Yale University

This phase II trial tests whether adding bipolar androgen therapy (cycles of testosterone) to the standard Sipuleucel-T vaccine can boost the immune response in men with metastatic castration-resistant prostate cancer. About 26 participants will receive both treatments, and resea…

This study tests a drug called trastuzumab deruxtecan (T-DXd) in 40 adults with advanced breast cancer that has no HER2 protein (HER2-0). Participants get the drug every 3 weeks. The goal is to see if it shrinks tumors and which patients benefit most.

This study tests whether the drug elacestrant can clear traces of cancer DNA found in the blood of people with hormone receptor-positive breast cancer who are at risk of late recurrence. About 50 adults whose blood tests positive for tumor DNA but show no visible spread will take…

This study compares two patient navigation models for people recently involved in the criminal legal system who have substance use disorders. One group gets standard navigation, while the other can choose from a menu of services like in-person clinics, mobile health units, or tel…

This study investigates whether reducing calories to lower fat in the liver and muscles can improve how the body responds to insulin. Researchers will measure changes in insulin sensitivity and fat levels in 250 healthy but insulin-resistant adults with a family history of type 2…

This phase 2 trial tests the drug afatinib in 50 women with a rare, aggressive uterine cancer (HER2-positive uterine serous carcinoma) that has persisted or returned. Afatinib is a daily pill that blocks a protein driving cancer growth. The main goal is to see if it can keep the …

This study tests a new way to give radiation before T-cell therapies (CAR T or bispecific antibodies) for people with relapsed or refractory diffuse large B-cell lymphoma. Each participant's tumor is split in half: one side gets once-daily radiation, the other gets twice-daily ra…

This study tests whether a program of exercise and nutrition counseling helps women with ovarian or endometrial cancer stick with their chemotherapy plan. About 200 women who are about to start chemotherapy will be randomly assigned to either receive weekly coaching sessions on p…

This study tests if guselkumab can help people with Hailey-Hailey disease, a genetic condition causing painful blisters and sores in skin folds. Ten adults with moderate to severe disease will receive the drug and be monitored for changes in skin severity and quality of life. The…

This phase 2 trial tests whether a series of procedures to remove cancerous tumors, given one after another, can improve outcomes for people with stage IV foregut cancers (like stomach, pancreas, or bile duct cancer) who have no detectable cancer DNA in their blood after initial …

This study tests a lower-dose radiation regimen for people with non-small cell lung cancer located near the center of the chest. The goal is to see if giving a total of 45 Gray in three sessions can control the tumor while reducing damage to nearby organs like the heart and major…

This study tests whether a bladder wash with a low-dose antiseptic (chlorhexidine) during routine catheter changes can reduce urinary tract infections and unplanned healthcare visits. Seventy adults with a long-term suprapubic catheter and a history of UTIs will receive the wash …

This early-stage trial is testing a new drug called AB821 in 50 adults with advanced melanoma or other solid tumors that respond to immune therapies. The main goal is to check safety and find the right dose. Participants receive AB821 by IV every 2 or 3 weeks for up to two years.

This study looks at whether surgery to remove remaining cancer spots can help people with advanced bladder cancer that has been controlled by drug therapy. About 32 adults whose cancer has not spread widely will receive surgery on the main tumor and any other treatable spots. The…

This study tests a digital tool called EMBED that helps emergency doctors identify patients with opioid use disorder and start them on buprenorphine, a medication that reduces cravings and withdrawal. The tool is built into the electronic health record and guides doctors through …

This phase 2 trial is testing whether combining two drugs—pembrolizumab (Keytruda) and brentuximab vedotin (Adcetris)—can shrink tumors in people with a type of T-cell lymphoma that has returned or not responded to at least one prior treatment. The study enrolls adults with CD30-…

This early-phase study tests whether dichloroacetate (DCA), a drug used safely for decades in a rare metabolic disorder, can improve brain function during low blood sugar (hypoglycemia) in people with type 1 diabetes. Sixteen participants with a history of severe hypoglycemia or …

This study tests whether the drug apremilast can help people with alcohol use disorder drink less. About 80 adults aged 21-65 will receive either apremilast or a placebo, and researchers will measure how much alcohol they consume during a lab drinking session. The goal is to see …

This study tests whether enoxaparin, a blood thinner, can prevent blood clots caused by central venous catheters in critically ill children. Researchers will enroll 258 children up to 17 years old and adjust the dose based on age. The goal is to see if age affects how well the dr…

This study tests whether a behavioral sleep intervention combined with the drug varenicline can help heavy smokers quit. Researchers will measure sleep quality, smoking habits, and brain activity in 114 participants. The goal is to see if improving sleep reduces negative emotions…

This study tests a stepped care program called PCT+2HOPE for women with opioid use disorder who have also experienced intimate partner violence and PTSD symptoms. The program adds group and individual therapy to standard medication treatment. Researchers will see if it helps wome…

This study tests whether a higher starting dose of buprenorphine in the emergency room helps more people with opioid use disorder engage in treatment within 10 days. It also looks at whether the higher dose reduces cravings, withdrawal symptoms, and use of illicit opioids. The tr…

This study compares two breathing support methods—high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV)—in heart failure patients after their breathing tube is removed. The goal is to see which method better prevents the need for re-insertion of the breathing tube or …

This study tests whether a low dose of digoxin, a drug normally used for heart problems, can help people with a severe type of fatty liver disease called NASH (also known as MASH). The trial will involve 144 adults with biopsy-confirmed NASH and liver scarring. Participants will …

