OPIOID USE DISORDER

This study tested whether offering hepatitis C (HCV) treatment right at methadone clinics helps more people get cured compared to sending them to outside specialists. Over 600 adults on opioid addiction therapy took part across 13 clinics in Ukraine. Some clinics provided simplif…

This study tests a small ear device that gently stimulates nerves to see if it helps people with both PTSD and opioid use disorder stay on buprenorphine therapy. Twenty participants will use either the active device or a placebo for 12 weeks. Researchers will check if they keep t…

This completed trial tested a new approach for opioid use disorder: shining a specific type of near-infrared light on the scalp for just 4 minutes. The idea is to stimulate a healthier side of the brain to reduce addiction. Researchers compared the active light treatment to a sha…

This phase 2 trial tested whether cannabidiol (CBD) can reduce craving and anxiety in 76 adults with opioid use disorder who were already on opioid agonist therapy (like methadone). Participants took CBD or a placebo twice daily for 4 weeks, then all took a higher dose of CBD for…

This study tested whether a mobile health unit that offers HIV prevention, treatment, and medication for opioid use disorder all in one place helps people who inject drugs stay on treatment. About 447 adults with opioid use disorder took part. The goal was to see if this approach…

This trial tests whether a team-based approach, including a dedicated nurse care manager, can help primary care clinics provide medication treatment for opioid use disorder. The study involves 12 clinics across five U.S. states, with half using the new approach and half continuin…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This pilot study looked at whether giving e-cigarettes to adults aged 50 and older who are in treatment for opioid use disorder could help them cut down on smoking. The 36 participants were not trying to quit smoking at the start. Researchers measured how many people switched to …

This study looked at different ways to help people with opioid use disorder start treatment. It compared usual care, patient navigation (help from a guide), and patient navigation plus starting buprenorphine right away. The goal was to see which approach gets more people into tre…

This study looked at whether giving a special research e-cigarette to people who are stable on medication for opioid use disorder and smoke daily could help them smoke fewer regular cigarettes. 41 adults who weren't ready to quit smoking were randomly assigned to get the e-cigare…

This study tested whether offering medication for opioid use disorder (MOUD) via telehealth to women in jail helps them start treatment after release. 900 women across 9 Kentucky jails took part. Some also got a peer navigator for support. The goal was to see if these services in…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This early-phase study tested whether adding a medication called Auvelity (a combination of dextromethorphan and bupropion) to standard buprenorphine treatment is safe and might help reduce cravings, withdrawal, and negative feelings in people with opioid use disorder. 18 adults …

This early-stage study tested a new implant that slowly releases naltrexone, a medication used to treat opioid use disorder. The implant is placed under the skin and left for three months. The trial involved 16 healthy adults to check safety and how the drug enters the bloodstrea…

This study tested whether people with opioid use disorder and severe injection-related infections can be safely treated at home with antibiotics and buprenorphine (a medication for opioid use disorder). 71 participants were enrolled. The goal was to see if this integrated approac…

This study tested whether cannabidiol (CBD) can reduce cravings and prevent relapse in people with opioid use disorder who are already taking standard medications like buprenorphine or methadone. Thirty-five participants received either CBD or a placebo for 28 days while in resid…

This study tested a smartphone app designed specifically for women to help them stay engaged with their medication for opioid use disorder. 39 women who had recently started medication treatment were randomly assigned to use the app plus standard care, or standard care alone. Res…

This study tested a comprehensive program to help women involved in the criminal justice system start and stay in opioid addiction treatment. The program included peer support, housing help, overdose training, and transportation or childcare. Half of the 42 women also joined a tr…

This study tested whether a pharmacist-led program could help people leaving jail get treatment for opioid use disorder and prevent overdoses. Participants received overdose training, Narcan nasal spray, counseling, and referrals to medication treatment after release. The goal wa…

This study tested a collaborative care model for people with opioid use disorder and depression, anxiety, or PTSD. 567 adults received medication (buprenorphine-naloxone or naltrexone) along with therapy and support from a primary care team. The goal was to reduce opioid use and …

