Researchers will track 100,000 healthy adults over time using online tests and surveys. Participants may also access brain-training tools and coaching. The goal is to identify factors that support thinking, wel…

This study creates and tests a training course for Care Food Specialists in Taiwan to help long-term care workers better support eating and oral health. About 150 healthy students in care programs will take the course and be assessed before and after. The goal is to improve their…

This study looks at how the experimental drug PF-07328948 is absorbed, distributed, and removed from the body in healthy men aged 18 to 64. Participants will take the drug by mouth and by injection, and provide blood, urine, and stool samples. The goal is to understand the drug's…

This study tests whether a mild electrical stimulation behind the ear (called taVNS) can affect insulin, C-peptide, and blood sugar levels in healthy adults aged 18-70. Researchers will compare active stimulation to a control group and measure changes in blood and heart rate. The…

This study looks at whether stopping cannabis for at least 4 weeks can improve brain cell connections in people with cannabis use disorder. Researchers will use brain scans to measure these connections and test memory before and after quitting. The study involves 51 participants,…

This study looks at how cooling down the thigh muscles changes the way nerves activate them. Researchers will use special sensors to measure muscle signals in 24 healthy adults aged 18-35. The goal is to see if this method works well and to gather information for larger future st…

This study looks at how bacteria in your gut might be linked to brain aging and diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will compare 200 people—healthy young and older adults, plus those with early Alzheimer's, Parkinson's, or MS—using brain sc…

This study looks at whether giving magnetic pulses to the brain at the right moment in your natural brain wave cycle can make movement training more effective. Researchers will test healthy adults and people who had a stroke at least 6 months ago. The goal is to understand how th…

This study is testing whether wearable devices like smartwatches can accurately track movement problems in people with Huntington's disease. About 100 participants, including healthy volunteers, will wear sensors and complete surveys and interviews at home. The goal is to find be…

This study looks at how the gut and brain work together to control appetite. Researchers will give healthy adults different food-related sensations (like stomach stretching or tasting calories) and use brain scans to see which areas light up. The goal is to understand why we feel…

This early-stage study is testing a new drug called BI 3776528 in 142 healthy men aged 18 to 50. The main goal is to see if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo. This study does not aim to treat any disease.

This study looks at how healthy adults feel after drinking caffeinated beverages. About 150 people aged 18 to 55 who already drink caffeine regularly will try a test drink and rate their mood and energy. They will also use a wearable device to track body responses. The goal is to…

This study looks at whether the phase of your menstrual cycle (follicular vs. luteal) changes how your body responds to sprint interval training. Researchers will measure endurance performance and muscle changes in 24 healthy women over 2 weeks. The goal is to understand if timin…

This study looks at how different caffeinated drinks change how people feel and their body's reactions. It involves 75 healthy adults aged 18-55 who already drink caffeinated beverages regularly. Participants will try different versions of a caffeinated drink and report their fee…

This study looks at how the drug LY3537031 is processed by the body in people with mild, moderate, or severe liver problems compared to healthy volunteers. About 32 adults will receive a single injection under the skin. The goal is to measure drug levels in the blood and check fo…

This study is testing a device called Electrical Impedance Tomography (EIT) that creates images of the lungs without using radiation. It will be used in children with chronic lung diseases, neuromuscular disorders, and healthy volunteers to see if it can provide useful informatio…

This study looks at how genetic differences affect the way healthy adults process the blood thinner warfarin. Researchers will give small doses of warfarin and other drugs to 1000 volunteers aged 20-50 to measure how their bodies break down these medicines. The goal is to better …

This study is checking if taking a supplement called palmitoylethanolamide (PEA) every day for a year is safe for healthy adults. About 200 people aged 18 and older will take either PEA or a placebo pill, and researchers will track any side effects. The goal is to see if long-ter…

This study watches how babies and toddlers aged 6 to 24 months chew baby cereals with different textures. Researchers want to see if certain textures help children learn to chew better at different ages. About 153 healthy children will take part, and their chewing will be recorde…

This early-stage study tests an experimental oral drug called AS-S603, designed to target proteins linked to Alzheimer's disease. The main goal is to check the drug's safety and how the body processes it in 88 healthy adults, including Korean and Caucasian volunteers and older Ko…

This study looks at how healthy hearts work at rest and during exercise in people of different ages. Researchers will measure pressures inside the heart using a thin tube. The goal is to understand normal heart function, not to test a treatment. About 80 healthy adults will take …

This study looks at a part of the brain called the reticulospinal system, which helps control movement like walking and reaching. Researchers will use loud sounds and motion tracking to measure how this system works in healthy people and in those with spinal cord injuries. The go…

This study looks at how the drug MK-1084 (calderasib) moves through the body in people with liver problems compared to healthy people. About 58 adults will take a single dose, and researchers will measure drug levels and check for side effects. The goal is to understand if liver …

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders (like spinal cord injury, stroke, or multiple sclerosis) control assistive devices just by thinking about moving. Researchers will use EEG to read brain signals and comb…

This study tests a teacher-led program called the Early Childhood Friendship Project in 600 preschoolers from diverse backgrounds. The program aims to reduce physical and relational aggression, increase prosocial behavior, and improve social and academic skills. Researchers will …

This early-stage study tests a new medicine, PF-07985631, in healthy adults to see if it is safe and how the body handles it. The medicine is being developed for a kidney disease called IgA nephropathy. Participants receive either the drug or a placebo as an injection or IV, and …

This study aims to see how breathing muscle training at different intensities affects oxygen levels in the chest muscles of healthy adults. About 27 physically active volunteers will have their muscle oxygen measured before, during, and after training sessions. The goal is to und…

This study looks at whether brain activity can predict when someone will make a mistake during a typing task, up to 1 second before it occurs. Researchers will use brain scans (MRI and MEG) to compare brain patterns before errors versus correct actions. The goal is to understand …

This early-stage study tests whether a new drug called LY3867070 is safe and how the body handles it. About 196 healthy adults will receive the drug orally and have blood tests. The goal is to check for side effects and measure drug levels, not to treat any disease.

