COCAINE USE DISORDER

This study tested whether psilocybin, the active ingredient in magic mushrooms, could help people reduce or stop using cocaine. Forty adults who wanted to quit cocaine were given either psilocybin or a placebo (diphenhydramine, an antihistamine) in a controlled setting. Researche…

This early-stage trial tested whether a drug called STP7 (mavoglurant) can safely reduce the physical and psychological effects of cocaine in 21 adults who use cocaine but are not seeking treatment. Participants received either STP7 or a placebo, then were given intravenous cocai…

This study looked at whether pioglitazone, a drug used for diabetes, can help people who recently stopped using cocaine stay off the drug when combined with talk therapy. 61 adults with cocaine use disorder took part. The goal was to see if the drug improves brain health and redu…

This study tested whether a low dose of cariprazine, a medication used for bipolar disorder, could help people with both opioid and cocaine use disorders reduce cocaine use. Participants were already stable on buprenorphine-naloxone for opioid use. The trial lasted about 11 weeks…

This study tested whether a combination of two extended-release medications (naltrexone and buprenorphine) could help adults reduce cocaine use. Over 400 people who wanted to cut back or quit cocaine took part. The approach uses monthly injections to manage cravings and use, aimi…

This study tested whether combining a brain stimulation technique called theta burst stimulation (TBS) with the medication N-acetylcysteine (NAC) could reduce cocaine cravings and brain responses to cocaine-related images. Thirty-two adults with cocaine use disorder participated.…

This study tested whether low-intensity focused ultrasound (LIFU) can safely reduce cravings in people with cocaine use disorder. 25 adults received either real or fake (sham) ultrasound while their brain activity was measured with MRI. The goal was to see if LIFU lowers craving …

This study tested whether a single dose of the antibiotic minocycline, given before guided memory recall, could reduce the strength of intrusive memories in people with PTSD or cocaine use disorder. 138 participants took either minocycline or a placebo and then imagined a persona…

This completed study looked at how genes influence addiction and related behaviors. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, drug users, and people with psychiatric disorders) complete questionnaires and computer tasks. The goal was to …

This study looked at how the supplement n-acetylcysteine (NAC) affects brain glutamate levels and drug cravings in 12 people who use both opioids and cocaine. Participants were given either NAC or a placebo while on a steady dose of hydromorphone, and then underwent brain scans a…

This study tested whether a drug called SXC-2023 interacts with cocaine in the body. Nineteen adults who use cocaine but were not seeking treatment took part. Researchers measured side effects and vital signs like heart rate and blood pressure after giving cocaine. The goal was t…

This study tested whether a mental exercise called Episodic Future Thinking (EFT) could change how people with cocaine use disorder make decisions and reduce their cocaine use. 141 participants were asked to vividly imagine positive future events or control events. Researchers me…

This study looked at whether brain signals and thinking skills can predict how well Veterans with cocaine addiction respond to a behavioral therapy called contingency management. In this therapy, patients earn chances to win prizes for providing cocaine-free urine samples. The go…