This study is for people with a common type of breast cancer (ER-positive, HER2-negative) that has a moderate to high risk of coming back based on tumor size and lymph node involvement, but a low genetic risk score. Instead of chemotherapy after surgery, participants can choose t…

This study is for people with metastatic triple-negative breast cancer that has not responded to one prior treatment. It tests two combinations of drugs: one with sacituzumab govitecan and nivolumab, and another that adds a third drug, relatlimab. The goal is to see which combina…

This study tests a program called Fathers for Change (F4C) for 280 fathers who struggle with substance misuse and have been violent toward family. The program aims to help them control emotions, stop substance use, and prevent violence. Researchers compare F4C to standard drug co…

This study tests if empagliflozin, a diabetes drug, can reduce sugar absorption during peritoneal dialysis in 30 adults with end-stage kidney disease. Participants will receive either the drug or a placebo in a crossover design, followed by an 8-week open-label phase where everyo…

This phase 2 pilot study is testing a new drug called CUE-101, alone or combined with pembrolizumab, in 30 people with newly diagnosed, locally advanced HPV-16 head and neck cancer. The goal is to see if the combination boosts the immune system's ability to fight the cancer befor…

This study is testing whether the etonogestrel contraceptive implant can be placed under the skin near the shoulder blade instead of the usual upper arm spot. Researchers will check hormone levels and side effects in 62 women over two years. The goal is to see if this alternative…

This study tests whether adding a short, 30-day course of the oral hormone drug Relugolix to standard targeted radiation (SBRT) works better than radiation alone for men with intermediate-risk prostate cancer. About 60 men will be randomly assigned to one of the two treatments. T…

This small pilot study at Yale tests whether semaglutide (a drug used for diabetes and weight loss) can help people who have had bariatric surgery and now struggle with alcohol use disorder. Ten adults will take the drug for three months and be followed for three more months to s…

This study compares two medicines—apixaban (a blood thinner) and aspirin—in people who have had a brain bleed (intracerebral hemorrhage) and also have an irregular heartbeat (atrial fibrillation). The goal is to see which drug better prevents future strokes or death. About 700 pa…

This study compares two medications—methadone and buprenorphine—given in a doctor's office to treat opioid use disorder. Researchers want to see which one helps people stay in treatment longer over 168 days. About 600 adults starting a new treatment episode will take part. The go…

This study tests a stent graft that doctors modify to fit each patient's unique aneurysm in the chest and abdomen. The goal is to see if this less invasive approach is as safe and effective as traditional open surgery. About 80 people aged 50 and older with large aneurysms will t…

This early-stage study tests whether the psychedelic drug DMT, combined with psychotherapy, can help people with alcohol use disorder. 63 participants will receive either a moderate or low dose of DMT, or a placebo, and their safety and desire to drink will be measured. The goal …

This study tests a therapy called Fathers for Change (F4C) for fathers who have been violent with their partner. The goal is to see if this 18-week program helps fathers control their emotions and communicate better, reducing violence toward partners and children. About 1,080 fat…

This early-phase study tests two cancer drugs—lenvatinib (a daily pill) and pembrolizumab (an IV infusion)—in 20 adults with HPV-related recurrent respiratory papillomatosis (RRP) that has spread to the lungs. The goal is to see if the combination can shrink papillomas and reduce…

This study tests adding the drug mogamulizumab to standard chemotherapy for people with aggressive T-cell lymphoma, a type of blood cancer. About 22 adults with newly diagnosed or returning lymphoma will receive the combination treatment. The goal is to see if more patients achie…

This early-phase trial is testing a new oral drug called iadademstat combined with radiation therapy and the immunotherapy atezolizumab in people with extensive-stage small-cell lung cancer that has persisted, returned, or worsened after first-line treatment. The study will enrol…

This study compares using an electric breast pump (or hand stimulation) to standard oxytocin infusion for inducing labor in nearly 1,000 first-time mothers. The goal is to see if nipple stimulation leads to more spontaneous vaginal deliveries and better experiences for moms and b…

This pilot study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with HIV reduce their alcohol use. Thirty participants will receive the drug along with support from a pharmacist and psychiatrist. The goal is to see if this approach is feasibl…

This Yale study tests two ways to help people with high blood pressure: a remote monitoring program alone, or that program plus a community health worker who helps with home monitoring, appointments, and social needs like food or housing. 1,440 participants with elevated blood pr…

This Phase II trial tests whether combining luspatercept and darbepoetin alfa can help people with a certain type of lower-risk myelodysplastic syndrome (MDS) need fewer red blood cell transfusions. The study enrolls 60 adults who currently rely on transfusions. Participants rece…

This early-stage study at Yale is testing whether a combination of two medications (naltrexone and bupropion) plus cognitive-behavioral therapy can help people who are considering bariatric surgery lose weight and stop smoking. Twenty participants will receive the treatment for f…

This study tests whether e-cigarettes or nicotine pouches help adult smokers reduce their cigarette use. 256 participants who smoke will be given one of these products for 4 weeks, with different flavors and nicotine levels. Researchers will track how many cigarettes they smoke a…

This study tests whether adding an SGLT2 inhibitor (a type of diabetes medicine) to standard hospital care helps people with heart failure who also develop acute kidney injury. Researchers will compare outcomes like survival, need for dialysis, and symptom relief between those wh…

This Phase 2 trial tests whether guanfacine, a drug used for high blood pressure and ADHD, can help people with alcohol use disorder drink less. Researchers will compare guanfacine to a placebo in 160 men and women, measuring alcohol consumption in lab sessions and during a treat…

