Opiate dependence

This study tests whether adding a gentle brain stimulation technique (tDCS) along with computer-based thinking exercises can improve brain function and self-control in people being treated for opioid use disorder with buprenorphine. About 160 adults will either get real or fake s…

This study tests a mobile health app called uMAT-R, designed to help Black adults recover from opioid or stimulant use and manage depression or anxiety. Participants are recruited from community treatment centers and use the app to track substance use and mental health symptoms. …

This study looks at whether follow-up care for opioid use disorder via telehealth works as well as in-person visits after starting treatment in the emergency department. About 528 adults who received buprenorphine in the ER will be assigned to either telehealth or in-person clini…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce opioid cravings and prevent relapse. Researchers will compare active stimulation to a sham (fake) version in 100 adults with opioid use disorder who recently started medication like bupreno…

This study tests an updated computer tool for emergency room doctors that includes information about a patient's social risks—like unstable housing or food insecurity—alongside standard opioid use disorder treatment guidance. The goal is to see if this social-risk-informed tool h…

This early-stage trial is testing whether low-intensity focused ultrasound (LIFU) can safely help people with opioid or other substance use disorders. The device sends sound waves to specific brain areas to calm cravings. 29 adults in outpatient treatment will receive both real a…

This study tests whether a long-acting buprenorphine injection can be used to start treatment for opioid use disorder without causing severe withdrawal. Thirty adults with opioid use disorder will stay in a hospital for three days, receive fentanyl to prevent withdrawal, and then…

This Phase 2 trial tests whether adding brenipatide to standard buprenorphine treatment helps people with opioid use disorder stay off opioids longer. About 465 participants will receive either brenipatide or a placebo injection alongside their usual medication. The study measure…

This study compares two patient navigation models for people recently involved in the criminal legal system who have substance use disorders. One group gets standard navigation, while the other can choose from a menu of services like in-person clinics, mobile health units, or tel…

This study tests a smartphone app designed to help young adults aged 18 to 25 who want to reduce their combined use of alcohol and opioids. The app sends timely tips based on users' daily reports. The goal is to see if the app is usable, satisfying, and worth testing in larger st…

This study tests whether a smartphone app can help people reduce their use of illegal opioids while they are in treatment for opioid addiction. The app uses a short test to predict the chance of relapse in the next week and adjusts medication doses accordingly. About 225 adults w…

This trial tests a short virtual therapy called IMPROVE, designed to help people on medication for opioid use disorder who also drink heavily. Participants attend three one-hour online sessions and use a mobile app to learn skills for managing emotional distress that can trigger …

This pilot study tests whether deep brain stimulation (DBS) of the nucleus accumbens can help people with opioid use disorder who keep relapsing despite standard treatments. Only 3 participants will receive the implanted device. The main goal is to see if it is safe and whether i…

This study tests whether showing doctors a warning flag in electronic health records for patients at high risk of opioid overdose can lead to safer prescribing. About 1,350 adults who recently received an opioid prescription will be included. Doctors in some clinics will see a si…

This study tests whether a program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) can help people reduce risky alcohol and drug use. About 400 adults visiting family planning clinics will either get SBIRT or usual care. Researchers will track changes in d…

This study tests a digital tool called EMBED that helps emergency doctors identify patients with opioid use disorder and start them on buprenorphine, a medication that reduces cravings and withdrawal. The tool is built into the electronic health record and guides doctors through …

This study tests new ways to help people with opioid use disorder continue their buprenorphine medication after starting it in the emergency department. About 3,500 adults will take part. The goal is to see if better coordination between the ER and outpatient clinics helps patien…

This study tests whether a 12-week group therapy program called Mom Power can help new mothers with opioid use disorder improve their mood, reduce stress, and strengthen the bond with their child. About 160 mothers with a child aged 5 or younger will be assigned to either the Mom…

This study tests whether a monthly extended-release buprenorphine injection works better than daily sublingual tablets for adults with opioid use disorder who are about to be released from jail. 240 participants will be randomly assigned to one of the two treatments while still i…

This study will enroll 1,000 adults with both opioid use disorder and a mental health condition. Participants will receive standard medication for opioid use disorder, with some also getting a team-based support program called MISSION. The goal is to see if MISSION helps people s…

This study tests a stepped care program called PCT+2HOPE for women with opioid use disorder who have also experienced intimate partner violence and PTSD symptoms. The program adds group and individual therapy to standard medication treatment. Researchers will see if it helps wome…

This study compares a once-monthly injection of buprenorphine to daily sublingual buprenorphine for treating opioid use disorder in people who use fentanyl or other strong synthetic opioids. About 60 adults aged 18–65 will be enrolled and followed for 4 weeks after starting treat…

This study tests whether a slow-release form of dexamphetamine, a drug used for ADHD, can help people with cocaine and opioid addiction reduce their cocaine use. About 204 adults who are already on methadone for opioid addiction will receive either dexamphetamine or a placebo for…

This pilot study tests whether offering financial incentives (contingency management) can help people who started medication for opioid use disorder in the emergency department keep attending outpatient treatment. Thirty adults will be randomly assigned to receive either standard…

This study tests whether a higher starting dose of buprenorphine in the emergency room helps more people with opioid use disorder engage in treatment within 10 days. It also looks at whether the higher dose reduces cravings, withdrawal symptoms, and use of illicit opioids. The tr…

This study aims to reduce racial disparities in opioid overdose deaths by training peer recovery coaches and using an AI-driven texting tool. The coaches will send personalized texts to participants (Black and Latinx adults with opioid use disorder) to help them connect with trea…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help people with moderate to severe opioid use disorder stay in treatment and use fewer opioids when added to their regular buprenorphine medication. About 310 adults who recently started buprenor…

This study tests whether adding buprenorphine (a partial opioid) to the standard shot XR-naltrexone helps people with opioid use disorder stay in treatment and avoid relapse. 180 adults will receive either the combo or a placebo for 24 weeks. The goal is to see if the combo impro…

This study tests a health system strategy called SAIA to improve care for people with opioid use disorder as they leave jail and connect to community clinics. Researchers will work with jail and clinic staff to identify bottlenecks and improve treatment continuity. The study invo…

This study tests whether a mobile app can help people in addiction treatment avoid relapse. 150 participants will either receive standard care or standard care plus the app, which monitors warning signs and sends alerts. The goal is to see if the app improves long-term recovery.

