OPIOID USE DISORDER

This study tested whether offering hepatitis C treatment right at methadone clinics helps more people get cured than sending them to other clinics. Over 600 adults on opioid addiction therapy took part across 13 clinics in Ukraine. Some clinics provided on-site care with or witho…

This study tested a web-based program that combines cognitive behavioral therapy with pain self-management for 160 adults who have both opioid use disorder and chronic pain. Participants were already taking methadone or buprenorphine. The program aimed to improve treatment adhere…

This study tested a new way to treat people with opioid use disorder who also have severe infections from injecting drugs. Instead of staying in the hospital, patients received antibiotics at home along with medication for their addiction. The goal was to see if this combined app…

This study looked at whether adding lofexidine to the standard opioid treatment buprenorphine can reduce both PTSD symptoms and opioid relapse in veterans. 84 veterans on stable buprenorphine therapy were enrolled. The goal was to see if the combination is safer and more effectiv…

This study tested a smartphone app made just for women with opioid use disorder to help them stay on their medication treatment. 39 women who had recently started medication for opioid use disorder used the app along with their usual care. Researchers checked if women found the a…

This study tested different combinations of counseling, rewards, and text reminders to help people on methadone reduce methamphetamine use and improve HIV control. 667 participants from methadone clinics in Vietnam took part. The goal was to find the best approach to support long…

This study tested a new way to help people with opioid use disorder who use fentanyl. Participants received medically supervised IV fentanyl until they were comfortable, then switched to daily oral opioid medication. The goal was to see if this approach is safe and helps people s…

This study tested two short counseling programs to help people with opioid use disorder take their medication (buprenorphine-naloxone) as prescribed. 48 adults starting treatment were randomly assigned to one of two groups: one that used rewards for sticking to medication, and an…

This study tested a new medication called INDV-2000 in 300 adults with moderate to severe opioid use disorder who had recently started or completed withdrawal treatment. The goal was to see if INDV-2000 could help them stay opioid-free for 3 months without needing another opioid …

This study tested a group model of well child care for mothers in treatment for opioid use disorder and their infants. 49 mother-infant pairs were randomly assigned to either group or individual well child care and followed for 18 months. The goal was to see if group care improve…

This study tested whether cannabidiol (CBD) can reduce cravings and prevent relapse in people with opioid use disorder who are already taking standard medications like buprenorphine or methadone. 35 adults participated, taking either CBD or a placebo daily for 4 weeks while in re…

This study tested a telehealth platform designed to help people with opioid use disorder get connected to medication and reduce the risk of overdose. Researchers worked with 33 people who had already experienced at least one overdose. The goal was to see if the platform could hel…

This study looked at two different methods to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults who had been involved with the justice system in the last 6 months and had a history of opioi…

This small pilot study tested a program called PEERS, where people starting medication for opioid use disorder get regular sessions with a certified recovery specialist. The goal was to see if the program is practical and acceptable, not yet to prove it works. 13 adults from Penn…

This study looked at whether having a peer support specialist (a person with lived experience) can help people with opioid use disorder begin and continue taking buprenorphine, a medication that reduces cravings. Ninety adults from rural South Carolina joined the study and were c…

This early-stage study tested a small implant placed under the skin that slowly releases naltrexone, a medicine used to treat opioid use disorder. The implant stays in for 3 months and is then removed. The study involved 16 healthy adults to check safety and how much drug gets in…

This study tested a remote video monitoring system to help people with opioid use disorder take their methadone safely at home. Fifteen adults already on methadone treatment used a web-based platform to record each dose. The goal was to see if the system could track adherence and…

This study looked at whether adding mindfulness-based relapse prevention (MBRP) to standard medication-assisted treatment (MAT) helps people with opioid use disorder stick with their medication and avoid using opioids after leaving a residential treatment program. About 105 adult…

This study tested a collaborative care model for adults with opioid use disorder (OUD) and depression, anxiety, or PTSD. 567 participants received medication for OUD along with mental health support in primary care. The goal was to see if this team-based approach reduces opioid u…

This study tested whether a mobile health unit that offers addiction treatment, HIV care, and prevention in one place can help people who inject drugs get the care they need. 447 adults with opioid use disorder and recent injection drug use took part. The goal was to see if this …

This study tested whether a trained peer recovery specialist could help low-income, minority individuals stay on their methadone treatment for opioid use disorder. The approach used a brief behavioral activation program called Peer Activate, compared to usual care. 200 participan…

This study followed 480 adults with opioid use disorder who were taking SUBLOCADE, a long-acting medication to control cravings and withdrawal. Researchers watched participants for up to 4 years to see how their drug use, health, and daily life changed over time. The goal was to …

This study tested a program to help people in Chicago who recently had an overdose reversed by first responders start medication for opioid use disorder. 251 adults who were not already in treatment were randomly assigned to either the new program or usual care. The program provi…

