COCAINE USE DISORDER

This study is testing if a smartphone app can help people who use both opioids and cocaine stay in methadone treatment longer and use drugs less often. Participants are randomly assigned to receive either standard methadone treatment or the same treatment plus the app. The app as…

This study is testing if a smartphone app that gives cash rewards can help people with opioid, cocaine, or methamphetamine addiction stay drug-free. The app tracks participants' progress with at-home drug tests and rewards them with money for clean results. Researchers want to se…

This study is testing if adding the medication pioglitazone to standard talk therapy (CBT) can better help people stay off cocaine after they've recently quit. Researchers want to see if the drug can help repair brain damage from cocaine use, which might make the therapy more eff…

This UCLA study is checking if a single 25mg dose of psilocybin (the active compound in 'magic mushrooms') is safe for people trying to quit cocaine. Ten participants with cocaine addiction will take the capsule in a supervised lab setting while researchers monitor their heart ra…

This study is testing if semaglutide, a medication currently used for diabetes and weight loss, can help people with cocaine addiction. Researchers will give the drug alongside cognitive behavioral therapy to 75 participants to see if it reduces cravings and actual cocaine use. T…

This study is testing whether a combination of gentle brain stimulation and mental training can help people with cocaine addiction reduce their cravings. Researchers will enroll 120 adults with cocaine use disorder to receive either real or fake stimulation while practicing techn…

This early-stage study is testing whether a medication called pentoxifylline can reduce the rewarding effects of cocaine. It will involve about 30 adults with cocaine use disorder who are not currently seeking treatment. In a controlled lab setting, researchers will see if taking…

This study is testing if a medication called clonidine can help reduce cravings in people hospitalized for cocaine or crack addiction. It will compare clonidine to another medication, clonazepam, over two weeks. The main goal is to see which drug better lowers the patients' self-…

This study aims to understand how cocaine addiction physically changes the brain. Researchers will use special brain scans (PET and MRI) to compare the brain connections of 80 people with cocaine addiction to those of healthy volunteers. The goal is to measure differences in brai…

This early study aims to understand how brain chemistry changes when people use both opioids and cocaine, and whether a dietary supplement called NAC can help. Researchers will enroll 24 adults who use both drugs and are not seeking treatment. They will measure brain activity and…

This study aims to better understand a specific behavioral problem linked to crack-cocaine addiction. Researchers will observe 20 people with severe crack addiction by having them wear a wrist-worn activity tracker for three weeks to see how their movement and sleep change around…