HIV-1-INFECTION

This early-stage study tests whether a single dose of an experimental drug called IAP086 is safe in 30 adults with HIV whose virus is already well-controlled by standard antiretroviral therapy. Participants receive one intravenous infusion and are monitored closely for 28 days. T…

This early-stage study tests a new antibody called BNT351 in 67 adults, both with and without HIV. The goal is to check safety, how long the antibody stays in the blood, and whether it can lower HIV levels in people with the virus. It is a first step toward possibly controlling H…

This study offers continued access to HIV medications for children and adolescents who completed a previous Gilead HIV treatment study. About 350 participants will receive their study drug or switch to a standard HIV medication, and researchers will monitor for side effects. The …

This study tests whether a special T-cell vaccine, combined with an immune-boosting drug (vesatolimod) and two powerful antibodies, can help people with HIV control the virus without needing daily antiretroviral therapy. The trial involves 36 adults who started HIV treatment soon…

This study tests a daily combination pill (TLD) as first-line HIV treatment for 100 people who became infected with HIV despite receiving long-acting cabotegravir PrEP in the past year. Researchers will check if the pill can suppress the virus to undetectable levels after 6 month…

This phase 2 trial tests whether adding tesamorelin (a growth-hormone-releasing hormone analogue) to a home-based exercise program can improve physical function in 100 adults aged 50-80 with HIV. Participants are randomly assigned to receive tesamorelin or a placebo injection dai…

This study is testing a long-acting injectable medication for children aged 2 to 12 who have HIV and whose virus is already under control. The goal is to see if switching from daily pills to a shot given every few weeks is safe, tolerable, and effective. About 90 children will pa…

This study tests whether semaglutide (Ozempic) helps people with HIV and obesity lose more weight than diet and exercise alone. About 80 participants will receive either semaglutide injections or standard lifestyle advice for 28 weeks. Researchers will also check how the drug aff…

This study tests a long-acting HIV medicine called lenacapavir (Sunlenca®) in 12 adolescents and children with HIV who have tried other treatments. Participants take lenacapavir as pills and injections along with their other HIV drugs. The goal is to see if the combination is saf…

This study tests a phone-based therapy called Acceptance and Commitment Therapy (ACT) to help people with HIV who drink heavily. The goal is to reduce alcohol use and improve symptoms of depression and anxiety. 300 participants will be randomly assigned to ACT or a standard brief…

This study compares two HIV medications, doravirine and dolutegravir, in people who have never taken HIV treatment before. About 610 adults with HIV-1 will receive one of these drugs along with standard medicines. The goal is to see if doravirine works just as well as dolutegravi…

This study is testing an experimental drug called CL-197 in 24 adults with HIV-1 who have never taken any anti-HIV drugs. The goal is to see if a single dose can lower the amount of virus in the blood and to check for side effects. Participants will be monitored for about two wee…

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

This trial looks at what to do when the HIV virus becomes resistant to the drug dolutegravir. It compares staying on dolutegravir versus switching to another drug combination (darunavir/ritonavir) to see which better lowers the virus level. About 392 people with HIV and specific …

This study is testing a new rapid diagnostic device called TruPlex that can detect HIV, Hepatitis B, and Syphilis from a small blood sample. Researchers will enroll 1000 adults at risk for these infections to see how accurate and easy the test is to use in clinics and point-of-ca…

This early-stage study tests a vaginal gel containing specially modified bacteria that produce an anti-HIV drug. The goal is to see if it is safe for healthy women and whether it can be cleared with antibiotics. If successful, this could become a long-lasting, woman-controlled HI…

This study will follow 5,000 HIV-negative adults in Italy who are taking PrEP, a daily pill that prevents HIV. Researchers want to see how well PrEP works in real life, how many people stick with it, and what barriers they face. The goal is to use this information to improve HIV …

This study follows 420 adults with HIV whose virus is fully suppressed by medication. Researchers want to see if switching to a different HIV drug regimen causes hidden drug resistance to appear. They will compare people who switch drugs with those who stay on their current treat…

This study looks at how cannabis ingredients (THC and CBD) affect decision-making, attention, and motivation in people with and without HIV. About 138 adults who use cannabis infrequently will take either THC, CBD, or a placebo for 5 days and complete thinking tests and brain flu…

This study looks at how women with HIV in the United States decide to feed their babies, whether by breastfeeding or formula. Researchers will interview mothers and track their choices and health outcomes. The goal is to fill gaps in knowledge and create a national registry to be…

This study looks at how a type of talk therapy for depression changes the gut microbiome, immune system, and brain function in people living with HIV. Researchers will enroll 150 adults with HIV and depression to understand these connections. The goal is to learn more about how t…

This study follows 6,600 people with HIV who have developed resistance to the drug dolutegravir. Researchers want to see if continuing the same medication with extra counseling can still suppress the virus. The goal is to learn more about how resistance develops and how to manage…