Can methamphetamine help uncover hidden HIV? a new study investigates

NCT ID NCT07584369

Not yet recruiting Knowledge-focused Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will give a single dose of oral methamphetamine to 20 people with HIV who are on effective antiretroviral therapy and have undetectable virus levels. The goal is to see if the drug can temporarily wake up dormant HIV hiding in cells, which could help researchers find new ways to target the viral reservoir. Participants will be closely monitored for changes in HIV activity and immune responses.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oral methamphetamine
What this could lead to: If successful, this could identify new ways to flush out hidden HIV, potentially pointing toward strategies to reduce the viral reservoir.
What could go wrong: This is a very small, early-phase study with only 20 participants. The drug itself carries risks, and the findings may not translate into a cure or benefit for all people with HIV.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease methamphetamine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV-1-INFECTION METHAMPHETAMINE USE

Contacts and locations

Locations

University of California, San Francisco

San Francisco, California, 94110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.