New brain imaging tool could unlock secrets of depression and Alzheimer's
NCT ID NCT06874205
First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times
Summary
This study tests a new radioactive tracer called 11C-JMJ-129 to see how well it can image a protein called PDE4D in the brain and body of healthy volunteers. PDE4D is linked to thinking and mood, and may play a role in disorders like Alzheimer's and depression. Researchers will also test if a medication called disulfiram can improve the quality of the brain images by preventing the tracer from breaking down too quickly. About 40 healthy adults aged 18 and older will take part.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HEALTHY are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a new oral drug change future treatments? early safety trial begins
- Can brain scans unlock the secret to hearing in crowded rooms?
- Can a Light-Guided device make arterial sticks easier?
- Water workouts could be the key to back pain relief
- Could everyday disinfectants be harming us? a new study investigates
- Can a new drug keep the Heart's beat steady? trial puts verducatib to the test