OPIOID USE DISORDER

This study tests a new method called SINI to help people with opioid use disorder start taking buprenorphine. Participants receive small doses of naloxone until mild withdrawal symptoms appear, then take buprenorphine under the tongue. The goal is to see if this approach is safe …

This study looks at whether mobile health clinics and peer support specialists can help people with opioid use disorder start and stay on medication treatment. Researchers will follow 750 adults in rural South Carolina for 6 months. The goal is to increase treatment success and p…

This study tests whether semaglutide (a weekly injection used for diabetes and weight loss) can reduce cravings and prevent relapse in people with opioid use disorder who are also taking buprenorphine. About 46 adults will receive either semaglutide or a placebo for 12 weeks. The…

This early study tests whether deep brain stimulation (DBS) can help people with severe opioid addiction who keep relapsing despite standard treatments. Only 3 participants will receive DBS to a brain region linked to reward and craving. The goal is to see if it is safe and can r…

This study tests two ways of giving rewards to encourage people with opioid or cocaine use disorder to stay drug-free. 600 adults will use a smartphone app that tracks drug tests and offers incentives that either increase or decrease over time. The goal is to see which approach h…

This study tests whether a gentle, non-invasive brain stimulation technique (tDCS plus ultrasound) can reduce drug use and pain in people with opioid addiction and chronic pain. About 126 adults on methadone treatment will receive either real or fake stimulation over several week…

This study tests whether mailing buprenorphine (a medication for opioid use disorder) to people after they leave the hospital can help them stay in treatment. The goal is to overcome common barriers like transportation and pharmacy access. Twenty adults who started buprenorphine …

This study tests whether a smartphone app with a friendly virtual coach can help people stick with their buprenorphine treatment for opioid use disorder. Researchers will enroll 100 adults who recently started buprenorphine at Boston Medical Center. Participants use the app for d…

This study tests a new care model for women with opioid use disorder who have also experienced intimate partner violence and PTSD. The program, called PCT+2HOPE, starts with therapy and adds extra support if needed. Researchers want to see if it helps more women stay in treatment…

This study tests two long-acting buprenorphine injections (Sublocade and Brixadi) to see which helps people with opioid use disorder stay in treatment after leaving prison. About 60 participants will either choose their preferred shot or be randomly assigned one. Researchers will…

This study tests a new treatment for people with severe opioid addiction that hasn't improved with other treatments. It uses low intensity focused ultrasound to target brain areas linked to addiction. 34 adults aged 22-60 will be randomly assigned to receive the real ultrasound o…

This study tests whether adding tirzepatide (a drug used for diabetes and weight loss) to standard buprenorphine treatment helps people with moderate to severe opioid use disorder stay in treatment longer and reduce opioid use. About 310 adults who recently started buprenorphine …

This study compares e-cigarettes to nicotine patches plus counseling for reducing cigarette smoking in people with opioid use disorder who are on methadone or buprenorphine. About 300 participants will be randomly assigned to one of two groups and followed for 6 months. The goal …

This study enrolls 500 adults who come to the emergency department with opioid use disorder. Researchers will test a two-stage treatment plan that adjusts based on how each person responds, with the goal of increasing how long they stay on buprenorphine. The main focus is on help…

This study tests a program called Youth Opioid Recovery Support (YORS) to help young adults aged 18-28 with opioid use disorder stick to their medication and avoid relapse. The program provides extra support from family and community teams. The goal is to see if this approach imp…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid addiction who still use illegal opioids even while taking methadone. About 240 participants will receive a high, medium, or low dose of psilocybin and be fo…

This study looks at whether a therapy program with a mobile app helps pregnant people taking buprenorphine for opioid use disorder stay in treatment longer, compared to just tracking their medication. About 37 pregnant women will be randomly assigned to either four therapy sessio…

This study compares two daily doses of buprenorphine (16 mg vs. 24 mg) to see if a higher dose helps people with opioid use disorder stay in treatment longer and reduce cravings. Researchers will enroll 250 adults who have used fentanyl and are starting or continuing buprenorphin…

This study tests a health systems strategy called SAIA to help people with opioid use disorder stay in treatment after leaving jail. Researchers will work with clinics and jails to improve care coordination and follow-up. Over 4,000 adults in King County, Washington, who receive …

This study tests whether a long-acting injectable form of buprenorphine works better than the standard sublingual (under-the-tongue) version for treating opioid use disorder in people who use fentanyl or other strong synthetic opioids. About 60 adults aged 18–65 will be enrolled …