This study tests whether taking vitamin D daily for 6 months can improve menstrual regularity and mood in teenage girls with PCOS who also have low vitamin D levels. Sixty participants will be randomly assigned to receive either vitamin D or a placebo, and neither they nor their …

This study tests whether empagliflozin, a diabetes drug, can help people with cirrhosis and ascites (fluid buildup in the belly) get rid of excess salt and water. About 20 adults on stable diuretics will take the drug or a placebo for 14 days. Researchers will measure changes in …

This study tests whether trained community health workers can help people in Nepal prevent and control high blood pressure. Over 3,500 participants with high blood pressure will receive home visits and group counseling from health workers. The goal is to see if this approach lowe…

This study tests a drug called sacituzumab govitecan in 20 people whose cervical cancer has returned or persisted after at least one prior chemotherapy. The drug is an antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells. The main goal is to see how m…

This Phase 2 trial tests whether the hormone pregnenolone can help people with alcohol use disorder drink less heavily. 150 adults aged 18-70 will take either 300 mg of pregnenolone or a placebo daily for 12 weeks. The main goal is to see if more people in the pregnenolone group …

This study tests whether the diabetes drug metformin can protect kidney cells in people with a rare kidney disease called FSGS. About 30 adults will receive either metformin or a placebo for 6 months, alongside their usual treatments. The goal is to see if metformin reduces kidne…

This early study tests whether delivering focused ultrasound pulses to the liver and a nearby nerve bundle can improve blood sugar control in people with type 2 diabetes. Thirty adults on stable oral diabetes medications will receive the ultrasound treatment. The main goal is to …

This study tests whether starting antiretroviral therapy within 7 days of an HIV diagnosis can reduce stigma and improve health outcomes for people who inject drugs. Researchers will develop a rapid-start strategy and pilot it with 135 participants at HIV clinics. The goal is to …

This pilot study tests a program where a clinical pharmacist talks with people with HIV about the risks of drinking alcohol (with or without cannabis) while taking multiple medications, especially those that affect the brain. The goal is to see if this approach can reduce falls a…

This study tests a program called T1CARE, where a community health navigator helps young adults with type 1 diabetes address social needs like housing, food, and healthcare access. 100 participants will be randomly assigned to get the navigator right away or after a wait. The goa…

This study tests whether the medication varenicline can help adults quit using e-cigarettes. Researchers will compare varenicline to a placebo in 326 people who vape daily. The main goal is to see if more participants can stop vaping for at least a week by the 12-week mark, with …

This study tests whether prazosin, a blood pressure medicine, can help people with alcohol use disorder who also have withdrawal symptoms drink less heavily. About 150 adults will receive either prazosin or a placebo for 12 weeks, along with weekly counseling. The main goal is to…

This study tests whether precisely targeted radiation can control kidney cancer that has started growing in a few spots while a patient is on immunotherapy. About 30 adults with metastatic renal cell carcinoma will receive radiation to up to 5 progressing tumors and continue thei…

This study is testing a device that uses sound waves to break up calcium buildup in the leg arteries of people with peripheral artery disease. The goal is to improve blood flow, reduce pain, and help people walk better. About 50 participants will be followed for one year to see i…

This study tests whether a structured nutrition and exercise program can improve the chance of a complete response to pre-surgery chemo-immunotherapy in women with triple-negative breast cancer. About 160 women who are not currently exercising or eating many fruits and vegetables…

This phase 2 trial at Yale University is testing whether the diabetes drug ertugliflozin can help people with chronic heart failure manage fluid buildup better than a standard diuretic (metolazone) or a placebo. Sixty adults on daily diuretics will take one of the three treatment…

This study tests a program to expand medication-assisted treatment for opioid addiction in Kazakhstan, Kyrgyzstan, and Tajikistan. Researchers will train local health officials and track how many people start and stay on treatment. The goal is to reduce HIV spread among people wh…

This study looks at whether using a positive airway pressure (PAP) machine to treat obstructive sleep apnea can help people recover better after an ischemic stroke. About 360 participants who have had a stroke and have moderate to severe sleep apnea will be randomly assigned to r…

This study tests whether a self-administered fingerstick glucose tolerance test done at home can accurately measure blood sugar levels compared to the standard clinic-based test. Researchers will enroll 60 people at risk for or recently diagnosed with type 1 diabetes. If accurate…

This study tests a digital health program to help women involved in the criminal justice system start PrEP (a daily pill to prevent HIV) and get treatment for opioid use disorder. Researchers will compare the program to a simpler decision aid alone. The goal is to reduce stigma a…

This study tests a decision aid that helps women in sexual and reproductive health clinics decide whether to take PrEP, a daily pill that prevents HIV. The tool will be used during counseling visits. Researchers will see if it increases PrEP use and if it's practical for clinics.…

This study tests a community-driven program to reduce gun violence in seven high-risk New Haven neighborhoods. It provides housing financial assistance and financial education to recently incarcerated people and their families, and trains local residents in trauma-informed counse…

This study aims to reduce COVID-19 illness and death among people who live or work in prisons. Researchers will test different ways to encourage COVID-19 vaccination in Pennsylvania prisons, involving over 37,000 participants. The goal is to find what works best to increase vacci…

This study tests whether the Thrive AI Health app can help adults with type 2 diabetes or overweight improve their daily habits like diet, exercise, and sleep. About 20 participants will either use the app or not, and researchers will compare changes over time. The app uses artif…

