Yale University

This study is testing if a medication called guselkumab, already approved for psoriasis, can help people with Hailey Hailey Disease (HHD), a rare and painful genetic skin condition. Ten participants with moderate-to-severe HHD will receive injections of the drug over 24 weeks to …

This study compares two types of common heart medications (beta-blockers vs. calcium channel blockers) for older adults with stable chest pain and multiple other health conditions. Researchers want to see which medication works better to improve quality of life, reduce symptoms, …

This study is testing a new method to personalize a treatment called heated chemotherapy (HIPEC) for people with advanced appendix or colorectal cancer that has spread to the lining of the abdomen. Doctors will test a sample of the patient's tumor in a lab to see which chemothera…

This study is testing a non-invasive, focused ultrasound device on patients in the intensive care unit who are experiencing ongoing seizures that haven't stopped with standard medications. The goal is to see if directing gentle sound waves at specific brain areas can reduce or st…

This study is testing a comprehensive 24-week program for people who have both opioid addiction and long-term pain. The program combines standard addiction medication with therapy, exercise groups, and stress-reduction techniques like tai chi and relaxation training. Researchers …

This study aims to find the safest and most effective medication to prevent future strokes in people who have survived a brain bleed (intracerebral hemorrhage) and also have an irregular heart rhythm called atrial fibrillation. Researchers will compare a newer blood thinner (apix…

This study is testing if pills containing THC and CBD, the main compounds in cannabis, can help people who have both chronic pain and an addiction to opioid drugs. The 147 participants are already receiving standard methadone treatment. Researchers want to see if different doses …

This study is testing whether a personalized nutrition and exercise program can help chemotherapy work better for women with a specific type of breast cancer. About 160 women receiving chemotherapy before surgery will be randomly assigned to either follow the new lifestyle progra…

This Yale University study is testing whether pregnenolone, a natural hormone supplement, can help people with alcohol use disorder reduce heavy drinking. 150 participants will take either pregnenolone or a placebo pill twice daily for 12 weeks while receiving counseling support.…

This study is testing whether providing free continuous glucose monitors (CGMs) to low-income adults with poorly controlled type 2 diabetes helps improve their blood sugar levels and quality of life. Researchers will give CGMs to 17 participants who can't afford them and track th…

This study is for people with advanced kidney cancer whose immunotherapy is working for most of their body, but a few tumors (1-5) have started growing again. It tests whether using very precise, high-dose radiation to treat just those few growing tumors can help patients continu…

This study is testing whether combining two existing multiple myeloma drugs—belantamab mafodotin and elotuzumab—is safe and more effective than using them separately. It's for patients whose cancer has returned or stopped responding after at least three prior treatments. Research…

This study is testing if digoxin, a medication used for heart conditions, can help treat a serious liver disease called NASH (now called MASH). Researchers will give 144 people with NASH either digoxin or a placebo pill daily for 24 weeks to see if it reduces liver inflammation a…

This study is testing whether a medication called ertugliflozin helps people with chronic heart failure manage their body fluid levels better than a standard water pill or a placebo. Researchers will compare how these treatments, when added to a patient's usual diuretic, affect b…

This study is testing if using a positive airway pressure (PAP) machine to treat sleep apnea can help people recover better after a stroke. Researchers will compare recovery in 180 stroke patients who use the PAP machine to 180 who receive usual care. The main goal is to see if t…

This small pilot study is testing whether a combination of an existing medication and counseling from a pharmacist is a practical and acceptable way to help people with HIV reduce their alcohol use. The 12-week program is being offered to 30 veterans in Atlanta who have HIV and d…

This study is testing which of two parent-only therapy programs works better to reduce anxiety in teenagers. Researchers at Yale University will compare the SPACE program against the PES program over 12 weekly sessions. The goal is to see which approach helps teens feel less anxi…

This study is testing whether trained community health workers can help people in Nepal better manage high blood pressure. Over 3,500 adults with high blood pressure will either receive regular home visits and group meetings from a community worker for a year, or continue with us…