This study looks at whether follow-up care for opioid use disorder works better through telehealth or in-person visits after starting treatment in the emergency department. About 528 adults who received buprenorphine in the ER will be assigned to either telehealth or in-person cl…

This study tests whether a combination of THC and CBD, taken by mouth, can help people with both opioid use disorder and chronic low back pain. Participants are already on methadone treatment. The goal is to see if these cannabis compounds can reduce pain sensitivity and curb cra…

This study tests whether a smartphone app can help people with opioid addiction stay off illicit drugs during treatment. The app predicts the chance of relapse in the next 7-10 days and adjusts medication doses accordingly. About 225 adults who are starting methadone or buprenorp…

This study looks at whether a non-invasive brain stimulation technique called tDCS, combined with computer-based cognitive training, can help people with opioid use disorder who are already on buprenorphine maintenance. Researchers will measure changes in brain connectivity and t…

This study tests whether a smartphone app can help people who are already on methadone for opioid use disorder also reduce their use of cocaine and opioids. About 240 adults who use both opioids and cocaine will either get standard methadone treatment or standard treatment plus t…

This study compares two medications—methadone and buprenorphine—given in a doctor's office to treat opioid use disorder. Researchers want to see which one helps people stay in treatment longer. About 600 adults starting a new treatment episode will take part. The goal is to find …

This study looks at whether support from trained peers who have personal experience with addiction and recovery can help people stick with their medication treatment for opioid use disorder. About 218 adults starting treatment will either get standard care alone or standard care …

This study tests whether special alerts in electronic health records can help doctors prescribe opioids more safely for patients at high risk of overdose. About 1,350 adults who have taken opioids in the past year will take part. The goal is to see if these alerts lead to safer p…

This study is for Black and Latinx adults in New York City who use opioids and want to start treatment. Researchers will train peer recovery coaches using a video about cultural understanding and give people an AI texting tool for support. The goal is to see if these tools help p…

This study tests a smartphone app that lets people with severe opioid use disorder take their methadone at home while being monitored remotely. The goal is to see if the app helps patients stay in treatment longer, reduces opioid use, and lowers healthcare costs. About 100 adults…

This study tests a vaccine that targets oxycodone, a commonly abused prescription opioid. The vaccine works by training the body to produce antibodies that bind to the drug in the blood, preventing it from reaching the brain and reducing its pleasurable effects. Researchers will …

This study tests whether adding a new drug called brenipatide to standard opioid-use-disorder treatment (buprenorphine) helps people stay off opioids longer. About 465 adults with opioid use disorder will receive either brenipatide or a placebo injection for up to 144 weeks. The …

This study tests a new approach to starting extended-release buprenorphine, a medication for opioid use disorder. Thirty adults who use opioids will stay in the hospital for 3 days. They will receive fentanyl to prevent withdrawal, then a single injection of buprenorphine. Resear…

This study tests whether a once-monthly injection of buprenorphine helps veterans with opioid use disorder stay in treatment and avoid opioids better than the standard daily tablet. About 952 veterans will take part for up to a year. The goal is to find a more effective way to ma…

This study tests whether a special clinic that combines infectious disease and addiction care can help people who use injected opioids or stimulants avoid repeat hospital stays for infections. About 304 adults hospitalized with an infection linked to their drug use will either ge…

This study looks at whether starting a long-acting buprenorphine shot in jail helps people with opioid use disorder stay on treatment after they leave. About 200 adults who already take daily buprenorphine will either switch to the shot or stay on their usual pills. The goal is t…

This study tests a program called Youth Opioid Recovery Support (YORS) to help teens aged 13-21 with opioid use disorder stick with their medication. The program includes family involvement, outreach, and rewards for staying on track. Researchers want to see if it increases the t…

This study tests a community program for youth aged 12-17 with opioid use disorder. It combines medication, counseling, and peer support to help them stay in treatment and stop using opioids. Researchers will track how many stay in treatment and how many days they go without opio…

This study tests a program called THRIVE, where trained peer support specialists help people with opioid use disorder after they leave the hospital. Participants get one in-person session and weekly texts for 12 weeks. The goal is to see if this support lowers the chance of a non…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms in pregnant women with opioid use disorder when starting treatment. About 40 participants will receive either the patch or standard care during the required withdrawal period before taking buprenorphine…

This study tests whether giving a higher-than-standard dose of buprenorphine (32 mg instead of 12 mg) to people with opioid use disorder in the emergency department is safe and helps more of them start addiction treatment within a week. About 140 adults who test positive for fent…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can improve brain function and reduce opioid use in 36 adults already on medication for opioid use disorder. Participants receive either a high or low dose and are followed for one yea…