This study looks at how a gentle brain stimulation technique called tDCS affects attention and thinking. Researchers will test healthy adults and people with schizophrenia using computer tasks and brain wave recordings. The goal is to learn more about how the brain works, not to …

This study looks at how well physiotherapy students and their teachers agree on the students' non-technical skills—like teamwork, leadership, and communication—during clinical simulations. About 100 second-year students and their teachers will take part. The goal is to better und…

This study looks at how using common skin creams—like antifungals, mild steroids, and moisturizers—changes the community of bacteria living on your skin. Researchers will test these creams on healthy adults over a short time to see which bacteria increase or decrease. The goal is…

This early-stage study is testing a new drug, HY8931, in 60 healthy adults aged 18 to 45. The main goal is to see if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo and be monitored for up to 90 days.

This pilot study in 12 healthy volunteers aims to see if biological sex influences how quickly people recover from unconsciousness caused by the sedative dexmedetomidine. Researchers will also test if a brain measurement technique called TMS-EEG can safely track brain activity du…

This early-stage study is testing a new drug called SRK-439 in 76 healthy adults aged 18 to 55. The main goal is to see if the drug is safe and how the body processes it. Participants will receive either a single dose or multiple doses of the drug. This study does not aim to trea…

This study looks at how growth hormone, alone or with liraglutide (a diabetes drug), affects appetite signals, energy use, and blood sugar in healthy adults and those with growth hormone deficiency. Participants will receive different treatments over 21-day periods. The goal is t…

This study looks at how olomorasib moves through the body in 120 healthy adults. Participants take the drug by mouth and stay overnight at the research center 10 times over about 7 weeks. The goal is to measure drug levels in the blood and how fast the body clears it.

This study looks at how healthy bone marrow cells use a nutrient called glutamine. Researchers will give a special labeled form of glutamine to 20 healthy adults aged 18-60, then take a small bone marrow sample to measure how the cells process it. The goal is to understand normal…

This study looks at how the brain, memory, thinking, and movement change over time in people with Lewy body disease, Alzheimer disease, and healthy volunteers. Researchers will use brain scans and brain-wave tests to learn more about these disorders. The goal is to better underst…

This study tests new MRI software to see if it helps doctors perform image-guided ablation more accurately. Researchers will compare the new sequence to standard methods in 100 healthy volunteers and patients already scheduled for an MRI-guided procedure. The goal is to improve t…

This study looks at how one session of moderate or high-intensity exercise changes blood vessel function in healthy people and those with slightly high blood pressure (prehypertension). Researchers will measure artery stiffness and blood flow before and after exercise in 45 adult…

This study tests whether healthy people can learn to control a part of their brain (the medial prefrontal cortex) that is linked to worrying about bad events. Participants will use real-time brain scans (fMRI) to see their brain activity and try to change it. The goal is to see i…

This study takes tiny tissue samples from the rectum of people with Irritable Bowel Syndrome (IBS) and healthy volunteers to measure how gut nerves work. Researchers will use special imaging and lab tests to see how these nerves react to different substances and foods. The goal i…

This study looks at whether brain wave tests (EEG) can help predict how chronic low back pain changes over time. Researchers will track 130 adults with chronic low back pain and healthy volunteers for 5 months, measuring brain activity and pain levels. The goal is to find brain m…

This study tests a community workshop called I CAN that teaches people how to take action to reduce cancer in Western New York. About 200 healthy adults will attend the workshop and share their feedback. The goal is to see if this approach is practical and acceptable for building…

This study uses a special type of MRI, called hyperpolarized xenon MRI, to take detailed pictures of the lungs in 260 healthy young adults. The goal is to find early signs of lung problems that could lead to chronic lung disease later in life. Participants are already part of a l…

This study looks at how much harmful chemicals firefighters are exposed to when fighting structural fires. Researchers will collect urine and cheek cell samples from 60 firefighters before and after a fire call. The goal is to measure changes in biomarker levels to better underst…

This study is testing whether a low-dose fisetin supplement (100 mg daily for 7 weeks) is safe and can reduce signs of aging in healthy adults aged 50 and older. Researchers will measure inflammation and other aging markers in 120 volunteers. The goal is to see if this popular 'a…

This early-stage trial tests the safety and how the body handles a new drug called BI 3804379 in 106 healthy adults. Participants receive either the drug or a placebo as a single or multiple doses. The goal is to check for side effects and measure drug levels in the blood, not to…

This study enrolls 330 healthy adults to see if two different autoinjectors deliver the same amount of the drug tulisokibart into the body. Researchers will measure drug levels in the blood and watch for any side effects. The goal is to make sure both devices work the same way be…

This study looks at how people with temporal lobe epilepsy (TLE) remember spatial information, like directions, over several weeks compared to healthy volunteers. Researchers want to understand if these patients forget spatial details faster than usual, which can affect daily lif…

This study looks at how two natural compounds in food—oxalate and citrate—interact in the body and affect kidney stone risk. Researchers will give potassium citrate to 24 adults (some with a history of kidney stones, some without) and measure changes in their urine over six hours…

This study tests whether a single dose of oxytocin nasal spray changes how healthy adults react to threats in a virtual predator-prey game. Researchers measure escape success, brain activity, and anxiety levels. The goal is to understand how oxytocin influences defensive behavior…

This study looks at how short (10 minutes) and longer (30 minutes) exercise sessions affect hunger, appetite-related hormones, and how much men eat after a meal. Fourteen healthy men will have their blood tested and appetite tracked. The goal is to understand when and how exercis…

This early-stage study tests whether ZT003 injection is safe and how the body processes it. About 76 healthy and overweight volunteers will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels, not to treat any disease.