This study is testing two team-based approaches to help people control their high blood pressure in community settings. Researchers are comparing remote blood pressure monitoring with medical support alone, versus adding a community health worker to help with social needs. They w…

This study compares two forms of ketamine treatment for people with depression that hasn't responded to standard antidepressants. Researchers will test whether an IV ketamine drip works as well as the FDA-approved nasal spray Spravato®. The trial will measure how much depression …

This is the first study in humans testing a new drug called AB821 for people with advanced melanoma and other solid tumors that have spread. The main goal is to find a safe dose and understand how the drug works in the body. Researchers will also check if the drug helps shrink tu…

This study is for people with advanced cancer that started in the upper digestive tract (like the stomach, pancreas, or bile ducts) and has spread to only a few other places. After three months of chemotherapy, if a special blood test finds no cancer DNA, patients are randomly as…

This study is testing whether connecting young adults with type 1 diabetes to a community health navigator helps them resolve social needs like housing or food insecurity. Researchers will compare 100 participants who receive this support to those who continue with usual care. Th…

This study is testing whether brief phone counseling from pharmacists can help people with HIV who drink alcohol and take multiple medications reduce their risk of falls and thinking problems. The program involves medication reviews, personalized risk discussions, and home alcoho…

This study is testing whether the drug afatinib can help control a specific type of aggressive uterine cancer that has returned or persisted after previous treatments. It will enroll about 50 women whose cancer tests positive for a protein called HER2. The main goal is to see if …

This study is testing whether nipple stimulation works as well as the standard medication (oxytocin) for inducing labor in first-time mothers. Researchers want to see if this natural approach leads to more unassisted vaginal births, better breastfeeding success, and fewer complic…

This study is testing whether taking vitamin D supplements can help control the symptoms of Polycystic Ovary Syndrome (PCOS) in teenage girls who have low vitamin D levels. Researchers will give 60 participants either vitamin D or a placebo pill for six months to see if it improv…

This pilot study is testing whether a combination of medication and counseling is practical, acceptable, and helpful for reducing alcohol use in people living with HIV. The 12-week program involves an existing medication (used 'off-label' for alcohol) along with support from a cl…

This study is testing whether guanfacine, a medication typically used for high blood pressure and ADHD, can help people with alcohol use disorder reduce their drinking. Researchers will give 160 participants either the medication or a placebo pill and measure how much alcohol the…

This study aims to find out if a newer balloon catheter device works better than the standard sponge-like dilators to gently open the cervix overnight before a second-trimester abortion procedure. Researchers at Yale University will compare the two methods in 50 participants to s…

This early-stage study is testing the safety of a three-part treatment for extensive-stage small cell lung cancer that has persisted, returned, or worsened after standard therapy. The treatment combines a new drug called iadademstat with an existing immunotherapy (atezolizumab) a…

This early-phase study is testing whether a combination of two existing cancer drugs can help control a rare condition where HPV causes recurring wart-like growths in the airways and lungs. The trial will enroll about 20 adults to see if the drugs are safe and can shrink the grow…

This study is testing if a medication called valbenazine can help adults with trichotillomania, a condition that causes a strong urge to pull out one's own hair. For the first 12 weeks, participants will be randomly assigned to receive either the study drug or a placebo (inactive…

This study is testing an experimental drug called sacituzumab govitecan for women whose cervical cancer has returned or persisted after prior chemotherapy. The drug is designed to deliver chemotherapy directly to cancer cells. Researchers will measure if tumors shrink, how long p…

This Yale University study is testing whether people with overweight or obesity can learn to control their brain's response to food images using real-time feedback during MRI scans. Researchers want to see if this 'neurofeedback' training helps reduce food cravings and improves e…

This study is testing whether giving radiation therapy once or twice daily works better for patients with aggressive lymphoma who are about to receive immune-based treatments. Researchers will treat different parts of the same tumor with different schedules to directly compare ef…

