HEALTHY

This phase 3 study tests a new quadrivalent seasonal influenza vaccine in healthy infants aged 6 months to under 3 years. The goal is to see if the vaccine triggers a strong immune response and is safe compared to an existing flu shot. About 245 children will take part, and resea…

This study tested whether getting a different COVID-19 vaccine for the second shot (instead of the same one) is safe and boosts immunity. 100 healthy adults who had already received one dose of the AZD1222 vaccine were randomly assigned to get either the same vaccine or a differe…

This study looked at whether people who had COVID-19 more than 5 months ago need only one dose of the Pfizer mRNA vaccine, instead of the usual two. It included 267 healthy adults aged 18-45 or 65 and older, some with prior infection and some without. Researchers measured antibod…

This early-stage study tested a new vaccine called V118 Formulation C in 65 healthy adults to see if it is safe and well-tolerated. Participants received either the new vaccine, an existing pneumonia vaccine (Prevnar 20), or a placebo. Researchers monitored for side effects like …

This study tested a new vaccine called IVX-A12 that targets two respiratory viruses: RSV and hMPV. It involved 264 healthy adults aged 60 to 85. The goal was to see if the vaccine is safe and boosts the immune system to fight these viruses.

This study tested a new vaccine called V330 to see if it is safe and how well it triggers an immune response against norovirus, a virus that causes vomiting and diarrhea. The trial included 245 healthy adults aged 18-49 and 60-79. Participants received either the vaccine or a pla…

This study looked at whether giving Regeneron's antibody treatment (casirivimab+imdevimab) along with the Moderna COVID-19 vaccine changes how well the vaccine works. About 295 healthy adults took part. Researchers measured immune responses and checked safety to see if the timing…

This study compares a new 'accordian' gum graft method to the standard free gingival graft for people with less than 2 mm of attached gum. The goal is to see which technique leads to better gum thickness and less discomfort. About 36 adults with missing teeth and thin gums will t…

This trial tests whether an 8-week gamified cooperative exergaming program, delivered during regular physical education lessons, can improve motivation, increase physical activity, and reduce sedentary behavior in primary school children aged 8 to 12. The program combines dance-b…

This study investigates whether a single dose of collagen hydrolysate, a dietary supplement, can reduce the rise in blood sugar and insulin after a meal. Researchers are testing two different doses in both prediabetic and healthy adults. The trial uses a double-blind, placebo-con…

This study tests whether orforglipron, an experimental oral drug for weight management, works the same when given as a tablet versus a capsule. Healthy adults with a BMI between 27 and 40 take the drug for about 22 to 25 weeks, and researchers measure how much of the drug enters …

This study tested whether a seaweed-derived supplement called Aquamin® can reduce gut permeability (often called 'leaky gut') in people with ulcerative colitis, irritable bowel syndrome with diarrhea, and healthy volunteers. Thirty-five adults took Aquamin capsules for 90 days. R…

This early-stage study tests an experimental oral drug called LY3502970 in healthy adults who are overweight or obese. The main goal is to see how the drug enters the bloodstream and how the body clears it, as well as to check for any safety issues. Participants will take the dru…

This study tests whether a mouthwash containing O-cymen-5-ol, an antiplaque ingredient, disrupts the natural balance of bacteria in the mouth. Healthy women aged 18 to 35 use the mouthwash twice daily for 28 days. Researchers compare its effects on tongue and saliva microbes agai…

This study compares three dietary approaches—intermittent fasting (16:8 schedule), a clean ketogenic diet (20g carbs per day from whole foods), and a combination of both—in healthy adults. Researchers measure changes in body composition, cholesterol, triglycerides, and blood suga…

This early-stage trial tested a new drug called PF-07209326 in 52 people, first in healthy volunteers and then in patients with sickle cell disease. The main goal was to check safety and how the body processes the drug. Researchers also looked for any early signs that the drug mi…

This study tested an oral drug called LY3502970 in 72 healthy overweight and obese adults to see if it is safe and how the body processes it. Participants took the drug by mouth, and researchers monitored side effects and drug levels in the blood over up to 42 days. The goal was …

This early-phase study tested a new drug called ABX1100 in 46 people, including healthy volunteers and patients with late-onset Pompe disease. The main goal was to check safety and how the drug moves through the body. Researchers gave single or multiple doses to find the right am…

This study tested a new oral drug called LY3549492 in 92 Japanese volunteers, some with type 2 diabetes and some healthy. The main goal was to check safety and how the body processes the drug. Participants took multiple doses over several weeks, and researchers monitored side eff…

This early-stage trial tested a new drug, RAY1225, in 68 healthy and obese adults in China. The main goal was to check if the drug is safe and how the body processes it. Researchers also looked at changes in body weight and waist size as early signs of effectiveness.

This study tested two different antiseptics used to clean skin before surgery to see which one works better. 122 healthy adults took part. Researchers measured how many bacteria were left on the skin after applying the antiseptics in different ways. The goal is to help reduce inf…

This study tested whether two specially prepared drinks, one made from freeze-dried watercress, can help the body get rid of harmful environmental chemicals that may cause cancer. Three hundred healthy adults, including smokers and non-smokers, drank the preparations three times …

This study tested whether a daily oral pill can safely and temporarily lower sperm counts in healthy men to prevent pregnancy. Ninety-two men took either the experimental drug (DMAU) alone, DMAU plus another hormone (LNG), or a placebo for 12 weeks. The goal was to see if sperm c…

This early-stage study tested whether a combination of two antibodies (casirivimab and imdevimab) is safe and tolerable in healthy adults. Forty-five volunteers received the antibodies either as a shot under the skin or through an IV. The main goal was to check for side effects, …

This Phase 2 study tested a drug called ciraparantag in 60 healthy adults aged 50 to 75 who were taking the blood thinner apixaban. The goal was to see if ciraparantag could quickly and safely reverse apixaban's blood-thinning effects, measured by clotting time. Participants rece…

This Phase 2 study tested a drug called ciraparantag in 69 healthy adults aged 50 to 75 who were given the blood thinner rivaroxaban. The goal was to see if ciraparantag could quickly reverse rivaroxaban's effects and restore normal clotting. Participants received either cirapara…

This study investigates whether a protein called FGF19, normally found in the intestine and gallbladder, appears at higher levels in the blood of people with breast or colorectal cancer compared to healthy individuals. Researchers will measure FGF19 and related markers in fasting…

This early-stage study tested whether a single oral dose of HB-2121 is safe in adults. Researchers monitored 18 participants for side effects and tracked how the drug moves through the body over 30 days. The goal is to develop a new way to diagnose celiac disease.

This early-phase study tests a new radioactive tracer called NeuCaVis in 12 healthy volunteers. Unlike standard PET scans that track glucose, NeuCaVis follows fructose, which is only used by inflamed tissues. The goal is to check safety and how the tracer spreads in the body, pot…

This study looked at whether an automated measuring device can improve the accuracy of bladder diaries in women with lower urinary tract symptoms. 187 women recorded their urine volume using both a traditional paper diary and an electronic device. The goal was to see if the devic…

Myofascial pain syndrome is common but hard to diagnose accurately. This completed study tested several imaging and electrical measurement tools—like ultrasound and muscle activity sensors—to find objective signs of the condition. Researchers studied 96 adults to see if these too…

This study tested a new blood test (pDrp1 assay) to measure platelet activity in 112 healthy and severely obese volunteers taking aspirin or clopidogrel. The goal was to see if the new test is as accurate as the current standard test (light transmission aggregometry). Researchers…

This completed study tested a high-density EEG (using up to 256 electrodes) to map brain areas involved in movement, sensation, language, and emotion. It included 122 people with epilepsy, brain tumors, or healthy controls. The goal was to see if this technique can more precisely…

This study tested a new device called Masimo INVSENSOR00057 that records a single-lead ECG, similar to a standard lead I. Researchers compared its heart rate and atrial fibrillation detection against standard measurements in 365 adults, including healthy people and those with AFi…

This study tested the ProSomnus RPMO2, a small device worn inside the mouth that measures oxygen levels and pulse rate. Researchers compared its readings to standard blood tests in 12 healthy adults. The goal was to see if the device is accurate enough for medical use.

This trial tests whether an AI-powered chatbot can improve health literacy about the HPV vaccine among Japanese caregivers of unvaccinated daughters aged 12–18. Participants will either interact with the chatbot or read a standard government leaflet, then complete surveys to meas…

This study used artificial intelligence to analyze sprinting motions and identify football players at risk for hamstring injuries. Players at medium or high risk then followed a four-month exercise program called FUNBALL, which has been shown to reduce thigh muscle injuries by ab…

This study tested whether atenolol, a widely used beta blocker for heart conditions, can prevent bone loss in postmenopausal women. 420 healthy women aged 50-75 took either atenolol or a placebo daily for a period. The main goal was to see if the drug slowed bone density loss in …

This study tested an experimental vaccine (G03-52-01) in 622 healthy adults to see if it could safely protect against botulinum toxin, the poison that causes botulism. Participants received either the vaccine or a placebo, and researchers measured side effects and immune response…

This study tested whether a higher-than-normal dose of MK-8527, a once-monthly pill to prevent HIV infection, affects heart rhythm. It involved 42 healthy adults and compared the drug to a placebo and an active control. The goal was to ensure the drug is safe for the heart before…

This study looked at whether a 12-week volleyball-specific warm-up program (VOLLEY12+) could improve balance and movement control in 24 male players aged 15-17. Half did the special warm-up, half did their usual routine. The goal was to see if the program could help prevent injur…

This study looked at whether a smartphone app and wearable device could help people aged 60 to 80 become more active and adopt healthier habits. About 237 participants either used the app or received standard health education. Researchers measured how often people used the app an…

This study tests whether a supplement called Phaseolean, made from white kidney beans, can help healthy adults keep their blood sugar steady after eating carb-rich foods like white bread. Twelve participants will take different doses of the supplement or a control before a meal, …

This study tests whether offering a prize after a medical procedure can reduce anxiety in children aged 6-17. About 187 kids will get standard support from a child life specialist, and some will also be offered a prize if they meet a coping goal. Researchers will compare anxiety …

This study tests whether taking Bragg apple cider vinegar before a high-carb meal can lower blood sugar spikes in healthy adults aged 20-50. Participants will drink either vinegar or water, then have blood drawn to measure glucose and insulin. The goal is to see if vinegar helps …

This study looks at whether a fermented papaya supplement can help older adults (ages 70-80) make fewer mistakes while driving. Participants take three doses of the supplement in one day and then complete a driving simulator test. The goal is to see if the supplement improves att…

This small pilot study tested whether a natural propolis-based solution (mixed with clove and willow bark) could help gums heal faster after a tooth extraction. Fourteen healthy adults each had two similar teeth pulled on opposite sides of the mouth. One socket got the propolis s…

This study tested whether an oral herbal supplement called PrimaVie can improve skin blood flow, hydration, elasticity, and barrier function. 45 healthy women aged 30-65 took either a low dose, high dose, or placebo pill twice daily for 14 weeks. Researchers measured skin changes…

This study tested an 8-session online logotherapy program for family members of people with schizophrenia. 42 family members took part, with half receiving the program and half not. Researchers measured changes in meaning in life, hope, and depression. The goal was to see if this…

This study tested an 8-month exercise program for 30 people aged 90 and older. The program included warm-up walks, strength exercises with light weights, games, and stretching. Researchers measured changes in body composition, muscle strength, and cardiorespiratory fitness. The g…

This study tested whether watching telenovela-style educational videos can help family caregivers of hospice patients feel more confident and less anxious. 59 caregivers participated over 8 weeks. The approach used weekly video lessons during regular hospice visits.

This early-stage study tested a new drug called FZ008-145 in 176 healthy adults to see if it is safe and how the body processes it. Researchers also checked if the drug could change how long people could keep their hand in ice water (a pain tolerance test). The goal was to gather…

This study tested a drug called TD-1211 in healthy volunteers and people with constipation caused by opioid painkillers. The goal was to see if it is safe and helps with bowel movements. Participants took different doses of TD-1211 or a placebo, and researchers monitored their sa…

This study tested a cosmetic product (RV2666C) to see if it helps skin heal faster after a laser treatment in adults with skin types IV to VI (darker skin tones). Twenty-two participants applied the product to a small laser-treated area on their arm for about three weeks. Researc…

This study tested a digestive enzyme supplement in 24 healthy adults to see if it helps break down fats, proteins, and carbs after a high-macronutrient meal. Participants took either the enzyme blend or a placebo and reported symptoms like bloating and gas. The goal is to find a …

This completed trial tested whether the Flourish app, a digital toolkit with science-based well-being practices, can improve mental health in students. Over 1,100 students either used the app at least twice a week for six weeks or continued with their usual mental health resource…

This study tested whether a mushroom blend can help with occasional stomach issues like bloating and constipation, and also improve mood. Forty healthy adults aged 30 to 60 who sometimes had digestive discomfort took either the mushroom supplement or a placebo. Researchers checke…

This study looked at whether taking sodium bicarbonate (baking soda) before exercise helps well-trained cyclists perform better during a long, intense ride. Nineteen athletes did two lab sessions: three hours of moderate cycling followed by a max-effort time trial. They took eith…

This study looked at whether progressive relaxation exercises could help first-year nursing students feel less stressed and more resilient before starting clinical practice. Eighty students were split into two groups: one did eight relaxation sessions over four weeks, the other d…

This study tested whether a combination pill called SJP-001 (which contains fexofenadine and naproxen) can reduce hangover symptoms after drinking alcohol. 47 healthy adults who drink moderately took the pill, a placebo, or each drug alone on different days, then rated their hang…

This study tested whether gargling with a mouthwash containing cetylpyridinium chloride and zinc could reduce cold and flu symptoms. 150 healthy adults either brushed their teeth alone or brushed and then gargled with the mouthwash twice daily for 90 days. Participants tracked th…

This study tested a cream made from natural plant extracts, niacinamide, and arbutin to see if it safely lightens dark spots (post-inflammatory hyperpigmentation) on the skin. Twenty-five healthy Malaysian adults used the cream twice daily for 20 weeks. Researchers measured chang…

This study tested whether a serum with low-dose alpha hydroxy acids (AHAs) and polyglutamate acid is safe for people with dark spots left after skin inflammation (post-inflammatory hyperpigmentation). 34 Malaysian adults used the serum for 8 weeks, with skin checks at the start, …

This study tested whether pine bark extract supplements can help reduce fatigue and improve recovery after high-intensity cycling. Fourteen healthy adults took either the extract or a placebo for four days. Researchers measured how long they could cycle until exhaustion and check…

This study tested whether writing about your deepest thoughts and feelings for 15 minutes a day over two weeks can help reduce anxiety and depression in young adults. Participants were split into three groups: writing to themselves, writing to a loved one, or writing a factual da…

This study tested whether a combination of supplements could help healthy adults feel less stressed and sleep better. 115 people took either the supplement or a placebo for a set time. Researchers measured stress levels, mood, and sleep quality using questionnaires and a sleep tr…

This study tested whether cold application (cryotherapy) works as well as standard numbing gels and sprays to reduce pain from dental injections in children. 100 kids aged 7 to 10 were divided into four groups: one received a lidocaine spray, one a benzocaine gel, one cold distil…

This early-stage study tested a new drug called CAN10, an antibody that blocks a protein involved in inflammation. Researchers gave single doses to 80 healthy adults and repeated doses to people with mild to moderate plaque psoriasis to see if it is safe and how the body processe…

This study tested an injection called AYP-101 to reduce fat under the chin (double chin) in 252 healthy adults aged 19 to 65. Participants received either the drug or a placebo, and doctors and patients rated fat reduction using a scale. The goal was to see if the injection safel…

This small pilot study tested whether giving night shift nurses access to a napping/relaxation room and blue/green light blocking glasses is practical and might improve their health and reduce burnout. Five nurses from one hospital took part. The study focused on whether nurses w…

This study tested a vibrating device called DigiVibe to see if it reduces pain from injections and fingersticks. Twenty healthy adults who dislike needles received standard shots and fingersticks, and the same procedures with the device. The goal was to compare pain scores and se…

This completed trial tested a special juice blend containing cherry, cocoa, and other nutrients to see if it could improve sleep in 15 healthy young football players. Each athlete tried the supplement and a placebo at different times, and their sleep was tracked with activity mon…

This study tested whether a special laser (940-nm diode) applied right after gum graft surgery can reduce pain and help the wound heal faster. 36 healthy adults received either the laser plus a protective mouth stent or just the stent alone. Researchers measured pain, painkiller …

This study tested a new exercise program called SI Kumbang gymnastics in 66 healthy women aged 60-70. Participants did the exercises three times a week for three months. Researchers measured their heart and lung fitness, muscle strength, balance, physical activity, and immune mar…

This study tested a 4-week movement program called Dance-Walk in 117 adults seeking mental health support. Participants either started the program right away or waited. The goal was to see if combining dance and walking could improve body awareness, energy, and reduce stress, anx…