This study checks if people can use a home kit to measure levels of urolithin A in their blood after taking Mitopure. About 250 healthy adults aged 18 to 80 will collect blood samples at home and send them for analysis. The goal is to see how reliable the kit is and if it can be …

This study is for 80 healthy adults aged 18-64. It tests a new way to stimulate the brain using focused ultrasound, guided by real-time brain wave monitoring (EEG). The goal is to learn how to best use this technology for future treatments of brain conditions. Participants will u…

This study tests two different injector pens that deliver the same medicine (Genotropin) under the skin. Healthy adults aged 18-60 will receive one dose with each pen and have blood samples taken to compare how much medicine gets into the blood. The goal is to see if the pens wor…

This study looks at how quickly healthy adults convert EPA (an omega-3) into DHA (another omega-3) in their blood. Researchers want to see if a person's sex and a specific gene affect this conversion rate. Participants will take EPA supplements for 12 weeks and give blood samples…

This study looks at how a 30-minute workout changes hunger and appetite-related hormones in healthy men who are also cutting calories. Researchers will compare three groups: one with normal eating, one with severe calorie restriction, and one with severe calorie restriction plus …

This study tests two ways of giving people real-time feedback from their own brain scans to help them control a specific brain region (the anterior insula). 90 healthy adults will try either continuous or intermittent feedback while watching painful pictures. The goal is to see w…

This study looks at how different types of strength training—using a steady beat, a variable beat, or no beat at all—change the way the brain talks to muscles. Researchers will measure brain activity and muscle strength in 60 healthy adults aged 18 to 40 over four weeks. The goal…

This early-stage study tests the safety and how the body handles a single dose of IBI3032 in 32 healthy adults. Participants are randomly assigned to receive either the drug or a placebo. The study is for research only and does not aim to treat any disease.

This study looks at how growth hormone affects beta-cells—the cells that make insulin—in women who had gestational diabetes. Researchers want to understand why some women develop this condition. The study involves 30 women with or without a history of gestational diabetes, and us…

This study translates and tests health questionnaires about pain, movement, and daily life for Albanian-speaking people. About 300 adults with muscle or joint pain, back pain, or other musculoskeletal issues will fill out the translated forms. The goal is to make sure these tools…

This study aims to learn how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 volunteers, including healthy individuals and those at higher risk for type 2 diabetes. Partici…

This study looks at how healthy adults' gut bacteria change when they take a fiber supplement called chicory inulin. Researchers want to see how quickly and how long the bacteria change, and if it affects mood, appetite, and bowel habits. About 52 people will take either inulin o…

This study looks at whether taking a probiotic called Lactobacillus rhamnosus GG (LGG) can affect changes in gut bacteria caused by common acid reflux medicines (PPIs). Researchers will give 30 healthy adults either a probiotic or a placebo alongside a PPI and compare stool sampl…

This study looks at how doing the "Xuong tan lac than" exercise for 12 weeks changes joint flexibility and muscle endurance in healthy adults. About 34 volunteers will practice the exercise daily and get tested every few weeks. The goal is to learn if this traditional exercise ca…

This study tests a new neck-strengthening device (TopSpin360) in 60 healthy junior hockey players. Researchers want to see if using the device improves neck strength, reaction time, and brain function. Participants will be measured before and after training, but no treatment is g…

This early-stage study is testing whether a new drug called BLKR201 is safe for people. About 128 healthy adults will take either the drug or a placebo and stay at a research clinic for several days. Researchers will monitor side effects, measure how the drug moves through the bo…

This study looks at whether current protein recommendations for children ages 8-10 are too low, especially for those who are very active and fit. Researchers will measure how the body uses protein in 30 healthy kids with different activity levels. The goal is to better understand…

This study looks at how drinking milk or eating yogurt affects thinking and memory in healthy children aged 9 to 14. Researchers will test kids' attention, memory, and mood after they consume different dairy products. The goal is to understand how dairy might help the brain throu…

This early-stage study tests the safety and tolerability of BT01001 eye drops in 32 healthy adults aged 18 to 50. Participants receive either the active eye drop or a placebo, and researchers monitor for side effects. The goal is to gather safety information, not to treat any dis…

This study aims to develop better MRI methods for looking at the brain's structure and activity. Healthy adults aged 18 and older will have yearly MRI scans, sometimes while doing simple tasks like listening or tapping fingers. The goal is to improve imaging technology, not to tr…

This study looks at whether salbutamol, a common asthma medication, can improve exercise performance in non-asthmatic endurance athletes. Researchers want to see if a specific group of athletes with breathing limitations might benefit from the drug. The study involves 64 healthy,…

