Small study probes brain effects of mixing opioids and benzodiazepines

NCT ID NCT05006079

Recruiting now Knowledge-focused Sponsor: Wayne State University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing how opioids (morphine) and benzodiazepines (alprazolam) affect mood, anxiety, and thinking when taken alone or together. Researchers will give 24 people with a history of using these drugs single doses in a lab and measure their responses. The goal is to understand the effects of combining these substances, which could inform future treatments or policies for polydrug abuse.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Morphine and Alprazolam
What this could lead to: If successful, this could help understand how combining opioids and benzodiazepines affects people, potentially guiding better treatment or policies for polydrug abuse.
What could go wrong: This is a small, early-phase study with only 24 participants, so results may not apply broadly. It tests single doses in a lab, not real-world use, and may not lead to direct treatments.

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Conditions

The condition(s) this trial relates to.

opiate dependence opioid abuse polysubstance abuse, susceptibility to

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BENZODIAZEPINE ABUSE OPIOID ABUSE POLYSUBSTANCE ABUSE

Contacts and locations

Locations

Tolan Park Medical Building
RECRUITING

Detroit, Michigan, 48201, United States

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