This study looked at whether a cocoa drink rich in flavanols (plant compounds) could protect blood vessel health in healthy older adults during 2 hours of sitting. Twenty participants aged 65+ drank either a high-flavanol or low-flavanol cocoa before sitting. Researchers measured…

This study looked at whether taking Rhodiola rosea supplements for 28 days helps basketball players perform better and feel less tired during simulated games. Forty-eight healthy male athletes took either the supplement or a placebo. Researchers measured game completion time, hea…

This study tested whether a short, 3-minute neck stretch could lower blood pressure in 25 healthy adults. Participants did a gentle stretch on one side of the neck, and researchers measured blood pressure, tissue stiffness, and heart rate changes. The goal was to see if stretchin…

This study tested remimazolam against midazolam for sedation during diagnostic upper gastrointestinal endoscopy. 132 healthy adults participated, and researchers measured total procedure time and sedation success. The goal is to see if remimazolam provides faster and more effecti…

This study tested an anti-aging face cream on 44 women aged 45 to 65 with sensitive skin and deep wrinkles. The cream was applied for about two months to see if it was gentle on the skin and eyes, and if it helped smooth wrinkles. The goal was to check how well the cream is toler…

This completed trial tested whether spending 30 minutes a day in nature, with quiet contemplation, could improve spiritual well-being in healthy adults. 41 participants were asked to walk, sit, and silently observe nature for 10 sessions over 14 days. The study measured changes i…

This study looked at whether listening to calming instrumental music before a coronary angiography (a procedure to check heart arteries) can help patients feel less pain and anxiety, and improve their comfort and satisfaction. Researchers divided 210 patients into two groups: one…

This study tested whether an oral drug called NG101 can reduce gastrointestinal side effects (like nausea and vomiting) caused by GLP-1 weight-loss medications such as semaglutide. 120 healthy adults with a BMI between 22 and 35 took either NG101 or a placebo for five days, and r…

This study aims to find the best way to record electrical signals from the stomach to the brain using a non-invasive technique called transcranial magnetic stimulation (TMS). Researchers will test different stimulation settings in 155 healthy adults to see what works best. The go…

This early-stage study tested a single dose of epaminurad in 34 healthy adults to see how safe it is and how the body processes it. Participants took the drug under fasting conditions, and researchers measured drug levels in the blood. Since this was a Phase 1 trial in healthy pe…

This early-stage trial is testing how aspirin behaves in the body when given as a quick injection into a vein compared with the same dose taken as a pill. Healthy adults aged 18 to 55 will receive both forms on separate occasions, and researchers will measure blood levels, effect…

This study tested a computer model, called a digital twin, to see if it could predict how muscles change with strength training. Twenty-three healthy adults did a 6-week strength program while researchers tracked their progress. The goal was to improve training guidelines and mak…

This study looks at whether doing sprint interval training during different phases of the menstrual cycle (follicular vs. luteal) changes how well your body adapts. Researchers will measure endurance performance and muscle changes in 24 healthy women who exercise regularly. The g…

This early-stage trial in healthy men aged 18 to 50 tests whether eating affects how much of the experimental drug BI 3731579 enters the blood. Each participant receives a single oral dose of the drug once with food and once without, allowing researchers to compare the levels in …

This early-stage trial is testing a new drug called BI 3731579 in healthy male volunteers to see if it is safe and how the body handles it. Participants receive a single oral dose of the drug or a placebo, with different groups getting higher doses. The study measures side effect…

This study tests whether two different injector pens deliver the same amount of Genotropin (a growth hormone) into the blood. About 26 healthy adults aged 18 to 60 will receive a single shot with each pen and have blood samples taken. The goal is to see if the pens work equally w…

This trial investigates whether genetic differences influence how paracetamol relieves pain and how the body processes it. One hundred healthy men aged 18 to 30 will receive either paracetamol or a placebo in two separate sessions, and researchers will measure pain thresholds and…

This pilot study is testing how different protein beverages affect amino acid levels and appetite hormones in healthy adults. Twenty-four participants will try several drinks in a random order. The goal is to see which drink leads to the best changes in appetite-related signals.

This early-phase trial in healthy men aged 18 to 45 asks whether taking N-acetylcysteine alongside acetaminophen (paracetamol) changes the drug's pain-relieving effect. Participants receive either the combination or a placebo, and researchers measure pain intensity from heat stim…

This study looks at how different caffeinated drinks change how you feel and your body's responses. About 150 healthy adults who regularly drink caffeine will try their usual drink and a test drink. They'll rate their feelings and use a wearable device to track body signals.

This study looks at how healthy adults who regularly drink sweetened, caffeinated beverages feel after trying different versions. Participants will rate their feelings and have their body's responses measured. The goal is to understand the effects of these drinks, not to treat an…

This study looked at how muscle strength and balance differ between healthy people and those with chronic ankle instability or ACL knee injuries. Researchers measured balance using a special platform. The goal was to better understand the link between strength and stability after…

This study is for healthy men aged 18-64 to see how the experimental drug PF-07328948 is absorbed and removed from the body. Participants will take the drug by mouth and by injection, and provide blood, urine, and stool samples. The study does not aim to treat any disease, just t…

This large observational study is investigating whether nitrate, nitrite, and phosphate—compounds found naturally in food and water and used as additives—are linked to chronic diseases like gastrointestinal cancers, heart disease, and respiratory conditions. Researchers will foll…

This early-stage trial is testing whether an experimental oral suspension called QEV-817 (doxapram) changes how the body handles the opioid hydrocodone. Healthy volunteers aged 18-55 will receive hydrocodone with and without doxapram to compare safety and drug levels in the blood…

This study looks at whether the strength and endurance of pelvic floor muscles are related to voice characteristics in healthy young adults aged 18 to 40. Researchers will measure pelvic floor muscle activity using EMG and analyze voice acoustic parameters like pitch and maximum …

This study looks at how early childhood relationships with caregivers affect the ability to form healthy, stable romantic partnerships in young adulthood. Researchers are following up with participants from a previous child development study, now aged 18 and older, who live with …

This study looks at how the drug MK-1084 (calderasib) moves through the body in people with and without liver problems. Researchers will measure drug levels in the blood and check for side effects. About 58 adults will take a single dose and be monitored. The goal is to understan…

This study tests a new formulation of survodutide, a medicine being developed for obesity and liver conditions. About 100 healthy adults aged 18-65 with a BMI between 27 and 40 will receive weekly injections of either the current or new formula for 28 weeks. Researchers will meas…

This trial is testing whether a new tablet form of the experimental drug PRAX-628 is absorbed by the body as well as the existing capsule form. Healthy volunteers will receive a single 40 mg dose of each version on separate occasions, and researchers will compare drug levels in t…

This study looks at how weight loss changes the way the body uses energy during exercise. Healthy normal-weight adults will either lose weight through diet or have their weight loss simulated using a special treadmill. The goal is to see if real weight loss affects exercise metab…

This study checks how well a new algorithm can detect irregular heartbeats using sensors on the finger and wrist. It involves 120 healthy adults aged 18 to 80. The goal is to see if the device works accurately compared to a standard heart monitor.

This study measures the height of the foot arch and how much it flattens when standing in adults aged 65 and older. Researchers want to establish typical values and see whether age, gender, or body weight influence these measurements. The goal is to create a reference for identif…

This study looks at how a structured physiotherapy program starting soon after cosmetic femoral lengthening surgery affects daily movement and physical function. Fifty-four healthy adults aged 18 to 45 will take part, doing exercises like stretching, strengthening, and walking tr…

This study investigates whether sex and obesity influence how blood vessels respond to low oxygen levels, a key factor in sleep apnea. Researchers will compare healthy-weight and obese men and women to see if differences in vessel constriction and dilation help explain why women …

This pilot trial tests whether a short-term, culture-tailored plant-based diet is feasible for healthy adults in Taiwan and whether it can improve markers of inflammation and metabolism. Thirty generally healthy omnivores will receive either a plant-based or general diet for two …

This early-stage study tests a new medicine, PF-08057418, in healthy adults to see if it is safe and how the body processes it. Eight participants will receive single doses (as a solution or tablet) once a week for 5 weeks. The study is not intended to treat any disease, but to g…

This early-stage study tests a single injection of a long-acting form of letrozole in 90 healthy post-menopausal women. The goal is to measure how the drug moves through the body and check for side effects. Participants receive one injection and are monitored closely. No direct h…

This study looks at how a new drug called LY3537031 gets into the blood and how the body clears it. It involves 46 healthy volunteers who receive the drug either under the skin in different spots or into a vein. The goal is to understand the best way to give the drug and check it…

This trial tests whether eating avocado with a breakfast of bread and jam can improve how the body handles blood sugar and signals hunger or fullness afterward. Thirty healthy adults will compare three different breakfasts — one with avocado, one with added fat and fiber to mimic…

This study tests three different skin adhesives on healthy women aged 18 to 40 to see which one stays attached for at least 72 hours and causes the least itching. Each volunteer wears six adhesive patches below the bra line and reports comfort at 24, 48, and 72 hours. The goal is…

This study compares a new infant formula that includes human milk oligosaccharides (special sugars found in breast milk) and a blend of optimized nutrients against standard formula and breastfeeding. About 240 healthy newborns will be followed for their first year, with measureme…

This study uses a research-dedicated 3T MRI scanner to develop and optimize imaging protocols in healthy adults. Researchers aim to reduce image distortions, improve contrast and resolution, and create new sequences for functional MRI. The work will help enable future studies in …

This study looks at how breathing exercises at different effort levels affect oxygen in the chest muscles of healthy adults. About 27 physically active volunteers will do breathing training sessions while their muscle oxygen is measured. The goal is to understand the body's respo…

This study examines whether carbamazepine, a common medication, changes how the body absorbs and clears orforglipron. Healthy volunteers receive orforglipron alone and then with carbamazepine to compare drug levels in the blood. The goal is to understand if dose adjustments are n…

This phase 1 study investigates whether the experimental drug ALXN2050 interacts with fluconazole (an antifungal) and rifampin (an antibiotic) in healthy adults. Researchers will measure how the body processes ALXN2050 when taken alone versus with each of these drugs. The goal is…

This study tests whether following a Mediterranean-style diet for just one week can improve mood and mental wellbeing in healthy UK adults who usually eat a low-Mediterranean diet. Participants attend an educational session on Mediterranean eating principles and then follow the d…

This completed Phase 1 study looked at how the drug MCI-186 (Edaravone) is processed in the body of people with severe liver impairment compared to healthy individuals. Twelve participants received a single intravenous dose. The goal was to measure drug levels and safety, not to …

This study investigates how kinesiotaping, applied with different tension levels using a fascia correction technique, affects the thickness of fascial layers and nearby muscles in healthy adults. Researchers use ultrasound to measure changes in the forearm's fascia, muscles, and …

This study looked at how the drug MCI-186 (also called edaravone) behaves in people with mild or moderate liver impairment compared to those with healthy livers. Twenty-two participants received a single dose of the drug. The goal was to see if liver problems affect how the drug …

This study looked at how the drug MCI-186 is handled by the body in people with mild or moderate kidney impairment compared to those with normal kidneys. Thirty adults received a single dose of the drug, and researchers measured its levels in the blood. The goal was to understand…

This pilot study tests a new technology called inDrop RNA-Seq to analyze individual immune cells in detail. Researchers will use it to study how healthy adults respond to the yellow fever vaccine, which is known to be very effective. The goal is to identify the specific cell type…

This early-stage study evaluates the safety and how the body handles LY3502970, an experimental oral drug, in healthy adults. Participants receive either a single dose or multiple doses of the drug or a placebo. The study does not aim to treat any medical condition but gathers es…

This early-stage study in 16 healthy adults aims to compare how well a new film-coated tablet of the experimental drug PF-07799933 is absorbed versus an older tablet form. It also checks whether taking the drug with a high-fat meal or with an acid-reducing medication changes drug…

This study looks at Chapman reflex points—small, palpable nodules in connective tissue thought to be linked to internal organ function—in healthy young adults. Researchers examine how often these points occur and whether they are associated with symptoms people may experience. Th…

This study tests whether a half-day training program can improve the ability of intensive care nurses and non-physician staff to recognize seizure-related patterns on EEG (brain wave recordings). Participants attend a lecture, complete knowledge tests, and fill out questionnaires…

This study compares three types of exercise—resistance training, plyometric (jump) training, and high-intensity interval training—to see how each affects leg muscle thickness, tendon thickness, muscle strength, joint position sense, and balance. The participants are healthy men a…

This study investigates how moderate and severe kidney impairment affects the way the body processes a single dose of the drug BI 764198. Researchers compare people with kidney disease to healthy volunteers with normal kidney function. The goal is to understand how kidney functio…

This trial studies three different oral versions of the experimental drug BI 764198 in healthy adults aged 18 to 55. The goal is to see how well each version is absorbed and whether taking the tablet with food changes that. Participants receive each formulation in a random order,…

This trial studies how the drug BI 764198 is absorbed into the body when given as different pill types (capsules vs. tablets) and with or without food. It involves 28 healthy adults aged 18 to 50. The goal is to find the best oral formulation for future use in patients hospitaliz…

This early-stage trial tests the safety and tolerability of a new drug, BI 764198, in healthy men aged 18 to 45. Participants receive a single rising dose of the drug or a placebo. The study measures side effects and how the drug moves through the body, but does not aim to treat …

This completed Phase 1 study in 14 healthy men tested whether taking multiple doses of itraconazole changes the amount of BI 764198 in the blood after a single dose. Participants took BI 764198 alone and then again with itraconazole to compare drug levels. The goal is to understa…

This completed Phase 1 trial in 14 healthy adults tested whether taking BI 764198 along with metformin changes how much metformin gets into the blood. Participants received both drugs together or metformin alone in a crossover design. The goal was to see if there is a drug intera…

This completed Phase 1 trial in 41 healthy adults tested whether multiple doses of MK-2828, a potential heart failure treatment, affect how the body processes rosuvastatin and furosemide. The goal was to check for drug interactions that could impact future dosing. The study provi…

This study investigates how the brain's use of glucose and oxygen changes when processing unpredictable sights and sounds. Healthy adults aged 21-35 will undergo combined PET and fMRI scans while performing tasks with predictable or random stimuli. The goal is to understand the l…

This study tested a wearable device that buzzes to remind surgical residents when they are slouching during operations. The goal was to see if the device helps them spend more time in an upright posture and reduces muscle pain. Twelve surgical residents took part in this complete…

This study tests whether a peer-supported orientation program, including videos made by senior students and guided hospital tours, helps first-year nursing students feel less shocked and more adapted during their first clinical placement. About 90 students will be randomly assign…

This Phase 1 trial evaluates the safety, tolerability, and how the body handles ABSK061, given as mini-tablets by mouth. Healthy adults aged 18 to 45 receive single or multiple doses to measure drug levels and any side effects. The study also checks whether taking the tablets wit…

This study looked at how a common heart medication, diltiazem, changes the amount of nemtabrutinib in the blood of 26 healthy adults. Researchers measured drug levels over time and checked for side effects. The goal was to understand if diltiazem affects how the body processes ne…

This study looked at how healthy men absorb, break down, and eliminate a single dose of an experimental drug called BI 764198. Twenty-four men took the drug by mouth, and researchers measured the drug and its breakdown products in blood, urine, and stool over several days. The go…

This early-stage trial tested the safety and tolerability of an experimental drug called BI 1569912 in 83 healthy men. Participants received either the drug or a placebo in multiple rising doses, with some also trying a gradual dose increase. The study is complete and focused on …

This study looked at whether taking a survey before or after a meal changes how people report their appetite and eating habits. 33 healthy adults completed questionnaires about their eating behaviors and weekly appetite, both before breakfast and 90 minutes after. The goal was to…

This study tested how a single bout of running in extreme cold (-10°C) affects red blood cell clumping in 30 healthy young men. Half ran in a cold chamber, half in neutral air. Researchers measured blood samples to see how cold exercise changes blood flow and oxygen transport. Th…

This study looked at how the heart fills and pumps blood when the body is tilted or exposed to lower body pressure. Researchers compared 30 people with type 1 diabetes and healthy volunteers. They used heart monitoring and ultrasound to measure changes, aiming to understand how d…

This study tested whether a face-to-face training session on perineal care improves knowledge among relatives of palliative care patients with incontinence. Eighty-four caregivers were randomly assigned to receive training or standard care. Researchers measured knowledge using a …

This study looked at how a single session of cycling reduces pain sensitivity in 90 healthy adults aged 18-30. Researchers measured pain thresholds and blood levels of certain compounds before and after exercise. The goal was to understand the mechanisms behind exercise-induced p…

This study tested whether inhaling hydrogen gas affects how the body uses fuel during light exercise. Twenty healthy women rode a stationary bike for 30 minutes while breathing either hydrogen or a placebo. Researchers measured metabolism, heart rate, and perceived effort. The go…