This phase 4 trial tests whether giving the NSAID ketorolac (Toradol) for the first five days after orthopedic trauma surgery can reduce the chance of patients still needing opioids six months later. About 458 adults aged 18–70 with acute musculoskeletal injuries requiring surger…

This pilot trial tests two long-acting injectable buprenorphine medications (Sublocade and Brixadi) in 60 incarcerated individuals with opioid use disorder who are about to be released from prison. Participants either choose their preferred medication or are randomly assigned one…

This study looks at whether different e-cigarette flavors can help people who smoke cigarettes and are being treated for opioid use disorder with buprenorphine to smoke fewer cigarettes. About 90 adults who smoke at least 5 cigarettes daily will try either a tobacco, sweet-coolin…

This study is testing whether a private Facebook group, called Wiidookaage'Win, can help Native American women in Minnesota stay off opioids. The group includes social support, mindfulness, and cultural practices. Sixty women who are already on medication for opioid use and have …

This study tests whether counseling plus a muscle relaxant (tizanidine) can help adults who have used opioids for a long time reduce their pain medication after elective surgery. About 375 participants will be randomly assigned to one of three groups: the combo treatment, counsel…

This study looks at whether adding a six-session group recovery program and a 90-day home telehealth program can help veterans with substance use disorders drink less and use fewer drugs. About 195 veterans from a VA psychiatric unit will be randomly assigned to one of three grou…

This study tests whether a telehealth pain management program can help veterans who have surgery outside VA hospitals avoid becoming long-term opioid users. About 400 veterans having orthopedic surgery will either receive the program or standard care. The goal is to see if the pr…

This study compares two medications—methadone and buprenorphine—given in a doctor's office to treat opioid use disorder. Researchers want to see which one helps people stay in treatment longer over 168 days. About 600 adults starting a new treatment episode will take part. The go…

This study tests a new approach called SINI to help people with opioid use disorder start buprenorphine treatment more comfortably. Participants receive small doses of naloxone to trigger mild withdrawal, then take buprenorphine to ease symptoms, followed by a long-acting injecti…

This study tests a program called Peer Activate, where trained peer recovery specialists help people with opioid addiction stay on their medication and cut down on other drug use. The program teaches skills like finding rewarding activities without drugs. Researchers will compare…

This pilot study tests a personalized deep brain stimulation (DBS) method for people with severe, treatment-resistant substance use disorders. Ten participants will first undergo detox, then have temporary electrodes placed in their brains to map addiction-related circuits, follo…

This study tests whether bringing mobile health clinics to rural communities and pairing patients with a certified peer support specialist (someone who has personally recovered from opioid use disorder) can help more people start and stay on medication for opioid use disorder. Re…

This study is testing two counseling approaches—Motivational Interviewing (MI) and Mindfulness-Oriented Recovery Enhancement (MORE)—to help people on methadone treatment reduce their use of tobacco, opioids, and other drugs. Researchers will enroll 420 adults who are currently on…

This study tests a vaccine that helps the body produce antibodies against oxycodone, a commonly abused prescription opioid. The goal is to reduce the drug's ability to reach the brain and lower its pleasurable effects. The trial involves 45 adults with opioid use disorder and foc…

This study looks at how to bring a program called Just Care for Families to more counties in Oregon. The program helps parents who use opioids or methamphetamine reduce their substance use and improve family outcomes, like being reunited with their children. Researchers will test…

This pilot study is testing whether mailing buprenorphine to people with opioid use disorder after a hospital stay can help them stay in treatment. The goal is to overcome common barriers like lack of transportation or trouble getting to a pharmacy. Researchers will track whether…

This study tests whether a special therapy program with a mobile app helps pregnant people stay on their buprenorphine medication for opioid use disorder, compared to just logging their doses. About 37 pregnant women will be randomly assigned to either the app-based therapy or da…

This early-stage study tests the safety of nalmefene implants in 24 healthy adults. Participants receive one or two implants that stay in place for 4 or 12 weeks. Researchers monitor side effects and how the drug moves through the body to plan future studies in people with opioid…

This study tests a smartphone app that lets people with severe opioid use disorder take their daily methadone at home while being recorded. The app helps clinics monitor safe use and cravings. Researchers will compare this approach to standard care in 100 adults to see if it keep…

This study tests whether an 8-week culturally responsive harm reduction program helps Black and Latinx people who use drugs engage more with services and reduce opioid or stimulant use. Researchers will compare the program to standard harm reduction services in 200 participants. …

This small study is testing whether MDMA-assisted therapy can help new mothers who have both post-traumatic stress disorder (PTSD) and opioid use disorder. Fifteen participants will receive MDMA in a controlled setting along with therapy sessions. The goal is to see if this appro…

This study compares e-cigarettes to standard counseling and nicotine patches/lozenges for reducing smoking in people with opioid use disorder. About 300 participants who smoke at least 5 cigarettes daily and are in treatment for opioid addiction will be followed for 6 months. The…