This study tested whether adding mindfulness-based relapse prevention (MBRP) to standard care helps people with opioid use disorder stay on their medication (extended-release naltrexone) and avoid drug use after leaving a residential treatment program. About 105 participants were…

This early-stage study tested whether a brief therapy program plus a mobile app could help pregnant and postpartum women stay on their buprenorphine medication for opioid use disorder. Fifteen pregnant women took part, attending therapy sessions and using the app for up to 9 mont…

This study tested a program called RIMO that helps people who recently survived an opioid overdose get into medication-assisted treatment (MAT). The program uses motivational interviewing and support to encourage people to start and stay on MAT. Researchers worked with first resp…

This completed Phase 4 trial tested a new way to start oral opioid addiction therapy for people who use fentanyl. Participants received medically supervised IV fentanyl until comfortable, then were given tailored doses of methadone or slow-release oral morphine. The study enrolle…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce methamphetamine use in people already receiving methadone maintenance therapy. Fifty-five adults with both opioid and methamphetamine use dis…

This pilot study tested a program where trained peer recovery specialists meet regularly with patients starting medication for opioid use disorder. The goal was to see if the program is practical and acceptable to patients. 13 adults took part, and the results will help design a …

This study looked at whether adding computer-based cognitive behavioral therapy (CBT4CBT) and peer recovery coaching to standard buprenorphine treatment helps reduce illicit drug use. 92 adults with opioid use disorder were randomly assigned to receive buprenorphine alone, bupren…

This study tested different combinations of counseling, rewards, and text reminders to help people on methadone therapy reduce methamphetamine use and improve HIV outcomes. 667 participants from methadone clinics in Vietnam took part. The goal was to find the best approach to sup…

This study tested whether a low dose of cariprazine, a medication used for bipolar disorder, could help people with both opioid and cocaine use disorders reduce cocaine use. Participants were already stable on buprenorphine-naloxone for opioid use. The trial lasted about 11 weeks…

This study tested a remote video monitoring system to help people with opioid use disorder safely take their methadone at home. Fifteen adults already on methadone treatment used a smartphone or computer camera to record each dose. The goal was to see if this method could track a…

This study tested a new drug called INDV-2000 in 300 adults with moderate to severe opioid use disorder who wanted to stop using opioids. Participants were randomly assigned to receive different doses of INDV-2000 or a placebo for 3 months. The main goal was to see if the drug co…

This pilot study tested two behavioral programs to help people with opioid use disorder take their medication as prescribed. One group could win gift cards when their urine tests showed they were taking their medicine. The other group had one-on-one sessions to set goals, find fu…

This study tested whether delivering pre-made meals to the homes of people in treatment for opioid use disorder could help with food insecurity. Fifty adults were split into two groups: one got nutrition education and community resources, while the other also received weekly meal…

This study tested whether training people on methadone to become peer educators could help their friends who inject drugs and have HIV get into treatment. The peer educators talked to their social network members about medication for drug dependence and accompanied them to the cl…

This study tested whether a trained peer recovery specialist could help low-income, minority individuals stick with their methadone treatment for opioid use disorder. 200 participants in Baltimore were assigned to either the peer-led support program or standard care. The goal was…

This study looked at whether peer support specialists (recovery coaches) can help people with opioid use disorder begin and continue buprenorphine treatment. 90 adults from rural South Carolina mobile health clinics took part. Researchers compared their treatment progress to past…

This completed study followed 480 adults with opioid use disorder who were already taking SUBLOCADE, a long-acting buprenorphine injection. Researchers observed participants for up to 4 years to see if they achieved remission, reduced opioid misuse, and improved their physical, m…

This pilot study tested a telehealth platform designed to encourage people with opioid use disorder to start and stay on medication treatment. 33 participants with a history of opioid overdose used the platform, which included chat-based support. The study measured whether they a…

This study tested whether a team-based care model can help people with both opioid use disorder and mental health issues like depression or anxiety. 254 adults in primary care received either full collaborative care for both conditions or just mental health support. The goal was …