This study tested whether a pharmacist-led program could help people leaving jail get medications for opioid use disorder and prevent overdoses. 267 participants received overdose training, Narcan, and counseling before release, with follow-up at 6 months. The goal was to see if …

This study tested a virtual reality (VR) program designed to help people in early recovery from opioid use disorder focus on their future and reduce drug use. 104 participants who had been abstinent for at least 14 days were split into a VR group and a control group. Researchers …

This pilot study tested whether a combination of brief therapy sessions and a mobile app can help pregnant and postpartum women with opioid use disorder stay on their buprenorphine medication. Fifteen women participated, attending therapy appointments and using the app. The goal …

This study tested whether a low dose of cariprazine (1.5 mg daily) can help people who are already stable on buprenorphine-naloxone for opioid use disorder also reduce or stop cocaine use. About 26 adults with both opioid and cocaine use disorders took either cariprazine or a pla…

This study tested a pop-up clinic inside a van to help women who inject drugs and exchange sex get HIV prevention medicine (PrEP), treatment for opioid use disorder, and quick testing for sexually transmitted infections. Fifty women took part in Seattle. The goal was to see if th…

This study tested an online parenting program called Family Check-Up Online for rural families where a parent may misuse opioids or other substances. About 356 parents of young children (18 months to 5 years) took part. The program aimed to improve parenting skills, reduce stress…

This early-phase study looked at whether adding a drug called AUVELITY (a mix of dextromethorphan and bupropion) to standard treatment with buprenorphine/naloxone is safe and might help reduce cravings, withdrawal, and negative feelings in people with opioid use disorder. 18 adul…

This study tested whether wearing a bright light device could improve sleep and reduce drug cravings in 23 adults receiving medication treatment for opioid use disorder. Participants used the light therapy alongside their usual care for several weeks. The goal was to see if this …

This study looked at whether a 12-week supervised aerobic exercise program can help mid-life adults with opioid use disorder feel less pain and move better. Only 6 people took part, so the main goal was to see if such a program is possible to run. The results will help design lar…

This early study tested whether palmitoylethanolamide (PEA), a natural molecule available as a supplement, can help people with opioid use disorder feel less stress, craving, and pain. Twelve adults already on stable medication (buprenorphine or methadone) took PEA or a placebo t…

This study tested whether CBD (a compound from cannabis) can help people use fewer opioids and feel less pain. 126 adults with opioid use disorder were given either CBD or a placebo for 12 weeks. The goal was to see if CBD could reduce pain, opioid use, and anxiety while improvin…

This small pilot study tested whether blocking a nerve cluster called the SPG can reduce withdrawal symptoms in people with opioid use disorder. Only 3 people took part, and the goal was to see if the approach is feasible and safe, not to provide treatment. The study did not invo…

This study looked at whether CBD (a cannabis compound) can lower craving and anxiety in people with opioid use disorder who are already on methadone. 66 adults received either CBD or a placebo, and brain scans were used to see how CBD affects brain activity. The goal was to under…

This pilot study looked at whether providing overnight infant care (respite) could help new mothers with substance use disorder get better sleep and feel better. 41 mothers living in residential treatment programs took part. The goal was to see if this approach is feasible and ac…

This study tested an online program called 'Empowered Relief' to see if it could help people with chronic pain who misuse prescription opioids. 234 adults took part, comparing the program to a general health education course. The goal was to reduce pain, opioid cravings, and misu…

This study looked at whether suvorexant, a sleep medication, can improve sleep and reduce stress in people recovering from opioid use disorder. About 138 adults on medication-assisted treatment (like methadone or buprenorphine) took either suvorexant or a placebo for 8 weeks. Res…

This study tested whether a mobile app could help reduce anxiety and depression in adults who are already receiving medication for opioid use disorder. 63 participants used the app or continued their usual care for 4 weeks. The goal was to see if the app was easy to use and could…

This pilot study tested whether adding exercise and pain-focused therapy to residential drug treatment is practical for adults with opioid use disorder and chronic pain. 63 participants were enrolled to see if they would stick with the program. The goal was to explore if this app…

This study tested whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) could reduce cravings and attention to drug-related cues in 23 adults with both opioid and tobacco use disorders who were stable on buprenorphine. Participants received four …

This study tested whether a walking program, combined with pain education, could help veterans with opioid use disorder and chronic pain. 60 veterans receiving medication for opioid addiction took part. The goal was to see if the program was acceptable and helpful for managing pa…

This study tested whether suvorexant, a sleep medication, can reduce drug use and cravings while improving sleep and stress in people being treated for both opioid and stimulant use disorders. Twenty adults already stable on methadone or buprenorphine took part. The goal was to s…

This study tested a new brain-training method to help people with heroin addiction reduce their cravings. 28 people in early treatment watched drug-related videos while getting real-time feedback on their brain activity, learning to match the brain patterns of people further alon…

This small study tested whether people with chronic pain and opioid problems would actually do art on their own at home, and if it helped their pain and mood. Thirty-one adults completed surveys before and after up to four art sessions. The results suggest that self-guided artmak…

