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Weight-Loss drug may curb stimulant cravings, brain scans suggest

NCT ID NCT07693608

Not yet recruiting Disease control Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tests whether tirzepatide, a drug approved for weight management, can help people who are obese and have a moderate to severe stimulant use disorder (like methamphetamine or cocaine). Participants receive weekly injections for 20 weeks, along with counseling and brain scans (fMRI) to track changes. The goal is to see if the drug reduces drug use and body weight, and to identify brain markers linked to success.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
tirzepatide
What this could lead to
If it works, this could point toward a new treatment that helps people with stimulant addiction lose weight and reduce drug use.
What could go wrong
This is a small early-stage pilot study with only 45 participants, so results may not apply broadly. Tirzepatide can cause nausea, vomiting, and other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cocaine dependence methamphetamine dependence Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COCAINE USE DISORDER METHAMPHETAMINE USE DISORDER OBESITY STIMULANT USE DISORDERS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UT Southwestern Medical Center

    Dallas, Texas, 75247, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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