Could a Two-Drug combo curb cocaine cravings? new study says maybe
NCT ID NCT05262270
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a combination of two extended-release medications (naltrexone and buprenorphine) could help adults reduce cocaine use. Over 400 people who wanted to cut back or quit cocaine took part. The approach uses monthly injections to manage cravings and use, aiming for better control of the disorder.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Addictions Institute of Mount Sinai
New York, New York, 10029, United States
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Berman Center for Outcomes and Clinical Research at Hennepin Healthcare
Minneapolis, Minnesota, 55404, United States
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Center on Substance Use and Health (CSUH)
San Francisco, California, 94102, United States
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Cove Behavioral Health
Tampa, Florida, 33605, United States
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Mountain Manor Treatment Center
Baltimore, Maryland, 21229, United States
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UCLA Vine Street Clinic
Los Angeles, California, 90038, United States
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UTSW Medical Center, Center for Depression Research and Clinical Care
Dallas, Texas, 75247, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35209, United States
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University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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University of Illinois at Chicago
Chicago, Illinois, 60608, United States
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University of Texas Health San Antonio
San Antonio, Texas, 78229, United States