This study is testing whether a private Facebook group can help Native American women in Minnesota stay free from opioid use. Participants are women already on medication for opioid use disorder and have been abstinent for at least one month. The study will measure how well the F…

This study tests whether starting buprenorphine at a low dose is safe and effective for people with opioid use disorder. About 70 adults will be randomly assigned to different starting methods. The goal is to see if patients are willing to join and follow the low-dose plan, pavin…

This study aims to expand medication-assisted treatment (MAT) for opioid use disorder in Kazakhstan, Kyrgyzstan, and Tajikistan. By increasing access to MAT, researchers hope to reduce HIV infections among people who inject drugs and their partners. The study involves 900 partici…

This study tests a bundle of services—telehealth check-ins, a peer support specialist, the medication buprenorphine, and help connecting to addiction treatment—for people who have had an opioid overdose and are leaving the emergency department. The goal is to see if this approach…

This study compares two forms of buprenorphine medication to help people with opioid addiction stay in treatment after leaving jail. Researchers will follow 240 adults who are about to be released from jail, giving half a monthly injection and half daily tablets. The goal is to s…

This study tests a program called CHORUS+ that helps people who inject opioids quickly get HIV prevention medication (PrEP) and addiction treatment (MOUD). Participants receive HIV self-test kits, rapid prescriptions, and 6 months of peer coaching. The goal is to see if this appr…

This study tests whether offering counseling, advocacy, and basic support can prevent opioid misuse and mental health problems in homeless youth aged 14 to 24. About 300 participants will be randomly assigned to different combinations of services at a drop-in center. Researchers …

This study tests whether a special type of talk therapy for PTSD, delivered by video at syringe service programs, is practical and helpful for adults who are also taking medication for opioid use disorder. Researchers want to see if the therapy reduces PTSD symptoms and helps par…

This study tests whether low-intensity focused ultrasound (LIFU) can help reduce chronic back pain, opioid cravings, and anxiety in adults aged 18-65. Participants will receive LIFU and be monitored for side effects, changes in heart rate, blood pressure, and mood. The goal is to…

This study looks at whether doing yoga or physical therapy at opioid treatment programs can help people with chronic back pain and opioid use disorder feel better and use fewer opioids. About 180 adults will be assigned to 12 weeks of yoga, physical therapy, or their usual care. …

This study tests whether a 7-day buprenorphine skin patch can safely control pain after ankle fracture surgery and reduce the need for addictive opioids. About 100 adults who have never taken opioids before will receive either the patch or a placebo, along with standard pain care…

This study tests whether morning bright light therapy can improve sleep and brain health in 105 adults recovering from opioid use disorder. Participants on stable medication will receive either bright or dim light for 30 minutes daily over two weeks. Researchers will measure slee…

This study looks at whether adding acceptance and commitment therapy (ACT) and a care management app can help people who are already taking buprenorphine for opioid use disorder and also have chronic pain. About 123 adults will be assigned to different groups to see if these tool…

This early-stage study tests whether cannabis can reduce withdrawal symptoms in people with opioid use disorder who are not currently seeking treatment. Researchers will measure how cannabis affects withdrawal severity, drug liking, and breathing. The goal is to see if cannabis c…

This study tests whether a non-invasive device that stimulates the vagus nerve can reduce withdrawal symptoms in people with opioid use disorder. About 103 participants will stay in the hospital for one week, receive the stimulation or a sham, and complete surveys and brain scans…

This early study tests whether low intensity focused ultrasound (LIFU) can safely help treat opioid and other substance use disorders. About 29 adults aged 18-60 who are already in outpatient treatment will receive the ultrasound procedure. The main goal is to check for side effe…

This study tests whether addressing loneliness can help people with opioid use disorder. 300 participants will be assigned to one of three groups and attend 6 weekly sessions. The goal is to see if reducing loneliness also reduces opioid use.