This pilot study tests if patients recovering from shoulder surgery can safely and effectively give themselves liquid acetaminophen (Tylenol) using a pump, instead of waiting for a nurse to bring pills. About 24 adults will be enrolled, and researchers will measure how many agree…

This study tests a 10-session LGBTQ-affirmative cognitive behavioral therapy (CBT) delivered via telehealth to sexual minority women who drink heavily and have anxiety or depression. Researchers will compare it to standard LGBTQ-affirmative therapy to see if it better reduces hea…

This study tests whether a mobile app called Tools for Coping with Cancer can help people with a history of cancer reduce distress and improve mood and quality of life. About 50 adults who have had cancer will use the app at home for 8 weeks and fill out questionnaires about thei…

This study tests whether a six-week at-home light therapy program is practical and helpful for childhood cancer survivors who have nerve pain or numbness from chemotherapy. Twenty survivors aged 5 and older will use a light therapy device on their symptoms for 15 minutes, three d…

This study explores whether group drumming or music listening can improve pain, stress, and brain function in people with early Alzheimer's, mild dementia, or mild cognitive impairment, as well as their caregivers. Over 8 weeks, 60 participants will attend weekly sessions while r…

This early-stage study tests whether mavoglurant, a drug taken as a pill, can reduce alcohol cravings and drinking in people who drink heavily. Researchers will give the drug or a placebo to 63 adults with Alcohol Use Disorder and measure how much they drink and crave alcohol. Th…

This study tests whether a special brain training technique, called mindfulness-based neurofeedback, can help adults with borderline personality disorder (BPD) get more out of their regular talk therapy. Researchers will use real-time brain scans to help participants learn to con…

This study tests whether real-time fMRI neurofeedback can help teens aged 10-16 with Tourette Syndrome reduce their tics. Participants learn to control activity in a brain region linked to tics by watching their own brain activity on a screen. The trial compares this to a control…

This study tests a drug called fezolinetant to see if it can reduce hot flashes in women who have had breast cancer and are taking hormone therapy. About 92 women will be randomly assigned to receive either fezolinetant or a placebo daily for 12 weeks. The main goal is to measure…

This study tests whether a sleep medication called eszopiclone can help people with obstructive sleep apnea use their CPAP machine more consistently and improve their thinking skills. About 250 adults with a new sleep apnea diagnosis will receive either eszopiclone or a placebo f…

This study tests whether using RECELL® — a device that creates a spray from a patient's own skin cells — can improve skin color matching after head and neck reconstructive surgery. Twenty adults who need this surgery will receive the treatment, and their color match, healing, and…

Researchers at Yale University are testing whether a smartphone app called Caravan Wellness can improve quality of life, reduce stress, and ease symptoms of anxiety and depression. The app offers short mindfulness and light exercise modules like yoga and meditation. The study wil…

This study tests whether a smartphone app called Change4Better (C4B) can help reduce problem gambling compared to standard treatment alone. About 128 adults who gamble and want help will use the app for 6 months. Researchers will track changes in gambling symptoms and how often p…

This study tests a combination of sleep-promoting and circadian-aligning treatments (a "sleep chronobundle") in 160 critically ill ICU patients. The goal is to see if realigning the body's internal clock can improve sleep quality and metabolism. Participants will receive the bund…

This study compares two forms of ketamine for people with depression that hasn't improved with other treatments. One is given through an IV drip, the other as a nasal spray. Researchers want to see which works better, is more acceptable to patients, and has fewer side effects. Ab…

This early-phase study at Yale tests whether cannabidiol (CBD) is safe and can reduce pain and opioid cravings in 34 adults with opioid use disorder and chronic pain. Participants are already on methadone or buprenorphine and will receive different doses of CBD or a placebo in a …

This study tests whether a small, home-use device that gently stimulates a nerve in the ear can help young adults (ages 18-29) manage pain and other symptoms of irritable bowel syndrome (IBS). Eighty participants will use either the active device or a sham (inactive) version twic…

This study compares two common types of heart medications—beta-blockers and calcium channel blockers—in adults aged 65 and older who have stable angina (chest pain) and at least two other chronic conditions. The goal is to see which drug works better and is easier to tolerate, fo…

This study tests a handheld device called PoRI that moves the hand for people who had a stroke within the past 2 days to 2 months. It compares the device to standard hand therapy in 12 participants. The goal is to see if the device improves hand function, reduces pain, and is eas…

This early-phase trial at Yale tests whether dronabinol (Marinol), a synthetic form of THC, can reduce pain sensitivity and improve attention and mood in 36 adults with opioid use disorder who are stable on methadone or buprenorphine. Participants receive either 2.5 mg, 5 mg of d…

This early-stage study at Yale is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug openly (everyone knows they get it) and be f…

This study follows 200 people with chronic low back pain who are scheduled for a procedure called basivertebral nerve ablation. The goal is to see how much pain and function improve over two years and to figure out which patients benefit the most. Participants will answer weekly …

This study tests whether brief training in mindfulness or cognitive-behavioral techniques can reduce heavy drinking in young adults aged 18-26. Participants will complete 1-4 training sessions and report their drinking via smartphone. The goal is to see if these techniques help p…

This study tests a 6-week mindfulness-based program designed to improve sleep and reduce stress in Black women with insomnia. Researchers will enroll 340 women and track changes in sleep quality, stress levels, and how acceptable and feasible the program is. The goal is to see if…