This study looks at how people who speak two languages (like Mandarin and English) or a spoken language and sign language (like ASL and English) control which language they use. Researchers will have 360 healthy adults do tasks like naming pictures or sorting words in different l…

This study looks at whether a 16-week ideomotor group exercise program can improve thinking, movement, and overall well-being in healthy adults aged 50 and older. About 158 participants will be compared to a group doing standard cognitive training. The goal is to see if this gent…

This study looks at whether slow, steady breathing at 6 breaths per minute can lower stress more than breathing at a normal pace or just sitting still. Researchers will compare three groups of healthy adults to see if the specific rhythm offers unique benefits. Participants will …

This study aims to collect normal measurements of tongue strength and movement in 300 healthy children aged 4 to 17. Researchers will use a simple device to measure tongue pressure and check for tongue-tie restrictions. The goal is to establish reference values that can help diag…

This early-stage study is the first time CAY001 is being tested in humans. The main goal is to see if it is safe and how the body handles it. About 24 healthy adults will receive either a single dose of the drug or a placebo. Researchers will monitor for side effects and measure …

This study compares a 9-week group cycling program to a single training session for adults who rarely cycle. Researchers want to see if the longer program helps more people start cycling and improves their health and well-being. About 268 adults will take part, and the study will…

This study looks at how a single dose of ulonivirine changes the way the body processes atorvastatin and metformin. It involves 12 healthy adults and is purely for gathering information, not for treating any disease. The results will help guide future use of ulonivirine with thes…

This study aims to understand what causes Visual Snow Syndrome (VSS), a condition where people see constant flickering dots. Researchers will use brain scans and visual tests to find which brain pathways are involved. About 100 adults with VSS, migraine, or healthy vision will pa…

This study looks at how HIV may still harm the brain even when the virus is controlled with medication. Researchers will use special PET and MRI scans to measure brain cell connections and inflammation in 70 people with HIV and healthy volunteers. The goal is to better understand…

This early-stage study tests the safety of a new drug called DF5112 in 48 healthy adults aged 18 to 55. Participants receive a single dose of the drug or a placebo and are monitored for about a week in a clinic, with follow-ups for a month. The goal is to check for side effects a…

This study looks at whether eating dinner earlier in the day can improve how the body burns fat and handles blood sugar. Researchers will compare early versus late dinner in 32 adults, including healthy-weight individuals and those with obesity and prediabetes. The goal is to und…

This early-stage study is testing a new drug, SYNT-101, to see if it is safe and how the body processes it. The study involves 64 healthy adults, including some who are overweight or have obesity. Participants will receive either the drug or a placebo, and researchers will monito…

This early-stage study tests whether a new drug called IMP761 is safe in healthy adults aged 18 to 55. Participants receive either the drug or a placebo and are closely monitored for side effects and changes in vital signs. The study does not aim to treat any disease, but to gath…

This study is testing a portable ultrasound device that uses sound waves to measure bone density in the lower leg, without any radiation. Researchers will compare its results to standard DXA X-ray scans in 350 healthy men and women aged 21 to 55. The goal is to see if the new dev…

This study watches how babies and toddlers at high or low risk for autism develop helpful behaviors and brain connections. Researchers will use play-based tests, EEG, and MRI scans during natural sleep to compare the two groups. The goal is to understand early differences that ma…

This study tests a new wrist-worn device that measures blood pressure without a traditional arm cuff. It compares the readings to standard cuff devices in healthy volunteers and people with high blood pressure. The goal is to see if the cuff-less method is accurate and comfortabl…

This study checks whether a new drug called vicadrostat affects the heart's electrical activity in healthy adults. About 45 volunteers will receive single doses of vicadrostat, a placebo, or an active control (moxifloxacin) in a crossover design. The main goal is to see if vicadr…

This early-stage study tests the safety of a new drug called LY4066708 in 104 healthy volunteers. Researchers will measure how much drug enters the blood and brain, and how fast the body clears it. The study lasts up to 24 weeks and does not aim to treat any disease, but will hel…

This study looks at two different ways to give oxygen to healthy adults before anesthesia. Researchers will measure oxygen levels in the breath and blood to see which method works better. The goal is to learn more about how to prepare patients safely for medical procedures.

This study collects blood samples from 400 healthy adults aged 18 to 65 to learn how platelets work and cause inflammation and blood clots in diseases. Participants give blood at the Cleveland Clinic. No treatment or medication is given. The goal is to build a biorepository for f…

This study tests a new prostate cancer drug called opevesostat in 14 healthy men to see how it behaves in the body when taken with or without another drug, itraconazole. The goal is to understand how the body processes opevesostat, which may help guide future dosing for prostate …

This study looks at whether a temporary, non-invasive brain stimulation technique called TMS can affect how healthy people respond emotionally to stress. About 55 participants will do tasks during an MRI scan, then receive both real and fake TMS on different days to compare effec…

This early-stage study enrolls 32 healthy volunteers to measure how much aramchol gets into the blood after taking two different single doses of a new tablet form. Participants will have blood samples taken to track drug levels. The goal is purely to gather information on drug ex…

This study tests a new drug called LY3981314 in healthy volunteers to see if it is safe and how the body handles it. About 76 participants will receive a single injection under the skin and be monitored for up to 25 weeks. The goal is to gather safety data, not to treat any disea…

This study aims to understand how the body's immune cells react to a new type of vaccine (neoantigen vaccine) that helps the immune system recognize and fight cancer. Researchers will collect blood samples from 24 people with solid tumors or healthy volunteers to study immune cel…

This study is for people with a change in the GBA1 gene, which raises the risk of Parkinson's disease. Researchers will use 15 simple, non-invasive tests to look for very early signs of Parkinson's that can appear up to 20 years before symptoms start. The goal is to create a mode…

This early-stage study is testing whether an inhaled drug called CPD704 is safe and how it behaves in the body. It involves 90 healthy Chinese adults aged 18–55. The goal is to check for side effects and measure drug levels in the blood, not to treat any disease.

