Methamphetamine dependence

This study tests whether a virtual session with a peer recovery coach can help incarcerated adults with substance use disorders connect to addiction treatment and recovery resources. About 550 participants in jail will either get the coaching or just standard information. Researc…

This study examines whether adding structured high-intensity physical exercise to a 3-month residential treatment program for substance use disorder improves patients' physical health, mental health, and quality of life. Researchers measure changes in oxygen uptake, leg strength,…

This study tests an experimental drug called CS-1103 in 40 healthy adults with methamphetamine use disorder who are not seeking treatment. Participants receive a single dose of methamphetamine along with CS-1103 to see if the drug can safely reduce the effects of intoxication. Th…

This trial tests whether a helmet that delivers focused ultrasound waves can safely change brain activity in people with moderate-to-severe substance use disorder who haven't responded to medication. Participants receive two MRI-guided sessions targeting brain regions linked to a…

This phase 2 trial tests whether mirtazapine, an antidepressant, can help adults who are already receiving medication for opioid use disorder to stop or reduce their methamphetamine use. Participants are randomly assigned to receive either mirtazapine or a placebo for 10 weeks, a…

This early-stage trial is testing whether low-intensity focused ultrasound (LIFU) can safely help people with opioid or other substance use disorders. The device sends sound waves to specific brain areas to calm cravings. 29 adults in outpatient treatment will receive both real a…

This study compares two patient navigation models for people recently involved in the criminal legal system who have substance use disorders. One group gets standard navigation, while the other can choose from a menu of services like in-person clinics, mobile health units, or tel…

This study tests a new type of brain stimulation that sends paired pulses to the cerebellum and prefrontal cortex. The goal is to reduce cravings and improve cognitive flexibility in 90 adults with moderate to severe methamphetamine use disorder. Participants will receive either …

This study tests whether a program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) can help people reduce risky alcohol and drug use. About 400 adults visiting family planning clinics will either get SBIRT or usual care. Researchers will track changes in d…

This study tests whether a drug called troiluzole can reduce the appeal of methamphetamine for people with methamphetamine use disorder. About 40 adults who use meth but are not seeking treatment will take the drug and then choose between meth and money in a lab setting. The goal…

This study tests whether pentoxifylline, an anti-inflammatory drug, can reduce how rewarding cocaine feels. Thirty adults with cocaine use disorder who are not seeking treatment will take the drug and then choose between cocaine and money. The goal is to see if calming immune inf…

This study tests whether reducing methamphetamine use—without requiring complete abstinence—can improve health and quality of life. Researchers will give 300 adults with methamphetamine use disorder payments for providing drug-free urine samples over 12 weeks. They will measure b…

This study tests whether semaglutide (Wegovy), a drug used for diabetes and weight loss, can help people with moderate to severe methamphetamine use disorder cut back or stop using. The trial has two parts: a small pilot study with 25 people, followed by a larger randomized trial…

This study tests whether a mobile app can help people in addiction treatment avoid relapse. 150 participants will either receive standard care or standard care plus the app, which monitors warning signs and sends alerts. The goal is to see if the app improves long-term recovery.

This pilot study tests a personalized deep brain stimulation (DBS) method for people with severe, treatment-resistant substance use disorders. Ten participants will first undergo detox, then have temporary electrodes placed in their brains to map addiction-related circuits, follo…

This study tests a program that gives rewards (like gift cards) to people in Hawaii who are trying to stop using methamphetamine after a serious injury. 40 adults who were hospitalized and tested positive for meth will visit a clinic up to three times a week for urine tests. Rese…

This study tests a new behavioral program called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines 12-step facilitation with motivational and cognitive-behavioral therapy. Researchers will compare it to standard therapy to see if it leads to more day…

This study looks at whether giving a high-dose prescription stimulant (lisdexamfetamine) for 25 weeks is feasible and acceptable for people with moderate to severe methamphetamine use disorder. About 80 participants will receive either the drug or a placebo alongside their usual …

This study tests a smartphone app designed to strengthen self-control in teens and young adults (ages 14-35) being treated for alcohol or cocaine use disorder. Participants will complete 12 short training sessions over about a month, plus booster sessions. The goal is to see if t…

This study tests whether giving financial incentives for negative drug tests can help people with opioid, cocaine, or methamphetamine use disorder stay abstinent. Six hundred participants use a smartphone app to submit saliva tests. Some receive escalating or de-escalating reward…

This study tests whether adding a high-dose stimulant medication and/or a reward-based program (contingency management) to standard care helps people reduce how often they use methamphetamine. About 440 adults with moderate to severe methamphetamine use disorder will be randomly …

This study tests whether trained peer recovery specialists can help Black individuals with substance use stick to their long-acting injectable HIV treatment or prevention. 186 participants will either get this peer support or standard care. The goal is to see if the peer program …

This early-stage study will test whether psilocybin, the active ingredient in magic mushrooms, is safe and tolerable for people trying to quit methamphetamine. Twenty adults in northern Louisiana who want to stop using meth will receive psilocybin in a controlled setting. Researc…

