OPIOID USE DISORDER

This small pilot study tested two different counseling approaches to help people with opioid addiction stick with their medication treatment. 48 patients starting treatment were randomly assigned to either receive gift card rewards for taking their medication or participate in mi…

This study tested a counseling program that involves the family and friends of people receiving treatment for opioid addiction and HIV in Tanzania. The goal was to see if this social support approach is practical and acceptable for helping patients stay in their methadone treatme…

This study tested a patient navigation program called NavSTAR, which helps people with opioid addiction start treatment after leaving the hospital. The program uses trained navigators to guide patients through the complex healthcare system to access medication treatment. The rese…

This study tested a flexible support program for people in Vietnam who are receiving methadone for opioid addiction but also use methamphetamine. The goal was to help them reduce meth use and, for those with HIV, improve their health outcomes. Researchers compared different combi…

This study tested whether two types of CBD (one with a tiny amount of THC, one without) could help people reduce their opioid use and manage pain. 126 adults with opioid use disorder were randomly assigned to take either CBD or a placebo pill daily for 12 weeks. Researchers measu…

This study tested a computer tool built into electronic health records to help primary care doctors better identify and treat patients with opioid use disorder. Over 10,000 patients across 30 clinics were involved to see if the tool improved how often addiction was diagnosed and …

This study tested whether a special smartphone app designed for women could help them stick with their medication treatment for opioid addiction. About 40 women who had recently started treatment were randomly assigned to either use the app along with their usual care or to recei…

This study explored whether people who inject opioids can safely complete a course of intravenous (IV) antibiotics at home. It tested a program that provides extra support, including addiction medication, health coaching, and case management, to help participants finish their tre…

This early-stage study tested whether a special virtual reality (VR) program could help people in early recovery from opioid use disorder. The VR experience was designed to help participants think more positively about their future, with the goal of reducing opioid use and increa…

This small, early-stage study tested whether a dietary supplement called PEA could help people with opioid addiction. The goal was to see if PEA could reduce stress, cravings, and pain sensitivity, which often lead to relapse. Twelve participants on stable medication treatment re…

This small pilot study tested whether adding exercise and pain-focused talk therapy to standard residential drug treatment is practical and helpful for adults with opioid addiction and chronic pain. Researchers wanted to see if participants could stick with the program and if it …

This study observed 12 people with opioid use disorder who had been stable on long-term medication treatment for at least 9 months. Researchers wanted to see how well they could stop treatment without relapsing into opioid use or experiencing severe withdrawal. The study followed…

This study tested whether adding peer recovery coaches to mobile health clinics helps people with opioid addiction start and stay on medication treatment. Researchers worked with 90 patients in rural South Carolina, comparing them to previous patients who didn't have coach suppor…

This study tested whether a new medicine called INDV-2000 could help people with moderate-to-severe opioid addiction stay off opioids. For 3 months, 300 participants who were starting treatment either received the new medicine or a placebo (dummy pill), while researchers tracked …

This study tested a computer tool designed to help emergency room doctors follow best practices for treating opioid addiction. The tool guides doctors through diagnosing addiction, checking withdrawal symptoms, and starting a medication called buprenorphine. The goal is to see if…

This study followed 480 adults with opioid addiction for up to 4 years to see how well SUBLOCADE injections work in real-world settings. Researchers tracked whether participants stopped using opioids, improved their symptoms, and maintained recovery over time. The goal was to und…

This small pilot study tested whether a special telehealth platform could help people with serious opioid addiction get to their first treatment appointment. The program was designed for people who had survived at least one overdose. Researchers checked if using the platform made…

This study tested whether a team-based care model in primary care clinics could effectively treat both opioid addiction and mental health conditions at the same time. It compared clinics that added addiction medication to their mental health care against clinics that only provide…

This study tested whether people with heroin addiction could learn to control their brain activity patterns to reduce drug cravings. Researchers used real-time MRI scans to show participants how similar their brain activity was to people further along in recovery. The goal was to…

This study tested whether coaching addiction treatment clinics could help more patients start and stay on medications for opioid use disorder and remain in care longer. Researchers worked with 30 clinics in New York, providing training on data-driven management and patient-center…

This study tested a support program for people in Chicago who had just survived an opioid overdose. Researchers compared a simple referral to addiction treatment against a more active support program called RIMO. The goal was to see if the RIMO program helped people start treatme…

This small, early-stage study tested whether adding a low dose of the medication cariprazine to standard buprenorphine treatment could help people with both opioid and cocaine addiction use less cocaine. About 26 participants who were already stable on buprenorphine and not using…

This study tested whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) could help people with both opioid and tobacco addictions. Researchers compared real TBS to a fake (sham) treatment to see if it reduced cravings and made people pay less att…

This study tested whether a prescription sleep medication called suvorexant could help people who are addicted to both opioids and stimulants like cocaine. Twenty participants who were already receiving standard treatment for opioid addiction were randomly given either the sleep …