This study is testing if a prescription medication called varenicline, which helps people quit smoking cigarettes, is also effective for helping adults quit using e-cigarettes. Researchers will randomly assign 326 adults who vape daily to receive either the real medication or a p…

This study is testing whether adding metformin, a common diabetes medication, to standard care can help protect specialized kidney cells called podocytes in people with Focal Segmental Glomerulosclerosis (FSGS). FSGS is a serious kidney disease that often progresses to kidney fai…

This study is testing if a drug called bexagliflozin, already used for diabetes, can help reduce the severity of sleep apnea. Over 160 overweight or obese adults with moderate to severe sleep apnea will take either the drug or a placebo pill daily for six months. Researchers will…

This study is testing two different drug combinations for people with advanced triple-negative breast cancer that has worsened after one prior treatment. The goal is to see if adding a newer immunotherapy drug to an existing treatment is safe and can better control the cancer. Ab…

This study aims to expand access to medication-assisted treatment for opioid addiction in Kazakhstan, Kyrgyzstan, and Tajikistan. Researchers will work with local healthcare providers to implement and improve treatment programs, with the goal of helping more people get treatment …

This study is testing three different support programs to help people with moderate to severe alcohol problems stay engaged in treatment after they leave the hospital. Researchers at Yale will enroll 450 diverse patients to see if combining a brief counseling session with medicat…

This study is testing if adding a pill called an SGLT2 inhibitor (a type of diabetes drug) to standard hospital care is safe and helps patients who are hospitalized with both worsening heart failure and sudden kidney injury. Researchers will enroll 130 adults and randomly give th…

This study aims to find out if switching to e-cigarettes or oral nicotine pouches helps adults who smoke reduce their cigarette use. Researchers will give 256 participants one of these products for 4 weeks, testing different flavors and nicotine strengths. The main goal is to see…

This study is testing if a shorter course of an oral hormone-blocking drug (Relugolix), given alongside a precise, high-dose radiation treatment (SBRT), works better than the radiation alone for men with a specific type of intermediate-risk prostate cancer. The goal is to see if …

This study is testing whether adding testosterone injections to an approved prostate cancer vaccine (Sipuleucel-T) can boost the immune system's attack on cancer cells. It will involve 26 men whose prostate cancer has spread and stopped responding to standard hormone-blocking tre…

This study is testing whether combining two drugs, luspatercept and darbepoetin alfa, can help patients with a specific, lower-risk form of myelodysplastic syndrome (MDS) who need regular blood transfusions. The main goal is to see if the treatment can help patients go longer per…

This study is testing whether a medication called elacestrant can prevent breast cancer from coming back years after initial treatment. It focuses on patients with ER+ breast cancer who have tiny amounts of cancer DNA circulating in their blood but no visible cancer on scans. The…

This study is testing whether having trained peers provide education and counseling helps people in Uganda complete their tuberculosis (TB) treatment and stay on their HIV medication. It will involve about 1,920 adults who are starting TB treatment, some of whom also have HIV. Th…

This early Yale University study is exploring whether applying focused ultrasound waves to the abdomen can help lower high blood sugar levels in people with type 2 diabetes. It will involve 30 participants who are already on stable diabetes medication. The main goal is to check i…

This study is observing 200 people with chronic low back pain who are getting a specific, approved, minimally invasive procedure called basivertebral nerve ablation (BVNA). The goal is to see how many people get significant pain relief or functional improvement over two years, tr…

This early-stage study is testing whether a single dose of the psychedelic substance DMT, combined with psychotherapy, can help people with alcohol use disorder reduce their drinking. Researchers will give 63 participants either DMT or a placebo, along with therapy, to check safe…

This study is testing two brief online writing programs designed to help parents in the Southeastern U.S. become more accepting and supportive of their LGBTQ+ children. It involves about 129 parent-child pairs where the child identifies as a sexual or gender minority. The goal is…

