COCAINE USE DISORDER

This study tests two ways of giving rewards to encourage people with opioid or cocaine use disorder to stay drug-free. 600 adults will use a smartphone app that tracks drug tests and offers incentives that either increase or decrease over time. The goal is to see which approach h…

This study tests whether a smartphone app can help people who are already on methadone for opioid use disorder also reduce their use of cocaine and opioids. About 240 adults who use both opioids and cocaine will either get standard methadone treatment or standard treatment plus t…

This study is testing whether semaglutide, a medicine used for diabetes and weight loss, can help people with cocaine use disorder reduce their cravings and use of cocaine. About 75 adults who meet the criteria for cocaine use disorder and have a BMI of 25 or higher will receive …

This early-stage study tests whether pentoxifylline, an anti-inflammatory drug, can reduce the rewarding effects of cocaine in 30 adults with cocaine use disorder. Participants will choose between cocaine and money to see if the drug lowers cocaine's appeal. The goal is to find a…

This study tests whether a gentle brain stimulation technique called tDCS can help people with cocaine addiction feel less craving. 120 adults will receive the stimulation while doing thinking tasks, and researchers will use brain scans to see how it works. The goal is to develop…

This study tests whether clonidine, a drug typically used for high blood pressure, can help reduce cravings in people hospitalized for cocaine or crack use disorder. 36 participants will be randomly assigned to receive either clonidine or an active placebo (clonazepam). The main …

This study looks at how crack cocaine affects movement and sleep. Researchers will have 20 people with severe crack addiction wear a device that tracks their activity for 3 weeks. They also take blood tests to look for biological markers. The goal is to better understand a behavi…

This study uses a special brain scan (PET) to compare the density of connections between brain cells in people with cocaine use disorder versus healthy volunteers. Researchers aim to understand how cocaine affects brain wiring. Participants undergo imaging and assessments, but no…

This study follows 32 people with cocaine use disorder during inpatient detox to see how their sleep changes from active use through early and late withdrawal. Using wearable devices and hormone tests, researchers will compare objective sleep data with how well participants feel …