This study tested a new video monitoring system for people taking methadone at home to treat opioid addiction. The goal was to see if this remote method could make treatment safer by ensuring the medication is taken correctly and not misused, while also making it more convenient …

This study tested whether a mobile health clinic could help people who inject drugs get better access to addiction treatment and HIV care. 447 adults with opioid use disorder were assigned to either receive services from the mobile clinic or get help navigating to existing commun…

This study tested a decision-making tool designed to help adults with opioid addiction understand their treatment options and stay engaged in care. Over 7,500 participants in California used the tool, and researchers tracked their progress for up to two years, looking at drug use…

This study tested whether counseling sessions led by trained peers (people with their own recovery experience) could help low-income minority patients in Baltimore stay on their prescribed medication for opioid addiction. The program focused on building positive daily routines an…

This small pilot study tested whether a new peer support program could help people stay in medication treatment for opioid addiction. Thirteen adults starting treatment met regularly with a trained recovery coach for six months. The main goal was to see if the program was practic…

This study tested a mobile pop-up clinic in Seattle to provide healthcare to women who inject drugs and exchange sex. The van offered HIV prevention medication (PrEP), treatment for opioid addiction, and rapid testing for sexually transmitted infections. Researchers wanted to see…

This study tested an online parenting program for rural parents who misuse opioids or other substances. It aimed to improve parenting skills, reduce stress, and help prevent future substance use problems in both parents and their young children. Researchers compared the online pr…

This study tested whether a prescription sleep aid (suvorexant) could improve sleep and reduce daily stress for people in early recovery from opioid addiction. Participants were already receiving standard medication-assisted treatment (like methadone or buprenorphine) and reporte…

This study tested whether a local anesthetic block, given through small tubes near the breastbone, could reduce the need for strong opioid painkillers after open-heart surgery. Researchers compared the anesthetic to a saltwater placebo in 340 patients. The main goal was to see if…

This study tested a smartphone app designed to help people who are receiving medication for opioid addiction. The goal was to see if using the app could reduce their anxiety, depression, and drug cravings. 63 adults used the app for four weeks while researchers checked if it was …

This small pilot study tested if numbing a specific nerve bundle in the nose (called an SPG block) could reduce the symptoms of opioid withdrawal. The goal was to see if this could help people get through withdrawal, which is a major barrier to starting proven addiction medicatio…

This small, completed study explored whether listening to music could help reduce cravings for opioids. Researchers worked with 28 adults who have opioid addiction and are in stable treatment. Participants were shown drug-related images, and those who listened to music they chose…

This small study explored whether a supervised 12-week exercise program could help adults being treated for opioid use disorder. It aimed to see if regular aerobic exercise could reduce their pain and improve their ability to move. The main goal was to test if this type of progra…

This small, completed study explored whether people with chronic pain and opioid use disorder would use simple, self-guided art kits at home. Researchers gave 31 participants kits for activities like mandala painting and weaving to see if the practice could provide temporary reli…

This study tested an online program called 'Empowered Relief' designed to help people who have chronic pain and misuse prescription opioids. Researchers compared the skills-based program to a general health education course to see which was better at reducing pain and opioid crav…

This study tested whether providing overnight infant care helps new mothers who are in treatment for substance use disorders. For six weeks, about 20-25 mothers received help caring for their babies for three nights a week so they could get more rest. Researchers wanted to see if…

This study tested whether a simple, 4-week program combining pain education with a pedometer-guided walking plan could help veterans manage chronic pain while they are also receiving treatment for opioid addiction. The goal was to see if this approach was practical and acceptable…

This small, completed study aimed to understand how opioid addiction and withdrawal affect a person's ability to make decisions. Researchers used brain scans (MRI) and computer gambling tasks to see how the brain works during these choices in 12 people with opioid use disorder. A…

This early-stage study aimed to understand how the body absorbs and processes buprenorphine when taken as a pill, compared to an injection. Researchers gave 18 healthy volunteers different doses of the medication during short hospital stays to measure drug levels in their blood. …

This Yale University study used brain imaging to understand how vitamin D might affect brain chemistry in people with opioid use disorder. Researchers compared brain scans from a small group of participants with the disorder to healthy volunteers after giving them either vitamin …

This study aimed to understand the connection between how people with opioid addiction experience pain and their cravings for opioids. Researchers enrolled 89 adults with both opioid use disorder and chronic pain. Participants attended a single session where they received brief e…

This study used brain imaging to understand how CBD might help people with opioid addiction. Researchers scanned the brains of 66 people on methadone treatment after giving them either CBD or a placebo. The goal was to see how CBD affects brain activity and chemistry related to d…

This study tested a new web-based toolkit designed to help jail staff provide better care for pregnant women with opioid addiction. Jail staff at four locations used the toolkit and shared their experiences through surveys and interviews over a year. The goal was to understand wh…