Brain scans and cognitive tests may predict opioid recovery outcomes

NCT ID NCT06136247

Recruiting now Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how opioid use disorder affects thinking skills like memory and attention, and whether these changes can predict how well people do in treatment. Researchers will use brain scans, computer-based cognitive tests, and machine learning to analyze data from 192 adults on stable medication for opioid use disorder. The goal is to better understand why some people struggle with treatment and relapse, which could lead to more personalized care in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could lead to better ways to predict who will benefit from treatment and help design more personalized therapies for opioid use disorder.
What could go wrong: This is an observational study, not a treatment trial. It will not directly improve health, and results may not apply to all people with opioid use disorder.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID-USE DISORDER

Contacts and locations

Locations

University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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