This study tested whether a numbing medicine injected near the chest wall could reduce the need for strong painkillers after heart surgery. 340 adults having open-heart surgery through a breastbone incision took part. Half received the nerve block with a local anesthetic, and the…

This study tested a method called measurement-based care in opioid treatment programs. It involved 35 clinic leaders and providers who used patient surveys to guide treatment. The goal was to see if this approach could improve patient attendance and reduce opioid use. The study c…

This study looked at how opioid maintenance therapy affects sensation, balance, walking, posture, and reaction time in people with opioid use disorder. Researchers compared 80 adults on therapy with healthy individuals. The goal was to understand these physical effects, not to te…

This early-phase study looked at how brain glutamate levels change in people dependent on opioids who also use cocaine. Researchers tested whether the supplement N-acetylcysteine (NAC) could reduce cocaine and opioid demand during withdrawal. Twelve participants completed the stu…

This study tested a patient decision aid designed to help adults with opioid use disorder choose the right medication-assisted treatment. Over 7,500 participants from California took part, and researchers tracked their drug use, treatment retention, and health outcomes for up to …

This study tested a computer program that helps primary care doctors identify and treat patients with opioid use disorder. Over 10,000 adults from 30 clinics took part. The tool gave personalized treatment suggestions based on each patient's health records. The goal was to see if…

This study looked at whether listening to music can lower cravings for opioids when people see drug-related images. Twenty-eight adults on stable medication for opioid use disorder took part. Researchers compared cravings before and after exposure to music versus silence to see i…

This study tested whether a team-based care model (Collaborative Care) can effectively treat both opioid use disorder and mental health conditions like depression or anxiety in primary care clinics. 254 adults with opioid use disorder and a mental health condition took part. The …

This study tested a program to help women recently involved with the criminal justice system get and stay in opioid addiction treatment. The program included peer support, housing help, overdose training, and childcare. Researchers wanted to see if offering these services togethe…

This study looked at how pain affects opioid cravings in 89 adults with opioid use disorder and chronic pain. Participants attended a brief education session and then had their pain response measured. Researchers wanted to see if there is a link between how people react to pain a…

This study followed 12 adults with opioid use disorder who had been stable on SUBLOCADE for at least 9 months and decided with their doctor to stop treatment. Researchers tracked whether participants could successfully taper off without relapsing or needing to restart long-term m…

This study looked at how the body processes buprenorphine, a medication used to treat opioid use disorder, when given by mouth in low doses. Healthy adults with past opioid use received single doses of buprenorphine in different forms, and blood samples were taken to measure drug…

This study tested a program that brings in family and friends to support people receiving methadone treatment for opioid addiction in Tanzania. The goal was to see if this social support approach is acceptable and practical. About 20 people on methadone and up to 60 of their supp…

This study tested different methods to help emergency room doctors start medication (buprenorphine) for patients with opioid use disorder. Over 1,100 patients took part. Researchers compared tools like nurse prompts and patient resources to see which best increased treatment rate…

This study looked at whether training staff with computer simulations (called participatory system dynamics) helps more veterans start and finish effective treatments for PTSD, depression, and opioid use disorder. About 720 staff from 24 VA health systems took part. The goal was …

This study looked at whether people who inject opioids can safely complete their IV antibiotic treatment at home instead of in a hospital or nursing facility. Ten participants received medications for opioid use disorder (like Suboxone or methadone) along with social support such…

This study looked at how opioid use and withdrawal change the way people make decisions. Twelve adults with opioid use disorder played a gambling task while their brains were scanned. The goal was to understand the brain processes behind poor choices and to find a safe dose of a …

This study looked at the best ways to offer FDA-approved digital treatments (reSET and reSET-O) for substance use disorders in primary care clinics. Over 18,000 adults who screened positive for drug or alcohol problems took part. Researchers tested whether health coaching or prac…

This study tested whether training and coaching could help addiction treatment clinics better use medications for opioid use disorder and keep patients in care longer. Nearly 8,000 patients from clinics in New York took part. Researchers developed tools and protocols to guide qua…

This study looks at a program called NavSTAR, which helps people with opioid use disorder start treatment after leaving the hospital. The program is designed to reduce barriers that often prevent racial minorities from getting care. Researchers will first test it with 32 patients…

This study looked at how hospital staff across 12 Colorado hospitals treat patients with opioid use disorder. Researchers surveyed 400 doctors, nurses, and social workers to understand current practices and improve care. The goal was to increase prescribing of medications like bu…

This study tested a web-based toolkit to help jails provide better care for pregnant people with opioid use disorder. Jail staff used the toolkit and shared their experiences through surveys and interviews. The goal was to learn what support jails need to offer pregnancy-specific…

This study looked at how vitamin D (calcitriol) affects dopamine receptors in the brains of people with opioid use disorder. Researchers used PET scans to measure brain activity in 5 participants. The goal was to understand the brain changes linked to opioid use, not to test a tr…