This study looks at whether a person's natural thinking and control abilities can predict how well they learn to control a specific brain region using real-time fMRI feedback. Forty healthy adults will undergo brain scans while performing tasks and trying to regulate their brain …

This early-stage study tests a new drug, AZD1613, in healthy volunteers to see if it is safe and how the body processes it. About 136 healthy adults, including people of Japanese and Chinese descent, will receive either the drug or a placebo. The goal is to gather information, no…

This study looks at how the drug mirdametinib is absorbed and removed from the body in people with moderate or severe liver problems compared to those with healthy livers. It involves 32 adults aged 18 to 80. The goal is to gather information, not to treat any condition.

This study looks at how natural changes in the female hormone estradiol affect the spinal cord's ability to adapt and change (called neuroplasticity). Researchers will use mild electrical stimulation to test spinal reflexes in 50 healthy young adults. No drugs or treatments are g…

This study watches 204 people with depression to see if brain activity returns to normal after taking antidepressants. If it does, doctors may try stopping the medication and check if depression stays away. Participants get brain tests, sleep recordings, and blood draws over seve…

This early-stage study in 39 healthy adults checks if a new heart failure medicine called MK-2828 affects how the body handles two common drugs: rosuvastatin and furosemide. The goal is to gather safety and interaction data, not to treat any disease. Participants must be in good …

This study looks at how different levels of liver function affect the way the body processes a new medicine called PF-07328948. Researchers will give a single tablet to 26 adults, some with liver problems and some healthy, and monitor them for about 6 days. The goal is to learn i…

This study tests a new microscope that shows live 3D images inside the eye during surgery. It includes up to 262 people with various eye conditions like retinal detachment, cataracts, or macular holes, as well as healthy volunteers. The goal is to see if this technology helps sur…

This study tests a new imaging tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. About 90 volunteers aged 50 and older, including healthy individuals, will get PET and MRI scans. The goal is to understand how infla…

This study tests a 21-day self-guided digital program designed to prepare healthy volunteers for a supervised psychedelic experience. Forty participants will be randomly assigned to either a daily meditation or music-listening routine before taking psilocybin. The main goal is to…

This study tests a new substance called [18F]-fluoromannitol, used in PET scans to help detect infections. Ten healthy adults will receive the tracer to see if it is safe and how it travels through the body. The goal is to gather safety data for future use in people with sickle c…

This study aims to improve diagnosis for people with rare genetic diseases that standard DNA tests cannot identify. Researchers will use RNA sequencing on skin cells from 105 participants, including healthy volunteers and patients with known or suspected genetic conditions. The g…

This study follows healthy women who are trying to get pregnant, as well as those who are not, to collect samples and data during the first two weeks after fertilization. The goal is to learn how the mother's body and the early embryo talk to each other at the molecular level. Th…

This early-stage study is testing a new drug, HY6725, in 74 healthy adults aged 18 to 55. The main goal is to check if the drug is safe and how the body processes it. Participants receive either the drug or a placebo as a single shot or multiple shots, and are followed for up to …

This study follows 10,000 healthy adults for up to 20 years to find ways to detect cancer earlier. Participants provide blood samples and answer questions about lifestyle and medications. The goal is to identify changes in proteins, RNA, and DNA that appear before a cancer diagno…

This study looks at how social media addiction and compulsive exercise are connected in healthy university students aged 18-24. Researchers will use surveys to measure social media use and exercise patterns. The goal is to understand the relationship between these behaviors, not …

This study looks at how the Q-Collar, a device worn around the neck, changes blood flow to the brain during rest and exercise. Twenty healthy adults aged 18 to 30 will complete two sessions—one with the collar and one without—while doing standing tests, breathing exercises, and b…

This study at the University of Oxford looks at how a drug called pimavanserin, which blocks a specific serotonin receptor in the brain, affects memory, emotional processing, and decision-making. Researchers will give the drug or a placebo to 80 healthy adults aged 18-45 and comp…

This study tests whether a non-invasive brain stimulation technique called HD-tDCS can improve hand movement in healthy older adults. Researchers will compare a standard dose to a personalized dose. The goal is to understand how the brain controls movement and whether tailored st…

This study looks at how the body processes a new medicine called BI 1291583 in people with and without liver problems. The drug is being developed for bronchiectasis, a chronic lung disease. About 32 adults will take a single dose of the drug, and researchers will measure its lev…

This study aims to learn more about the natural bacteria (microbiome) living in the vagina and mouth of healthy women. Researchers will collect swab samples from 520 participants visiting gynecology or dermatology clinics in Finland. No treatments or medications are involved—only…

This study looks at sleep issues in healthy Somali Americans and how they might affect blood pressure. Researchers will measure sleep quality and blood pressure in 240 adults. The goal is to find hidden sleep problems that could raise hypertension risk in this community.

