Methamphetamine dependence

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This trial explores whether a single dose of psilocybin, combined with motivational support therapy, can help people with HIV who have moderate-to-severe methamphetamine use disorder reduce or stop their meth use. Participants will be randomly assigned to receive either a higher …

This trial tests a program called ROOTS that places substance use counselors and peer recovery specialists directly in rural schools. The goal is to see if this approach helps teens who are referred or seek help on their own to engage in treatment and reduce their substance use. …

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This trial tests whether adding a relational health enhanced parenting support (RHEP) program to standard family-focused peer recovery services helps parents with substance use disorders. The study compares outcomes like parenting satisfaction, treatment retention, and substance …

This study tests whether a program called CourtConnect, where peer recovery specialists meet with people in courthouses, can increase substance use disorder treatment and reduce overdose and incarceration. The program provides information, referrals, and up to three months of fol…

This pilot study investigates whether adding Dialectical Behavior Therapy (DBT)-informed principles to standard short-term inpatient substance abuse treatment helps patients better manage emotions and reduce symptoms. About 70 adults in a 12-week program will either receive usual…

This study tests a new eight-session group therapy program for adults hospitalized with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and behavioral activation to help participants manage cravings and develop alternati…

This study tests whether tirzepatide, a drug approved for weight management, can help people who are obese and have a moderate to severe stimulant use disorder (like methamphetamine or cocaine). Participants receive weekly injections for 20 weeks, along with counseling and brain …

This phase 2 trial will test whether semaglutide, the drug in Ozempic, can help people with methamphetamine use disorder cut down their use. Forty adults who use methamphetamine at least 14 days per month will receive weekly injections for 12 weeks. The study will check if the tr…

This study tests whether a new four-session group program, called the First Step Program, can be delivered in hospital settings and help people with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and group support to bo…

This pilot study will test a clinic that treats both heart failure and methamphetamine use disorder at the same time. Fifty adults with heart failure and active meth use will receive counseling, incentives for staying clean, and optional addiction medications, plus standard heart…

This study will test an app called JomCare that sends personalized support to men who have sex with men when they are most likely to engage in chemsex (using drugs before or during sex). The goal is to reduce risky behaviors and prevent new HIV infections. About 482 HIV-negative …

This study tests whether offering rewards (contingency management) can help people who use methamphetamine reduce their use after a traumatic injury. Twenty adults admitted to the hospital with a positive meth test will receive urine tests and rewards for negative results, starti…

This study will bring medication for addiction and cognitive behavioral therapy to homeless veterans living in VA supportive housing. The goal is to help them stay housed and reduce substance use. About 8,000 veterans across multiple VA sites will take part.

This study tests if adding a safe dye to a drink can prove that urine samples are real and not tampered with. About 114 adults with substance use disorder will drink Gatorade with or without the dye, then provide a urine sample 15 minutes later. Researchers will check for the dye…

This study tests whether a social network approach can encourage people who inject drugs to start HIV prevention medication (PrEP) and addiction treatment (MOUD). About 398 participants will be assigned to either the LINKED intervention or a control group. The goal is to see if p…

This study tests two smartphone tools to help HIV-negative men who have sex with men take their daily HIV prevention pill (PrEP) regularly and reduce methamphetamine use. One hundred men with mild to moderate meth use disorder will use the apps for 6 months. Researchers will chec…

This trial tests whether Narrative Enhancement and Cognitive Therapy (NECT), a 12-session group program, can help adults with severe mental health disorders — including substance use disorders — overcome self-stigma and promote personal recovery. About 106 participants receiving …

This study tests a new 8-session group program designed to help people with substance use disorder better understand and regulate their emotions. About 20 adults receiving inpatient care at two hospitals in Korea will take part. The program combines motivational interviewing and …

This study tests whether a behavioral method called Emotional Brain Training (EBT) can help people in recovery from addiction manage stress, anxiety, and cravings. About 54 adults receiving standard addiction treatment will either continue their usual care or also attend weekly E…

This study tests whether equine-assisted therapy (working with horses) can improve mental health and reduce cravings in people recovering from addiction. Twenty-two adults who have completed detox will be randomly assigned to either receive 22 sessions of equine therapy over 24 w…

This study will give a single dose of oral methamphetamine to 20 people with HIV who are on effective antiretroviral therapy and have undetectable virus levels. The goal is to see if the drug can temporarily wake up dormant HIV hiding in cells, which could help researchers find n…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study looks at whether adding a clinical pharmacist to community mental health teams (called FACT teams) helps people with severe mental illness and substance use disorders feel better and manage their medications more effectively. About 160 adults will take part, and the st…

This study will observe 60 adults in residential therapeutic communities in Mexico to understand how recovery from substance use unfolds over time. Participants will answer quick mobile surveys several times a day about cravings, mood, and social interactions for 8 to 12 weeks. T…

This study tests if a 12-week one-on-one support program is easy to complete and acceptable for people supporting a loved one who recently finished substance use treatment. About 18 participants will attend weekly telehealth sessions and complete surveys and interviews. The goal …

This study will test a new visual scale designed to help people who use methamphetamine estimate how much they use each day. Researchers will compare the scale's results with hair samples and other methods to see if it is accurate and easy to use. About 100 people aged 20-40 who …

This study will test if simple, bedside heart tests (ultrasound, EKG, and blood tests) can accurately detect heart problems in pregnant women who regularly use methamphetamine. Researchers will compare these quick tests to a full heart ultrasound. The goal is to find a faster, ea…