This study tested a pop-up clinic inside a van for women who inject drugs and exchange sex in north Seattle. The goal was to see if offering HIV prevention pills, addiction medications, and quick STI testing in a convenient location would help more women start and stay on these t…

This study tested an online parenting program called Family Check-Up Online for rural families where a parent may misuse opioids. 356 parents of young children (18 months to 5 years) took part. The program aimed to improve parenting skills, reduce stress and depression, and preve…

This pilot study tested whether an 8-week group therapy program delivered over Zoom could help adults with both chronic pain and opioid use disorder. The therapy, called Emotional Awareness and Expression Therapy (EAET), teaches people to understand and express their emotions as …

This study looked at whether adding a type of talk therapy called prolonged exposure therapy (PET) to standard opioid addiction treatment can help reduce PTSD symptoms. 82 adults with both opioid use disorder and PTSD took part. Some got only addiction treatment, while others als…

This early-phase study tested whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) could reduce withdrawal symptoms in 25 adults with opioid use disorder who were gradually reducing their methadone dose. Participants received either real HBOT at two …

This study tested a new medicine called BXCL501 to see if it can safely reduce the unpleasant symptoms people feel when they stop taking opioids. 225 adults with opioid use disorder took part. The medicine was given as a film under the tongue, and researchers measured withdrawal …

This study tested a telephone helpline designed to support people with opioid dependence. The helpline offered education, coping strategies, and referrals to medication-assisted treatment. Researchers enrolled 31 participants and measured satisfaction with the service. The goal w…

This study tested whether a heart rate variability biofeedback program—using a sensor and smartphone app to guide slow breathing—is practical and helpful for adults in residential treatment for opioid use disorder. Thirty-two participants practiced daily for three weeks. Research…

This study looked at whether adding lofexidine to standard buprenorphine treatment can improve symptoms of both PTSD and opioid use disorder in veterans. 84 veterans on stable buprenorphine therapy were enrolled. The goal was to see if the combination reduced opioid use and PTSD …

This study tested a web-based program that combines cognitive behavioral therapy and pain self-management for people being treated for opioid use disorder who also have chronic pain. The program includes online lessons and daily text surveys to track pain and activity. Researcher…

This pilot study tested whether wearing bright light therapy glasses can improve sleep and reduce cravings in people being treated for opioid use disorder. Twenty-three adults on stable medication-assisted treatment (methadone or buprenorphine) with insomnia used either active or…

This pilot study tested whether adding exercise and pain-focused therapy to residential drug treatment is practical and helpful. 63 adults with opioid use disorder and pain took part. The goal was to see if they would stick with the program and if it could reduce pain, cravings, …

This study looked at whether listening to music can help lower cravings for opioids when people see drug-related cues. Twenty-eight adults with opioid use disorder, all on stable medication treatment, either listened to their favorite relaxing songs or sat in silence. Researchers…

This study tested whether a nerve block placed near the breastbone after heart surgery can reduce the need for opioid painkillers. 340 adults having heart surgery through a standard chest incision were randomly assigned to receive either the numbing drug ropivacaine or a saltwate…

This study looked at whether people with chronic pain and opioid use disorder would do art on their own at home, and if it helped their pain and mood. 31 adults tried self-directed artmaking up to four times. Researchers measured how many people stuck with it and whether anxiety,…

This study tested whether peer-led therapy sessions could ease depression and anxiety in people recovering from opioid use disorder in rural areas. Forty adults receiving medication for opioid use disorder took part, with some getting extra support from a certified peer specialis…

This study tested a walking program for veterans with opioid use disorder and chronic pain. Sixty veterans receiving medication for opioid addiction took part. The program included pain education and a step-by-step walking plan using a pedometer. The goal was to see if this appro…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This study tested whether a virtual reality experience where people see an avatar of their future self could help those in early recovery from opioid use disorder reduce drug use and stay abstinent. 104 participants were split into a VR group and a control group. Researchers meas…

This study tested whether suvorexant, a sleep medication, can reduce drug use and cravings while improving sleep and stress in people being treated for both opioid and stimulant use disorders. Twenty adults stable on methadone or buprenorphine took either suvorexant or a placebo …

This study tested a digital program called 'Empowered Relief: On-Demand' to see if it could help people with chronic pain who misuse prescription opioids. 234 adults with chronic pain and opioid misuse were randomly assigned to either the digital pain relief program or a health e…

This study tested whether CBD (a compound from cannabis) can help people who want to reduce their pain and opioid use. 126 adults took either CBD or a placebo for 12 weeks. Researchers measured changes in pain, opioid use, and other factors like anxiety and sleep.

