Could a bipolar medication curb cocaine use in opioid patients?
NCT ID NCT05063201
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a low dose of cariprazine, a medication used for bipolar disorder, could help people with both opioid and cocaine use disorders reduce cocaine use. Participants were already stable on buprenorphine-naloxone for opioid use. The trial lasted about 11 weeks, with 26 participants receiving either cariprazine or a placebo, and urine tests tracked cocaine use. The goal was to see if cariprazine could lower the number of cocaine-positive urine samples.
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Conditions
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Locations
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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