This study is creating and testing a new program to help people who are planning weight-loss surgery. The goal is to help them quit smoking and lose weight at the same time before their operation. The program combines two medications with behavior change therapy. Researchers will…

This study compares two breathing support methods for heart failure patients coming off ventilators. Researchers want to see which approach better prevents patients from needing the ventilator again within 72 hours. The trial includes 50 adults with weakened heart function who ha…

This study is for people with advanced bladder cancer that has spread to a few other spots in the body. It tests if adding surgery or radiation to remove the main tumor and its spread, after initial drug therapy has controlled the cancer, can help keep the cancer from growing bac…

This Yale University study is testing if prazosin, a medication usually used for high blood pressure, can help people with alcohol use disorder who experience withdrawal symptoms. 150 participants will take either prazosin or a placebo pill for 12 weeks while also receiving weekl…

This study is testing whether a brief online training program can help young adults who drink heavily gain better control over their alcohol cravings and reduce their drinking. Researchers at Yale University will enroll 177 participants aged 18-26 and randomly assign them to diff…

This study is testing a drug called trastuzumab deruxtecan (T-DXd) in adults whose advanced breast cancer has spread and has tested completely negative for a protein called HER2. The goal is to see if this drug, which combines a targeted antibody with a chemotherapy agent, can sh…

This study is testing whether giving extra support and training to case managers helps them better use a structured care plan for veterans. The plan focuses on managing pain and risky substance use, especially for veterans who have recently left military service. Researchers want…

This study is testing a device that uses sound waves (shockwaves) to break up hard calcium deposits in the main artery of the thigh. It aims to see if this procedure improves pain, walking ability, and blood flow for 50 people with severe peripheral artery disease. Researchers wi…

This small pilot study is testing whether a medication not officially approved for alcohol problems, combined with counseling from a pharmacist, can help people living with HIV reduce their drinking. The goal is to see if this approach is practical, safe, and acceptable to patien…

This study aims to find the safest and most effective malaria treatments for children, especially those also living with HIV. Researchers in Uganda will follow 380 children for two years, comparing two common malaria drugs and checking how they interact with HIV medication. The g…

This study compares two common medications for opioid addiction—methadone and buprenorphine—to see which one helps people stay in treatment longer when prescribed in a regular doctor's office. About 600 adults starting new treatment for opioid addiction will be randomly assigned …

This study is testing whether starting HIV medication very quickly after diagnosis can help reduce the stigma felt by people who inject drugs. It will involve 135 participants, including people from the general community and those in prison. The goal is to see if this faster trea…

This study is testing whether a smartphone app called Kick-Nic! can help high school students quit vaping. 306 teens who want to quit will be randomly assigned to use the app or visit a government quit-vaping website for 8 weeks. Researchers will check in with participants for 6 …

This study is testing whether adding a drug called mogamulizumab to standard chemotherapy works better for aggressive T-cell lymphoma. Researchers will enroll 22 adults with newly diagnosed or returning lymphoma to see if this combination leads to complete remission. The goal is …

This study is testing whether empagliflozin, a medication typically used for diabetes, can help reduce dangerous fluid buildup in the abdomen (ascites) of people with advanced liver scarring (cirrhosis). Researchers will give the drug or a placebo to 20 patients for 14 days to se…

This study is testing whether a portable, low-strength MRI machine can accurately measure brain changes called white matter hyperintensities. Researchers will scan 100 people with conditions like high blood pressure or diabetes using both the portable device and a standard MRI fo…

This study is testing a new device that measures pressure in the heart's main veins without using needles. It will be tried on 40 patients in the cardiac intensive care unit to see if it's safe and gives readings as accurate as the current needle method. The goal is to find a les…

This study is testing a portable MRI machine that can be brought to a patient's bedside to look for brain injury after their heart stops. Researchers want to see if this portable scanner works as well as traditional MRI machines at detecting injury, and if it can track how the in…