This study tests whether low-dose ketamine can reduce cravings and withdrawal symptoms in adults starting methadone treatment for opioid use disorder. Fifty participants will receive either a low or very low dose of ketamine four times over two weeks. Researchers will track cravi…

This study tests a non-invasive brain stimulation technique (tDCS plus ultrasound) to help people with opioid use disorder and chronic pain reduce drug use. Researchers will compare active stimulation to a sham (fake) treatment in 126 adults already on methadone. The goal is to s…

This study tests a new behavioral program called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines 12-step facilitation with motivational and cognitive-behavioral therapy. Researchers will compare it to standard therapy to see if it leads to more day…

This study tests a program called THRIVE, where a trained peer (someone with lived experience) meets with patients in the hospital and sends weekly texts for 12 weeks after discharge. The goal is to see if this support helps reduce non-fatal overdoses and skin infections compared…

This study tests a combination of telehealth, peer support, buprenorphine medication, and connections to addiction treatment programs for people who have had an opioid overdose and visited the emergency department. The goal is to help participants stay in treatment and prevent fu…

This study looks at whether adding addiction counseling and a community peer helper to regular primary care helps people with opioid use disorder stay on their medication (buprenorphine) and keep coming to their doctor visits. About 70 adults with opioid dependence and other medi…

This study tests a smartphone app designed to strengthen self-control in teens and young adults (ages 14-35) being treated for alcohol or cocaine use disorder. Participants will complete 12 short training sessions over about a month, plus booster sessions. The goal is to see if t…

This study tests whether support from trained peers who have personal experience with addiction can help people stay in medication treatment for opioid use disorder. About 218 adults starting treatment will either receive standard care alone or standard care plus up to 6 months o…

This study tests different treatment plans to help adults with opioid use disorder stay on buprenorphine longer. About 500 people from the emergency department will take part. Researchers will compare approaches to see which works best for keeping patients on medication and reduc…

This study tests if low intensity focused ultrasound (LIFU) can help people with severe opioid addiction who haven't improved with other treatments. About 34 adults aged 22-60 will receive either real or sham ultrasound to specific brain areas. Researchers will monitor safety and…

This study tests whether giving financial incentives for negative drug tests can help people with opioid, cocaine, or methamphetamine use disorder stay abstinent. Six hundred participants use a smartphone app to submit saliva tests. Some receive escalating or de-escalating reward…

This study looks at whether helping clinics offer more take-home doses of methadone (instead of daily visits) helps people stay in treatment for opioid use disorder. Researchers will work with 36 clinics and about 318 patients to see if this approach reduces emergency visits and …

This phase 2 trial tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid use disorder who continue using illicit opioids even while on methadone. Up to 480 participants will receive either a low (1 mg), medium (20 mg), or…

This study tests whether daily text reminders and mindfulness messages can help people taking medication for opioid use disorder stay on track with their treatment. About 60 adults who recently started or restarted methadone or buprenorphine will receive texts for up to 6 months …

This study compares a once-monthly injectable buprenorphine to the standard daily sublingual tablet (with naloxone) for treating opioid use disorder in 952 veterans. The goal is to see which formulation better keeps people in treatment and helps them stay opioid-free over 48 week…

This study at Duke University is testing whether a brain scan (MRI) can predict who will successfully quit opioids using buprenorphine, and whether adding brain stimulation (rTMS) to the treatment helps more than a sham version. 80 adults with opioid use disorder who are starting…

This study is testing whether switching to very low nicotine cigarettes can reduce cravings, withdrawal, and pain in people who smoke daily, have chronic pain, and are on buprenorphine for opioid use disorder. Sixty participants will be randomly assigned to either very low nicoti…

This study tests a new approach where nurses, rather than doctors, adjust methadone doses for people starting treatment for opioid addiction. The goal is to see if this makes it easier for patients to stay in care for at least three months. The trial will enroll 182 adults in Fre…

This study tests whether a non-invasive brain stimulation technique called TMS can help people with mental illness quit smoking. Forty daily smokers with psychiatric conditions will receive either TMS or standard care. The goal is to see if TMS is practical and effective in real-…

This phase 3 trial tests whether adding cannabidiol (CBD) to standard opioid addiction treatment can reduce cravings and prevent relapse. About 450 adults with opioid use disorder who are already on methadone or buprenorphine will receive CBD or a placebo for 24 weeks. The goal i…

This study looks at whether sending free meals to the home can improve food security for adults who are on medication for opioid use disorder. Forty participants will either get nutrition education alone or education plus weekly meal deliveries for 24 weeks. Researchers will trac…

This study tests a program called Youth Opioid Recovery Support (YORS) to help teenagers with opioid use disorder stay on their medication and avoid relapse. The program includes family involvement, easy access to medication, and regular check-ins. Researchers will enroll 80 teen…

This study tests whether a smartphone app featuring a friendly virtual coach can help 100 adults with opioid use disorder stay on their buprenorphine medication for at least a year. Participants use the app to get support and reminders, while researchers track how long they remai…

This study tests whether trained peer recovery specialists can help Black individuals with substance use stick to their long-acting injectable HIV treatment or prevention. 186 participants will either get this peer support or standard care. The goal is to see if the peer program …

This study tests whether a combined infectious disease and substance use disorder clinic can reduce infection-related hospital readmissions. 304 hospitalized adults with opioid or stimulant use disorder and related infections will be randomly assigned to either the integrated cli…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid use disorder who are already on medication. 36 participants will receive either a high or low dose and be followed for a year. The goal is to see if psilocy…

This early study tests whether personalized deep brain stimulation (DBS) can safely reduce cravings and opioid use in 6 adults with severe, treatment-resistant opioid use disorder. Researchers will first map brain activity to find each person's craving signals, then deliver targe…

