Small study probes brain effects of mixing opioids and benzodiazepines
NCT ID NCT05006079
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing how opioids (morphine) and benzodiazepines (alprazolam) affect mood, anxiety, and thinking when taken alone or together. Researchers will give 24 people with a history of using these drugs single doses in a lab and measure their responses. The goal is to understand the effects of combining these substances, which could inform future treatments or policies for polydrug abuse.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Morphine and Alprazolam
What this could lead to
If successful, this could help understand how combining opioids and benzodiazepines affects people, potentially guiding better treatment or policies for polydrug abuse.
What could go wrong
This is a small, early-phase study with only 24 participants, so results may not apply broadly. It tests single doses in a lab, not real-world use, and may not lead to direct treatments.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Tolan Park Medical Building
RECRUITINGDetroit, Michigan, 48201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••