Can a new drug keep the Heart's beat steady? trial puts verducatib to the test

NCT ID NCT07760246

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This Phase 1 trial is testing whether an experimental drug called verducatib affects the heart's electrical activity, specifically the QT interval, which is a measure of heart rhythm safety. Healthy adults aged 18 to 50 will receive multiple doses of verducatib, a placebo, or moxifloxacin (a drug known to affect the QT interval) to compare effects. The study uses ECG monitoring and blood samples to see if verducatib changes heart rhythm compared to placebo, with moxifloxacin serving as a reference to validate the methods.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Verducatib (BI 1291583), an experimental drug, compared against placebo and moxifloxacin (a known heart-rhythm-affecting antibiotic used as a positive control).
What this could lead to
If verducatib shows no significant heart-rhythm effects, it could support its safe development as a future treatment.
What could go wrong
This is an early Phase 1 trial in healthy volunteers, so results may not predict effects in patients. The drug could still affect heart rhythm, which would limit its use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CRS Clinical Research Services Mannheim GmbH

    Mannheim, 68167, Germany

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