This study aims to develop a simple decision tool for physical therapists to know when they should check vital signs like heart rate and blood pressure during outpatient therapy. Researchers will survey 100 experienced physical therapists over three rounds to agree on which signs…

This study looks at whether listening to music while running changes the forces your feet apply to the treadmill and your overall running form. Researchers will measure things like impact and how your body moves. The goal is to understand if music can affect injury risk or perfor…

This study looks at whether training that mixes mental tasks with physical exercises can improve thinking and movement in people with stroke or Moyamoya disease. Researchers will measure brain activity during these tasks using a special light-based scanner. The goal is to underst…

This study explores whether a non-invasive brain stimulation technique can help people quickly achieve a deep meditative state, normally requiring years of training. Twelve healthy adults who already meditate will undergo brain stimulation while wearing an EEG cap and performing …

This study tests whether a bile acid supplement called 7-keto lithocholic acid (7-KLCA) can change the types of bacteria in the gut and improve health markers like blood sugar and cholesterol. Researchers will give 40 healthy adults the supplement for 12 weeks and measure changes…

This study looks at how the body handles a single dose of the experimental drug PF-07328948 in adults with normal or reduced kidney function. About 28 participants aged 18 to 80 will take one tablet and stay at a clinic for 6 days for monitoring. The goal is to understand safety …

This study looks at how much protein male cyclists aged 65 and older need after a cycling workout. Researchers will use a safe, non-invasive method to measure protein needs in 8 healthy, active volunteers. The goal is to improve dietary advice for older athletes.

This study looks at how blind people use a white cane to sense the world around them, like feeling for curbs or obstacles. Researchers will test touch perception on a rod and measure brain activity with EEG and MRI. The goal is to understand how the brain treats the cane as an ex…

This study tests a new radioactive tracer called 11C-JMJ-129 to see how well it can highlight a protein called PDE4D in the brain and body of healthy volunteers. PDE4D is linked to thinking and mood, and may play a role in disorders like Alzheimer's and depression. Researchers wi…

This study looks at whether taking a daily carotenoid supplement (like those found in carrots) can improve eye health in healthy adults aged 18-75. Over 3 months, researchers will measure changes in the retina's protective pigment, blood flow, and vision sharpness. Participants w…

This study looks at how a gentle, noninvasive nerve stimulation (applied to the ear) changes activity in the brain and stomach. Researchers will use MRI scans and heart/stomach monitors to measure these effects in healthy adults and people with functional dyspepsia. The goal is t…

This study looks at how certain dietary supplements change proteins in the immune system of healthy adults. Researchers will give supplements or a placebo to 44 volunteers aged 18-45 and take blood samples to measure changes. The goal is to understand, not to treat any disease.

This study looks at how the brain's memory and reasoning areas develop in healthy teenagers (13–18) compared to adults (19–25). Participants will do memory tasks during brain scans (fMRI) over three visits, spaced 1.5 years apart. The goal is to understand how the brain changes w…

This study compares heart and lung blood pressure in healthy adults and those with congenital heart disease. Researchers will measure how the heart's blood vessels respond to exercise using MRI and a small tube in the heart. The goal is to collect data that helps doctors better u…

This study looks at how the brain processes optimistic and pessimistic signals in healthy people and those with Parkinson's disease. Researchers will use MRI scans while participants play a game to see if Parkinson's affects these signals. The goal is to better understand why cer…

This study looks at how the body absorbs a new drug called LY4064809. Eight healthy adults will receive the drug by mouth and by IV to compare how much enters the bloodstream. Participants stay at a research center for 14 days, and the whole study lasts about 21 days. The results…

This study looks at whether training the muscles you use to breathe can also make your tongue stronger and more enduring. Researchers will measure tongue strength and endurance in 60 healthy adults before and after a breathing muscle training program. The goal is to understand if…

This early-stage study tests a new drug called BI 3821001 in healthy men aged 18 to 55. The goal is to check if the drug is safe and how the body processes it. Participants receive a single dose and are monitored for side effects. No direct health benefit is expected, but results…

This study tests whether a home-based mobile app can help parents of 3-4 year olds improve their child's daily physical activity, sleep, and screen time. About 80 children who currently meet few or no movement guidelines will wear activity trackers and have motor skills tested. P…

This study looks at brain MRI scans and genetic information from up to 2000 children (healthy and with developmental delays) to create computer models that can better predict and explain developmental disorders. The goal is to learn more about how the brain grows and changes, not…

This study aims to uncover whether eczema (atopic dermatitis) and food allergies share unique genetic or biochemical markers. Researchers will collect blood and skin samples from 200 participants, including those with food allergies, eczema, or neither. The goal is to create a mo…

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 adults with and without metabolic syndrome. The goal is to find biological markers that predict disease progression and help design personalized prevention or treatment strategies. Part…

This study looks at how kidney blood flow changes during exercise in healthy young African American adults compared to White adults. Researchers want to understand why African Americans face higher risks of heart and kidney problems. Participants will do cycling, cold hand tests,…

This early-stage study tests whether an inhaled drug called RB042 is safe and how it moves through the body. About 90 healthy adults, including some who smoke, will receive either the drug or a placebo. The goal is to check for side effects, not to treat any disease.

This study tests whether a brain-training technique called real-time fMRI neurofeedback can help healthy adults reduce the spontaneous return of learned fear responses. Participants will receive feedback based on brain connections between the prefrontal cortex and hippocampus whi…

This study looks at how a gentle electrical current applied to the brain (called tACS) affects movement in people who had a stroke more than 6 months ago. Researchers will test two different frequencies and a placebo to see which works best. They will use brain scans (MRI) and br…

This study checks if a new tablet form of the drug tafamidis works the same as the current capsule in healthy adults. About 24 participants will take a single dose of each form under fed conditions. The goal is to measure drug levels in the blood, not to treat any disease.