This study compares music-backed mindfulness meditation to meditation alone for reducing stress and anxiety in people of African descent. 70 participants with anxiety or depression will join virtual sessions. The goal is to see if adding music makes stress management more effecti…

This study tests a mindfulness app called Calm Health in 10 young adults (ages 18-30) with type 1 diabetes or similar conditions. Participants use the app to track mindfulness, blood sugar, stress, and sleep, and get personalized feedback. The goal is to see if the app is easy to…

This study tests whether a noninvasive brain stimulation technique called rTMS can improve social abilities in adults with autism. Researchers will measure brain responses and eye gaze patterns before and after treatment. The goal is to see if this approach can ease core social c…

This early study tests whether a non-invasive brain stimulation technique called tDCS can improve voice quality in people with laryngeal dystonia (spasmodic dysphonia). Ten participants will receive active, sham, and no stimulation to compare effects. The goal is to see if target…

This study compares two FDA-cleared devices used to soften and open the cervix before a dilation and evacuation (D&E) procedure in the second trimester. One device is a balloon catheter, the other is a set of absorbent rods (osmotic dilators). The goal is to see which method work…

This study tests whether a daily medication called valbenazine can reduce hair-pulling in adults with trichotillomania. About 20 people will receive either the drug or a placebo for 12 weeks, then everyone gets the drug for another 12 weeks. The goal is to see if the drug safely …

This study is for veterans with long-term headaches after a head injury. It compares three different doses of a numbing medicine injected near a nerve in the scalp. Each participant will try all three doses, one week apart, to see which works best and feels most comfortable. The …

This study tests whether a smartphone app called Kick-Nic! can help high school students (ages 13-19) quit vaping. About 306 participants who want to quit will either use the app or visit a standard quit-vaping website for 8 weeks. Researchers will check if they've stopped vaping…

This small study at Yale is testing whether a single dose of MDMA (the drug in ecstasy) can improve social cognition—like reading emotions and feeling sociable—in adults with borderline personality disorder. Ten participants will take the drug and complete tasks and surveys. It's…

This study is testing whether a remote, video-based pelvic floor muscle therapy program is easy to use and practical for patients with pelvic floor disorders like prolapse, incontinence, or bowel issues. Twenty participants will follow an 8-week online course at home. The main go…

This study tests two types of talk therapy—individual LGBTQ-affirmative CBT and family-based therapy—delivered online to LGBTQ+ adults (age 20+) who have nonaccepting parents. The goal is to see if these therapies reduce depression and anxiety symptoms. The trial is currently rec…

This phase 2 study at Yale University is testing whether a combination of THC and CBD can reduce both pain sensitivity and opioid cravings in people who have opioid use disorder and chronic low back pain. The 147 participants are all on methadone therapy and will receive either a…

This study provides free continuous glucose monitors (CGMs) to 17 adults with poorly controlled type 2 diabetes. Researchers will track changes in blood sugar levels and quality of life over time. The goal is to see if easier access to CGM technology helps patients manage their d…

This study tests whether people with overweight or obesity and high food cravings can learn to change their brain's response to food cues using real-time neurofeedback. Participants will try to control a thermometer-like display reflecting their brain activity while viewing food …

This study tests whether taking warm water sitz baths for 10 minutes each night for a week can reduce pain after pelvic organ prolapse repair. 112 women will be randomly assigned to sitz baths or standard care. The main goal is to measure pain intensity one week after surgery usi…

This study tests a gentle exercise program combining Baduanjin (a traditional Chinese mind-body practice) with resistance training for older adults with osteoporosis and a slipped disc in the lower back. Researchers want to see if it can reduce pain, improve muscle strength, and …

This study tests whether a parent-only therapy (SPACE) can reduce anxiety in teens, compared to a parent education support group. About 108 adolescents with anxiety disorders will participate. Parents attend 12 weekly sessions, and researchers measure teen anxiety symptoms before…

This study tests a mobile app that gives personalized exercise coaching and feedback on blood sugar, sleep, and mood to help middle-aged adults with type 1 diabetes exercise more. Participants get a free Garmin smartwatch and program membership. The goal is to see if the app help…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study tests whether a gentle, non-invasive ultrasound treatment can reduce or stop seizure activity in people with a severe type of ongoing seizure called status epilepticus that hasn't improved with standard medications. Ten participants in the ICU will receive a 10-minute …

This study tests whether bexagliflozin, a drug used for diabetes, can reduce the severity of obstructive sleep apnea in overweight or obese adults. Over 6 months, participants will take either the drug or a placebo and undergo sleep tests and body scans. The goal is to see if the…

This study tests whether a mobile app can help patients do simple in-bed exercises after orthopedic surgery for spine, hip, or knee problems. About 100 participants will use the app or receive usual care. Researchers will measure how well patients recover their ability to move an…

This study is testing whether giving cancer patients in Maine free, medically tailored groceries plus nutrition counseling can improve their diet and well-being. One hundred adults with any stage or type of cancer will be split into three groups: one gets groceries and counseling…

This study creates a registry for people diagnosed with Wilson disease, a rare genetic condition that causes copper buildup in the body. Researchers will collect medical data and biological samples over time to help future studies improve diagnosis and treatment monitoring. The g…

This study tests a new method called mass-based response testing (MRT) to help doctors choose the best chemotherapy drugs for patients with advanced appendix or colorectal cancer that has spread to the abdomen. The MRT device analyzes live tumor cells to see which drugs work best…