This study tests whether giving a higher-than-standard dose of buprenorphine (a medication for opioid use disorder) in the emergency department is safe and helps more people start addiction treatment within a week. About 140 adults with moderate to severe opioid use disorder who …

This study compares a higher daily dose of buprenorphine (24 mg) to the standard dose (16 mg) to see if it helps people with opioid use disorder stay in treatment longer. About 250 adults who have used fentanyl will be randomly assigned to one of the two doses. The goal is to imp…

This study tests a new way to help people with opioid use disorder in rural Georgia. Emergency rooms will use video calls to connect patients with poison center doctors who can start medication (buprenorphine) and link them to peer recovery coaches. The goal is to see if this app…

This early-stage study tests whether a faster 'loading dose' of methadone can safely help people with opioid use disorder who use fentanyl. Researchers will enroll 24 adults and compare standard methadone starts to higher initial doses. The main goal is to find a dose that doesn'…

This study tests a community program called Young HEROES for youth aged 12-17 with opioid use disorder. It combines medication, counseling, and peer support to help them stay in treatment and stop using opioids. The goal is to see if this approach works better than usual care in …

This study tests a program called Youth Opioid Recovery Support (YORS) for young adults aged 18-28 with opioid use disorder. The program includes home delivery of medication, family involvement, and active outreach to help participants stay on their relapse prevention shots. The …

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with opioid use disorder reduce cravings and avoid relapse. About 46 adults who are already taking buprenorphine will receive either semaglutide or a placebo for 12 weeks. The goal is …

This study tests a program to expand medication-assisted treatment for opioid addiction in Kazakhstan, Kyrgyzstan, and Tajikistan. Researchers will train local health officials and track how many people start and stay on treatment. The goal is to reduce HIV spread among people wh…

This study tests a low-dose method of starting buprenorphine-naloxone for opioid use disorder, compared to standard guidelines. The goal is to see if this approach is safe, effective, and acceptable to patients. The trial enrolls 70 adults with opioid use disorder who are willing…

This early-stage trial tests a new long-acting naltrexone injection (IVL3004) against the approved drug Vivitrol in 40 healthy men. The goal is to compare how the drug moves through the body and check for safety. It does not yet test if it helps treat opioid or alcohol dependence…

This study tests whether starting a monthly extended-release buprenorphine injection (Sublocade) in jail helps people with opioid use disorder stay on treatment after release. Two hundred men entering jail with a daily buprenorphine prescription will be randomly assigned to eithe…

This study is testing whether a telehealth platform can help people with opioid use disorder, especially those in rural areas and Black and Hispanic communities, start and stay on buprenorphine treatment. Researchers will enroll 250 participants and measure how acceptable and fea…

This study works with 300 women in rural Kentucky jails who have opioid or stimulant use disorders. The goal is to lower their risk of overdose when they return to their communities. The program offers support and connects them to treatment options before and after release.

This study tests four different approaches to help people who inject drugs remember and stick with their daily HIV prevention pill (PrEP). Researchers will enroll 256 adults who are newly on medication for opioid use disorder and have started PrEP. The goal is to see which method…

This study tests a digital health program to help women involved in the criminal justice system start PrEP (a daily pill to prevent HIV) and get treatment for opioid use disorder. Researchers will compare the program to a simpler decision aid alone. The goal is to reduce stigma a…

This pilot study tests whether a peer-driven program can help people who inject drugs in Baltimore reduce their risk of HIV, hepatitis C, and overdose. Researchers will identify high-risk injection settings and train peers to promote safer practices, like carrying naloxone and av…

This study tests whether adding a trained family advocate to a proven parenting program can help prevent substance use and reduce childhood trauma. About 360 families from 36 high-risk communities in New Jersey will take part. The goal is to see if extra support makes the program…

This study tests a program called CHORUS+ that helps people who inject opioids get HIV prevention medication (PrEP) and treatment for opioid use disorder (MOUD). Participants receive HIV self-testing, rapid access to medications, and 6 months of support from a peer coach. The goa…

This study tests whether people who use opioids can be trained as peer educators to teach their friends and family how to prevent overdoses. Researchers will enroll 600 participants in Baltimore and compare those who receive overdose prevention training with those who get standar…

This study tests two counseling programs—one focused on motivation and coping skills, the other on strengths and advocacy—to prevent opioid misuse in 300 homeless youth aged 14-24. Participants are randomly assigned to one of the programs or standard services, and tracked for two…

This study tests whether acetazolamide, a drug used for other types of sleep apnea, can help people on methadone or buprenorphine who develop central sleep apnea. Forty participants will take either the drug or a placebo for 7 days, then have an overnight sleep study. Researchers…

This study is testing a short, values-based therapy for Veterans who have recently started medication for opioid use disorder (like buprenorphine). The therapy focuses on helping them clarify their personal values, set goals, and improve social connections. The study has three ph…

This early-stage study is testing whether inhaled cannabis can reduce withdrawal symptoms in people with opioid use disorder who are not currently seeking treatment. Researchers will give participants either cannabis or a placebo and measure how they feel, including withdrawal se…

This study tests a program called SKILLS that focuses on common factors across different mental health conditions, rather than treating each disorder separately. About 60 adults with stable psychiatric diagnoses will take part. The goal is to see if this approach reduces symptoms…

This pilot study is testing whether a one-time, 45-minute virtual reality (VR) session guided by an AI coach can help people with chronic pain who also misuse opioids. The session includes a check-in, pain coping skills training, and a stress reduction exercise. The study involve…

This study is testing a wearable device called Sparrow Link that sends gentle electrical pulses to nerves in the ear to help reduce opioid withdrawal symptoms. About 50 hospitalized adults with opioid use disorder will receive either the active device or a sham version, along wit…