This Mayo Clinic study tested whether a dietary supplement called Synaquell™ can affect brain function in 25 youth contact sport athletes. Participants took either the supplement or a placebo twice daily during their sport season. Researchers measured brain activity with EEG and …

This study tested whether a face-to-face training session on pressure ulcer prevention improves the knowledge of caregivers of palliative care patients. 70 caregivers participated, and their knowledge was measured before and after training. The goal was to see if this simple educ…

This study in 8 healthy men aims to understand how the experimental drug BI 1584862 is absorbed, broken down, and eliminated from the body. Participants take a single oral dose with a radioactive tracer and a tiny intravenous dose with a stable isotope. Researchers measure the dr…

This completed Phase 1 study in 24 healthy adults tested whether taking MDMA (the drug in ecstasy) alongside psilocybin (the active ingredient in magic mushrooms) reduces anxiety and negative feelings while boosting positive mood and trust. Researchers measured mood, blood pressu…

This study looked at how different proteins—from peas, whey, and faba beans—affect metabolism in 28 healthy women aged 18-45. Participants drank protein shakes on separate days, and researchers measured growth hormone and other markers in their blood. The goal is to understand wh…

This early-phase trial is testing a new drug called LY4005130 in 118 healthy volunteers to see if it is safe and how the body processes it. Participants receive either the drug or a placebo, given as an injection under the skin or into a vein. The study focuses on side effects an…

This completed phase 1 study in 14 healthy men looked at how the experimental prostate cancer drug opevesostat behaves in the body when taken with or without another drug called itraconazole. The goal was to measure drug levels and safety, not to treat cancer. Results will help g…

This study tested whether giving parents personalized nutrition advice and healthy recipes helps improve the diets of young children aged 24-42 months. 72 healthy toddlers took part, with some families receiving individual coaching on adding fresh meat and vegetables to meals. Th…

This study looks at how being physically fit changes the bacteria in your gut. Researchers will compare the gut microbes of 30 healthy men, from inactive to elite athletes, by testing their exercise capacity and analyzing stool samples. The goal is to find connections between fit…

The BARITONE study aims to find biological markers in blood and urine that show what people actually eat—like meat, fish, or vegetarian meals. One hundred healthy adults will eat three different diets for a week each, with a break in between. The goal is to improve how researcher…

This study looks at whether a new solid pill form of the drug ABX-002 works the same as the liquid version. It also checks if eating a high-fat meal changes how the body absorbs the solid pill. The trial involves 18 healthy adults who receive a single dose of each form under diff…

This study tested the safety and tolerability of a single dose of HB0043, a lab-made antibody that targets two inflammatory proteins (IL-17A and IL-36R), in 52 healthy adults aged 18 to 55. Participants received either the drug or a placebo, and researchers monitored for side eff…

This study investigates how a medication called lorazepam, which boosts the calming brain chemical GABA, changes emotional brain activity in people with psychosis. Participants aged 16–60 with conditions like schizophrenia or bipolar disorder, along with healthy volunteers, will …

This study tested a new radioactive tracer called [18F]Fluotriopride in 29 healthy adults using PET/CT scans. The goal was to see how the tracer moves through the body and brain, and to check its safety. This is an early-phase study that helps develop better tools for brain imagi…

This early-stage trial tested two different forms of MK-1167, an experimental drug aimed at treating Alzheimer's symptoms, in 16 healthy adults. Researchers measured how the drug moves through the body and checked for safety. The goal is to find a safe dose before testing it in p…

This study looked at how different visual prompts—like words, pictures, or colors—activate the brain's smell center in 30 healthy adults. Using fMRI scans, researchers aimed to find the best way to trigger a sense of smell through imagination. The goal is to use this knowledge to…

This study looked at how breathing ozone, a common air pollutant, affects the lungs' ability to clear out dead cells and debris. Healthy adults aged 18-35 were exposed to either filtered air or ozone, and then had their lung cells examined. The goal was to understand how environm…

This study tested whether a pre-filled syringe and a pre-filled pen deliver the same amount of survodutide into the body. Fifty-six healthy or overweight adults received a single dose of each version in random order. Researchers measured drug levels in the blood to see if the two…

This study tested how a single session of upper body resistance training, with or without extra static stretching, affects the heart and muscle recovery in 28 healthy men. Researchers measured heart workload and muscle oxygen levels right after exercise and 30 minutes later. The …

This study looks at how a new drug called ulonivirine changes the way the body processes two common medications: atorvastatin (for cholesterol) and metformin (for diabetes). Twelve healthy adults will take these drugs with and without ulonivirine to compare drug levels in the blo…

This study looked at how over-the-counter warming and cooling gels change skin temperature, blood flow, and how they feel on the skin. Twenty-one healthy adults had gels applied to their back and arms. The goal was to understand the physical effects of these products, not to test…

This study adapted a questionnaire called the Cervical Cancer Screening Uptake Questionnaire (CCSTQ) into Turkish and tested it with 530 women aged 21-65. The goal was to see if the Turkish version accurately measures factors like knowledge, social norms, and beliefs that affect …

This study looked at whether regular physical activity can improve thinking and memory in middle-aged adults (40-65) who have a family history of Alzheimer's disease. About 180 participants were randomly assigned to an exercise program or a comparison group and were followed for …

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This study tested whether water biking in hot water (35°C) helps athletes adapt to heat better than biking in neutral water (25°C). Twenty-four healthy recreational athletes completed 10 training sessions over two weeks. Researchers measured changes in distance traveled during a …

This study looked at how different core exercises affect serve and spike speed in elite young male volleyball players aged 11-14. Thirty-one players did either static (holding positions) or dynamic (moving) core exercises for six weeks. The goal was to see which type improves bal…

This study tests whether a digital platform called mindline.sg can improve mental health knowledge, emotional wellbeing, quality of life, and work performance in healthy adults in Singapore. About 300 participants with mild to moderate mental health symptoms will either use the p…

This study tested whether foam rolling helps elite swimmers recover faster after intense sprint training. Fifteen national-level swimmers did hard sprints, then either used foam rolling or swam gently to recover. Researchers measured heart rate variability to see which method wor…

This early-stage study in 28 healthy adults aims to compare how well a new formulation of the drug SYT-510 is absorbed, and whether food changes its effects. Part 1 looks at single doses under different conditions, while Part 2 tests multiple doses to check safety and how the dru…

This study looked at how people with temporal lobe epilepsy (TLE) remember spatial information, like directions, compared to healthy volunteers. Researchers tested memory right after a navigation task and again six weeks later. They wanted to see if people with TLE forget spatial…

This early-stage study tested a new injectable form of aspirin against standard oral aspirin in 40 healthy adults. Researchers compared how the body absorbs each version, how well they affect blood clotting, and any side effects. The goal is to see if the injection offers any adv…

This study tested whether a special nerve-tracking feature on an ultrasound machine helps beginners find nerves more accurately. 80 medical students and residents participated. The goal was to see if the technology improves learning for those new to ultrasound-guided procedures.

This study looked at whether feeling full changes how people sense their own body size and movement. 108 healthy volunteers drank water until full and then performed tasks to measure body awareness. The goal was to understand how signals from the stomach influence the brain's bod…

This study looked at immune cells from 4 healthy people shortly after they got a smallpox vaccine. Researchers wanted to see if these cells already show signs of long-term memory. The goal was to understand how the body builds lasting protection after vaccination.

This study used brain scans to look at two things in people with depression or bipolar disorder: a glutamate receptor called mGluR5 and the density of connections between brain cells (synapses). Researchers compared 120 participants, including healthy volunteers, using PET and MR…

This study looked at how the body processes a drug called LY4064809. Seven healthy adults received the drug by mouth and by IV to compare how much enters the bloodstream. The goal was to understand the drug's absorption, not to treat any disease. Participants stayed at a research…

This study looked at how the drug LY3502970 behaves in people with healthy kidneys compared to those with kidney problems. Researchers measured how much drug gets into the blood and how fast the body clears it. The goal is to understand if kidney impairment changes drug levels, w…

This study tested a new prototype foam dressing on 120 healthy volunteers to see how well it stays in place compared to two similar dressings already on the market. Dressings were applied to thighs and shins and checked after 1, 3, and 7 days. The main goal was to show the new dr…

This early-stage trial tested the safety and tolerability of single doses of BI 3000202 tablets in 68 healthy men. It also looked at how taking the tablet with or without food affects the drug's levels in the blood. The study is complete and provides basic information for future …

This study looked at 53 healthy older adults to find the best combination of physical activity (light or moderate) and cognitive tasks (easy or challenging) for short-term brain benefits. Participants tried each of the four combinations on separate days and took thinking tests be…

This study looked at memory complaints in 426 people, including those with brain tumors, breast cancer, and healthy volunteers. Participants filled out questionnaires about their memory, mood, and fatigue. The goal was to understand how cancer and its treatments might affect ever…

This study looked at how enlicitide, an experimental drug, enters the bloodstream when given in different tablet forms. Thirty healthy adults took part to help researchers understand the drug's behavior and check for any side effects. The goal was to compare the new tablet versio…

This early-stage study tested two different forms of the drug aramchol in 16 healthy adults to see how well each is absorbed. One form was a granule mix for oral suspension, the other was a tablet. The goal was to measure drug levels in the blood, not to treat any disease. Result…

This study looked at how a common antifungal drug, itraconazole, changes the levels of an experimental drug called BI 1584862 in the blood. Fourteen healthy men took BI 1584862 alone and then again with itraconazole to see if the combination altered drug exposure. The results wil…

This study looked at how a 16-week moderate-to-vigorous physical activity program changes physical fitness and gut bacteria in healthy school-aged children. 113 kids were randomly assigned to either the exercise program or a control group. The goal was to measure fitness scores a…

This early-phase trial tested the safety and how the body handles a single dose of the experimental drug BI 425809 (iclepertin) in 83 healthy men. Researchers compared different forms (drinking solution vs. tablet) and looked at whether food changes drug absorption. The goal was …

This study looked at how healthy adults absorb, break down, and eliminate the experimental drug ARV-471. Twelve participants each took a single radioactive dose of the drug. Researchers measured levels in blood, urine, and stool to understand the drug's path through the body. Thi…

This early-stage study tested the safety of a new drug called VIS954 in 24 healthy adults aged 18 to 55. Participants received either the drug or a placebo, and researchers monitored side effects and how the drug moved through the body. The goal was not to treat any disease, but …

This study looked at how fermented dairy (like yogurt) and non-fermented dairy (like milk) affect bowel habits and thinking skills in healthy women who have bowel movements every other day or less. 96 women took part, eating 300g of dairy daily for 4 weeks. The goal was to see if…

This early-stage study tested a new oral drug called LY3502970 in 26 healthy adults. The goal was to see how quickly the drug enters the bloodstream and how long it takes the body to clear it, comparing different pill versions. Participants took multiple doses over several weeks,…

This study tested a powered bone marrow aspiration device against the standard manual device in 15 healthy adults. Each volunteer received both procedures on opposite sides of the pelvis. Researchers measured pain, time to get a sample, and the quality of the bone marrow specimen…

This completed Phase 1 study enrolled 120 healthy volunteers to measure how much olomorasib enters the bloodstream and how quickly the body eliminates it. Participants took a single dose of the drug by mouth and stayed overnight at the research center for 10 nights over about 7 w…

This study measured normal anal function in 90 healthy adults aged 18-65. Researchers compared two types of catheters to establish baseline values. The goal was to improve future diagnosis of bowel disorders.

This study looked at how two common antibiotics (amoxicillin and azithromycin) affect the trillions of microbes living in healthy people. Researchers measured changes in metabolism, immune markers, and energy use before, during, and after a short course of antibiotics. The goal w…

This completed Phase 1 trial tested whether the experimental drug SP-624 affects brain electrical activity in 26 people — some healthy, some with major depression. Participants took SP-624 or a placebo daily for two weeks. Researchers used EEG and AI to look for changes in brain …

This study tested how different electrical waveforms (biphasic vs. monophasic) affect comfort and tolerability of transcutaneous auricular vagus nerve stimulation (taVNS) in 30 healthy adults. Participants received one hour of stimulation while reporting discomfort and heart rate…

This study looked at whether different doctors can consistently measure certain angles on pelvic X-rays. Thirty-three healthy adults had X-rays taken while sitting and standing. Four doctors then measured the same images to see if they agreed. The goal is to find out if these mea…

This study looked at how the drug quinidine changes the amount of orforglipron in the blood of 27 healthy adults. Participants took both drugs by mouth, and researchers measured drug levels over time. The goal was to understand how the body processes these drugs together, not to …

This study looked at how two different versions of the drug LY3502970 behave in the body. Thirty-nine healthy adults took part to help researchers measure drug levels in the blood and check for any safety issues. The goal was to gather information, not to treat a disease.

This study looked at how the antibiotic clarithromycin changes the amount of LY3502970 in the blood of 26 healthy adults. Participants took LY3502970 alone and then with clarithromycin to see if there is a drug interaction. The study was completed and lasted about 85 days per per…

This study looked at how the drug LY3502970 enters the bloodstream and leaves the body in people with different levels of liver function. 29 participants, including healthy volunteers and those with mild to severe liver impairment, took a single dose. The goal was to understand d…

This early-stage trial tested an experimental oral drug called LY3502970 in 34 healthy adults. Researchers measured how much of the drug gets into the blood and how the body processes it, both after eating and on an empty stomach. The main goals were to check safety and understan…

This study looked at how immune cells in the lungs respond to tuberculosis (TB) proteins in 17 adults—some with latent TB (no symptoms) and some never exposed. Researchers used a thin tube to deliver the protein directly into the lung and collected cells to measure immune reactio…

This completed phase 1 study looked at how the drug cyclosporine changes the levels of an experimental drug called LY3502970 in the blood. Thirty-two healthy adults took LY3502970 alone and then with cyclosporine. The goal was to understand the interaction, not to treat any disea…

This completed Phase 1 study in 10 healthy adults measured how much of the drug LY3502970 enters the bloodstream after being taken by mouth compared to directly into a vein. The goal was to understand the drug's absorption and breakdown in the body. Results will guide dosing for …

This study tested whether a generic gefitinib tablet (made by Hunan Kelun) works the same as the brand-name drug Iressa in 38 healthy Chinese men. Each participant took a single dose of either the generic or brand-name drug after a meal, then switched to the other. Researchers me…

This early-stage study gave a single radioactive dose of the experimental drug LY3502970 to 6 healthy men. Researchers measured how much of the drug appeared in blood, urine, and stool over time to understand how the body absorbs and eliminates it. The study is complete and does …

This early-stage study looked at how a single dose of TD-1211 is processed in the body when taken with itraconazole, a drug that blocks certain liver enzymes. Twenty healthy adults aged 18 to 50 participated. The goal was to measure drug levels in the blood and check for side eff…

This study looked at how the experimental drug BI 1569912 is absorbed, broken down, and removed from the body. Eight healthy men took a single oral dose with a radioactive tracer, plus a tiny intravenous dose with a different tracer. The goal was to measure how much of the drug e…

This early-stage study tested the safety and how the body processes a new drug called DA-7503. It involved 90 healthy adults and elderly volunteers who took either the drug or a placebo. The goal was to measure drug levels in the blood and check for side effects, not to treat any…

This study tested whether a training program for daycare providers could improve how they interact with children and support their social, emotional, and language development. About 200 daycare providers took part, with some receiving the training and others serving as a control …

This completed Phase 1 study looked at how orforglipron, an experimental drug, changes the way the body processes several common medications (digoxin, simvastatin, rosuvastatin, acetaminophen, and midazolam) in 50 healthy overweight or obese adults. The goal was to measure drug l…

This early-phase trial tested the safety and tolerability of an experimental drug called BI 1569912 in 56 healthy Japanese men. Participants received either single or multiple doses of the drug or a placebo. The study aimed to see how the body processes the drug and if it causes …

This completed phase 1 trial in 18 healthy adults examined how multiple doses of the experimental drug BI 1569912 change the way the body processes three common medications: repaglinide (for diabetes), midazolam (for sedation), and bupropion (for depression or smoking cessation).…

This study looked at whether breast cancer survivors have reduced arm exercise capacity and oxygen use compared to healthy people. Researchers tested 60 women (30 survivors and 30 healthy) using an arm bike and muscle oxygen monitor. The goal was to better understand long-term ef…

This completed phase 1 study looked at how the antifungal drug fluconazole changes the way the body handles the experimental cancer drug olomorasib. Fifteen healthy volunteers took olomorasib alone and then with fluconazole, and researchers measured drug levels in their blood. Th…

This study looked at whether a newly developed balance assessment system gives accurate and repeatable results. Forty healthy adults aged 18-25 took part in balance tests on two different devices, one week apart. The goal was to see if the new system works as well as an existing …