This study follows 350 older adults (65+) who return home after an ICU stay to see what help they still need with daily activities. Researchers will track disabilities, hospital readmissions, and deaths over six months. The goal is to identify gaps in care so better programs can …

This study looks at how cooling ingredients like WS-3 and menthol in e-cigarettes affect how much people like them and find them addictive. Researchers will have 66 adult e-cigarette users try different e-liquid mixtures and report their feelings of liking, craving, and harshness…

This study looks at the immune cells in the lymph nodes near kidney tumors to learn how the body fights the cancer. Researchers will analyze tissue samples from 10 adult kidney cancer patients to find clues about why some treatments work and others don't. The goal is to discover …

This study investigates how acetate, a substance produced when the body breaks down alcohol, is used by the brain in heavy drinkers. Researchers will use a special imaging technique to track acetate metabolism and measure stress hormone levels. The goal is to understand the link …

This observational study at Yale University aims to understand how people with opioid use disorder (OUD) learn to avoid pain compared to healthy individuals. About 180 participants will perform a learning task inside an fMRI scanner to measure brain activity. Those with OUD will …

This study looks at how the brain's arousal systems work when we see, hear, or feel things. Researchers will use brain scans, eye tracking, and electrical recordings in healthy volunteers and epilepsy patients. The goal is to understand shared brain pathways that help us stay ale…

This study aims to find the smallest amount of nicotine that smokers find rewarding or addictive. Researchers will test different nicotine doses in 45 adult smokers to see which dose they can identify and prefer. The goal is to better understand how addiction develops, which coul…

This study at Yale University investigates how two people's brains synchronize during live face-to-face interactions. Researchers will use brain stimulation (TMS and tDCS) along with EEG and eye tracking to measure changes in brain activity and social behaviors. The goal is to be…

This study at Yale investigates how people with OCD process fear and safety signals in the brain. Researchers will use mild electrical stimulation (tDCS) to see if it can improve fear extinction learning, which is key to exposure therapy. 180 adults with OCD will undergo brain sc…

This study uses a special PET scan tracer to measure a brain protein called PDE4B in people with PTSD or alcohol use disorder. Researchers want to see if levels of this protein differ from healthy individuals. The study involves 160 adults aged 18 to 70 and does not offer treatme…

This study is testing whether a culturally responsive, peer-delivered motivational interviewing program can help Latinos with serious mental illness engage in mental health treatment. Thirty participants who are not currently in treatment will receive six weekly one-hour coaching…

This study looks at women born with an irregularly shaped uterus (congenital uterine anomaly) to see if they have higher chances of certain cancers, like breast or ovarian cancer. Researchers will also try to find genetic or environmental reasons for the condition. About 300 wome…

This study looks at how feeling disconnected from others affects the brain in people aged 55 and older. Researchers will use brain scans like MRI and PET to measure brain activity and connections. The goal is to understand the link between social isolation and suicide risk in lat…

This study is a large registry that collects information from hospitals across the U.S. on pregnant women who receive general anesthesia during a cesarean delivery. Researchers aim to understand why general anesthesia is used, how it is managed, and what outcomes occur for both m…

This study looks at how long-term phosphate therapy affects the kidneys, blood vessels, and heart in people with two rare bone disorders: X-linked hypophosphatemia (XLH) and hereditary hypophosphatemic rickets with hypercalciuria (HHRH). Researchers will measure hormone levels an…

This study uses repeated fMRI brain scans to track changes in people receiving medication for opioid use disorder. Ten participants will be scanned every two weeks for six months while performing tasks. The goal is to understand how the brain changes during recovery and identify …

This study aims to understand how the brain learns and remembers new ways of speaking. Researchers will use brain scans (fMRI) and magnetic pulses (TMS) to see which brain areas are involved. 50 healthy, right-handed, fluent English speakers with normal hearing will participate. …

This study looks at immune cells in the gut to understand how they might be linked to multiple sclerosis, Parkinson's disease, and REM sleep behavior disorder. Researchers will collect colon tissue samples from 100 adults during colonoscopy. The goal is to map these cells and the…

This early-phase study looks at whether adding dapagliflozin, a diabetes drug, to standard chemotherapy changes insulin-related markers in the blood. It involves 20 women with early-stage HER2-negative breast cancer who also have high insulin levels. The goal is to gather safety …

This study looks at why some people with heart failure don't get rid of excess fluid with standard water pills (diuretics). Researchers will test adding two other types of diuretics—bendroflumethiazide and amiloride—to see if they improve the body's response. Fifty adults with he…

This study aims to understand why some heart failure patients do not respond well to diuretics (water pills). Researchers will give 75 heart failure patients different doses of a diuretic called bumetanide and measure how their kidneys handle sodium. The goal is to identify biolo…

This study aims to discover the genetic reasons behind recurrent pregnancy loss (RPL) by analyzing DNA from parents and pregnancy tissue. Researchers at Yale University will enroll 500 women who have had multiple pregnancy losses. The goal is to identify genetic markers that pred…

This study looks at why some people with heart failure don't respond well to diuretics (water pills). Researchers will give 50 participants either ammonium chloride or a placebo, along with standard diuretics, to see how it affects kidney function. The goal is to understand the b…

This study aims to create a lab-based test to help screen medications for Alcohol Use Disorder (AUD). Researchers will observe how 90 adults with AUD resist drinking in a controlled setting. The goal is to develop a reliable method to test new treatments, not to provide direct th…

This observational study at Yale University will follow 150 people who have had an ischemic stroke to see how changes in blood pressure affect their recovery. Researchers will use brain scans and thinking tests to understand the connection. The goal is to find better ways to mana…