This study is testing how accurate a new at-home finger-prick glucose test is compared to the standard blood draw done in a clinic. It involves 60 people who are at risk for or have recently been diagnosed with type 1 diabetes. The goal is to see if this easier, home-based method…

This study is testing whether a short, simple exercise test done before surgery is better than standard questionnaires at predicting who might suffer heart injury after an operation. Researchers will enroll 61 adults aged 45+ who are scheduled for moderate to high-risk non-heart …

This study tests whether providing housing assistance and mental health support can prevent gun violence in New Haven neighborhoods. It focuses on helping families who have a member currently or recently incarcerated. The goal is to see if this community-driven approach makes nei…

This study aims to find the best ways to increase COVID-19 and flu vaccination rates in prisons. Researchers are working directly with prison communities to test different strategies across Pennsylvania's prison system. The goal is to reduce illness and death from COVID-19 among …

This study is testing whether a personalized AI chatbot on a smartphone can help encourage more men in Malaysia to get tested for HIV. About 300 men who have sex with men will be randomly assigned to either use the AI chatbot or receive standard health messages. The main goal is …

This study compares two ways to help people with substance use disorders who have been involved with the justice system. Researchers want to see which approach works better at getting people to start HIV prevention medication (PrEP) or treatment (ART) and substance use treatment.…

This study is testing a new counseling tool designed to help women make informed decisions about starting HIV prevention medication (PrEP) during their regular sexual and reproductive health clinic visits. Researchers will compare the new decision aid to standard information to s…

This study is testing a suicide prevention program in rural Nepal's primary healthcare system. It aims to help local healthcare workers better identify and support people at risk of suicide. The program is being developed with input from people who have personal experience with s…

This small pilot study is testing whether patients can safely and effectively self-administer liquid acetaminophen (Tylenol) for pain after shoulder replacement surgery. Researchers want to see if this approach is practical and acceptable to patients compared to nurses giving pil…

This study is testing whether a home-based device that gently stimulates a nerve in the ear can help young adults with Irritable Bowel Syndrome (IBS) manage their pain and other symptoms like anxiety and fatigue. Researchers will compare a real stimulation device to a fake one to…

This study is testing whether taking warm sitz baths after surgery for pelvic organ prolapse helps reduce pain and improve recovery. Researchers will compare pain levels in women who use sitz baths versus those who receive usual care after their operation. The goal is to find sim…

This study is testing if the compound CBD (cannabidiol) can safely help people who have both opioid addiction and long-term pain. Researchers will give different doses of CBD to 34 people who are already receiving standard medication treatment for their addiction. They will measu…

This Yale University study is testing if a very low dose of a prescription cannabis pill (dronabinol) can help people in recovery from opioid addiction. The goal is to see if it can safely reduce their pain sensitivity, ease cravings, and improve mood and thinking. The study invo…

This Yale University study is testing whether a safe, noninvasive brain stimulation technique can improve how the brain processes social information in adults with autism. Researchers will measure brain activity and eye movements before and after a single stimulation session to s…

This study is testing whether providing specially tailored groceries, with or without nutrition counseling, helps people with cancer eat better and feel better. It will involve 100 adults in Maine who have been diagnosed with cancer, comparing three groups over six months. The ma…

This Yale University study is testing whether a single dose of MDMA (commonly known as ecstasy) can help adults with Borderline Personality Disorder better understand social situations and recognize emotions in others. Researchers will measure changes in sociability and emotional…

This study is testing a bundle of non-drug treatments to help fix the sleep and internal body clock of patients in the intensive care unit (ICU). It will involve about 160 critically ill adults and combines bright daytime light, scheduled meals and activity, and overnight sleep p…

This study is testing two types of online therapy for LGBTQ adults who have parents who struggle to accept their identity. The goal is to see if these therapies can reduce symptoms of depression and anxiety. One therapy works with the individual, while the other involves family s…

This Yale University study is testing whether virtual, community-based programs that combine music and mindfulness can help people of African descent better manage stress, anxiety, and depression. The research focuses on creating culturally relevant support, as these groups are o…