This study tested whether a gentle electrical current applied to the scalp (transcranial electrical stimulation) could help healthy adults perform a complex computer task faster and more accurately. Forty-four volunteers with advanced degrees completed a track-and-capture task wh…

This completed study compared two preoxygenation techniques—non-invasive ventilation alone versus non-invasive ventilation combined with high-flow nasal oxygen—in 30 healthy volunteers. Researchers monitored oxygen levels in the breath and blood over 3-minute sessions to see whic…

This study looked at how two different forms of MDMA (R-MDMA and S-MDMA) affect healthy people. 26 volunteers took part to measure feelings like mood and empathy, as well as physical changes like blood pressure and heart rate. The goal was to understand which form might be better…

This early-stage trial tested the safety and how the body handles multiple doses of an experimental drug called BI 425809 in 96 healthy young and elderly volunteers. Participants took the drug or a placebo daily for 12 days, and some also compared morning versus evening dosing. T…

This study looked at how different messages affect Japanese parents' willingness to get the HPV vaccine for their daughters aged 12-18. Over 1300 parents took part in surveys and experiments. The goal was to find better ways to communicate about the vaccine and increase acceptanc…

This study tested whether 40 sessions of hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) could improve aerobic and anaerobic fitness in healthy athletes. 59 participants, aged 18-25 or 40-50, underwent either real or sham treatment over two months. Rese…

This study checks whether prazosin capsules made in Barceloneta (Puerto Rico) and Ascoli (Italy) are absorbed and processed the same way in the body. About 69 healthy adults will take the capsules and give blood samples. The goal is to confirm the manufacturing site change does n…

This completed Phase 1 trial studied 14 healthy men to see if taking itraconazole (an antifungal) changes how the body absorbs an experimental drug called BI 1815368. Participants received BI 1815368 alone and then again with itraconazole. The goal was to measure drug levels in t…

This study looked at two different methods for measuring balance during walking: a force plate and a 3D motion-capture system. Fifty healthy adults walked normally and quickly while both tools recorded their movements. The goal was to see which method gives more consistent result…

This study looked at whether a probiotic called Saccharomyces boulardii can help strengthen the gut's natural barrier in healthy adults. Researchers measured how well the gut keeps unwanted substances from leaking into the body. The study involved 56 healthy participants and comp…

This study looked at how healthy adults absorb frankincense, lemon, and wild orange essential oils when taken in different types of capsules. Nineteen people took part, and researchers measured oil levels in the blood over 24 hours. The goal was to see if the capsule type changes…

This early-stage study tested a long-acting injectable form of the HIV drug rilpivirine, alone or with another drug called cabotegravir, in 126 healthy adults. The goal was to see how the body processes the drugs and whether they are safe. This trial does not test treatment or pr…

This study looked at whether intermittent fasting or quitting smoking can change DNA markers linked to aging and cancer risk. 156 healthy women aged 30-60 followed a 6-month program with coaching and optional exercise. Researchers measured changes in DNA methylation patterns to s…

This study looked at how a common seizure medicine, carbamazepine, changes the amount of mirdametinib in the blood. 36 healthy adults took both drugs by mouth. The goal was to understand how the body processes mirdametinib when taken with carbamazepine, which can help doctors dec…

This study looked at how two common heartburn medications, famotidine and rabeprazole, affect the levels of nirogacestat in the blood of 24 healthy men. Participants took nirogacestat alone and with each heartburn drug to see if the combination changes how much medicine gets into…

This study looked at how taking VRN110755 with food or with a common stomach-acid drug (rabeprazole) changes the amount of drug in the blood. Twenty-five healthy adults took the drug under different conditions. The goal was to learn the best way to take the medicine in future stu…

This study tested whether a wearable device called AuReha can measure arm movements as accurately as the usual method (a goniometer). 96 healthy volunteers performed exercises while wearing the device and being measured with standard tools. The goal was to see if the wearable cou…

This completed Phase 1 study tested whether a high-CBD hemp extract is safe for healthy male athletes in contact sports. Thirty-four participants took increasing daily doses of CBD (up to 30 mg per kg of body weight) over several weeks. Researchers monitored brain and heart funct…

This completed Phase 1 trial in 8 healthy volunteers compared how naloxone works when given as a nasal spray versus an injection. Researchers measured drug levels in the blood and effects on heart rate and blood pressure. The goal was to improve computer models that predict how n…

This study looked at how a single dose of an experimental drug called MK-1084 changes the way the body processes two common medicines: rosuvastatin (for cholesterol) and metformin (for diabetes). Sixteen healthy adults took part in this crossover study, where each person received…

This completed Phase 1 study tested how the antifungal drug fluconazole changes the levels of the experimental drug BI 425809 in the blood. Fifteen healthy men took a single dose of BI 425809 alone, and later took it while also taking fluconazole daily. The goal was to see if flu…

This study looked at how a single session of low-intensity exercise with blood flow restriction (BFR) changes pain perception in 20 healthy young adults. Researchers measured pain thresholds and the body's natural pain-fighting system before and after the exercise. The goal was t…

This study checked whether taking iclepertin (a drug being tested for other conditions) changes how the body handles a common birth control pill. Nineteen healthy women took the birth control pill with and without iclepertin, and researchers measured hormone levels in their blood…

This study tested whether foam rolling the calf muscles could immediately improve how far healthy adults can bend their neck forward and backward. 90 participants were randomly assigned to either foam rolling or a control group. Neck flexibility was measured before and right afte…

This study looked at whether using the tensegrity concept (a way of thinking about how structures balance tension and compression) in massage can make it more effective. Fifty-four healthy men aged 19-24 received either a tensegrity-based massage or no massage. Researchers measur…

This early-stage study looked at how the migraine drug zolmitriptan behaves in the body when given as a pill or a nasal spray. Eight healthy adults took both forms, and researchers measured drug levels, heart rate, and blood pressure over 24 hours. The goal was to better understa…

This completed pilot study tested a 3D-printed ingestible pill designed to trap bacteria from the gut, including the hard-to-reach small intestine. Ten healthy adults swallowed the pill, which passes naturally through the body. Researchers checked safety and how well the pill cap…

This early-stage study tested a new drug called HEC30654AcOH in 43 healthy adults to see if it is safe and how the body processes it. Participants received either single or multiple doses of the drug. The goal was to check for side effects and measure drug levels in the blood, no…

This study tested whether adding a steady beat (metronome or music) to eye-head exercises improves the reflex that keeps vision clear when you move your head. Twelve healthy adults did 15-minute training sessions in silence, with a metronome, or with music. Researchers measured c…

This early study tested whether using a laser, microneedles, or a bandage before applying Metvixia cream helps the cream get deeper into the skin. Ten healthy volunteers had small areas on their back treated with each method, and the amount of cream that penetrated was measured b…

This study looks at whether the drug nirogacestat affects how the body breaks down other common medications. Twenty healthy men will take nirogacestat along with a mix of five other drugs to measure any changes. The goal is to understand safety and dosing, not to treat any diseas…

This study tested whether doing leg strength exercises while restricting blood flow (using a cuff) builds more muscle and strength than regular training. Eight healthy adults completed different types of leg workouts. The goal was to see if blood flow restriction could make low-l…

This study looked at how appetite, food intake, and energy levels change during different phases of the menstrual cycle in healthy women aged 18-35. Researchers measured eating behavior in both lab and real-life settings, along with hormones, metabolism, and body composition. The…

This early-phase study tested the drug Iclepertin (BI 425809) in 25 healthy men to see how much of it reaches the brain and how it affects certain brain chemicals. Participants took multiple doses of the tablet, and researchers measured drug levels in blood and spinal fluid. The …

This completed Phase 1 study looked at how moderate and severe liver impairment changes the way the body handles a single dose of palovarotene, compared to healthy people. Thirty-one participants were split into three groups based on liver function and received up to 10 mg of the…

This completed Phase 1 trial compared a generic tenofovir disoproxil fumarate tablet to the brand-name Viread in 47 healthy Chinese adults. Participants took a single 300 mg dose under fasting or fed conditions to see if the generic version is absorbed similarly. The study focuse…

This study tested different recruitment messages to see what motivates nurses and nursing assistants from other EU countries to consider working in Denmark. Over 110,000 people were randomly assigned to receive a behaviorally informed message, a simple message, or no message at a…

This early-stage trial tested a new compound called LEO 158968 in 120 healthy adults aged 18 to 60. The main goal was to check for side effects and see how well the drug is tolerated, as well as how it moves through and leaves the body. Participants received either the drug or a …

This study looked at whether getting protein from whole food (lean red meat) is better than from a supplement (whey protein) for building muscle during resistance training. 81 healthy adults did a 12-week exercise program and had either lean red meat, whey protein, or a placebo d…

This study tested whether a generic lidocaine and prilocaine cream works the same as the brand-name EMLA® cream. Forty healthy adults had each cream applied to their thigh on separate days, and researchers measured how much of the drug got into their blood. The goal was to check …

This study looked at whether the drug delgocitinib changes heart rhythms in 40 healthy adults. Participants took the drug or a placebo, and their heart activity was measured with ECGs. The goal was to check for possible heart risks, not to treat any disease. Since it involved hea…

This early-stage trial tested the safety and tolerability of a new drug called LEO 153339 in 108 healthy adults. Participants received either a single dose or multiple doses of the drug or a placebo. The study focused on how the body absorbs and processes the drug, and whether it…

This early-stage study looked at how healthy adults process a drug called lobeglitazone, given as two different tablet types (a standard tablet and a melt-in-the-mouth tablet). Twenty-one participants took single doses under fasting and fed conditions to measure drug levels and s…

This early-stage study tested the safety and how the body processes an experimental drug called AVP-786. 48 healthy adult men took single or multiple doses of the drug or a placebo. The goal was to measure drug levels in the blood and check for side effects, not to treat any dise…

This study tested how a single upper-body resistance training session, with or without added static stretching, affects blood vessel function, muscle performance, and blood pressure in 27 healthy men. Participants were measured before, right after, and 30 minutes after exercise. …

This early-stage trial tested whether delgocitinib cream, a potential eczema treatment, makes skin more sensitive to light. Thirty-five healthy adults received a single application of the cream and a placebo on different skin spots, then were exposed to UV light. Researchers chec…

This completed Phase 1 trial tested whether delgocitinib cream, a potential eczema treatment, can cause a UV-light-induced allergic skin reaction (photoallergy). Sixty healthy adults had the cream or a placebo applied to their skin and were then exposed to UV light. Researchers c…

This early-stage study tested how much of the drug tacrolimus gets into the bloodstream when applied twice daily to healthy skin. Twenty-four healthy adults took part. The goal was to measure drug levels and check for side effects, not to treat any disease.

This study tested a new device called Seismofit to see if it can accurately measure fitness (VO2 Max) without needing to exercise. 30 healthy adults had their VO2 Max measured both by the Seismofit at rest and by a traditional cycling test. The goal was to see if the Seismofit co…

This early-phase study looked at how a single dose of cannabidiol (CBD) affects brain inflammation and pain sensitivity in 28 healthy adults. Researchers used brain scans to measure inflammation and a skin cream test to check pain response. The goal was to understand CBD's potent…

This early-stage trial tested a new drug, AVP-786, in 56 healthy adult men to see how the body processes it and whether it is safe. The drug is a modified version of dextromethorphan combined with quinidine. Because this is a Phase 1 study in healthy people, it does not test whet…

This early-stage study looked at how a common antifungal drug (itraconazole) changes the levels of two experimental drugs, AVP-923 and AVP-786, in the blood. Twenty-four healthy adults took part to help researchers understand potential drug interactions. The goal was to gather sa…

This early-stage trial tested the safety and tolerability of a new drug called MK-1167 in 30 healthy adults. Researchers monitored for side effects and how the body processes the drug. The study did not aim to treat any disease, but to gather essential safety data for future rese…

This study looked at how consistently tongue muscle strength and endurance can be measured in healthy children aged 4 to 17. Researchers tested kids twice to see if the results were the same each time. The goal was to understand if these measurements are reliable for future resea…

This study looked at how the drug LY3537031 moves through the body in people with different levels of kidney function. It included 31 adults with normal kidneys, kidney impairment, or end-stage kidney disease. The goal was to measure drug levels in the blood and how long it takes…

This study tested three different tablet versions of the experimental drug BI 425809 (also called Iclepertin) in 18 healthy adults. The goal was to see how the body absorbs each version, not to treat any disease. Participants took a single dose of each tablet on separate days, an…

This study looked at how a single dose of tralokinumab moves through the body when given by two different injection devices. 101 healthy adults aged 18 to 55 took part. The goal was to compare drug levels and safety, not to treat any disease.

This study looked at how a breathing technique called ELTGOL affects air distribution in the lungs of people with COPD and healthy volunteers. Participants lay on their side while researchers measured lung activity using a special imaging method. The goal was to understand how ma…

This phase 1 trial compared a single dose of CT-P6, a biosimilar of the cancer drug trastuzumab, to the approved Herceptin in 200 healthy men. The goal was to see if the two drugs behave similarly in the body and have comparable safety. Results will help determine if CT-P6 can be…

This study tested a virtual reality (VR) afterschool program for 32 children ages 9-17. The goal was to see if kids would use and enjoy the VR system, and to measure their physical activity. This was a pilot study to gather information, not to treat or cure any disease.

This study looked at how different squat depths (partial, parallel, and full) affect leg muscle activation and jump performance. Fourteen healthy, experienced exercisers did squats at each depth while their muscle activity was measured, and their jump height was tested before and…

This study looks at whether the size and shape of a person's arm, forearm, and hand are related to how well they can use their hands and how fast they react. Researchers measured 46 healthy young adults aged 18 to 25 and tested their hand skills with a pegboard and their reaction…

This study looked at whether watching someone else perform a reaching movement can improve your own ability to perform the same movement. Sixty healthy adults were split into three groups: one watched videos of arm movements, one watched lights turning on in a sequence, and one w…

This study tested a new way to give furosemide (a water pill) by injecting it under the skin instead of into a vein. Sixteen healthy volunteers received both versions to see how well the body absorbs the drug. The goal is to find out if the under-the-skin shot works as well as th…

This study checked whether a new HIV medicine called MK-8507 (ulonivirine) causes any changes in heart rhythm. 62 healthy adults took either the study drug, a placebo, or a control drug to compare effects. The main goal was to see if the drug safely affects the heart's electrical…

This study looked at whether taking a new drug called BI 425809 with or without food changes how the body absorbs it. Sixteen healthy adults took the drug once with a meal and once on an empty stomach. The results will help doctors decide the best way to take this medicine in fut…

This completed study tested whether taking L-arginine, a natural amino acid, could prevent blood vessel damage caused by the painkiller celecoxib. Forty-four healthy men took either celecoxib alone, celecoxib plus L-arginine, or placebos for one week. Researchers measured changes…

This early-stage study tested the safety of a new drug, MORF-440, in 80 healthy adults. Participants received either a single dose or multiple doses to see how the body handles it and if any side effects occur. The goal was not to treat a disease but to gather important safety in…

This study tested whether a heart-rate-lowering drug called ivabradine can improve the flexibility of arteries in healthy people. 20 volunteers with a resting heart rate of 70 or higher took either the drug or a placebo for 8 days. Researchers measured artery stiffness and other …

This early-phase study tested the safety and how the body processes a new drug called epaminurad, alone and with naproxen, in 57 healthy adults. The goal was to check for drug interactions and measure drug levels in the blood. Since it involved only healthy people, it does not te…

This study tested whether a new generic version of pramipexole extended-release tablets works the same as the brand-name drug (MIRAPEX ER) in 49 healthy Chinese adults. Participants took a single dose of either the generic or brand-name drug, and researchers measured drug levels …

This early-phase study tested whether PRO-232 eye drops, which combine an antibiotic (moxifloxacin) and a steroid (dexamethasone), are safe and tolerable for healthy adults. Twenty-eight volunteers received either the active drops or a placebo. Researchers monitored for unexpecte…

This early-phase study looked at how the experimental drug BI 425809 (iclepertin) changes the way the body processes four common medications: midazolam, warfarin, omeprazole, and digoxin. Thirteen healthy men took these drugs with and without BI 425809 to see if there were any in…

This completed Phase 1 trial enrolled 16 healthy Chinese men to see how the body processes MK-4482 after single and multiple doses. Participants took 800 mg of MK-4482 by mouth, first as a single dose and then every 12 hours for several days. The study measured drug levels in the…

This completed Phase 1 study tested how the experimental HIV prevention drug MK-8527 moves into breast milk. Thirteen healthy lactating women took a single oral dose, then provided milk and blood samples over five days. The goal was to measure how much drug reaches the baby throu…

This completed Phase 1 study from Merck followed 6 healthy adults to see how the drug elpipodect (MK-8189) is absorbed, broken down, and eliminated. Participants took a single oral dose, and researchers measured the drug in blood, urine, and feces over time. The goal was purely t…

This study looked at how the experimental drug calderasib is absorbed, distributed, and removed from the body in 8 healthy adults. Participants took a single dose with a tiny radioactive tracer so researchers could measure the drug in blood, urine, and feces. The goal was to unde…

This study enrolled 18 healthy adults to compare how the body absorbs miricorilant from different tablet types. Participants received the drug in various forms and doses on separate days. The goal is to find which formulation works best for future trials. This is an early-stage s…

This study looked at how different amounts of simulator motion (no motion, small motion, or full motion) affect how well pilots fly while using a mixed-reality headset. Thirteen healthy pilots completed two flight tasks, and researchers measured their speed and accuracy. The goal…

This early-stage study tested an inhaled form of granisetron (called AZ-010) in 36 healthy adults to see if it is safe and how the body absorbs it. Participants received either a single inhaled dose of AZ-010 (at different strengths), a placebo, or an IV injection of granisetron …

This study tested whether a 1-minute 51-second animated video called FAST BEE helps people learn and remember stroke warning signs. Over 300 healthy adults and teens watched the video and then answered questions about what they learned. The goal was to see if the video improves r…

This study looked at how healthy young women keep their balance, both front-to-back and side-to-side. Researchers measured stability in 111 participants and checked if body mass index (BMI) played a role. The goal was to understand normal balance patterns without any treatment or…

This completed study tested whether a head-mounted sensor and mild electrical stimulation on the ear could help healthy adults stay focused and resist cybersickness during virtual reality tasks. 45 volunteers completed attention, multitasking, and motion-sickness tests while rece…

This completed study tested how much discomfort people feel when transcranial magnetic stimulation (TMS) is applied to different parts of the scalp and with different pulse patterns. Twenty healthy adults received TMS over six scalp locations and three stimulation types, rating t…

This completed Phase 1 trial studied the safety and how the body handles the experimental antifungal drug fosmanogepix in 54 healthy Chinese adults. Participants received single or multiple doses of the drug either by mouth or through an IV, or a placebo. The study measured drug …

This early-stage trial looked at how the drug DA-1229_01 is absorbed and processed in 36 healthy adults when taken with food. Participants received a single dose of the drug in two different forms to compare their safety and levels in the blood. The study is complete and focused …

This early-stage trial tested the safety and tolerability of a new drug called SUVN-I6107 in 64 healthy adults. Participants received either the drug or a placebo tablet, and researchers monitored for side effects and how the drug moves through the body. The study also looked at …

This study looked at how iron supplements change the way the body handles a drug called MT-6548. It involved 61 healthy Japanese men and measured drug levels in the blood. The goal was to gather safety and drug interaction data, not to treat any disease.