This study is testing whether low doses of ketamine can reduce cravings and withdrawal symptoms like depression and poor sleep in adults with opioid use disorder who are starting methadone treatment. About 50 participants will receive either a low or very low dose of ketamine fou…

This study tests a short, tailored alcohol intervention for 60 adults who are taking buprenorphine for opioid use and also drink alcohol. The program aims to reduce drinking and improve treatment satisfaction. Researchers will check if the approach is practical and liked by parti…

This study explores whether MDMA-assisted therapy can help new mothers who struggle with both post-traumatic stress disorder (PTSD) and opioid use disorder. Fifteen participants will receive the therapy 6 to 12 months after childbirth. The goal is to see if it is safe and helpful…

This early-stage study tests whether adding lacosamide, a seizure medication, to standard opioid therapy is safe and tolerable for people with long-term abdominal pain from chronic pancreatitis. About 24 adults will take the drug for 7 days and be monitored for side effects and p…

This study tests a group therapy program done over Zoom for adults who have both chronic pain and opioid use disorder. The therapy focuses on helping people understand and express their emotions to reduce pain, disability, and related problems like depression and anxiety. About 3…

This study looks at whether taking methadone once or twice a day is better for managing both chronic pain and opioid use disorder. About 150 adults currently on methadone will be randomly assigned to one of two dosing schedules. Researchers will track changes in pain levels and p…

This early-stage study tests whether adding two doses of psilocybin (the active ingredient in magic mushrooms) to standard buprenorphine/naloxone treatment is safe for people with opioid use disorder. Ten adults on stable medication will be monitored for side effects, withdrawal …

This study tests a therapy called HOPE for people who have both opioid use disorder and PTSD. Participants must already be on medication for opioid use disorder, like suboxone or methadone. Over 10 to 12 weeks, they will attend therapy sessions and complete surveys to see if thei…

This study tests whether cannabidiol (CBD) is safe and can help reduce pain and opioid cravings in 34 adults who are already on medication (methadone or buprenorphine) for opioid use disorder and also have chronic pain. Participants will receive CBD or a placebo in random order o…

This study is adapting an existing texting chatbot, Penny, to better support pregnant and postpartum women who are dealing with opioid use disorder. The new chatbot, called Penny COPILOT, will send supportive texts and respond to messages to help reduce loneliness and keep women …

This study is creating and testing a smartphone app to help people with opioid use disorder sleep better. The app uses proven techniques like cognitive behavioral therapy for insomnia. Researchers will enroll 40 adults who are stable on buprenorphine and have poor sleep. The goal…

This study tests whether an experimental medicine called BI 1356225 can help people with opioid use disorder (addiction) control their impulses. About 60 adults aged 18-65 who are already taking buprenorphine will either receive the study drug or a placebo daily for 8 days. Resea…

This pilot study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. The goal is to see if the app is acceptable and helpful for adults who are in recovery from opioid use disorder and also have chronic pain. Ten participants will use the app and p…

This study tests whether buspirone, a medication used for anxiety, can help reduce withdrawal symptoms and cravings in people with opioid use disorder. About 100 adults will take buspirone or a placebo during a 10-12 day supervised detox. The goal is to see if buspirone makes the…

This study looks at how well a culturally tailored screening and brief intervention program works for chronic pain and opioid misuse in American Indian and Alaska Native communities. About 225 adults who receive care at three participating clinics and have chronic pain or opioid …

This study looks at whether having a trained peer recovery specialist in the emergency room helps people with substance use disorders connect to treatment and support. Researchers will follow 400 adults who visit the ER for substance-related issues, comparing those who work with …

This study looks at whether a patient navigation program called NavSTAR can help people with opioid use disorder start treatment after being in the hospital. Researchers will first test it with 32 people, then with 720 people across Philadelphia hospitals. The goal is to see if t…

This study looks at how past childhood experiences might affect memory and brain function in people with opioid use disorder. Researchers will compare three groups: people with opioid use disorder on buprenorphine, people without the disorder on buprenorphine, and healthy adults.…

This study looks at how opioid use disorder affects thinking skills like planning and decision-making. Researchers will use brain scans and computer models to find patterns that predict who might relapse or struggle with treatment. The goal is to better understand these links so …

This study looks at how people with opioid use disorder handle stress. Researchers will use tasks that test thinking and emotions to see if they match how resilient people say they are. The goal is to create a better way to measure resilience in this group.