This study looked at whether a sleep medication called suvorexant can improve sleep and reduce stress in people recovering from opioid addiction. About 138 participants on medications like methadone or buprenorphine were given either suvorexant or a placebo for 8 weeks. The goal …

This study tested a smartphone app designed to reduce anxiety and depression in people already receiving medication for opioid use disorder. 63 adults were randomly assigned to use the app for four weeks or to continue their usual care. The goal was to see if the app was feasible…

This study tested whether blocking a nerve cluster called the SPG can reduce withdrawal symptoms in people with opioid use disorder. Only 3 people took part, and the goal was to see if the approach is safe and worth studying further. It did not provide addiction treatment or medi…

This study looked at how cannabidiol (CBD) affects the brain in people with opioid use disorder who are also taking methadone. Researchers used brain scans to see if CBD could reduce cravings and anxiety. The study involved 66 adults and tested a single dose of CBD or a placebo, …

This study tested whether a type of brain stimulation called theta burst stimulation (TBS) could reduce cravings and attention to drug-related cues in 23 people with both opioid and tobacco use disorders. Participants received four sessions of real or fake TBS in one day while th…

This small, early-stage study tested whether a dietary supplement called palmitoylethanolamide (PEA) could help people with opioid use disorder feel less stress, craving, and pain. Twelve adults already on stable medication for opioid use took PEA or a placebo for three weeks. Th…

This small pilot study tested whether a 12-week supervised walking program could help middle-aged adults with opioid use disorder reduce pain and improve mobility. Only 6 people took part, and the main goal was to see if such a program was feasible—whether people would join and s…

This study tested a program designed to make medication for opioid use disorder more culturally appropriate for American Indian and Alaska Native communities. Researchers worked with four healthcare sites to help them better support patients starting and staying on these medicati…

This completed study looked at how genes influence addiction and related behaviors. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, drug users, and people with psychiatric disorders) complete questionnaires and computer tasks. The goal was to …

This study tested a training program for prenatal healthcare providers to help them use medication-assisted treatment (MAT) for opioid use disorder during pregnancy. Researchers looked at data from over 1,000 patients to see if the program increased use of MAT and improved health…

This study tested a computer tool designed to help emergency room doctors follow best practices for treating opioid use disorder. Researchers looked at whether the tool increased the use of standard assessments and buprenorphine treatment. The study involved 267 adults with moder…

This study looked at brain activity in pregnant women with opioid use disorder who were taking medication therapy. Researchers compared their brain scans to those of healthy pregnant women to see if there were differences. The goal was to learn more about how the body processes t…

This study looked at whether changes in a person's voice can help detect opioid use in people being treated for opioid use disorder. Researchers collected voice samples from 41 patients and used machine learning to find patterns linked to opioid intoxication or withdrawal. The go…

This study looked at how opioid maintenance therapy affects sensation, balance, walking, posture, and reaction time in people with opioid use disorder. Researchers compared 80 adults on buprenorphine/naloxone therapy to healthy individuals. They measured things like foot sensatio…

This study tested whether a training program called Modeling to Learn (MTL) helps clinic staff improve how many veterans start and finish evidence-based treatments for PTSD, depression, and opioid use disorder. The program uses computer simulations to let staff try out changes to…

This study looked at how the supplement n-acetylcysteine (NAC) affects brain glutamate levels and drug cravings in 12 people who use both opioids and cocaine. Participants were given either NAC or a placebo while on a steady dose of hydromorphone, and then underwent brain scans a…

This study looked at how hospital doctors, nurses, and social workers feel about treating opioid use disorder (OUD) while patients are in the hospital. Researchers surveyed 400 healthcare workers across 12 hospitals in Colorado. The goal was to understand current practices and se…

