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Mindfulness may boost opioid treatment success

NCT ID NCT05042388

Completed Disease control Sponsor: West Chester University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding mindfulness-based relapse prevention (MBRP) to standard care helps people with opioid use disorder stay on their medication (extended-release naltrexone) and avoid drug use after leaving a residential treatment program. About 105 participants were randomly assigned to either MBRP or usual treatment and followed for three months after discharge. The goal was to see if MBRP improves medication adherence and reduces opioid relapse and craving.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Mindfulness-Based Relapse Prevention (MBRP) behavioral therapy
What this could lead to
If it works, this could offer a practical way to help people with opioid use disorder stay on their medication and reduce the chance of relapse after leaving residential treatment.
What could go wrong
This is a small, completed study (105 participants) testing a behavioral program, not a new drug. Results may not apply to everyone, and the benefits may be modest or hard to maintain long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Behavior, Addictive opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID-USE DISORDER

Contacts and locations

Locations

  • Gaudenzia, Inc. (West Chester House)

    West Chester, Pennsylvania, 19382, United States

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