This study tests whether an accelerated form of Transcranial Magnetic Stimulation (TMS) can help people with moderate to severe methamphetamine use disorder. Twenty participants will receive either real or sham TMS to the brain's prefrontal cortex. Researchers will check if the t…

This study tests whether deep transcranial magnetic stimulation (dTMS) can help veterans with methamphetamine use disorder. Researchers will stimulate a brain region called the insula, which is involved in cravings and decision-making. Thirty veterans will receive either real or …

This study tests whether a 'practice coaching' program can help opioid treatment clinics offer more HIV and hepatitis C testing to their patients. Clinics are randomly assigned to receive either coaching focused on HIV testing, coaching that adds hepatitis C testing, or just info…

This pilot trial tests a counseling program called CHOICES-PLEAS for women in a jail-based substance use treatment program. The goal is to reduce the risk of substance-exposed pregnancies by helping women change their substance use and risky sexual behaviors. Participants receive…

This study tests two approaches to help men who have sex with men and use methamphetamine start or restart HIV prevention (PrEP) or treatment (ART). 400 participants will receive either contingency management (rewards for filling prescriptions) alone or combined with motivational…

This study tests whether adding a trained family advocate to a proven parenting program can help prevent substance use and reduce childhood trauma. About 360 families from 36 high-risk communities in New Jersey will take part. The goal is to see if extra support makes the program…

This study tests a web-based platform called KulaMind-Recovery designed to help loved ones of people recovering from substance use disorders. The platform offers skill-building modules, one-on-one video sessions, text-based coaching, and a community forum. Researchers will see if…

This study is testing whether music therapy can help people with substance use disorder. 600 participants across Europe will be randomly assigned to either active music-making, music listening, or standard treatment. The goal is to see if music therapy improves addiction severity…

This early study tests whether combining a non-invasive brain stimulation technique (rTMS) with a mental exercise called Episodic Future Thinking (imagining positive future events) can help people with methamphetamine use disorder make less impulsive choices and reduce their desi…

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study tests whether peer support workers—people with lived experience of substance use—can help people who use drugs feel safer and stay in the emergency department until their care is complete. The study will compare what happens when peer workers are on shift versus when t…

This study tests whether a special team of doctors, nurses, and peer supporters can help people with substance use disorders get the follow-up care they need after a hospital stay. The team meets patients in the hospital and provides support and treatment after they leave, helpin…

This study follows 700 people with substance use disorders over two years to see how addiction symptoms, especially craving, are connected and whether those connections change as addiction severity shifts. Participants complete annual diagnostic assessments and two-week periods o…

This study tests a bundle of smartphone-based tools, including a mobile health app and other online resources, to see if they are practical and helpful for people who use drugs. The goal is to lower overdose risk by improving access to prevention services. Forty participants will…

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study aims to see if a digital version of the WHO's mental health guide for substance use disorders can be used effectively in primary care settings in Pakistan. Researchers will train 300 primary care doctors in three major cities using this digital tool. The goal is to und…

This study looks at whether using a special counseling style called Motivational Interviewing during the first visit can help people stay in addiction treatment. Researchers will compare this approach to the usual intake process. About 150 adults seeking outpatient addiction trea…

This study looks at heart electrical patterns (ECGs) in 240 people hospitalized for methamphetamine use, comparing those with and without psychosis. Researchers will check ECGs at admission and before discharge to see if psychosis is linked to more heart strain. The goal is to be…

This study measures two blood proteins, LRFN5 and OLFM4, in people with methamphetamine use disorder, those with methamphetamine-induced psychosis, and healthy volunteers. Researchers want to see if these markers are linked to inflammation and symptom severity. The study involves…

This study looks at whether a tool called MyPath helps women with substance use disorder make better decisions about birth control after having a baby. About 400 women will use the tool during pregnancy or right after delivery. The goal is to see if it helps them pick a method th…

This study is looking at 120 people who are already in treatment for abusing opioids and/or benzodiazepines (anti-anxiety drugs). Researchers want to understand why people use these drugs together, which greatly raises the risk of overdose and death. Participants will complete in…

This study aims to develop and test a supervision strategy for clinical supervisors in substance use disorder treatment programs. The goal is to reduce counselor burnout and turnover, and improve their well-being and performance. About 43 supervisors and counselors from residenti…

This study is testing a cooking and nutrition program for 50 people in Texas who are recovering from opioid use and living in recovery homes while on medication therapy. The program aims to improve their eating habits and confidence in cooking skills. Participants will fill out q…

This study is following 10,000 people who are seeking help for substance or behavioral addictions. Researchers will track their medical, brain, social, and psychological health over several years using interviews, questionnaires, and cognitive tests. The goal is to better underst…

This study looks at whether having a specially trained peer recovery specialist in the emergency department helps people with substance use disorders connect to treatment and support services. Researchers will follow 400 adults who visit the ER for substance-related issues, compa…