This study tests whether olanzapine, a medication typically used for mental health conditions, can reduce opioid cravings and misuse in adults with cancer who are on long-term opioid pain therapy. About 87 participants will receive either olanzapine or a placebo to see if it help…

This study tests whether a non-invasive brain stimulation technique called TMS can improve recovery in people with opioid and alcohol use disorders. Sixty adults enrolled in an intensive outpatient program will receive daily TMS sessions for four weeks, alongside their usual ther…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) and a smartphone care management app can help people with both opioid use disorder and chronic pain. About 127 adults already on buprenorphine treatment will try one or both tools. The …

This study looks at whether a therapy called prolonged exposure, given through video calls, can help people with both opioid use disorder and PTSD. About 135 adults on stable medication for opioid use will take part. The goal is to see if this approach improves therapy attendance…

This study tests whether suvorexant, a sleep medication, can help people with opioid use disorder fall asleep and stay asleep. About 300 participants will receive either suvorexant or a placebo. The goal is to see if the drug improves total sleep time and is safe to use.

This study tests four different approaches—behavioral therapy, physical therapy, medication changes, and buprenorphine rotation—to help cancer survivors reduce their opioid use while keeping pain under control. It involves 294 veterans who have finished cancer treatment but still…

This study is testing a smartphone app designed to help people who are starting medication for opioid use disorder get better sleep. The app uses proven sleep therapy techniques and daily sleep diaries. Researchers will enroll 40 adults who are stable on buprenorphine and have po…

This pilot study tests whether probenecid, a drug currently used for gout, can reduce withdrawal symptoms in people with chronic pain who are voluntarily lowering their opioid dose. Researchers will enroll 40 adults and randomly assign them to take probenecid or a placebo for 12 …

This Phase 2 trial tests whether adding buspirone (an anxiety medication) to lofexidine (a withdrawal drug) can reduce opioid withdrawal symptoms and cravings during detox. About 100 adults with opioid use disorder will stay in a residential setting for 10–12 days, undergo a step…

This study is testing whether music therapy can help people with substance use disorder. 600 participants across Europe will be randomly assigned to either active music-making, music listening, or standard treatment. The goal is to see if music therapy improves addiction severity…

This study tests a program called the Transitional Pain Service Program for adults who have chronic pain and take opioids before surgery. The program includes pain education, therapy, and a mobile app to help patients manage pain and safely reduce opioid use. Researchers will com…

This pilot study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. The goal is to see if it is practical and acceptable for adults who are in treatment for opioid use disorder and also have chronic pain. Ten participants will use the app for 8 we…

This study tests whether a non-invasive brain stimulation technique called TMS can reduce cravings and opioid use in people with opioid use disorder. One hundred participants will receive either real or sham TMS sessions over 8 weeks, with follow-up visits for about 5 months. The…

This early-phase study at Yale tests whether cannabidiol (CBD) is safe and can reduce pain and opioid cravings in 34 adults with opioid use disorder and chronic pain. Participants are already on methadone or buprenorphine and will receive different doses of CBD or a placebo in a …

This study tests whether a continuous pump delivering numbing medicine into the belly can reduce pain and the need for narcotics after minimally invasive hysterectomy. About 120 women having surgery for non-cancer reasons will be randomly assigned to receive either a numbing drug…

This study tests whether a 7-day buprenorphine skin patch can safely control pain after ankle fracture surgery and reduce the need for addictive opioids. About 100 adults who have never taken opioids before will receive either the real patch or a placebo, along with standard pain…

This study looks at whether offering yoga or physical therapy at opioid treatment programs can help people with chronic back pain and opioid use disorder feel better and use fewer opioids. About 180 adults will be randomly assigned to 12 weeks of yoga, physical therapy, or their …

This study is testing whether a virtual reality version of a therapy exercise is practical and helpful for adults (ages 18-65) with psychiatric disorders. Participants will try one VR session and answer questions about their experience. The goal is to see if this approach is acce…

This study tests whether a non-invasive device that stimulates the vagus nerve in the neck can reduce withdrawal symptoms in people with opioid use disorder. About 103 participants will stay in the hospital for a week, receive either active or sham stimulation, and have brain sca…

This study looks at whether adding cognitive behavioral therapy (CBT) to standard education helps people who take opioids for chronic pain taper off them before spine surgery. About 45 adults scheduled for major spine surgery at least four weeks ahead will be split into two group…

This study is testing a type of talk therapy called Emotion Regulation Therapy (ERT) delivered over video for people in New York who struggle with worry, overthinking, or being hard on themselves. The goal is to see if the therapy helps people better manage their emotions and fee…

This early-phase trial at Yale tests whether dronabinol (Marinol), a synthetic form of THC, can reduce pain sensitivity and improve attention and mood in 36 adults with opioid use disorder who are stable on methadone or buprenorphine. Participants receive either 2.5 mg, 5 mg of d…

This study tests whether a specific injection technique called erector spinae plane block (ESPB) reduces pain and opioid use after lumbar spinal fusion better than standard subcutaneous anesthesia. Researchers will enroll 66 adults scheduled for one- or two-level lumbar fusion. P…

This study looks at how well and how safely a new sleep medication, lemborexant, works for people who have both a mental health condition and trouble sleeping. About 121 adults will take the drug for 8 weeks, and researchers will track changes in their sleep quality and any side …

This study tests whether adding pregabalin to the standard withdrawal drug lofexidine helps people with opioid use disorder feel less sick while quitting. About 150 adults who want to start long-acting naltrexone will take either the combination or a placebo for 8 days. The goal …

This study is adapting a friendly text-message chatbot called Penny to support pregnant and postpartum women who are recovering from opioid use disorder. The chatbot sends helpful messages and allows two-way conversations to reduce loneliness and keep women engaged in their care.…