This study looked at whether DMT, a psychedelic drug, can reduce pain in healthy adults. Seventeen participants received DMT, ketamine, or a placebo, and their pain responses to mild electrical shocks were measured. The goal was to see if DMT has pain-relieving effects, which cou…

This study tested a computer system designed to help doctors more accurately diagnose and manage complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected health data from 635 people visiting specialty clinics, including healthy volunteers, to see…

This completed study tested the accuracy of Philips FAST SpO2 pulse oximeters using Masimo sensors in 70 healthy adults with varying skin pigmentation. Researchers compared the device's oxygen readings to a gold-standard blood test to see if skin tone affects performance. The goa…

This study tested two new foam bandages on 135 healthy volunteers to see if they stay in place as well as current bandages. Bandages were placed on the knee and thigh, and checked after 1, 3, and 7 days. The goal was to make sure the new bandages don't peel off or expose the pad …

This study looked at whether the proteins in saliva affect how sensitive healthy men are to the bitter taste of caffeine. Researchers tested healthy male volunteers who do not smoke and have no mouth problems. The goal is to understand why some people perceive bitterness more str…

This study looked at how the experimental drug BI 3000202 is processed and removed from the body. In one part, 12 healthy adults took the drug as a liquid, and researchers measured how much came out in urine and stool. In another part, they compared taking a tablet versus getting…

This study aims to develop a method to measure how the body breaks down tryptophan, an essential amino acid. Ten healthy adults aged 18-45 will take a special tracer and provide blood and urine samples. The goal is to later use this method to improve nutrition for preterm babies …

This study looked at the gut's own nervous system in 16 healthy adults to understand how it normally works. Researchers took small tissue samples from the colon during an endoscopy and measured how the rectum responds to pressure. The goal is to use this information as a healthy …

This study looked at whether giving iodine supplements to pregnant women helps their children's brain development. Researchers tested 85 children at age 2 using a standard developmental assessment. The goal was to see if iodine, which is often low in French diets, makes a differe…

This completed Phase 1 trial enrolled 14 healthy men to see how taking bosentan (a drug for high blood pressure in the lungs) affects the amount of BI 425809 (iclepertin) in the blood. Participants took BI 425809 alone for 10 days, then both drugs together for 14 days. The study …

This early-stage trial tested the safety and how the body handles a single dose of an experimental drug called BI 425809 in 49 healthy Japanese and Chinese men. Participants received either the drug or a placebo, and researchers monitored side effects and drug levels in the blood…

This completed Phase 1 trial enrolled 16 healthy men to see how the antibiotic rifampicin affects the levels of an experimental drug called BI 425809 (iclepertin) in the blood. Participants took BI 425809 alone and then again after several days of rifampicin. The study measured d…

This study looked at how to best teach nursing students to care for a child trapped under rubble, focusing on fluid and electrolyte balance. 69 students were split into three groups: one got a 90-minute lecture, another got a 270-minute session combining lecture and simulation, a…

This early-stage trial studied how the drug DA-1229_01 is absorbed and processed in 42 healthy adults. Participants received a single dose of the drug in two different forms, and researchers measured drug levels in the blood. The goal was to check safety and how the body handles …

This early-stage study looked at how a new drug called BI 425809 affects the way the body processes another medicine, midazolam. Fifteen healthy men took both drugs to see if BI 425809 changes how quickly midazolam is broken down. The goal was to understand potential drug interac…

This study tested whether an audio-based educational program about puberty could improve self-concept and healthy behaviors in visually impaired teenage girls. Forty-six girls aged 12-18 from two schools in Egypt took part. The program used simple Arabic audio sessions and Braill…

This study looked at whether a supplement called OliPhenolia®, made from olives, can reduce inflammation and help healthy adults recover after exercise. 18 people took either the supplement or a placebo before and after a standard workout. Researchers measured blood markers of in…

This completed Phase 1 trial tested the drug LY4268989 (MORF-057) in 144 healthy volunteers, including Japanese and Chinese participants. The main goals were to measure how the body absorbs and processes the drug, check for side effects, and see how food or other drugs (like mida…

This study gave 6 healthy men a single dose of the experimental drug BI 425809 (with a radioactive tracer) to see how it moves through the body. Researchers measured how much of the drug came out in urine and stool, and how fast. The goal was to understand the drug's metabolism a…

This early-stage study tested whether giving regular insulin as nose drops is safe and tolerable in 24 healthy adults. Researchers aimed to find the highest dose that does not cause dangerously low blood sugar. The study was completed and focused on safety, not on treating any di…

This completed phase 1 trial enrolled 6 healthy men to measure how much of the experimental drug BI 425809 reaches the bloodstream when taken as a pill compared to a tiny IV dose. Participants received one 25 mg tablet and later a radioactive microtracer injection. The goal is to…

This study tested whether shining different colors of LED light (630nm, 830nm, and 590nm) on skin could speed up healing after a laser made small wounds. Ten healthy volunteers had tiny areas on their forearms treated with a fractional CO2 laser, then exposed to LED or no light. …

This study looked at whether drinking camel milk after intense exercise helps healthy men recover better than cow milk or water. Twelve recreationally active men did cycling tests and drank one of the three beverages. Researchers measured how long they could cycle, heart rate, mu…

This study looked at whether a person's natural sleep-wake pattern (chronotype) affects their motivation and grades when taught using a flipped classroom approach. 111 nursing students participated, with some learning through online videos before class. Researchers measured motiv…

This early-phase trial tested the safety and tolerability of a new drug called SPY001-001 in 96 healthy volunteers. Participants received either the drug or a placebo, and researchers monitored side effects and how the drug moves through the body. Since this is a first-in-human s…

This study looked at whether letting people choose their mindfulness practice (focusing on breath or sounds) makes it more beneficial than being assigned one randomly. Over 240 healthy UK adults took part, doing a 10-minute guided session or listening to an audiobook. The goal wa…

This early-stage trial tested the safety and how the body processes multiple doses of an investigational drug called BI 3810477. It involved 47 healthy adults aged 18 to 60. The study did not aim to treat any disease, but to gather important safety information for future research…

This study uses a special MRI technique with inhaled helium-3 gas to measure how fast air moves through the windpipe and lungs. Researchers will compare airflow in healthy volunteers and people with COPD or constrictive bronchitis. The goal is to gather real-world data to improve…

This study looked at how healthy young adults feel during arm versus leg cycling when electrical muscle stimulation is added. Researchers measured perceived exertion, fatigue, and energy levels in 120 participants. The goal was to understand if electrical stimulation can make dif…

This study looked at whether patterns in cell phone use (like calls and texts) are linked to blood pressure and metabolism over a 24-hour day. Six healthy adults aged 25-35 with Android phones participated. The goal was to better understand how daily behaviors relate to body func…

This study looked at brain activity in 64 people (some who had a stroke and some healthy) while they moved their arms with different levels of effort. The goal was to understand how the brain responds during rehabilitation exercises. Researchers used a special brain scanner (fNIR…

This study looked at how breathing carbon dioxide might affect thinking skills. Researchers measured immune cell activity in blood samples from 27 healthy adults after CO2 exposure. The goal was to better understand the biological reasons behind CO2-related cognitive impairment.

This early-stage trial tested the safety and tolerability of an experimental drug called LY3985863 in 24 healthy Chinese participants. The drug was given as an injection under the skin, and researchers monitored side effects and how the body processed the drug. Since this study w…

This study tested whether EEG can predict brain activity patterns measured by fMRI during cognitive tasks. 24 healthy adults completed two sessions of brain activity recording and neurofeedback. The goal is to make personalized neurofeedback more accessible by using simpler EEG t…

This study looked at how three different forms of the experimental drug BI 456906 are absorbed in the body. Thirty healthy adults each received a single dose of all three versions in random order. The goal was to see if the newer forms work similarly to the original, not to treat…

This study looked at 74 healthy adults aged 20 to 80 to understand how natural aging affects heart muscle scarring (fibrosis) and heart function. Participants had MRI scans, blood tests, and skin measurements to detect fibrosis. The goal was to learn how aging alone changes the h…

This completed phase 1 trial enrolled 16 healthy adults to compare two formulations of the drug BI 456906 (Survodutide). Participants received a single injection of each version in random order. Researchers measured how much drug got into the blood and how quickly, to see if the …

This study tested whether a daily multivitamin called Vitals+ improves health, mood, and thinking skills in healthy adults. Thirty-seven volunteers took either the multivitamin or a placebo for 3 months. Researchers measured blood vitamin levels, cognitive function, and gut healt…

This study looked at how two types of sweet oranges—one rich in certain nutrients called carotenoids and one without—affect inflammation and oxidative stress in healthy adults. Twenty healthy people ate one of the two orange varieties daily for four weeks. Researchers measured ch…

This study aims to develop and validate a test that uses time estimation to reveal emotional disorders in people with neurological diseases. Researchers first need to establish normal reference values in 150 healthy adults aged 20 to 92. The test measures how emotional video clip…

This study looked at how nabilone, a cannabis-like drug, changes a brain enzyme called FAAH in 10 healthy adults. Participants took nabilone for one week and had brain scans before and after. The goal was to understand the drug's effect on brain chemistry, not to treat any diseas…

This study looks at how a single injection of BI 456906, a drug being developed for obesity and liver disease, behaves in the blood of people with different levels of kidney function. Researchers will compare drug levels in 42 adults with normal kidneys to those with mild, modera…

This completed trial looked at whether a daily dietary supplement containing oleoylethanolamide (OEA), ginger extract, and lavender essential oil can affect gene expression and health markers in 92 healthy adults aged 18-64 with a BMI of 25-30. Participants took two capsules dail…

This completed study looked at whether taking a set of dietary supplements (including a nutrient drink, omega oils, probiotics, and copaiba oil) along with lifestyle changes can influence gene expression and blood markers in 97 healthy adults aged 30-55. Participants took the sup…

This study tested a new tablet that combines two drugs—etoricoxib (for pain and inflammation) and betamethasone (a steroid)—to see how well it is absorbed compared to taking each drug separately. 42 healthy Mexican adults took a single dose of the combination pill or the individu…

This early-stage study tested how a high-fat, high-calorie meal affects the way the body processes acoramidis, a drug being developed for a rare heart condition. Eighteen healthy adults took a single dose of the drug either with or without food. The goal was to see if food change…

This study looked at whether small molecules called microRNAs from broccoli can be absorbed into the blood and affect gut bacteria in 20 healthy adults. Participants ate broccoli, and researchers measured these plant molecules in blood and stool samples. The goal was to understan…

This completed Phase 1 trial tested whether a single capsule containing 90 mg ticagrelor and 100 mg aspirin works the same in the body as taking the two drugs separately. Twenty-four healthy adults in Mexico participated. The study measured how much of each drug reached the blood…

This study looked at how raising the head of the bed changes lung movement in 31 healthy adults aged 18 to 60. Researchers used a painless ultrasound to measure lung sliding at three different bed angles: flat, 20 degrees, and 40 degrees. The goal is to help doctors position pati…

This early-stage study tested a new drug, MH-001, in 58 healthy adults to see if it is safe and how the body handles it. Participants received either the drug or a placebo in single or multiple doses. The main goal was to check for any side effects, with no direct treatment benef…

This study looked at how a 250 mg caffeine pill (about 2-3 cups of coffee) affects anxiety, decision-making, and body awareness in 42 people—some with panic disorder and some healthy. Participants took caffeine or a placebo on different days while having their brain scanned in a …

This early-phase trial tested the safety and tolerability of an inhaled drug called DBM-1152A in 20 healthy Chinese adults. Participants received either the drug or a placebo once daily for 7 days at different dose levels. The study focused on side effects and how the drug moves …

This study tested a new way to measure fats in the blood after a meal using a technique called NMR spectroscopy. 14 healthy adults ate a test meal, and researchers collected blood samples to see how different fat types were absorbed. The goal was to improve methods for studying f…

This study looked at how a single dose of THC (the active ingredient in cannabis) changes immune-related genes and proteins in the blood. Researchers compared 56 adults with and without HIV to see if the effects differ. The goal was to understand THC's impact on the immune system…

This study looked at 30 women—half with lipedema and half without—to understand how the condition affects muscle strength, endurance, leg function, aerobic fitness, pain sensitivity, and swelling. Researchers used simple tests like walking and sitting to measure differences. The …

This study looked at how a new drug called CKD-508 interacts with two other medicines (midazolam and rosuvastatin) in 24 healthy adult men. The goal was to measure drug levels in the blood, not to treat any disease. It helps researchers understand safe dosing for future studies.

This study looked at how different parts of the brain work together to help us remember events. Researchers used a gentle magnetic pulse (TMS) to briefly change brain activity in 41 healthy young adults while they performed memory tasks. The goal was to understand which brain reg…

This study looked at how branched-chain amino acids (BCAAs) help build muscle and process sugar in 24 healthy young adults. Participants drank a mix of amino acids, with or without BCAAs, and researchers measured muscle protein building and insulin sensitivity. The goal was to un…

This completed Phase 1 study enrolled 12 healthy lactating women to measure how much of the HIV drug MK-8591A (doravirine and islatravir) gets into breast milk. Participants took one oral tablet and provided breast milk and blood samples over 24 hours. The goal was to estimate th…

This study looked at how sleeping at low versus moderate altitude changes sleep test results in 44 healthy adults who live at high altitude. Participants spent one night at low altitude and one at moderate altitude, and their sleep was monitored with a full set of sensors. The go…

This completed pilot study examined how the body's molecules change during intense exercise. Researchers analyzed blood and saliva from 80 healthy male elite cyclists and recreational athletes before, during, and after a bike test. The goal was to better understand the complex bi…

This early-stage study looked at how eating a high-fat or low-fat breakfast changes the way the body absorbs a new drug called HMPL-523. Eighteen healthy Chinese adults took a single 300 mg tablet under different meal conditions. The goal was to see if food affects drug levels in…

This study looked at how the drug calderasib moves through the body when taken as two different tablet types and with or without food. 52 healthy adults took part to help researchers understand the drug's absorption and safety. The study does not aim to treat any disease.