This study will follow 10,000 people who need hip surgery to compare two approaches: hip preservation surgery (which tries to keep the natural hip joint) and total hip replacement (which replaces the joint). The goal is to see which surgery leads to better pain relief, function, …

This study at Yale University is testing whether the body can store sodium without holding onto extra water, a concept called 'water-free sodium storage.' Ten adults on peritoneal dialysis with heart failure will receive either a special dextrose solution or standard dialysis flu…

This study tests a new program designed to help liver doctors provide treatment for alcohol use disorder. The program includes education for doctors and patients, decision support tools, and feedback on performance. Researchers want to see if this approach is practical and accept…

This study looks at whether a quick, low-intensity exercise test called SHAPE™ can help doctors assess fitness in adults over 60 before moderate- to high-risk surgery. About 371 participants will take the test and answer questions about their activity level. Researchers will then…

This study tests a nutrition education program for first-time pregnant women in northern Ghana. The program teaches women how to eat a wider variety of local foods, get more protein and iron, and gain healthy weight. Researchers will measure changes in health knowledge, diet, and…

This study at Yale University is testing whether blocking a specific brain receptor (AMPA) stops ketamine from reducing suicidal thoughts. Thirty adults with depression, bipolar disorder, or PTSD who have current suicidal thoughts will receive either perampanel (an AMPA blocker) …

This study looks at how ketamine works in the brain to relieve depression. Researchers are giving people with hard-to-treat depression either a placebo or a drug called perampanel before a dose of ketamine. They will use brain scans to see if blocking certain brain receptors chan…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study uses a special PET scan tracer called [11-C]OMAR to measure cannabinoid receptors in the brain. Researchers will compare healthy volunteers to people with schizophrenia, cannabis dependence, PTSD, opioid use disorder, and other conditions. The goal is to understand how…

This study uses brain scans to compare a specific receptor (CB1) in people with opioid use disorder who are on methadone treatment versus healthy volunteers. The goal is to understand how the endocannabinoid system works differently in addiction. No new treatment is tested; it is…

This study looks at how stress impacts pain, hormone levels, and mood in 120 people with and without HIV, cannabis use disorder, and depression. Participants will complete two sessions of a pain stress task and provide blood samples to measure cortisol and other stress hormones. …

This study looks at how the active ingredient in cannabis, THC, affects men and women differently. Researchers will give THC to 100 healthy adults who have used cannabis before and measure their feelings of being 'high' and memory performance. The goal is to understand why men an…

This study is testing whether a short exercise test done before surgery can help predict complications in adults over 45 having moderate- to high-risk operations. Researchers will collect data from routine care and exercise tests to see if results link to heart, lung, or other pr…

This study is testing a new radioactive tracer called [18F]GATT-44 to see how well it can image GABA transporters in the brain using PET scans. The goal is to understand how the tracer moves through the body and binds to brain cells, and to measure the radiation exposure. About 3…

This study looks at whether a non-invasive brain stimulation technique called TMS can change brain activity related to understanding others' thoughts (mentalizing) in young adults with autism. Researchers will compare brain scans before and after stimulation in 80 participants, i…

This study in Uganda tests whether trained peer counselors can help people with tuberculosis (TB) and HIV stay on track with their medications. About 1,920 adults will take part, and researchers will compare treatment success rates between clinics using peer-led education and tho…

This study looks at brain changes in people who use cannabis heavily and want to quit. Researchers will use brain scans to measure a protein linked to brain cell connections, both before and after at least 4 weeks of not using cannabis. They will also test memory to see if brain …

This study aims to find the brain areas responsible for depression in people with Parkinson's disease. Researchers will use brain scans to compare 120 participants aged 40-80 who have both conditions. The goal is to identify targets for future treatments, not to test a new therap…

This study creates a live registry of up to 40,000 heart failure patients across the Yale New Haven Health System. Researchers will track hospitalizations and use of recommended therapies like beta blockers and ACE inhibitors. The goal is to monitor and improve heart failure care…

This study looks at whether briefly stopping Wilson disease medication can give a clearer picture of copper levels in the body. Researchers will monitor 30 stable patients for 4 days off treatment, measuring urine copper and blood markers. The goal is to find a better way to trac…

This study looks at how cannabis use changes brain connections in adults aged 50 and older. Researchers will use a special PET scan to measure synaptic density in the hippocampus, a key memory area. The goal is to understand, not treat, so no drug is given—just one scan. Results …

This study looks at how THC, the main active part of cannabis, affects older adults aged 65 and up. Researchers want to understand how the body processes THC when taken as a pill or inhaled, and how it impacts pain and the risk of misuse. Twenty healthy volunteers with past canna…

This study is testing a virtual reality (VR) program called Life at 100.4 to help teens and young adults with cancer, along with their caregivers, learn about their diagnosis and treatment in an immersive way. About 45 participants will use the VR tool, and researchers will measu…

This study explores how the brain learns and remembers speech movements. Researchers will have 330 healthy adults say words while hearing their own voice slightly altered through headphones. The goal is to understand which brain areas help us adapt and retain new speech patterns,…

This study looks at how the brain learns and remembers new ways of speaking. Researchers will use brain stimulation and brain scans in 160 healthy adults to see which brain areas are important for speech motor learning and retention. The goal is to better understand the basic sci…

This study looks at why standard heart failure medications may not fully block a hormone called aldosterone. Researchers will give 20 adults with stable heart failure either a placebo or the drug spironolactone, then measure how the body handles salt and water. The goal is to und…