This study tests two approaches—mindfulness training and patient-centered pain management visits—to help adults with chronic pain who take long-term opioids. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. About 300 participants will be f…

This study looks at whether taking methadone once a day or twice a day works better for people who have both chronic pain and opioid use disorder. About 150 adults currently on methadone treatment will be randomly assigned to one of the two dosing schedules. Researchers will trac…

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study tests whether sailing can help people with psychiatric disorders feel better. Forty adults in France will either take sailing lessons or continue their usual care. Researchers will measure changes in quality of life, mental well-being, and self-esteem to see if sailing…

This phase 2 study at Yale University is testing whether a combination of THC and CBD can reduce both pain sensitivity and opioid cravings in people who have opioid use disorder and chronic low back pain. The 147 participants are all on methadone therapy and will receive either a…

This study tests if delivering lidocaine (a numbing medicine) and steroids directly into an artery in the scalp can safely relieve the intense headaches that follow a type of brain bleed called subarachnoid hemorrhage. The goal is to reduce pain and the need for strong opioid pai…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help relieve severe pain in people with advanced cancer when opioids don't work. Fifteen participants will receive psilocybin capsules along with therapy sessions. The goal is to see if this approa…

This study tests whether reducing loneliness can help people with opioid use disorder. 300 adults who feel lonely and use opioids will receive 6 weekly sessions. Researchers will measure changes in loneliness and opioid use over time.

This study tests whether a combination of psilocybin (the active ingredient in magic mushrooms) and talk therapy can help adults with chronic pain safely reduce or stop their opioid painkillers. Ten participants will receive one or two psilocybin sessions over 8 weeks, with follo…

This study tests a therapy called HOPE for people who have both opioid use disorder and PTSD. Participants must already be on medication for opioid use disorder (like Suboxone or methadone). Over 10-12 weeks, they will attend therapy sessions and complete surveys to see if their …

This study tests whether peer support workers—people with lived experience of substance use—can help people who use drugs feel safer and stay in the emergency department until their care is complete. The study will compare what happens when peer workers are on shift versus when t…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study is testing whether low-intensity focused ultrasound (LIFU) — a noninvasive device that sends sound waves to the brain — can help people with chronic back pain, opioid cravings, and anxiety. Researchers will enroll 25 adults and measure safety, mood, heart rate, and oth…

This study looks at three different ways to manage pain after childbirth in women who are on medication for opioid use disorder. The goal is to find which method works best for pain control and whether it also helps reduce anxiety, depression, and improve overall well-being. Abou…

This study tests whether morning bright light therapy can improve sleep and brain function in 105 adults recovering from opioid use disorder. Participants on stable medication will receive either bright or dim light for 30 minutes daily over two weeks. Researchers will measure sl…

This early-phase study is testing whether adding two doses of psilocybin (the active ingredient in magic mushrooms) to standard buprenorphine/naloxone treatment is safe for adults with opioid use disorder. Ten participants will receive psilocybin along with counseling, while rese…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…

This study aims to create a large data repository by collecting smartphone data and daily surveys from 10,000 adults who use alcohol or drugs. Participants will use an app that tracks phone activity and location, and answer short surveys about mood and substance use. The goal is …

This study looks at whether federal policy changes made during the COVID-19 pandemic helped more veterans get and stay on medication for opioid or alcohol use disorder. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using data …

This study looks at how people with opioid-use disorder learn and make choices compared to those without the disorder. Participants will complete a computer task where shapes are paired with different food odors. The goal is to understand if differences in learning and decision-m…

This study is developing a way to measure resilience in people with opioid use disorder. Researchers will have 125 adults complete tasks that test thinking, emotions, and sense of control, both with and without stress. The goal is to see if these tasks match how resilient people …

This early-phase study at the University of Maryland is testing whether suvorexant, a sleep medication, can reduce the desire for drugs in people with opioid use disorder. Researchers will measure how much participants are willing to 'pay' for a study drug in a lab task, and whet…

This study compares two ways to help adults with mental health issues get follow-up care. One group gets usual care after an emergency room visit, while the other uses a new system that books a psychiatrist appointment within 48 hours through their general doctor. Researchers wil…

This observational study at Yale University aims to understand how people with opioid use disorder (OUD) learn to avoid pain compared to healthy individuals. About 180 participants will perform a learning task inside an fMRI scanner to measure brain activity. Those with OUD will …

This study looks at the mental health of 200 teenagers aged 12 to 16 who attend special educational institutes (ITEPs) in France. Researchers will use psychiatric interviews to find out how many have conditions like depression or anxiety. The goal is to better understand their ne…

This study is testing whether a short, tailored alcohol intervention is practical and well-liked by people who are taking buprenorphine for opioid use and also drink alcohol. About 60 adults will take part. The goal is to see if this approach could work in a larger future study.