This study is testing if adding a specific exercise program called Baduanjin to usual post-surgery care can help elderly patients with osteoporosis and herniated discs in their lower back. Researchers want to see if the exercises reduce pain, build strength, and improve quality o…

This study is testing a new phone app designed to help middle-aged adults with type 1 diabetes exercise more often and with more confidence. The app uses data from the person's continuous glucose monitor, along with their exercise, sleep, and mood, to provide personalized encoura…

This study is testing whether an online mindfulness program can help Black women who have trouble sleeping. Researchers want to see if this approach can reduce insomnia and stress, which are linked to heart and metabolic health problems. The program is delivered by nurses in comm…

This study is testing if a mobile phone app can help older adults recover better after hip, knee, or spine surgery. The app reminds patients to do safe, in-bed exercises and adjusts the difficulty based on how they feel. Researchers will see if using the app helps patients do bet…

This small Yale study is testing whether a gentle, non-invasive form of brain stimulation can improve voice quality for people with laryngeal dystonia, a condition that causes involuntary spasms in the voice box. Ten participants will have their brains scanned and then receive th…

This early-stage study from Yale University is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' is safe and tolerable for people whose daily lives are impacted by symptoms of depression, anxiety, trauma, or addiction. The study will enroll 50…

This study is testing whether a virtual, community-based program combining music with mindfulness exercises can help reduce stress, anxiety, and depression. It focuses on People of African Descent in America, a group disproportionately affected by stress. Researchers will compare…

This study is testing whether a mindfulness app called Calm Health can help young adults with type 1 diabetes. Participants will use the app to receive mindfulness guidance and see how their practice relates to their blood sugar, stress, and sleep. The goal is to see if the app i…

This small pilot study is testing whether a video-based pelvic floor muscle therapy program is easy to use and acceptable for patients. Twenty participants with pelvic floor disorders will try an 8-week course of guided exercise videos, starting and ending with a therapist visit.…

This study is testing if a daily pill called fezolinetant can reduce the frequency and severity of hot flashes in women who are taking hormone therapy for early-stage breast cancer. Researchers will compare the pill's effects against a placebo in 92 participants over 12 weeks. Th…

This study aims to create a national patient registry in Turkey for people with PTEN Hamartoma Tumor Syndrome (PHTS), a rare genetic condition. It will follow 100 children and adults with PHTS for three years to collect detailed health information. The goal is to better understan…

This study is testing a new imaging tracer called [18F]GATT-44 to see how it moves through the body and brain during PET scans. Researchers are enrolling 32 healthy adults to measure how the tracer behaves, how much radiation it delivers, and how consistently it works. The goal i…

This study aims to understand the genetic reasons why some people experience multiple miscarriages. Researchers will analyze the complete DNA of 500 families who have had unexplained recurrent pregnancy loss. The goal is to identify specific genetic patterns that could lead to be…

This study aims to find the best low-strength numbing medicine to use as a comparison in future headache research. It involves 12 veterans with chronic headaches after a head injury. Each participant will receive three different strengths of a numbing injection in the back of the…

This study aims to understand how magnetic brain stimulation affects brain activity related to social understanding in young adults with autism. Researchers will use a non-invasive technique called transcranial magnetic stimulation (TMS) while participants play a social game duri…

This study aims to understand how depression affects the brain in people with Parkinson's disease. Researchers will use PET and MRI scans to compare brain activity in four groups: people with Parkinson's and depression, Parkinson's without depression, depression alone, and health…

This Yale University study aims to understand how the brain changes when people with cannabis use disorder stop using it for at least four weeks. Researchers will use brain scans and memory tests to see if brain connections linked to memory improve during abstinence. The study co…

This study aims to understand how a parenting therapy program affects brain activity and thinking patterns in mothers recovering from opioid addiction. Researchers will enroll 15 mothers in treatment to complete brain scans and questionnaires before and after 12 therapy sessions.…