This study looks at how different people with opioid use disorder experience withdrawal symptoms while tapering off medication. Researchers will measure withdrawal severity using a standard questionnaire. The goal is to better understand withdrawal patterns, not to test a new tre…

This study tests whether a telehealth platform can make opioid use disorder treatment more accessible for vulnerable populations. Researchers will enroll 250 people starting or restarting buprenorphine treatment and measure how acceptable, appropriate, and feasible the program is…

This study is developing and testing a simple decision aid to help people with opioid use disorder decide whether to start buprenorphine treatment in the emergency department. About 20 adults will try the tool and share their feedback. The goal is to see if the tool helps patient…

This study looks at how to help people with opioid use disorder stay in treatment longer. Staying on medications like methadone or buprenorphine improves outcomes, but many leave early. Researchers will compare two approaches—giving clinics quality measures and a toolkit, with or…

This study tests whether wearable devices like smartwatches can detect physical signs of opioid withdrawal and cravings. Twenty adults with opioid use disorder will wear sensors for 14 days. The goal is to see if body signals match reported symptoms, which could help improve moni…

This study is testing a mobile app designed to help people in recovery from both opioid and alcohol use disorders. Researchers want to see if the app is easy to use and acceptable to patients. The study involves 50 people enrolled in Michigan Medicaid who are already taking medic…

This study follows 100 pregnant women with opioid use disorder who are already receiving standard treatment. Researchers will track whether mothers relapse or if their babies develop withdrawal symptoms (NOWS). The goal is to find better ways to predict and prevent these outcomes…

This study looks at how psilocybin (a psychedelic drug) changes brain activity related to motivation and self-control in people with opioid use disorder. Twenty-four adults will receive either a low or high dose of psilocybin and have their brains scanned with fMRI before and aft…

This study looks at how a specific brain receptor (CB1) works in people with opioid use disorder compared to healthy volunteers. Researchers will use a special PET scan tracer to measure these receptors. The goal is to better understand the brain chemistry behind opioid addiction…

This study is creating a new tool to measure opioid cravings in people receiving treatment for opioid use disorder. Researchers will show participants opioid-related images and objects to trigger cravings, then interview them about their feelings and thoughts. The goal is to deve…

This study is creating a Canada-wide registry of people who come to emergency departments after an opioid overdose. Researchers will track what treatments patients receive and look for patterns to help predict who is at highest risk of dying within 60 days. The goal is to find th…

This study tests a new center in Seattle that offers short-term care (under 24 hours) for people who have had an opioid overdose. The center provides monitoring, medication to manage withdrawal, and connections to ongoing treatment. Researchers will compare outcomes like repeat o…

This study follows 20,000 adolescents aged 12-17 who receive opioid painkillers after major surgery. Researchers want to identify early warning signs that could lead to opioid use disorder within the first year. Participants complete surveys and allow access to their medical reco…

This study looks at 80 people starting buprenorphine to quit opioids. Researchers want to see if an MRI brain scan can predict who will stay off opioids, and if adding a type of magnetic brain stimulation (rTMS) helps more than a fake version. Participants get MRIs, 30 sessions o…

This study looks at why people taking medications for opioid use disorder often have trouble sleeping. Researchers will test special light-sensitive cells in the eye that help control sleep and body rhythms. The goal is to find new ways to improve sleep and reduce relapse. About …

This study looks at how social interactions and feelings of closeness affect treatment for opioid use disorder. Researchers will collect daily reports from 230 patients and their close friends or family members. The goal is to find patterns that could lead to more personalized tr…

This study uses PET brain scans to measure cannabinoid receptors in healthy volunteers and people with conditions like schizophrenia, cannabis dependence, PTSD, and opioid use disorder. The goal is to understand how these receptors differ across conditions and over time. Particip…

This pilot study is testing whether connecting people to recovery community centers (RCCs) can improve recovery outcomes for those taking medications for opioid use disorder (MOUD). Researchers will compare two groups: one that visits an RCC and one that does other recovery activ…

This study tests a computer tool designed to help emergency room doctors follow best practices for treating opioid use disorder with buprenorphine. Researchers will enroll 300 adults with moderate to severe opioid use disorder to see if the tool improves care. The goal is to make…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs change brain processing. Researchers use brain scans, computer tasks, and interviews to measure shifts in learning, perception, and electrical activity. The goal is to predict…

This study looks at whether a 12-session parenting program can change brain activity in mothers recovering from opioid use disorder. Researchers will use EEG to measure brain responses to baby faces and cries before and after the program. The goal is to see if supporting the moth…

This study looks at how stress changes the way opioid painkillers work in people with long-term back pain. Researchers want to understand if high stress levels make it more likely for someone to misuse their pain medication. About 120 adults with daily back pain will take part in…

This study tests whether a telemedicine program is practical and well-received for treating substance use disorders in people living with HIV in Alabama. About 30 participants who misuse opioids or stimulants will receive care via video or phone. The main goal is to see if they a…

This study follows 600 pregnant women who are taking buprenorphine for opioid use disorder. Researchers want to learn which genetic and clinical factors lead to better treatment responses in mothers and lower risk of withdrawal in newborns. The goal is to improve care for both mo…