Can a new drug keep the Heart's beat steady? trial puts verducatib to the test
NCT ID NCT07760246
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This Phase 1 trial is testing whether an experimental drug called verducatib affects the heart's electrical activity, specifically the QT interval, which is a measure of heart rhythm safety. Healthy adults aged 18 to 50 will receive multiple doses of verducatib, a placebo, or moxifloxacin (a drug known to affect the QT interval) to compare effects. The study uses ECG monitoring and blood samples to see if verducatib changes heart rhythm compared to placebo, with moxifloxacin serving as a reference to validate the methods.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Verducatib (BI 1291583), an experimental drug, compared against placebo and moxifloxacin (a known heart-rhythm-affecting antibiotic used as a positive control).
- What this could lead to
- If verducatib shows no significant heart-rhythm effects, it could support its safe development as a future treatment.
- What could go wrong
- This is an early Phase 1 trial in healthy volunteers, so results may not predict effects in patients. The drug could still affect heart rhythm, which would limit its use.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CRS Clinical Research Services Mannheim GmbH
Mannheim, 68167, Germany
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