This study looks at how strong desires (cravings) change the way people make decisions. Researchers will use brain scans and decision-making tasks to see how craving for opioids or a specific snack affects what people are willing to pay for items. The study involves 160 adults, i…

This study aims to improve suicide prevention for people who move between healthcare and the criminal-legal system. Researchers will link health records, Medicaid data, and jail booking information to identify individuals at risk and coordinate care. Over 1,000 adults with past p…

This study is testing whether a smartwatch can pick up on body changes—like skin temperature—that happen during opioid withdrawal and cravings. Twenty people with opioid use disorder will wear the device for 14 days while their symptoms are tracked. The goal is to see if the watc…

This study looks at how psilocybin, the active ingredient in magic mushrooms, affects brain circuits linked to motivation and self-control in people with opioid use disorder. Twenty-four adults in the Philadelphia area will receive either a low or high dose of psilocybin, then un…

This study looks at whether older adults (55+) in methadone treatment for opioid use disorder can use smartphone-based cognitive games to track and possibly improve their thinking skills. Thirty participants will play short brain-training tasks twice a day for 15 days. The main g…

This study adapts a parenting program called 'Proud of Baby and Me' for new mothers who are receiving medication for opioid use disorder. The goal is to see if the program helps mothers stay in treatment, reduce stress, and improve bonding with their baby. Ten women will particip…

This study looks at how social behaviors and feelings of connection impact treatment for opioid use disorder. Researchers will collect daily reports from 230 patients and a close friend or family member over several weeks. The goal is to find patterns that could lead to more pers…

This study uses repeated fMRI brain scans to track changes in people receiving medication for opioid use disorder. Ten participants will be scanned every two weeks for six months while performing tasks. The goal is to understand how the brain changes during recovery and identify …

This study looks at how different e-cigarette flavors appeal to adults who have opioid use disorder and are on buprenorphine treatment. Participants will smell and rate 11 flavors for sweetness, coolness, strength, and how likely they'd use them again. The goal is to find flavors…

This study looks at how difficult childhood experiences might affect memory and brain function in people with opioid use disorder. Researchers will use brain scans and memory tests to compare three groups: people with opioid use disorder on buprenorphine, people without the disor…

This study uses brain scans (MRI, MRS, EEG) to see how ibogaine affects the brain in 20 people with moderate to severe opioid use disorder. Participants will already be receiving legal ibogaine treatment outside the U.S. The research team only observes and measures brain activity…

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study is testing how the drugs alprazolam (Xanax) and oxycodone (an opioid) interact when taken together. Researchers will give small, non-therapeutic doses to 25 healthy adults who already use these drugs. They will measure how much participants like the drug combination, a…

This early-stage study is testing a new implantable pellet (BICX104) that slowly releases naltrexone over 3 months. Researchers want to see how the body processes the drug and if it's safe, comparing it to a standard monthly naltrexone shot. The study involves 30 healthy adults a…

This study looks at why people taking medications for opioid use disorder often have trouble sleeping. Researchers think special light-sensitive cells in the eye might be involved. They will measure pupil responses, brain waves during sleep, and daily sleep patterns in 200 adults…

This study is testing whether a smartphone app can help people in Michigan on Medicaid who are recovering from both opioid and alcohol use disorders. The app uses rewards to encourage healthy behaviors. Researchers want to see if people find the app useful and easy to use, and if…

This study is testing a new center in Seattle where people who have had an opioid overdose can stay for up to 24 hours. The center offers monitoring, medication for opioid use disorder, and connections to ongoing care. Researchers will compare outcomes like repeat overdoses and t…

This study aims to see if a digital version of the WHO's mental health guide for substance use disorders can be used effectively in primary care settings in Pakistan. Researchers will train 300 primary care doctors in three major cities using this digital tool. The goal is to und…

This study looks at whether a special training and support program can help addiction clinics start using contingency management, a proven method that gives rewards to patients who stay off stimulants. Researchers will work with 76 clinics and track how many patients and counselo…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study is collecting information on lifestyle, quality of life, and health markers from 2,000 adults in Greece, including people with chronic diseases, opioid use disorders, and those in prison. The goal is to understand why some groups have worse health and to suggest polici…

This study uses a special PET scan tracer called [11-C]OMAR to measure cannabinoid receptors in the brain. Researchers will compare healthy volunteers to people with schizophrenia, cannabis dependence, PTSD, opioid use disorder, and other conditions. The goal is to understand how…

This study uses brain scans to compare a specific receptor (CB1) in people with opioid use disorder who are on methadone treatment versus healthy volunteers. The goal is to understand how the endocannabinoid system works differently in addiction. No new treatment is tested; it is…

This study looks at whether giving opioid treatment programs (OTPs) regular reports on how well they retain patients, plus a quality-improvement toolkit, can help more people stay in treatment for at least 90 days. Some clinics will also get extra help from an outside facilitator…

This study follows 100 pregnant women with opioid use disorder who are already receiving standard treatment. Researchers will track health outcomes for both mothers and babies, such as relapse and withdrawal symptoms. The goal is to find better ways to predict and prevent complic…

This study follows 20,000 adolescents aged 12-17 who receive opioids after major surgery. Researchers track pain, opioid use, and other factors for one year to identify early warning signs of opioid use disorder. Participants complete surveys and allow access to their medical rec…

This study aims to help Oregon decision-makers—like health officials, community leaders, and policymakers—use up-to-date, easy-to-understand data to improve substance use services and prevent overdoses. About 341 adults who have authority over substance use policies or programs w…

This study looks at whether a program with a nurse case manager can help people leaving prison visit a doctor or clinic instead of the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra support from …

This study is developing and testing a simple decision aid for people with opioid use disorder who visit the emergency department. The tool helps them understand their options for starting buprenorphine treatment. About 20 adults will try the aid and share whether it helped them …

This study is building a Canada-wide registry of people who come to emergency departments with opioid poisoning. Researchers will track treatments and outcomes for up to 7,200 patients. The goal is to learn what works best and create a tool to predict who is at highest risk of dy…

This study looks at whether using a special counseling style called Motivational Interviewing during the first visit can help people stay in addiction treatment. Researchers will compare this approach to the usual intake process. About 150 adults seeking outpatient addiction trea…

This study is testing a new way to reduce opioid overdoses on Chicago's West Side. Researchers will train friends and family members of people who use opioids to become harm reduction champions. These champions will learn about tools like naloxone and fentanyl test strips, and th…