This study aims to understand how gut bacteria process food and how that process is different in young people with obesity and insulin resistance. Researchers will measure how the body breaks down fat and makes sugar after participants ingest a special carbohydrate. The goal is t…

This study aims to understand how to successfully start breast cancer screening in primary health centers in Abuja, Nigeria. Researchers will interview clinic staff, health officials, and local women to identify the challenges and solutions. The goal is to create a practical plan…

This study aims to test new software that measures calcium deposits in the skin of people with scleroderma using CT scans. Researchers want to see if these detailed measurements match up with patients' reports of pain and disability. The goal is to create better tools for future …

This study aims to find the best place on the body to monitor for dangerous blood loss. Researchers will use a special chamber to simulate gradual blood loss in 120 healthy volunteers. They will compare readings from the finger, ear, forehead, and nose to see which spot gives the…

This Yale University study uses special brain scans to understand how cannabis use affects brain connections in adults aged 50 and older. Researchers will scan the brains of 24 participants to measure changes in brain cell connections. The study aims to gather knowledge about can…

This study is creating a large collection of health information and biological samples from people with various rheumatic diseases, like rheumatoid arthritis and lupus. The goal is to help scientists compare different diseases to learn more about what causes them and how they pro…

This study aims to create a large registry of people with Myasthenia Gravis (MG) to help researchers better understand the disease. It will enroll 800 adults with MG who are receiving care at Yale Neurology. The registry will collect health information, blood, and stool samples t…

This study aims to understand how a specific rehab technique called blood flow restriction training affects the body's immune cells and metabolism in people recovering from ACL knee surgery. Researchers will measure changes in blood chemicals and cell activity in 20 healthy adult…

This study is testing whether a simple, 35-minute fitness test called SHAPE can be easily used to check older adults' heart and lung health before surgery. Researchers want to see if this test is better than current questionnaires at predicting who might have complications after …

This study aims to understand how cocaine addiction physically changes the brain. Researchers will use special brain scans (PET and MRI) to compare the brain connections of 80 people with cocaine addiction to those of healthy volunteers. The goal is to measure differences in brai…

This Yale University study aims to understand how different brain areas work together when people learn and remember new speech patterns. Researchers will use brain stimulation and altered audio feedback with 330 healthy adults to test whether sensory areas are just as important …

This study is testing a virtual reality education tool designed to help young cancer patients and their caregivers recognize and respond to dangerous fevers during treatment. Researchers at Yale are working with 45 participants to see if this immersive VR experience is practical …

This study aims to understand how different amounts and speeds of nicotine delivery affect both the rewarding 'high' and the relief from smoking cravings. Researchers at Yale will give 70 smokers controlled intravenous nicotine doses that mimic smoking, while they puff on a nicot…

This study aims to understand if stressful moments can cause heart failure to get worse. Researchers will follow 112 heart failure patients for 6 months, measuring their heart pressure and stress levels both in a lab and in daily life. The goal is to learn how stress affects the …

This Yale University study aims to understand how the brain learns and remembers new speech movements. Researchers will use brain scans and safe, non-invasive stimulation on 120 healthy adults to see which brain areas are most important for this learning. The goal is to build a b…

This study aims to understand how the brain learns and unlearns fear in people with Obsessive-Compulsive Disorder (OCD). Researchers will test if a safe, non-invasive brain stimulation technique (tDCS) can help normalize brain connections and improve this learning process. The st…

This study is creating a live registry using the health records of 40,000 heart failure patients within the Yale New Haven Health System. Its purpose is to monitor patients in real-time to identify gaps in recommended treatments and understand patterns in hospital readmissions. T…

This study aims to understand how HIV affects the brain's connections, even when the virus is controlled by medication. Researchers will use special brain scans (PET and MRI) and memory tests on 70 people—some with well-controlled HIV and some without HIV—over two years. The goal…

This Yale University study aims to understand how brain activity differs in people with a family history of alcoholism. Researchers will use MRI brain scans to compare participants' responses to rewards and alcohol-related cues after they take either a single dose of an experimen…