This study looks at how well healthy adults can stick out and hold their tongue. Researchers will measure tongue strength and endurance using a special device. The goal is to understand normal tongue function and how it relates to handgrip and breathing muscles. 300 healthy adult…

This early-stage study tests the safety and how the body processes a new drug called NSHO-101. About 24 healthy adults will take the drug so researchers can measure its levels in the blood and check for side effects. This study does not aim to treat any disease; it simply gathers…

This study looks at whether drinking beetroot juice (which contains natural nitrates) before bed can improve sleep quality and how well your brain and blood vessels work at night. Researchers at Mayo Clinic will study 60 healthy adults, both younger (18-35) and older (65-80). Par…

This study looks at whether giving mirikizumab as one shot under the skin works the same as giving it as two shots. About 450 healthy adults will take part, and researchers will check safety and how the body handles the drug. The study lasts about 15 weeks per person.

This study tests a new portable CPAP device designed to help people with sudden breathing problems before they reach the hospital. Researchers will check how easy it is to use and how well it works in 50 healthy volunteers and hospitalized patients with low oxygen levels. The goa…

This study looks at how certain drinks change amino acid levels and appetite hormones after a meal in healthy adults aged 20 to 50. About 24 participants will try different beverages in a random order. The goal is to understand the body's short-term response, not to treat any dis…

This study looks at whether blood flow in fat tissue changes as we age. Healthy adults aged 18-35 or 65-80 will have their fat blood flow measured, provide two small fat samples, and drink a sugary drink. The goal is to understand basic aging processes, not to treat any disease.

This study checks how well the Owlet OSS 3.0-M1 sensor measures pulse rate and blood oxygen levels in healthy children aged 19 months to 5 years. About 90 kids will wear the sensor while their readings are compared to a standard medical device. The goal is to see if the sensor is…

This study aims to accurately measure how many calories healthy Chinese people burn each day using a special water test called doubly labelled water. Researchers will track 240 volunteers across China, collecting data on body measurements, blood tests, and activity levels. The re…

This study gathers detailed eye scans from 180 adults with healthy eyes or conditions like retinal disease, glaucoma, or corneal disease. The goal is to collect data that may help doctors better understand and diagnose these conditions in the future. Participants will have their …

This study is looking for 2000 healthy adults who have a close family member with a blood cancer like multiple myeloma. The goal is to find early warning signs of the disease by collecting blood samples and health data over time. Researchers hope this will lead to better ways to …

This early-stage study tests a new medicine, PF-07985631, in healthy adults to see if it is safe and how the body processes it. The drug is being developed for a kidney disease called IgA nephropathy. Participants receive either the drug or a placebo as a single injection and are…

This study looks at how the brain works during tasks involving emotions, attention, and memory in both healthy volunteers and people with depression. Researchers use brain scans and gentle brain stimulation to measure activity. The goal is to gather information that could lead to…

This study tests whether a probiotic called Saccharomyces boulardii can improve the gut's ability to control what passes into the body. Researchers will give the probiotic or a placebo to 56 healthy adults and measure changes in gut permeability, inflammation, and digestive sympt…

This study will measure how fast 360 healthy young people (ages 6-20) need to walk to get health benefits. Researchers will track steps per minute and heart rate to create simple, personalized walking guidelines. The goal is to replace vague advice like 'walk briskly' with clear …

This study aims to better understand how many calories a person needs to eat to stay at the same weight. Researchers will use a whole-room indirect calorimeter, a special room that measures the energy your body burns, to find a more accurate way to calculate energy balance. 34 he…

This early-stage study is testing a single dose of an experimental medicine called PF-08653944 in 54 overweight or obese adults. The goal is to see how the drug is absorbed when injected into the thigh, upper arm, or abdomen. Researchers will also monitor safety through blood tes…

This study tests whether a safe, mild electrical current applied to the scalp can change brain activity and thinking speed in healthy adults. About 196 younger (20-40) and older (60-80) adults will do computer tasks while receiving real or fake stimulation, with brain scans to se…

This study checks how well a new algorithm can detect irregular heartbeats using sensors on the finger and wrist. It involves 120 healthy adults aged 18 to 80. The goal is to see if the device works accurately compared to a standard ECG. No treatment or medication is given.

This study aims to find out if children with primary ciliary dyskinesia (PCD) also have a condition called bronchial hyperresponsiveness, which makes airways overly sensitive. Researchers will compare 40 participants (those with PCD and healthy volunteers) using breathing tests. …

This study tests a new wireless pill that measures temperature inside the gut. The goal is to see if it can help detect diseases like Crohn's disease. Ten healthy adults will swallow the capsule and researchers will check if it sends accurate temperature readings.

This study checks if two different versions of the drug survodutide are absorbed the same way in the body. It involves 80 healthy adults who are overweight or obese. Participants will receive both formulations at different times to compare drug levels in the blood.