This study looks at how the drug calderasib (MK-1084) behaves in people with moderate or severe kidney problems compared to healthy volunteers. Researchers will measure drug levels in the blood after a single dose to see if kidney function changes how the body processes it. The s…

This completed Phase 1 study tested how food, different pill forms, and a common heartburn drug (a proton pump inhibitor) change the levels of the experimental drug calderasib in the blood. Fifty-six healthy adults each took a single dose of calderasib under various conditions. T…

This completed phase 1 study tested whether two experimental drugs, DWC202511 and DWC202512, change how the body processes the diabetes medicine DWP16001. Eighteen healthy adults took DWP16001 alone and then with each of the other drugs. The goal was to see if there are any drug …

This completed pilot study looked at how two different beverages—one with mixed nutrients and one with a single nutrient—affect appetite hormones and hunger ratings in 12 healthy adults aged 20 to 50. Participants drank each beverage on separate days, and researchers measured hor…

This completed Phase 1 study looked at how two common drugs—itraconazole (an antifungal) and phenytoin (a seizure medicine)—change the amount of calderasib in the blood of 28 healthy adults. Researchers measured calderasib levels over time after a single dose, alone and with each…

This study looked at whether APF530, a drug for nausea, changes the heart's electrical activity (QT interval) in healthy adults. Fifty-six volunteers received APF530, a placebo, or other comparison drugs in a random order. The goal was to check for heart rhythm risks before the d…

This study looked at how different types of exercise affect physical performance and readiness in 44 healthy young adults in a reserve officer training program. Participants were split into three groups: high-intensity functional training, traditional strength training, or a mix …

This study looked at whether showing people their real-time blood sugar levels (using a continuous glucose monitor) changes how much they value a milk drink made with mulberry leaf extract. About 170 non-diabetic Chinese adults aged 45-75 took part. The goal was to see if seeing …

This completed Phase 1 study enrolled 54 healthy Chinese adults to compare two different tablet formulations of the experimental drug HMPL-523. Participants received a single 300 mg dose of each version in random order, and researchers measured drug levels in the blood to see if …

This study tested a non-invasive robotic platform that uses motion-tracking cameras to keep a person's head steady in real time. Twenty healthy volunteers took part to see how well the system could limit head movement. The goal is to use this device during brain radiation therapy…

This study looked at 80 adults aged 40-60 to see if sitting for long periods slows down gut transit time and changes gut bacteria in ways that could lead to colon polyps. Participants wore activity monitors, ate blue muffins to track digestion time, and provided stool samples. Th…

This study tested how well nutrients from two blueberry varieties and a processed berry bar are absorbed by the body. Twenty-nine healthy adults ate each food and had their blood and urine analyzed for 185 plant compounds. The goal is to see if breeding or processing can make fru…

This early-stage study tested the safety and tolerability of two different forms of an experimental drug called solrikitug in 32 healthy adults, both Japanese and non-Japanese. Participants received a single shot under the skin, and researchers monitored for side effects and how …

This study tested how to best apply STAR particles—tiny particles covered with microneedles—to healthy skin. The goal was to find the right pressure and rubbing method to create small punctures that could help future topical medications work better. Twenty healthy adults took par…

This study looked at how common medications like methylphenidate and nicotine affect mood and drug preference in 25 healthy adults. Participants rated their liking and perceived value of the drugs. The goal was to understand the psychological effects of these medications, not to …

This study looked at how eating dinner early versus late affects metabolism in 41 healthy adults aged 18-30. Researchers timed meals based on each person's natural body clock and took blood samples to measure sugar and fat levels. The goal was to understand how meal timing impact…

This completed Phase 1 trial studied how the antifungal drug itraconazole changes the way the body processes an experimental drug called BI 3031185. Fourteen healthy men took a single dose of BI 3031185 with and without multiple doses of itraconazole. The goal was to see if itrac…

This study tested custom carbon fiber ankle braces in 9 healthy adults to see how they change forces across the ankle joint. Researchers varied the brace design and used a computer model to estimate joint contact stress. The goal was to improve the model and understand how brace …

This early-stage study tested the safety and tolerability of a new drug called PROT-001 in 102 healthy adults. Researchers also looked at how the drug moves through the body and how it interacts with other common medications. The goal was not to treat any disease, but to gather e…

This study tested whether a small device that collects blood from the arm (instead of a needle in the vein) works as well for measuring levels of the drug zavegepant. Fourteen healthy adults took the nasal spray and gave blood samples using both methods. The goal was to see if th…

This study collected blood from 43 healthy adults aged 18-60 to serve as a control group for a test that detects circulating tumor cells in cancer patients. Volunteers provided about 20 mL of blood at up to 20 different times. The goal is to make the cancer detection test more ac…

This study looked at whether a home-based exercise app called Physitrack helps handball players stick to their workout routines and improve their jumping ability. Twenty-eight healthy male players from a club in Spain followed an 8-week program using the app. Researchers measured…

This study looked at how a new HIV medicine (MK-4646) interacts with a tuberculosis drug (rifabutin) in 18 healthy adults. Researchers measured drug levels in the blood and checked for side effects when the two were taken together. The goal was to gather safety and dosing informa…

This study looked at how different types of massage—manual, vibration, and percussion—affect brain activity in 12 male taekwondo athletes when given at different times of day. The athletes were all healthy black belts with years of training. Researchers used EEG to measure brain …

This completed Phase 1 study looked at how the drug bulevirtide (Hepcludex) behaves in the body of people with normal liver function and those with liver impairment. Researchers measured drug levels in the blood and how quickly it is cleared. The study involved 74 participants an…

This completed Phase 1 study tested two different ways to give the drug remternetug: an auto-injector and a prefilled syringe. 72 healthy volunteers received a single injection to see how much drug gets into the blood and how fast the body clears it. The goal was to compare the t…

This completed study tested a small device called Tasso+™ that collects blood from the upper arm, aiming to make blood draws easier for clinical trials and pandemic monitoring. About 200 healthy adults used the device, and researchers checked if the blood samples were good enough…

This completed Phase 1 study involved 40 healthy adults to see how two experimental drugs, denifanstat and resmetirom, affect each other's levels in the body. Participants took both drugs, and researchers measured drug concentrations in the blood. The goal was to understand if on…

This study follows 191 healthy teens who were part of the Beginnings study as infants. Researchers want to see if early diet influences growth and body composition at age 14. Participants had their body composition measured. No treatments or medications were given.

This early-stage study looked at how a new drug called BI 1291583 is broken down and removed from the body. Eight healthy men took a single dose with a radioactive tracer so researchers could track it in urine and stool. The goal was to understand the drug's metabolism and recove…

This study looked at how small genetic differences in the GLP-1 receptor affect insulin production in healthy adults. Researchers measured insulin release during fasting and when blood sugar was high. The goal was to better understand how these gene variations influence blood sug…

This study tested a new drug called ZE63-0302 in 82 healthy adults to see if it is safe and how the body handles it. Participants received either the drug or a placebo by mouth. The goal was to measure side effects and drug levels in the blood, not to treat any disease.

This study followed 600 healthy infants from 2 months to 6 years old to see how being fed mostly breast milk, milk-based formula, or soy-based formula affects their growth, body composition, and brain function. Researchers measured physical development and neurobehavioral milesto…

This study looked at whether a supplement called MIB-626 (a form of vitamin B3) can improve physical fitness, muscle energy, and brain function in healthy, highly fit adults aged 19 to 40. Participants took either the supplement or a placebo twice daily for 10 weeks, with some al…

This early-stage study tested a tablet made from mulberry twig alkaloids (WH006) in 62 healthy and overweight/obese adults in China. The main goal was to check safety and how the drug moves through the body. Researchers measured side effects and drug levels after single doses, co…

This study looked at how two different capsule forms of the drug olomorasib are absorbed into the blood, and whether food changes that absorption. It involved 191 healthy Japanese participants over about 6 weeks. The goal was to gather information, not to treat any disease.

This early-stage study tested a new drug called NEU-627 in 74 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored side effects and drug levels in the blood. The goal was to gather basic s…

This small study looked at whether dairy products like skim milk and Greek yogurt, taken right after intense exercise, affect bone turnover and inflammation in healthy young adults. Twenty participants did high-intensity exercise and then consumed either dairy, a carbohydrate dri…

This study looked at how taking multiple doses of carbamazepine changes the way the body processes a single dose of evobrutinib. Fourteen healthy adults participated, staying at a research unit for 20 days. The goal was to measure drug levels in the blood and check for side effec…

This study tested whether special window films can affect thinking, comfort, and health in 41 healthy adults. Participants spent time in a room with window films and took cognitive tests. The goal is to see if these low-cost, quick upgrades can make homes more energy-efficient wi…

This study tested four different cuff designs for carbon fiber ankle-foot orthoses (braces) in 35 healthy adults and people with ankle arthritis or injury. Researchers measured comfort, pain, foot pressure, and walking mechanics to see which cuff design people liked best. The goa…

This study looked at how a single session of strength training with a metronome (a device that produces a regular beat) affects the connection between the brain and muscles. Thirty healthy men aged 18 to 40 did leg exercises at a set pace, either with a regular beat or a more var…

This early-phase study tested a drug called LY4064809 in 10 healthy Chinese adults. The main goal was to see how much of the drug gets into the blood and how fast the body gets rid of it. Researchers also checked for safety and side effects. The study lasted about 21 days and the…

This early-stage study tested the safety and how the body processes ARC-520, an experimental drug for hepatitis B, in 40 healthy adults. Participants received a single dose at different infusion speeds. The goal was to check for side effects and measure drug levels in the blood, …

This study looked at whether special physical activity cards, combined with Life Kinetik exercises, could improve attention, memory, and problem-solving in healthy 11-14 year old students. 36 middle schoolers participated, and researchers measured their cognitive skills before an…

This completed Phase 1 study looked at how a radioactive form of the drug ulonivirine is absorbed, broken down, and removed from the body. Eight healthy adults took a single oral dose, and researchers measured the drug and its breakdown products in blood, urine, and stool. The go…

This study looked at how a new drug, zongertinib, changes the way other common drugs (dabigatran, rosuvastatin, metformin, and furosemide) are processed in the body. It involved 32 healthy men who took these drugs with and without zongertinib. The goal was to measure drug levels …

This study looked at brain activity in 29 healthy, right-handed adults during real hand movements and during the illusion of movement caused by tendon vibration. Researchers repeated each task 20 times to find out the fewest repetitions needed to get clear brain signals. The goal…

This completed Phase 1 trial enrolled 15 healthy adults to compare two different formulations of the drug nerandomilast and to see if food affects how the new formulation is absorbed. Participants received single doses in a crossover design. The study focuses on drug levels in th…

This early-stage trial tested a single injection of the experimental drug BI 3006337 in 80 healthy men to see if it is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored side effects and drug levels in the blood. Sinc…

This completed Phase 1 trial in 32 healthy adults compared how two different combinations of vicadrostat and empagliflozin are absorbed by the body. It also looked at whether food changes drug levels. Participants received a single dose of each combination in random order. The go…

This study looked at how soreness in the calf muscle (gastrocnemius) affects other muscles in the back and legs, as well as balance and endurance. Fourteen healthy young adults did exercises to safely create muscle soreness, then had their muscle properties, strength, and trunk e…

This study tested a mobile app called Virtual Promotoras (VIP) for young Latina women aged 16-21 in Alabama who hadn't had a sexual health visit in 18 months. The app provided educational modules, a goal-setting tool, and a chat room. The goal was to see if the app was feasible a…

This study tested whether a non-invasive device that uses electrical signals to estimate stroke volume (the amount of blood the heart pumps with each beat) gives consistent results on different days. Twelve healthy volunteers (6 men, 6 women) had their heart function measured at …

This study tested a new, safe ultrasound method to measure tongue stiffness and fat in 55 healthy adults. The goal was to create a standard protocol for future research on conditions like sleep apnea. Participants lay on their backs while a painless ultrasound was done under thei…

This completed study looked at the food habits and preferences of 200 older adults aged 60 and above living in Singapore. Researchers interviewed participants from different ethnic backgrounds to understand what they eat and why. The goal was to gather information, not to test an…

This completed Stanford study looked at how ketamine changes activity in brain areas linked to reward and risk. Thirteen healthy adults who had used ketamine before underwent brain scans while performing tasks. The goal was to understand ketamine's effects on brain circuits, not …

This completed study at Stanford University used brain scans to see how MDMA (ecstasy) changes the way our brains process risk and reward. Twenty-two healthy adults who had used MDMA before took either a low dose, high dose, or placebo. They then performed tasks while their brain…

This study looked at how low blood sugar (hypoglycemia) affects the body's automatic nervous system, which controls heart rate and blood pressure. Researchers tested whether the drug spironolactone could block these effects in 28 healthy adults. Participants underwent controlled …

This study followed 373 healthy young athletes aged 8-16 from Poland for one year. Researchers measured their sports specialization, performance, and quality of life, then tracked who got injured. The goal is to understand how these factors relate to injury risk and help keep you…

This early-stage study tested the drug SR750 in 40 healthy Chinese adults to see how safe it is and how the body processes it. Participants received either SR750 or a placebo in single or multiple doses. The goal was to gather basic safety and drug-level information, not to treat…

This study looked at how well two different autoinjectors deliver the drug mirikizumab into the bloodstream of healthy people. About 500 healthy adults received a single injection under the skin using either a standard 1-mL autoinjector or a newer 2-mL version. The goal was to se…

This study tested 14 elite male road cyclists to see how different bike saddle designs affect oxygen and carbon dioxide levels in the penis. Riders used a stationary trainer while researchers measured blood gas changes over time. The goal was to compare a new 3D-printed saddle wi…

This Mayo Clinic study tested a wearable headset that uses mild electrical pulses to help people hear tones and understand speech. Researchers placed electrodes on the skin to deliver sound information directly to the brain. The study involved 68 healthy volunteers and measured h…

This early-stage trial tested a new oral drug called YUQ-A1007 in 47 healthy adults aged 18 to 65. The drug is designed to activate a protein in the gut that may help treat inflammatory bowel disease (IBD). The main goal was to check the drug's safety, tolerability, and how the b…

This early-stage study tested the safety and how the body processes ARC-520 in 54 healthy adults aged 18-55. Participants received either the drug or a placebo to check for side effects. The goal was not to treat any disease but to gather safety information for future research.

This completed study tested a wearable device that delivers electrical stimulation to multiple leg muscles to help stroke survivors walk more naturally. Researchers first measured muscle activity in 30 healthy adults to understand normal walking patterns. The next step will be to…

This study aims to establish normal values for nerve fiber density in the skin using small biopsies from 300 healthy adults aged 20-80. By comparing results across age and sex, researchers hope to improve the accuracy of diagnosing small fiber neuropathy, a condition that affects…

This study looked at how a new drug called BI 3000202 changes the way the body handles two other medicines: rosuvastatin (for cholesterol) and digoxin (for heart conditions). Fourteen healthy adults took part to help researchers understand if the new drug could affect how these m…

This study looked at how many medical students have immunity against hepatitis B and varicella-zoster (chickenpox) viruses. Researchers tested 401 students to see their protection levels and vaccination rates. The goal was to understand if current immunization programs are workin…

This study aims to establish normal values for a breathing test called the interrupter technique in healthy adults. The test requires very little cooperation from the patient, making it ideal for people who have difficulty performing standard lung function tests. Researchers meas…

This study looked at how a new drug called MT-8554 changes the way the body processes two common cholesterol-lowering medicines, simvastatin and rosuvastatin. Twenty-eight healthy men took the statins alone and then with MT-8554 to see if their blood levels changed. The goal was …

This study looked at how the body absorbs and processes different manufacturing batches of an experimental tablet called evobrutinib. Twenty-eight healthy adults took a single dose of each batch, and researchers measured drug levels in the blood and checked for side effects. The …

This early-stage study tested a new drug called BI 3006337 in 36 healthy Japanese men to see if it is safe and how the body handles it. Participants received either a single shot or multiple shots over 6 weeks. The goal was to measure side effects and drug levels in the blood, no…

This early-stage study tested a single dose of MT-8554, a new drug being developed for pain, in 20 healthy men. Researchers measured how the drug affects the body's response to a cold-induced pain test and checked for safety. The goal was to gather initial data, not to treat any …

This early-phase trial tested the safety and tolerability of a new drug called MT-8554 in 135 healthy adults. Participants received either the drug or a placebo, and researchers monitored vital signs, heart activity, lab results, and side effects. The study did not aim to treat a…

This pilot study tested a 6-week training program called BPIT in 23 healthy adults. The program uses five intensity levels based on body position, from ground exercises to high-impact moves. Researchers measured changes in strength, heart rate variability, and injury rates. The g…

This study looked at whether a specific serotonin receptor, called 5-HT7, could be used as a biomarker for multiple sclerosis (MS). Researchers measured the receptor on different blood cells from 100 people, including those with MS and healthy volunteers. The goal was to better u…

This study tested how accurately a special treadmill delivers controlled pushes and pulls to a person's balance. Twelve healthy adults walked on the treadmill while sensors measured the belt's movements. The goal was to see if the treadmill's commands matched what actually happen…

