COCAINE USE DISORDER
Clinical trials for COCAINE USE DISORDER explained in plain language.
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New drug combo shows promise in cocaine addiction trial
Disease control CompletedThis study tested whether a combination of two long-acting medications (naltrexone and buprenorphine) can help people reduce or stop cocaine use. Over 400 adults who wanted to cut down on cocaine received either the drug combo or placebo injections for 8 weeks. The main goal was …
Matched conditions: COCAINE USE DISORDER
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated May 17, 2026 02:07 UTC
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Could a pill tame Cocaine's effects? new study investigates
Disease control CompletedThis study tested whether a drug called STP7 (mavoglurant) can safely change how cocaine affects the body and mind. Twenty-one adults who used cocaine but were not seeking treatment received either STP7 or a placebo, then were given intravenous cocaine. Researchers measured heart…
Matched conditions: COCAINE USE DISORDER
Phase: PHASE1 • Sponsor: Stalicla SA • Aim: Disease control
Last updated May 17, 2026 02:04 UTC
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Could a diabetes pill help cocaine users stay clean?
Disease control CompletedThis study looked at whether pioglitazone, a drug used for diabetes, can help people who recently stopped using cocaine stay off it when combined with counseling. 61 adults with cocaine use disorder took part. The goal was to see if the drug improves brain health and reduces crav…
Matched conditions: COCAINE USE DISORDER
Phase: PHASE2 • Sponsor: The University of Texas Health Science Center, Houston • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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Could a tiny daily pill curb cocaine cravings in opioid patients?
Disease control CompletedThis study tested whether a low dose of cariprazine (1.5 mg daily) can help people who are already stable on buprenorphine-naloxone for opioid use disorder also reduce or stop cocaine use. About 26 adults with both opioid and cocaine use disorders took either cariprazine or a pla…
Matched conditions: COCAINE USE DISORDER
Phase: PHASE2 • Sponsor: Kyle Kampman • Aim: Disease control
Last updated Apr 29, 2026 15:15 UTC
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Antibiotic may help dull painful memories in PTSD and addiction
Symptom relief CompletedThis study tested whether minocycline, an antibiotic, can reduce intrusive memories in people with PTSD or cocaine use disorder. 138 adults participated, and researchers measured changes in memory frequency and brain activity. The goal was to see if blocking a certain enzyme coul…
Matched conditions: COCAINE USE DISORDER
Phase: NA • Sponsor: Psychiatric University Hospital, Zurich • Aim: Symptom relief
Last updated May 15, 2026 11:55 UTC
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Can a supplement curb cocaine cravings during opioid withdrawal?
Knowledge-focused CompletedThis early-phase study looked at how brain glutamate levels change in people dependent on opioids who also use cocaine. Researchers tested whether the supplement N-acetylcysteine (NAC) could reduce cocaine and opioid demand during withdrawal. Twelve participants completed the stu…
Matched conditions: COCAINE USE DISORDER
Phase: EARLY_PHASE1 • Sponsor: William Stoops • Aim: Knowledge-focused
Last updated May 17, 2026 02:04 UTC
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Can imagining tomorrow curb cocaine cravings today?
Knowledge-focused CompletedThis study looked at whether a technique called Episodic Future Thinking (imagining positive future events) could help people with cocaine use disorder make less impulsive decisions and reduce their desire for cocaine. 141 adults who wanted to cut down on cocaine use participated…
Matched conditions: COCAINE USE DISORDER
Phase: NA • Sponsor: Virginia Polytechnic Institute and State University • Aim: Knowledge-focused
Last updated May 17, 2026 02:01 UTC
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Veterans' brain waves could hold key to cocaine recovery
Knowledge-focused CompletedThis study looked at brain signals and thinking skills in 63 Veterans with cocaine use disorder to understand how a behavioral treatment called Contingency Management (CM) works. CM uses rewards to encourage staying drug-free, but it doesn't work for everyone. Researchers measure…
Matched conditions: COCAINE USE DISORDER
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated May 11, 2026 20:53 UTC