This study aims to understand which parts of the brain help us learn and remember new ways of speaking. Researchers will use brain scans and magnetic pulses to observe brain activity in 120 healthy adults. The goal is to learn more about how speech motor learning works, not to te…

This study aims to develop a better way to measure calcium deposits under the skin in people with scleroderma. Researchers will use CT scans and special software to see if these measurements match how patients report their symptoms. About 56 adults with scleroderma and calcium de…

This study is building a large registry and biorepository of 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers at Yale University will collect medical data and biological samples over time to better understand these condit…

This study tests whether a virtual, community-based program combining music and mindfulness can help People of African Descent manage stress, anxiety, and depression during COVID-19. Researchers will measure brain activity and feelings of social connection in 48 participants as t…

This study looks at the best way to help parents get online access to their child's medical records. About 5,200 parents will either get a text, a message through their own patient portal, or no message at all. Researchers will then compare which group had more parents successful…

This study follows 380 children in Uganda for two years to understand how malaria and HIV treatments interact. Half the children have HIV and half do not. Researchers will measure changes in body weight, blood sugar, and drug levels to find the best ways to treat both infections …

This study uses a special brain scan (PET) to measure the density of connections between brain cells in people with psychotic disorders (like schizophrenia) or cannabis use disorder, compared to healthy volunteers. The goal is to understand how brain connection changes relate to …

This study looks at how different types of insulin resistance (in fat or muscle) affect the liver's production of fats called triglycerides. Researchers will measure fat production after a meal, with and without exercise beforehand. The goal is to understand why some people have …

This study is testing whether an AI-powered chatbot on a smartphone can encourage more men in Malaysia to get tested for HIV. The study will enroll 296 men who have sex with men and have not been tested recently. Participants will use the chatbot and report every 30 days whether …

This study tests a portable MRI machine to look for brain injury in patients who have had a cardiac arrest. Researchers will scan the brain multiple times over several days to see how injuries change. The goal is to make brain imaging available at hospitals without specialized sc…

This study looks at how the fermentation of food in the gut affects metabolism in young people aged 15–22 with obesity. Researchers will give participants a sugar called lactulose to trigger fermentation and measure changes in fat breakdown and sugar production. The goal is to un…

This study looks at whether acute stress can cause sudden worsening of congestive heart failure. Researchers will monitor 112 heart failure patients who have an implanted device that measures pressure in the lung artery. They will compare pressure readings during stressful and ca…

This study tests a suicide prevention package (PSuPP) in rural Nepal's primary care clinics. Researchers will train healthcare workers to better identify and support people at risk of suicide. The pilot involves 147 participants and focuses on whether the program is practical and…

This study uses a special chamber that creates mild blood-pooling in the legs to safely mimic early blood loss in 120 healthy adults aged 20-45. Researchers will compare signals from different body monitors to see which one best detects the change. The goal is to find a more reli…

This study tests a new device that measures blood pressure in a neck vein to estimate pressure in the heart's central veins, without needing a catheter. About 40 adults in the cardiac ICU will have both the non-invasive test and the standard invasive measurement to see if the new…

This study is developing and testing two short online writing exercises to help parents in the Southeast US become more accepting of their sexual and gender minority children (ages 15-29). About 129 parents who identify as heterosexual and cisgender and who report some non-accept…

This study is creating a registry for children with PTEN Hamartoma Tumor Syndrome (PHTS), a rare genetic condition that increases cancer risk. Researchers will follow 100 participants for 3 years to link genetic changes with health outcomes. The goal is to develop better monitori…

This study tests whether using a special cuff to partly block blood flow during exercise can improve recovery after ACL reconstruction. Twenty adults will have two training sessions—one with the cuff inflated and one without—so researchers can compare changes in immune cells and …

This study is creating a registry of 800 adults with myasthenia gravis at Yale University. Participants donate blood and stool samples, which will be used for future research to better understand the disease. The goal is to collect data and samples to support many research projec…

This study looks for early clues that someone might develop multiple sclerosis (MS) before they have any symptoms. Researchers will collect health data and samples from 1,000 adults who have risk factors like a family history of MS or past Epstein-Barr virus infection. The goal i…

This study looks at whether a 12-session parenting program can change brain activity in mothers recovering from opioid use disorder. Researchers will use EEG to measure brain responses to baby faces and cries before and after the program. The goal is to see if supporting the moth…

This study uses brain scans to understand why some people relapse to opioid use during treatment. Researchers at Yale will follow 240 adults recently started on methadone or buprenorphine, tracking their brain connectivity and drug use for six months. The goal is to identify patt…

This early-phase study at Yale University is investigating how the drug mavoglurant affects brain activity in people with a family history of alcoholism. Researchers will give 80 participants a single dose of mavoglurant or a placebo and use MRI scans to measure brain responses t…

This study looks at how THC, the active ingredient in cannabis, temporarily affects memory, learning, and balance in adults aged 21 to 55 who have used cannabis before. Ten participants will complete memory tasks and balance tests inside an fMRI scanner after taking either THC or…

This study uses PET scans with a special tracer to measure brain synapse density in 80 people—some with cocaine use disorder and some healthy controls. Researchers aim to see if cocaine changes brain connections, especially in areas linked to decision-making and addiction. Partic…

This study uses special PET scans to measure brain synapse density in people with HIV who are on effective treatment. Researchers want to understand why some still develop thinking or memory problems. They will compare 70 participants (with and without HIV) over two years using b…