This study looked at whether using regular patient surveys to guide treatment can help people with opioid use disorder stay in treatment and stop using opioids. Researchers worked with 35 clinic leaders and providers to train them on this approach. They compared patient attendanc…

This study tested a group well child care program for mothers in treatment for opioid use disorder and their infants. Instead of standard one-on-one checkups, mother-infant pairs attended group visits together from 1 to 18 months of age. The goal was to see if this approach impro…

This study tested a digital version of a family training program called CRAFT. It was designed to help concerned family members (called CSOs) encourage a loved one with opioid use disorder to enter treatment. 45 adults who had a loved one struggling with opioid use participated. …

This study looked at how pain influences opioid cravings in 89 adults with opioid use disorder and chronic pain. Participants attended a brief education session and then had their pain response and cravings measured. The goal was to better understand the connection between pain a…

This study looked at the best ways to bring FDA-approved digital treatments (reSET and reSET-O) for opioid and other substance use disorders into primary care clinics. Over 18,000 adults who screened positive for substance use took part. Researchers tested whether health coaching…

This study tested a web-based toolkit called MOM CARE designed to help jail staff provide better care for pregnant people with opioid use disorder. The toolkit includes medical guidance and best practices from intake to release. Researchers worked with 22 jail staff members to se…

This completed study tested different strategies to help emergency doctors start buprenorphine treatment for people with opioid use disorder. Researchers used a computer system to prompt nurses and doctors, and gave patients educational materials. The goal was to see which combin…

This completed study looked at 12 people with opioid use disorder who had been stable on SUBLOCADE injections for at least 9 months. Researchers wanted to see if they could successfully stop the medication without relapsing or restarting long-term treatment. The goal was to under…

This study tested a new brain-training method to help people with heroin addiction reduce cravings. Participants watched drug-related videos while getting real-time feedback on their brain activity, learning to match the brain patterns of people further along in recovery. The goa…

This study looked at whether people who inject opioids can safely finish a course of IV antibiotics at home instead of staying in the hospital. Ten participants received home antibiotic therapy along with addiction medication and support from a health coach and case manager. The …

This study tested a patient decision aid designed to help adults with opioid use disorder choose the best medication-assisted treatment for them. Over 7,500 people took part, and researchers tracked their drug use, treatment retention, and health outcomes for up to 24 months. The…

This completed Phase 1 study at Yale University looked at how vitamin D (calcitriol) affects dopamine receptors in the brains of people with opioid use disorder. Five participants received either vitamin D or a placebo and had PET scans to measure brain activity. The goal was to …

This study tested a coaching and training program for addiction clinics to help them better treat opioid use disorder. The program included training on tracking patient progress, using medications for opioid use disorder, and improving patient retention. Researchers worked with n…

This completed early-phase study looked at how opioid use disorder changes the way people make decisions. Twelve adults with moderate to severe opioid use disorder completed gambling tasks and had brain scans while receiving oxycodone, placebo, or remifentanil. The goal was to un…

This completed Phase 1 study tested how the body processes different doses of oral buprenorphine compared to an intravenous dose. Eighteen healthy adults with past opioid use received three different doses in separate visits. Researchers measured drug levels in the blood over 24 …

This study tested whether combining a policy change with professional training can reduce stigma toward substance use in mental health clinics. Twelve providers from two sites participated. The goal was to see if the combined approach improves how often substance use is addressed…

This study tested a program that brings in family and friends to support people receiving methadone treatment for opioid use disorder in Tanzania. The goal was to see if this social support approach is acceptable and practical, and whether it helps people stick to their methadone…

This study tested a computer tool called the Opioid Wizard that helps primary care doctors identify and treat patients with opioid use disorder. Over 10,000 patients from 30 clinics participated. The tool works within the electronic health record to provide tailored treatment rec…

This study looks at whether a patient navigation program can help more people with opioid use disorder start treatment after being in the hospital. The program, called NavSTAR, was tested in 4 Philadelphia hospitals with 32 patients. The goal is to learn how to make this program …