This study looks at whether a new quality measurement and coaching strategy can improve treatment for people with opioid use disorder in New York State. Researchers will work with clinic staff to improve how they track and use quality measures. The study involves 35 participants …

This study is testing whether a smartwatch can detect when someone uses opioids or experiences withdrawal. Researchers will collect biometric data from 420 people with opioid use disorder who wear the watch for 14 days. The goal is to train a machine learning algorithm to recogni…

This study looks at whether a tool called MyPath helps women with substance use disorder make better decisions about birth control after having a baby. About 400 women will use the tool during pregnancy or right after delivery. The goal is to see if it helps them pick a method th…

This pilot study tests whether telemedicine can help people living with HIV in Alabama who also struggle with opioid or stimulant misuse get follow-up care. Thirty participants will receive either telemedicine or standard care. The goal is to see if telemedicine is feasible and a…

This study looks at how to get more medications for opioid use disorder (MOUD) to people in prison. Researchers will work with 120 prison sites to see which methods work best for increasing access to these life-saving drugs. The goal is to improve health and reduce harm for incar…

This study aims to understand why people with chronic pain or opioid use disorder often have worse pain after spine surgery. Researchers will analyze blood and skin samples from 40 participants to look for unique immune and genetic markers linked to pain. The goal is to find bett…

This study looks at how the brain activity of people with opioid use disorder aligns with a therapist during meditation. Researchers will measure brain synchrony and feelings of connection to see if they relate to opioid cravings. The goal is to better understand the brain proces…

This study tests whether low-dose buccal buprenorphine (a film placed in the cheek) can provide pain relief similar to a standard dose of oxycodone but with less potential for abuse. 120 healthy adults will receive different doses of buprenorphine, oxycodone, or placebo in separa…

This study is looking at 120 people who are already in treatment for abusing opioids and/or benzodiazepines (anti-anxiety drugs). Researchers want to understand why people use these drugs together, which greatly raises the risk of overdose and death. Participants will complete in…

This study is testing how opioids (morphine) and benzodiazepines (alprazolam) affect mood, anxiety, and thinking when taken alone or together. Researchers will give 24 people with a history of using these drugs single doses in a lab and measure their responses. The goal is to und…

This study follows 600 pregnant women who are taking buprenorphine for opioid use disorder. Researchers will collect genetic samples, perform MRIs, and track health outcomes to better understand why some mothers and babies have complications. The goal is to improve treatment and …

This study aims to develop and test a supervision strategy for clinical supervisors in substance use disorder treatment programs. The goal is to reduce counselor burnout and turnover, and improve their well-being and performance. About 43 supervisors and counselors from residenti…

This study looks at how opioid use disorder affects thinking skills like memory and attention, and whether these changes can predict how well people do in treatment. Researchers will use brain scans, computer-based cognitive tests, and machine learning to analyze data from 192 ad…

This study looks at whether a patient navigation program called NavSTAR can help people with opioid use disorder start treatment after a hospital stay and avoid going back to the hospital. Researchers will first test the program with 32 people at four hospitals in Philadelphia, t…

This study is testing a cooking and nutrition program for 50 people in Texas who are recovering from opioid use and living in recovery homes while on medication therapy. The program aims to improve their eating habits and confidence in cooking skills. Participants will fill out q…

This study is following 10,000 people who are seeking help for substance or behavioral addictions. Researchers will track their medical, brain, social, and psychological health over several years using interviews, questionnaires, and cognitive tests. The goal is to better underst…

This study is testing how well a culturally adapted screening and brief counseling program works for American Indian and Alaska Native adults who have chronic pain or misuse opioids. Researchers will work with three clinics to see if the program is easy to use and helpful. The go…

This study looks at whether a 12-session parenting program can change brain activity in mothers recovering from opioid use disorder. Researchers will use EEG to measure brain responses to baby faces and cries before and after the program. The goal is to see if supporting the moth…

This study aims to create a better tool for measuring opioid cravings in people being treated for opioid use disorder. Researchers will show participants opioid-related images and objects, then interview them about their feelings and thoughts. The goal is to improve how cravings …

This study looks at how stress changes the way opioid painkillers work in people with chronic back pain. Researchers will give participants oxycodone, a pain blocker, or a placebo in a lab setting to measure pain relief and drug liking. The goal is to understand why some people m…

This study uses brain scans to understand why some people relapse to opioid use during treatment. Researchers at Yale will follow 240 adults recently started on methadone or buprenorphine, tracking their brain connectivity and drug use for six months. The goal is to identify patt…

This study looks at whether having a specially trained peer recovery specialist in the emergency department helps people with substance use disorders connect to treatment and support services. Researchers will follow 400 adults who visit the ER for substance-related issues, compa…

This study is creating a program called START-VET to help veterans with mental illness or substance use disorders who have recently left prison. Researchers will work with 20 veterans to develop transition materials and tools. The goal is to improve quality of life and reduce cri…

This pilot study tests whether linking people who take medication for opioid use disorder to recovery community centers (RCCs) leads to better recovery outcomes. Researchers will compare two groups: one that visits an RCC and one that chooses other recovery activities. The goal i…

This study looks at how opioid withdrawal symptoms vary from person to person. Sixty adults with opioid use disorder will go through a medically supervised taper using hydromorphone and lofexidine. Researchers will measure withdrawal severity during the taper and after a naloxone…

This pilot study is testing whether a simple saliva test can help doctors prescribe mental health medications more safely and effectively. 200 adults in Manitoba who are starting or changing psychiatric drugs will provide a DNA sample. The results will be shared with their doctor…

This study looks at whether training psychiatric care teams to talk about sexual health with young patients (ages 15 and up) increases those conversations. Researchers will survey 770 teens hospitalized for psychiatric disorders about their sexual health and any side effects from…