Brain scans reveal recovery during cannabis abstinence

NCT ID NCT03104257

Completed Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how cannabis use affects brain receptors and electrical activity, and how these change when people stop using. Researchers used brain scans and EEGs in 162 people, including cannabis users and healthy controls. The goal was to understand the brain's recovery process during abstinence.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: [11-C]OMAR (a radioactive tracer used for PET scans)
What this could lead to: If successful, this study could help us understand how the brain recovers after stopping cannabis use, potentially guiding future treatments for cannabis dependence.
What could go wrong: This is an observational study, not a treatment trial. It only measures brain changes and does not test any therapy, so it won't directly lead to a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cannabis dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANNABIS DEPENDENCE HEALTHY

Contacts and locations

Locations

Conneticut Mental Health Center

New Haven, Connecticut, 06519, United States

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