This early-stage trial in 24 healthy adults compares how the body absorbs two different pill versions of the drug BI 1015550 (nerandomilast). It also checks whether taking the new commercial formulation with food changes drug levels. The study is complete and aims to guide future…

This study looked at how different nutrients change the types and activity of gut bacteria. Instead of having people eat the nutrients, researchers added them to fecal samples in a lab dish that mimics the human colon. The goal was to understand which nutrients help grow healthy …

This study tested whether a shortened FIFA 11+ warm-up program and female-specific soccer cleats change movement patterns linked to injury during cutting (sudden direction changes). Sixty-four healthy youth soccer players aged 13-17 took part. The warm-up part compared the FIFA 1…

This study looked at how pigments in different colored carrots (red, purple-red, and purple) affect the body's absorption of vitamin A and other nutrients. Twelve healthy adults drank each type of carrot juice over several weeks, and researchers measured changes in their blood. T…

This early-stage trial tested the safety of a new drug called THB335 in 60 healthy adults. Participants received either the drug or a placebo in single or multiple doses, and researchers monitored side effects and how the drug moved through the body. Since this is a Phase 1 study…

This study tested two new high-flow nasal cannula (HFNC) devices on 26 healthy adults to see how different airflow settings affect lung aeration. Participants wore the devices at various flow rates while their lung volume and comfort were measured. The goal was to understand how …

This early-stage study tested the safety and tolerability of a new drug called KBP-5074 in 26 adults, including healthy volunteers and those with mild to moderate kidney impairment. Researchers measured how the drug moves through the body and its effects on blood pressure and pot…

This early-stage study tested the safety and how the body processes different doses of KBP-5074 in 46 healthy adults. Researchers also looked at how food affects drug levels. The results will help choose the right doses for future studies in patients with kidney disease and high …

This completed Phase 1 study tested two forms of the drug sotatercept in 146 healthy women who cannot become pregnant. One form is a liquid in an autoinjector pen, the other is a powder that must be mixed before injection. The goal was simply to see how the body absorbs and proce…

This study tested a new breathing exercise device made in Turkey on 40 healthy adults aged 18-65. The device combines visual feedback and resistance training to improve lung function and breathing muscle strength. Participants used the device 5 days a week for 8 weeks, and their …

This study tested if brain stimulation works better when you're actively using your brain. 51 healthy adults received transcranial magnetic stimulation (TMS) while doing a cognitive or perceptual task. Researchers measured brain activity with EEG to see if the timing of the stimu…

This early-stage study looked at how a single dose of the experimental drug KBP-5074 is absorbed, broken down, and eliminated in 7 healthy men. Researchers measured radioactivity in blood, urine, and feces to understand the drug's path. The goal was not to treat any disease, but …

This early-stage study looked at how two common drugs—itraconazole (a fungal treatment) and rifampin (an antibiotic)—change the way the body processes KBP-5074, a potential medicine for high blood pressure or kidney disease. Twenty-four healthy adults took a single dose of KBP-50…

This early-stage study looked at how the drug KBP-5074 behaves in people with moderate liver impairment compared to healthy volunteers. Twelve adults received a single dose, and researchers monitored safety and drug levels in the blood. The goal was to see if liver problems chang…

This pilot study gave the BCG vaccine (used for tuberculosis) to 20 healthy older adults aged 55-80. Researchers measured changes in immune markers and Alzheimer's-related proteins in blood and spinal fluid over 90 days. The goal was to see if this common vaccine might influence …

This completed phase 1 study looked at how imlunestrant, a potential cancer drug, affects the body's handling of other medications like repaglinide, omeprazole, and dextromethorphan. It also tested how quinidine changes imlunestrant levels. 113 healthy women of non-childbearing p…

This early-stage study tested the safety and how the body handles a new drug called D-2570 in 100 healthy adults aged 18 to 45. Participants took either the drug or a placebo, and researchers measured side effects, vital signs, and drug levels in the blood. The goal was to gather…

This study looked at how Parkinson's disease changes the way people perceive time. Researchers measured eye movements in 40 participants (Parkinson's patients and healthy volunteers) to understand the role of dopamine in timing. Patients were tested both on and off their medicati…

This completed Phase 1 study looked at how food and other medications (omeprazole, itraconazole, carbamazepine, and midazolam) affect the levels of the experimental drug LY3484356 in the blood of 82 healthy women who cannot become pregnant. The goal was to measure how the body ab…

This completed Phase 1 study in 16 healthy adults looked at whether taking multiple doses of selpercatinib (a cancer drug) changes how the body processes repaglinide (a diabetes medication). Participants received both drugs in a fixed order, and researchers measured drug levels i…

This completed study examined the nutritional status and emotional well-being of 40 workers in the food supply chain. Researchers assessed diet, body composition, stress levels, and quality of life to identify health risks and differences between active and sedentary workers. The…

This was a first-in-human study to see if ZE50-0134 is safe and how it behaves in the body. 104 healthy adults received either the drug or a placebo. The study also looked at how the drug interacts with other medications like rabeprazole and itraconazole. Since this was only in h…

This completed Phase 1 study tested how multiple doses of evobrutinib, an experimental drug, affect the way the body processes four common medications: digoxin, metformin, rosuvastatin, and sumatriptan. Forty healthy adults participated in two parts, receiving evobrutinib along w…

This study looked at whether eating the fast-digesting carbs at the end of a meal (instead of at the start) changes blood sugar levels in 22 elite female athletes. Over 6 days, participants wore a continuous glucose monitor and followed different meal sequences for breakfast and …

This study looked at how a drug called LY3484356 enters the bloodstream and leaves the body. Sixteen healthy women who cannot become pregnant took a single dose with a radioactive tracer. Researchers measured the drug in blood, urine, and stool to understand its absorption and el…

This study looked at Netherton syndrome, a rare genetic skin condition, to better understand how it affects the body and immune system. Researchers studied 18 people with the disease, measuring immune markers in the blood and tracking skin changes. The goal was to find new target…

This early-stage study in 10 healthy men aims to understand how the experimental drug PF-07054894 is absorbed, broken down, and eliminated from the body. Participants receive a single dose with a tiny radioactive label to track the drug's path. The results will help guide future …

This early-stage trial tested how a new tiotropium inhaler compares to the standard Spiriva Respimat in 40 healthy volunteers. The goal was to measure drug absorption levels, not to treat any disease. Results will help determine if the test inhaler works similarly to the approved…

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This early-stage study looked at how taking multiple doses of an experimental drug (BI 1015550) changes the way the body handles two approved lung medications (nintedanib and pirfenidone). Fourteen healthy men received the drugs in a fixed order, and researchers measured drug lev…

This completed phase 1 trial in 16 healthy men examined whether taking multiple doses of the experimental cancer drug zongertinib changes how the body processes three common drugs: midazolam (a sedative), omeprazole (for heartburn), and repaglinide (for diabetes). Participants re…

This completed study tested whether adding arm exercise to leg cycling helps healthy people exercise longer. Ten healthy volunteers did cycling endurance tests with legs only and with arms plus legs. The goal was to see if the combined approach could be endured longer, which migh…

This study looked at whether the way a baby is born (C-section or vaginal) changes the nutrients in breast milk. Researchers analyzed milk from 250 healthy mothers in China. The goal was to understand differences in sugars, fats, and proteins, not to test any treatment.

This completed Phase 1 trial looked at whether taking multiple doses of the experimental drug BI 1015550 (nerandomilast) changes how the body processes midazolam, a common sedative. Fifteen healthy men aged 18-55 took part. The goal was to see if BI 1015550 affects a key liver en…

This study tested whether two different versions of the drug nerandomilast are processed the same way in the body. 64 healthy adults each took a single dose of both formulations at different times. The goal was to see if the new formulation works just like the one used in later-s…

This study checked if two different pill versions of the drug nerandomilast are absorbed the same way in the body. It involved 64 healthy adults who took a single dose of each version at different times. The goal was to confirm the new version works just like the one used in late…

This completed Phase 1 trial studied how the drug nerandomilast is processed in the bodies of 12 healthy Japanese men after a single dose. Participants took one tablet by mouth after fasting. The goal was to measure drug levels in the blood over time. This early-stage study does …

This completed Phase 1 trial in 18 healthy adults tested whether eating a high-fat, high-calorie meal changes how the body absorbs a single 18 mg dose of Nerandomilast (BI 1015550). Participants took the drug either after fasting overnight or right after a heavy meal, and researc…

This early-stage trial tested a single dose of the experimental drug BI 1015550 in 24 healthy Chinese adults. The goal was to see how the drug moves through the body and whether it is safe. No treatment benefit was expected, as this was a safety and dosing study in healthy volunt…

This small pilot study tested whether stimulating a nerve in the ear (the auriculotemporal nerve) with mild electrical pulses can change how healthy volunteers process pain. Twelve people received two types of stimulation, and researchers measured pain thresholds and pain modulat…

This early-stage study looked at how taking the experimental drug BI 1015550 with or without food changes its absorption in the body. Twelve healthy men aged 18 to 55 participated. The goal was to understand the best way to take the drug, not to treat any disease.

This completed Phase 1 trial tested whether taking the antifungal itraconazole changes how the body processes a single dose of the experimental drug BI 1015550 (Nerandomilast). Sixteen healthy men received the drug alone and then again while on a 12-day course of itraconazole. Re…

This completed Phase 1 trial tested whether a single dose of the experimental drug BI 1015550 (nerandomilast) affects the heart's electrical activity in 46 healthy adults. Participants received low and high doses of the drug, a placebo, and an open-label heart-safe drug (moxiflox…

This early-phase trial tested the safety and tolerability of an experimental drug called BI 1015550 in 42 healthy men. Participants received either single or multiple rising doses of the drug. The study aimed to understand how the body processes the drug and to check for side eff…

This study looked at how much of the drug BI 1015550 gets into the blood after taking it by mouth compared to directly into a vein. Eight healthy men took the drug as a pill and also received a tiny radioactive tracer dose. The goal was to understand the drug's absorption and pro…

This completed Phase 1 study tested how much chlorhexidine gluconate (CHG) and a breakdown product called PCA remain in different dressing patches after 7 days on healthy volunteers. 45 participants had patches applied to 7 sites each. The study was not designed to treat or preve…

This study looked at how the drug BI 1015550 is processed in people with and without kidney problems. 26 adults took a single dose, and researchers measured drug levels in their blood. The goal was to see if kidney impairment changes how the drug is absorbed, to guide future dosi…

This early-stage study tested a new drug called BI 1015550 in 16 healthy Japanese men to see if it is safe and how the body processes it. Participants received a single rising dose of the drug or a placebo. The goal was to check for side effects and measure drug levels in the blo…

This study tested different dilutions of a numbing drug (ropivacaine) on 17 healthy volunteers to find a dose that feels like a real nerve block but doesn't actually relieve pain. The goal is to create a convincing placebo for future research, so scientists can run fair tests on …

This early-stage study looked at how healthy men absorb, break down, and eliminate a single dose of the drug BI 1015550 (Nerandomilast). Six participants provided urine and stool samples over several days to measure how much of the drug and its byproducts leave the body. The goal…

This study followed 2,760 healthy infants from birth to age 3 to understand how diet and gut bacteria influence bone development. Researchers tracked what babies ate, measured their gut microbes, and checked bone strength using ultrasound. The goal was to learn how early nutritio…

This completed study looked at how a single serving of low lactose milk with added GOS (a type of fiber) affects digestion compared to regular milk. Twenty-four healthy Chinese adults drank 400 mL of one milk type, and researchers used MRI scans to measure stomach emptying, small…

This study looked at the different types of immune cells in the blood of 40 healthy Danish women aged 18-41. The goal was to create a reference for normal immune cell levels in women of reproductive age. This information will help future studies understand how the immune system a…

This study looked at whether using a blood flow restriction (BFR) cuff during low-load exercise can improve muscle strength and power as much as traditional strength training. Sixteen healthy adults did either BFR training or standard exercises for 16 weeks. Researchers measured …

This study looked at whether eating a diet with inulin (a type of fiber) for 7 days changes how many calories the body burns at rest. 61 adults who were either normal weight or overweight/obese took part. The goal was to see if inulin affects energy use, not to treat any disease.

This study tested a new drug called BI 3034701 for the first time in humans. It involved 125 healthy men and people with overweight or obesity to see how safe the drug is and how it moves through the body. Participants received either the drug or a placebo as an injection under t…

This study looked at 27 elite Polish rowers to see how intense exercise changes brain chemicals like serotonin and dopamine, and how these relate to energy levels and stress. Researchers measured these chemicals and asked athletes about their mood and recovery before, right after…

This study tested whether using a softer, more flexible catheter material reduces irritation and failure of intravenous lines. Twenty-seven healthy adults each received two catheters (one standard, one more flexible) in opposite arms for up to 72 hours. Researchers measured cathe…

This study looked at how many police officers in Bern, Switzerland had antibodies against COVID-19 over one year. About 1,024 officers volunteered to give blood samples at five different times. Researchers also asked about their work and home life to understand infection risks an…

This study tested whether drugs that boost serotonin—like psilocybin (magic mushrooms) and MDMA (ecstasy)—increase prosocial behavior compared to a dopamine-boosting drug (methylphenidate/Ritalin). 122 healthy adults received single doses and completed tasks measuring empathy, mo…

This study looked at whether using common asthma inhalers for four weeks can affect blood vessels and heart function in healthy young adults aged 18 to 40. Participants used either Ventolin, Symbicort, or a placebo inhaler and had tests like ultrasounds and exercise checks. The g…

This study looked at whether giving ketanserin, olanzapine, or lorazepam after taking LSD can make the psychedelic effects shorter or weaker. Twenty healthy adults took LSD and then one of these drugs or a placebo. The goal was to see how the drugs changed the intensity and durat…

This study tested how the drug azvudine moves through the body and whether it is safe in 24 healthy adults (ages 18-45) and healthy elderly people (ages 60-85). Participants took a single dose of 5 mg, then after a break took the same dose daily for 7 days. The goal was to measur…

This early-stage study tested a new combination pill (CTL02) that contains two diabetes drugs (alogliptin and empagliflozin) in a single tablet. Forty healthy adults received either the combo pill or the two drugs separately to compare safety and how the body processes them. The …

This study looked at how a new drug (DA-5222) and its three components are processed by the body after a single dose. Forty healthy adults took part, and researchers measured drug levels in the blood to compare the two approaches. The goal was purely to gather information, not to…

This study followed 198 runners in the 2015 Ultra-Trail Mont-Blanc to see if drinking only when thirsty ("at thirst") keeps blood sodium levels more stable compared to other drinking plans. The goal is to understand how hydration affects health during extreme endurance events. Re…

This study looked at how two devices—a radial pressure wave device (RPW2) and a TENS unit—temporarily change blood flow in the lower leg. Twenty healthy adults in the UK received both treatments, and their blood flow was measured with ultrasound before, during, and after each ses…

This study tested whether healthy adults can learn to increase communication between brain regions using neurofeedback – a technique where they see real-time feedback of their brain activity. The goal was to see if this heightened brain communication could improve visual percepti…

This study looked at 24 national-level male rowers to see how their motivation and body chemistry change during intense exercise. Participants completed a motivation questionnaire, performed a 6000-meter rowing test, and had blood samples taken before, right after, and one hour a…

This early-phase trial tested the safety and how the body handles a single dose of IBI3032 in 40 healthy adults. Participants were randomly assigned to receive either IBI3032 or a placebo, and some groups also looked at the effect of food on the drug. The study is complete and fo…

This study looked at how a drug called evobrutinib changes the way birth control pills work in 20 healthy women. Participants took both medications and had their blood tested to measure hormone levels. The goal was to see if evobrutinib affects how the body processes birth contro…

This study checked whether a single dose of evobrutinib affects the heart's electrical activity (QT interval) in 36 healthy adults. Participants received evobrutinib, a placebo, or a control drug in random order. The goal was to gather safety information, not to treat any disease…

This completed Phase 1 study looked at how imlunestrant, an oral drug, enters the bloodstream and leaves the body in women with and without liver impairment. 27 female participants took a single dose, and researchers measured drug levels over time. The goal is to understand if li…

This study tested how well a heart monitor patch (MCT Patch) sticks to the skin for up to 30 days. Fifteen healthy adults wore the patch and reported on comfort and skin reactions. The goal was to see if the patch stays on long enough to record clear heart signals.