This study looks at how lepodisiran enters the blood and leaves the body in people with mild, moderate, or severe liver issues compared to those with healthy livers. About 33 adults will receive a single injection and be monitored for up to 9 weeks. The goal is to understand how …

This study looks at how taking sialic acid by mouth changes the types and amounts of bacteria in the gut, especially harmful ones like E. coli. It involves 42 healthy adults aged 18 to 75. No treatment or cure is being tested—the goal is simply to learn more about how sialic acid…

This study is the first time BAL2420 is being tested in humans. It aims to check the safety and how the body processes the drug in 136 healthy adults. Participants receive either the drug or a placebo, and researchers monitor for side effects. The goal is to gather essential safe…

This study looks at whether a computer-animated character that explains medical illustrations helps people understand them better and feel less anxious. About 300 healthy adults who speak English or Spanish will take part. Some will see the character on a computer screen, some in…

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. The goal is to see if those with pain and fatigue have higher levels of brain inflammation. Researchers will compare…

This study looks at how physical fitness changes the bacteria in your gut. Researchers will compare gut microbes from inactive people to elite athletes to see if exercise boosts gut health. The goal is to understand which bacteria are linked to better fitness and create a sample …

This study looks at whether taking the blood pressure drug losartan changes how the antibiotic cephalexin is absorbed and removed from the body. 12 healthy adults will take cephalexin alone, with losartan, or three hours after losartan. The goal is to see if there is an interacti…

This study collects health information, lifestyle details, and biological samples from up to 100,000 adults aged 18 to 90. The goal is to help researchers better understand conditions like lupus, celiac disease, and kidney disease, and to develop improved tests and treatments. Pa…

This study is testing a new rehabilitation program for people with spinal cord injury (SCI) that combines walking downhill on a treadmill with mild electrical stimulation to activate weak muscles. Researchers will also check blood and spinal fluid for biomarkers to decide whether…

This study looks at how focusing your attention differently during calf-strength exercises might change the way you walk. Researchers will compare two types of external focus (like thinking about moving a marker) with an internal focus (thinking about your own muscles) in healthy…

This study looks at how eating berries, like cloudberries and lingonberries, changes tiny particles called extracellular vesicles that cells use to talk to each other. Researchers want to see if these berries affect the body's immune signals and gut bacteria. The study involves 6…

This study uses a special brain scan (PET) with a new tracer called [11C]APP311 to measure synaptic density—the connections between brain cells—in people with psychotic disorders or cannabis use disorder, compared to healthy volunteers. Researchers aim to understand how these con…

This study looks at how personality, brain activity, and behavior differ among young adults aged 18-22. Researchers want to see if certain patterns of attention and reward processing are linked to cannabis use. Participants will complete tasks and brain scans. The goal is to bett…

This early-stage study is testing a natural compound called fisetin in 60 healthy younger adults and older patients with multiple chronic conditions. Participants take fisetin or a placebo for two days and are followed for up to three months. The goal is to see if fisetin is safe…

This study aims to understand how being overweight or obese changes the way your heart and blood vessels respond during different breathing exercises and physical activity. Researchers will measure blood pressure in 80 healthy adults while they rest, exercise, and perform special…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography and CT scans in up to 4,000 adults, including healthy volunte…

This study checks if special sensors can accurately measure the forces inside a carbon-fiber leg brace. Researchers will test the brace on healthy adults, people who use braces regularly, and those with nerve damage in their feet. The goal is to improve how braces are designed an…

This early-phase study tests the safety and how the body processes a new drug called FZ008-145 in 190 healthy adults aged 18 to 65. Researchers will also measure pain tolerance using a cold water test. The goal is to gather safety data, not to treat any disease.

This study gives healthy volunteers psilocybin (the active ingredient in magic mushrooms) and uses brain scans and computer tasks to measure changes in thoughts and brain activity. The goal is to understand how the drug works, not to treat any disease. About 30 adults aged 18-75 …

This study aims to see if newly developed wearable sensors are comfortable and safe for healthy adults aged 18 to 99. Researchers will compare the sensors' readings of heart rate, breathing, and blood flow to those from approved medical devices. The goal is to gather information …

This early-stage study tests an experimental drug called LY4088044 in healthy people to see if it is safe and how the body processes it. About 104 participants will receive the drug or a placebo, either as a shot under the skin or into a vein. The study lasts up to 92 weeks and i…

This study follows 800 mothers and their babies to see if how much a pregnant woman sits, sleeps, and moves affects her child's weight and heart health up to age 2. Researchers will track activity with monitors and measure baby growth. No treatments are tested—only observation to…

This study aims to improve how we see inflammation in the brains of people with Alzheimer's disease. Current scans can't tell which brain cells are inflamed, but this new method uses two different tracers and math to separately track microglia and astrocytes. Researchers will sca…

This study aims to find the best way to record electrical signals from the stomach using a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS). Researchers will test different stimulation settings and locations in healthy adults to see what tri…

This study looks at adults who carry the gene for phenylketonuria (PKU) but do not have the disease. Researchers want to see if their brains handle the amino acid phenylalanine differently than people without the gene. Participants will take phenylalanine or a placebo, then under…

This study looks at whether measuring big toe strength can help doctors understand nerve damage caused by chemotherapy. Researchers will test 30 adults—some with nerve problems from chemo and some healthy—using a special device called ToeScale. Participants will also answer quest…

This study is testing a new 3D-printed pill that people swallow to collect bacteria samples from the gut, including the small intestine. Ten healthy adults aged 18-65 will take the pill and provide stool samples for comparison. The goal is to see if the pill is safe and can accur…

This early-stage study tests a new drug called M5542 in 49 healthy adults. Participants receive a single injection and are monitored for side effects and how the drug moves through the body. The goal is to gather safety information, not to treat any disease.

This study is building a large collection of human biological samples and health data to help scientists understand diseases better. It will collect samples from up to 10,000 people, including both healthy individuals and those with conditions like cancer, heart disease, and diab…