Brain scans may predict opioid relapse risk

NCT ID NCT06800703

Recruiting now Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study at Yale University aims to understand how people with opioid use disorder (OUD) learn to avoid pain compared to healthy individuals. About 180 participants will perform a learning task inside an fMRI scanner to measure brain activity. Those with OUD will also be followed for a year to track their opioid use, helping researchers see if brain patterns can predict future use or relapse.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could reveal brain patterns that predict opioid relapse, pointing toward new behavioral or brain-based treatments.
What could go wrong: This is an early observational study, not a treatment trial. It may not lead to direct therapies, and results may not apply to all people with opioid use disorder.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opiate dependence Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY CONTROLS GROUP - AGE AND SEX-MATCHED OPIOID USE DISORDER

Contacts and locations

Locations

Connecticut Mental Health Center, S105
RECRUITING

New Haven, Connecticut, 06519, United States

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