This completed phase 1 study in 20 healthy women of non-childbearing potential looked at how repeat doses of imlunestrant, an experimental cancer drug, affect the body's ability to process midazolam, a common sedative. Participants took both drugs orally, and researchers measured…

This study tested whether electrical impedance tomography (EIT), a non-invasive imaging technique, can detect lung damage in children and young adults with cystic fibrosis (CF). Researchers compared EIT results to CT scans to see if it can identify air trapping and other lung cha…

This study looked at why some people feel a sharp increase in pain when a numbing injection (nerve block) wears off after surgery. Researchers gave 40 healthy adults a nerve block in one arm and measured pain sensitivity as the block faded. The goal was to understand if the block…

This completed Phase 1 trial in 16 healthy men tested how taking carbamazepine (a strong enzyme inducer) changes the amount of zongertinib in the blood. Participants received a single dose of zongertinib alone, then later took increasing doses of carbamazepine for 18 days followe…

This completed Phase 1 trial enrolled 13 healthy men to compare two oral formulations of the drug BI 1810631. Researchers also tested how taking the drug with food or after multiple doses of the acid-reducer rabeprazole changes its absorption. The goal is to guide future dosing a…

This study tested a new drug called LY3522348 in 65 healthy people to see if it is safe and what side effects it might cause. Researchers also checked how the drug enters the blood and how long the body takes to get rid of it. The study had two parts, lasting up to about 6 to 8 w…

This completed Phase 1 trial tested the safety and tolerability of TML-6, an oral drug, in 72 healthy volunteers aged 18 to 80. Researchers gave single or multiple doses to see how the body processes the drug and whether food affects absorption. Since this study only involved hea…

This study looked at whether a 6-week training program delivered through a smartphone app could help high school athletes improve their agility and movement control. Nineteen athletes aged 14 to 18 used the app to do exercises four times a week. Researchers measured how often the…

This completed Phase 1 study gave a single IV dose of radiolabeled MK-5475 to 8 healthy men to see how the drug is absorbed, broken down, and removed from the body. Researchers measured levels in blood, urine, and feces over time. The study does not test treatment for any disease…

This study looked at how cannabis use affects brain receptors and electrical activity, and how these change when people stop using. Researchers used brain scans and EEGs in 162 people, including cannabis users and healthy controls. The goal was to understand the brain's recovery …

This study looked at how to best prepare blood platelets to measure their mitochondria, the tiny power plants inside cells. Researchers collected blood from 16 healthy adults aged 25-35 to fine-tune lab procedures. The goal was to ensure accurate and reliable results for future s…

This completed Phase 1 study gave a single IV dose of the antiviral PF-07304814 to 5 healthy adults. Researchers measured how much of the drug ended up in urine and feces, and how it was processed in the blood. The goal was simply to understand the drug's breakdown and eliminatio…

This study tested whether children aged 6 months to 5 years could have a brain MRI without being sedated. Researchers tried to see how many kids could complete the scan while awake. The goal was to find a way to avoid sedation for young children needing brain imaging.

This study looked at how a new drug, BI 655130, enters the bloodstream when injected in different places (belly or thigh) and in different amounts. 48 healthy adults took part. The goal was to learn about the drug's absorption, not to treat any disease.

This study looked at how the drug selpercatinib changes the way the body handles midazolam, a common sedative. Sixteen healthy adults took both drugs, and researchers measured drug levels in the blood. The goal was to gather safety and interaction data, not to treat any disease.

This study looked at whether applying cold (cryotherapy) for 20 minutes before or after exercise helps healthy young adults recover faster and perform better. Researchers measured muscle soreness, perceived exertion, and jump height in 22 participants. The goal was to understand …

This study looked at how belzutifan, a drug for certain cancers, changes the way the body handles metformin, a common diabetes medicine. Fourteen healthy adults took metformin alone and then with belzutifan, and researchers measured drug levels in their blood and urine. The goal …

This early-phase trial tested the safety and how the body handles a single dose of the drug Spesolimab (BI 655130) in 36 healthy adults. Participants received the drug either as a shot under the skin or through an IV. The main goal was to compare how much drug gets into the blood…

This study looked at how taking bosentan (a drug that can speed up liver breakdown of other drugs) changes the amount of nerandomilast in the blood. Sixteen healthy men took nerandomilast alone and then again after several days of bosentan. The goal was to see if bosentan lowers …

This study looked at how taking multiple doses of carbamazepine changes the way the body processes a single dose of nerandomilast. Sixteen healthy men aged 18 to 55 took part. The goal was to measure drug levels in the blood, not to treat any disease.

This study tested how healthy adults absorb different forms of bimagrumab, given alone or together with tirzepatide. The goal was to compare the body's concentration of these drugs, not to treat any disease. 125 healthy participants took part, and the study lasted about 4.5 month…

This study looked at how the brain adapts when people have a nerve injury in their dominant arm. Researchers used brain scans to see which parts of the brain help people move skillfully with their left, non-dominant hand. The study included 120 adults, some with a chronic nerve i…

This study looked at how the body digests and uses milk protein (casein) when it is intact versus when it is broken down (hydrolyzed). Twenty-six healthy adults ate a test meal containing one of these protein forms, and researchers collected blood, urine, and intestinal samples o…

This study looked at how Swedish massage and percussion therapy affect muscle stiffness, soreness, and jump performance in 24 healthy adults after exercise. Participants received one of the two treatments, and researchers measured muscle properties and strength. The goal was to s…

This completed study tested a low-power microwave imaging system on 50 healthy women aged 18-74. The goal was to see if the electrical properties of breast tissue match up with breast density seen on mammograms. Each participant had both breasts scanned six times. The results cou…

This study tested whether taking monosodium glutamate (MSG) for several days changes how quickly the stomach empties and how the body uses protein from a meal. Thirteen healthy volunteers took MSG or salt supplements. The goal was to see if MSG affects digestion through receptors…

This early-stage study tested a single oral dose of LY3526318 in 16 healthy women to see how it affects blood flow in the skin after exposure to cinnamaldehyde (a compound in cinnamon). The goal was to understand the drug's basic effects, not to treat any disease. The study is co…

This study looked at whether taking cold or warm water baths repeatedly can help healthy people recover muscle strength and reduce soreness after exercise. Thirty healthy adults took part, and researchers measured muscle strength, soreness, swelling, and blood markers. The goal w…

This study measured lung function in 2000 healthy Polish children and teens aged 3-18 to create normal reference values for a test called respiratory oscillometry. The goal is to help doctors better diagnose and monitor lung diseases in young patients. Participants had no chronic…

This completed Phase 1 trial enrolled 15 healthy men to understand how the experimental drug zongertinib is absorbed, broken down, and eliminated from the body. In one part, participants took a radioactive oral solution so researchers could track the drug in urine and stool. In a…

This completed study used non-invasive brain scans (EEG and MEG) to identify electrical signals linked to mental and physical tiredness in 169 healthy adults. Participants performed tasks designed to cause cognitive or physical fatigue while their brain activity was recorded. The…

This study tested a new, stronger version of the drug RPH-104 (goflikicept) in 130 healthy volunteers aged 18-45. Participants received a single injection either under the skin or into a vein at different doses. The goal was to check how the drug moves through the body, its safet…

This study looked at whether interleukin-6 (a protein involved in inflammation) changes how glucagon (a hormone) lowers amino acid levels in the blood. Twenty-six healthy volunteers received either a drug that blocks interleukin-6 or a placebo, then had their amino acid and hormo…

This study looked at how two natural brain chemicals, oxytocin and vasopressin, change the way brain waves interact. 120 healthy adults received nasal sprays of these chemicals and had their brain activity measured with EEG. The goal was to understand basic brain function, not to…

This study looked at whether taking a cornelian cherry supplement for four weeks could improve heart and blood vessel function in healthy amateur long-distance runners over age 45. Eighteen participants received either the cherry extract or a placebo in a crossover design. Resear…

This completed study looked at how temporary knee pain changes walking patterns in 34 healthy adults. Participants received two injections into the knee: one that caused brief pain and one that did not. Researchers measured their walking movements and pain sensitivity to see if t…

This study looked at how resistance exercise and leg immobilization affect muscle protein production in 15 healthy women aged 18-30. Participants did leg exercises with one leg while the other leg was immobilized. Researchers measured changes in muscle protein synthesis and break…

This completed Phase 1 trial tested how the HIV drug azvudine (FNC) interacts with another HIV drug, Aluvia (lopinavir/ritonavir), in 15 healthy adults. Participants took the drugs alone and together over three 5-day cycles. The goal was to measure drug levels in the blood and ch…

This study looked at how using a smartphone changes the angle of your head and neck when you are sitting versus standing. Researchers measured 30 healthy adults aged 18-30 who use their phones for over an hour daily. The goal was to understand the physical effects of phone use on…

This study looked at how disrupted sleep changes the way healthy adults feel pain and move their joints. Thirty participants received painful injections in the knee and shoulder after a night of fragmented sleep. Researchers measured pain intensity and movement patterns to unders…

This completed study in 20 healthy adults aged 40-70 examined how the body breaks down ornithine phenylacetate, a compound being explored for liver disease. Researchers used special tracers and collected blood, urine, and muscle samples to track its metabolism. The goal was to un…

This study aims to understand how the brain's wiring changes as people age. Ten healthy volunteers aged 18 to 50 had special MRI scans to map connections between brain regions. The goal is to create a detailed model of the brain's network, called the connectome, which could help …

This study looked at whether a probiotic called Weizmannella coagulans BC99 can help athletes digest protein and build muscle. 72 healthy adults took the probiotic for 12 weeks. Researchers measured changes in digestion, amino acids, body composition, and hormone levels to see if…

This completed study tested three different doses of a maqui berry extract called Delphinol in 10 healthy adults to see how it affects blood vessel function. Participants took each dose for 8 days, and researchers measured blood flow and related markers. The goal was to find the …

This completed study surveyed over 2000 healthy adults from different racial and ethnic groups to see if watching an educational video about epigenetics improves their knowledge and acceptance of using this science in medicine. Participants watched either an epigenetics video or …

This completed Phase 1 trial looked at how cannabidiol (CBD) is absorbed and processed in 24 healthy adults. Researchers gave different doses of CBD and measured its levels in blood and urine, along with any side effects. The goal was to understand the drug's pharmacokinetics, no…

This study looked at whether adding a mental task (like counting or word games) to standard exercise helps people with COPD improve their physical and mental abilities. 42 participants were split into two groups: one did standard pulmonary rehab, the other added cognitive tasks d…

This study tested a new medicine called PF-07264660 in 12 healthy Chinese adults to see if it is safe and how the body processes it. Participants received a single IV dose, with three-quarters getting the real medicine and one-quarter getting a placebo. The study lasted up to 181…

This study tested whether treating fruits like lemons, blood oranges, and cherries with melatonin before harvest helps the body absorb more healthy plant compounds. Twenty-two healthy adults drank juice from treated or untreated fruits and provided urine samples to measure absorp…

This early-stage study tested a new drug called LY3876602 in 74 healthy volunteers to see if it is safe and how the body handles it. Participants received either the drug or a placebo by IV, and researchers measured how much drug got into the blood and spinal fluid. The study is …

This small study looked at whether drinking a KETO5 XOGenius beverage every day could improve markers of heart health, thinking skills, and body measurements like weight and waist size. Six healthy adults aged 18 to 50 took part. The goal was to gather early information, not to t…

This study used a technique called transcranial direct current stimulation (tDCS) to apply a mild electrical current to the brain in 37 healthy adults. Researchers used advanced brain scans to measure changes in brain activity, connections, and dopamine levels during and after a …

This completed study looked at how caffeine and L-Arginine affect brain oxygen levels during mental tasks in 37 healthy adults aged 25-35. Participants took capsules containing caffeine, caffeine plus L-Arginine, or a placebo, and then performed memory tests while their brain oxy…

This study looks at how disrupted sleep changes the way common drugs (like painkillers, stimulants, and sedatives) work in the body. Researchers will disturb the sleep of 148 healthy adults in a lab and then measure how their brains respond to these drugs, including pain relief a…

This completed Phase 1 trial tested whether zongertinib tablets made by two different manufacturers are absorbed the same way in the body. Fifty-six healthy adults took a single dose of each version in random order. The goal was to compare drug levels in the blood to ensure the t…

This study in 16 healthy men tested whether taking the cancer drug zongertinib with a high-fat meal changes how much of the drug gets into the blood. Each participant took one dose on an empty stomach and another after a fatty meal, so researchers could compare. The results will …

This completed Phase 1 study looked at how a single 0.5 mg dose of the drug cenerimod is processed in 24 people — some with mild or moderate liver impairment and some healthy. The goal was to see if liver problems change drug levels or safety. Participants were monitored for side…

This study looked at how the drug cenerimod is processed in people with severe kidney impairment compared to healthy people. A total of 16 participants took a single 0.5 mg dose of cenerimod. Researchers measured drug levels in the blood and checked safety markers like heart rhyt…

This completed Phase 1 trial tested how taking multiple doses of itraconazole, a strong antifungal, changes the amount of the cancer drug zongertinib in the blood of 16 healthy men. The goal was to see if itraconazole increases zongertinib levels, which could require dose adjustm…

This completed Phase 1 study looked at how olomorasib, an oral drug, enters the bloodstream and leaves the body in people with mild, moderate, or severe liver impairment compared to healthy volunteers. 46 participants received a single dose. The goal is to understand if liver fun…

This early-stage study in 36 healthy adults tests how food and a common stomach-acid drug (esomeprazole) affect the body's processing of an experimental drug called LY4064809. Participants take a single dose of LY4064809 under different conditions, and blood samples measure drug …

This study tested whether dietary supplements like potato starch and sodium butyrate can change how the body controls heart rate and breathing. Fourteen healthy adults took each supplement for four weeks. Researchers measured gut bacteria byproducts and nerve reflexes. The goal i…

This completed study looked at how the human brain processes tool use and the ability to make tools better over time. Researchers used fMRI scans on 70 healthy adults while they performed tasks involving tools. The goal was to identify brain areas unique to humans that may explai…

This study looks at how meditation practice influences attention and emotion regulation in healthy adults aged 25 to 70. Researchers use brain scans (MRI, MEG, EEG) and stress biomarkers to understand the changes. The goal is to identify the mechanisms behind meditation's benefit…

This study looked at how two common drugs—itraconazole (an antifungal) and rifampin (an antibiotic)—change the way the body processes selpercatinib, a cancer medication. Twenty-four healthy adults took selpercatinib alone and then with each of the other drugs. Researchers measure…

This completed Phase 1 study looked at how food and the heartburn drug omeprazole affect the absorption of selpercatinib, a cancer medication. Twenty healthy adults took selpercatinib under different conditions—with a high-fat meal, on an empty stomach, and after taking omeprazol…

This completed study tested a radioactive tracer called [18F]PBR111 in 6 healthy adults (3 men, 3 women) to see how it spreads in the body and how much radiation it gives off. The tracer is designed to attach to a protein that appears during brain inflammation, which could help d…

This study looked at how the body processes the drug selpercatinib (LOXO-292) in people with different levels of kidney function. Researchers gave a single dose to 37 volunteers—some with healthy kidneys and some with kidney impairment—and measured drug levels in the blood and ur…

This completed Phase 1 trial studied how the antibiotic erythromycin changes the levels of a new drug called BI 1291583 in the body. Twenty healthy adults took both drugs to see if the antibiotic affects how the new drug is processed. The goal was to gather safety and dosing info…

This study looked at how different exercise intensities affect BDNF, a protein important for brain health. Twelve healthy young adults did three types of running: low, moderate, and high intensity. Researchers measured BDNF and lactate levels before and after each session to see …

This early-stage trial tested the safety and how the body handles single doses of an experimental drug called BI 706321 in 73 healthy men. The study had two parts: one to check safety and drug levels after increasing doses, and another to compare different pill forms and the effe…

This early-phase study tested two experimental drugs, JLP-2302 and JP-1366, in 55 healthy volunteers to see how the body processes them and whether they are safe. The trial is now complete. Since it only involved healthy people, it does not test whether the drugs work for any dis…

This completed Phase 1 study looked at whether a single dose of selpercatinib, a cancer drug, changes the heart's electrical activity (QT interval) in 32 healthy adults. Participants received selpercatinib, a placebo, or a control drug (moxifloxacin) in a crossover design. The ma…

This study looked at how the cancer drug selpercatinib changes the levels of rosuvastatin, a cholesterol-lowering drug, in the blood. It involved 28 healthy adults and lasted about 26 days. The goal was to understand any drug interactions and check safety when both are taken toge…

This completed Phase 1 trial in 14 healthy adults tested how the diabetes drug empagliflozin enters the body when taken as a whole tablet or dissolved in water and mixed with food. Researchers measured drug levels in the blood to compare absorption. The study aims to guide how th…

This study looked at how healthcare practitioners move their hands and fingers when inserting a peripheral IV catheter. Researchers measured the forces applied to the skin and veins, as well as the angle and speed of the needle. The goal was to gather data to design a more realis…

This study looked at how a week of low-calorie fasting affects both the body and brain in 12 healthy adults. Participants followed a structured fasting plan, and researchers used brain scans and blood tests to track changes. The goal was to understand the link between switching t…

This early-stage trial tested the safety of a new drug called OPT101 in 14 healthy volunteers. Participants received either OPT101 or a placebo, and researchers monitored for side effects, vital signs, and lab changes. The study was completed and focused only on safety and how th…