This Yale University study aims to understand how different parts of the brain work together when we learn new ways of speaking. Researchers will use safe, non-invasive brain stimulation and MRI scans on 160 healthy volunteers to see which brain areas are most important for remem…

This study aims to understand if a standard low dose of a common heart failure drug (spironolactone) fully blocks the effects of a harmful hormone called aldosterone. Researchers will give 20 stable heart failure patients infusions of this hormone and the drug in different combin…

This study aims to understand why some people relapse after starting medication treatment for opioid addiction. Researchers will use brain scans on 240 people recently starting treatment to look for patterns linked to staying drug-free. The goal is to learn how the brain changes …

This study aims to discover if the human body can store sodium without storing extra water, and if so, where it is kept. Researchers will carefully measure sodium and fluid levels in 10 people on peritoneal dialysis. Participants will receive two different dialysis fluids in a ra…

This Yale University study aims to understand how THC, the main active ingredient in cannabis, works in older adults aged 65 and up. Researchers will compare how the body processes THC taken as a pill versus inhaled as a vapor, and measure its effects on pain sensitivity, side ef…

This study is creating a large national registry to collect information on pregnant women who receive general anesthesia for cesarean delivery (C-section). It aims to understand why this type of anesthesia is chosen, how it is managed, and what factors make the procedure more dif…

This study is testing whether sending parents text messages or online portal messages helps them get access to their children's medical records. Researchers want to see which method works better than the current approach of just suggesting access during office visits. The study i…

This study aims to understand how specific deep-brain arousal circuits influence visual perception. Researchers will measure brain activity in epilepsy patients who already have implanted electrodes, while they perform simple visual tasks. The findings could help develop better t…

This study aims to understand how cooling chemicals added to nicotine e-cigarettes affect how much people like them and how addictive they might be. Researchers at Yale University will have 66 adult e-cigarette users try different e-liquids with varying levels of cooling additive…

This Yale University study uses brain scans to understand how THC, the main active ingredient in marijuana, affects memory, decision-making, and balance in adults. Ten participants will complete thinking tasks in an MRI scanner after receiving either THC or a placebo. The goal is…

This research study aims to understand how the immune system responds to kidney cancer by examining tissue samples from patients. Researchers will collect small amounts of tumor and lymph node tissue during standard medical procedures to study immune cells. The goal is to learn h…

This study aims to understand how brain connections differ in people with schizophrenia or cannabis use disorder compared to healthy people. Researchers will use a special brain scan (PET imaging) to measure these connections in 250 adults aged 18-65. The goal is to gather knowle…

This study aims to find a better way to monitor treatment for Wilson Disease, a condition where the body stores too much copper. Researchers will temporarily stop participants' standard medications for a few days to measure copper levels in their urine and blood. The goal is to s…

This study aims to understand how a new, more sensitive type of prostate cancer scan (PSMA-PET) affects patients' anxiety, decision-making, and quality of life. Researchers will follow 350 men with prostate cancer who are getting this scan for the first time, collecting surveys a…

This study aims to understand how opioid addiction affects the brain by comparing brain scans of people with opioid use disorder to healthy volunteers. Researchers will use special imaging to look at cannabinoid receptors in the brain. The goal is to gather knowledge about brain …

This study aims to understand how different types of insulin resistance affect the liver's production of triglycerides, a type of fat in the blood. Researchers will compare people with insulin resistance in different body tissues and test if a short bout of exercise before a meal…

This study aims to learn how to spot multiple sclerosis (MS) before it causes any symptoms. Researchers believe early detection could allow for treatment that prevents long-term disability. They are enrolling 1,000 adults who have risk factors for MS but no diagnosis to collect b…

This Yale University study aims to understand if a specific virtual reality program can create experiences similar to taking psychedelic drugs. Researchers will enroll 15 healthy volunteers to compare the virtual reality experience against known psychedelic effects using question…